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Volumn 48, Issue 4, 2007, Pages 263-272

A radiobiological review on melatonin: A novel radioprotector

Author keywords

Ionizing radiation; Melatonin; Radiobiology; Radioprotective; Radiotherapy; Repair enzyme

Indexed keywords

CELL SIGNALING; DISEASES; ENZYMES; HORMONES; RADIATION EFFECTS; RADIATION SHIELDING; RADIOACTIVITY; RADIOTHERAPY; REPAIR; TISSUE;

EID: 34547107081     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.06070     Document Type: Review
Times cited : (180)

References (65)
  • 3
    • 0037378956 scopus 로고    scopus 로고
    • Taysi, S., Koc, M., Buyukokuroglu, M. E., Alt?nkaynak, K. and Sahin, Y. N. (2003) Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J. Pineal Res. 34: 173-177.
    • Taysi, S., Koc, M., Buyukokuroglu, M. E., Alt?nkaynak, K. and Sahin, Y. N. (2003) Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J. Pineal Res. 34: 173-177.
  • 5
    • 1542651158 scopus 로고    scopus 로고
    • Melatonin Protects Rat Liver against Irradiation-induced Oxidative Injury
    • Koc, M., Taysi, S., Emin Buyukokuroglu, M. and Nuri Sahin, Y. (2003) Melatonin Protects Rat Liver against Irradiation-induced Oxidative Injury. J. Radiat. Res. 44: 211-215.
    • (2003) J. Radiat. Res , vol.44 , pp. 211-215
    • Koc, M.1    Taysi, S.2    Emin Buyukokuroglu, M.3    Nuri Sahin, Y.4
  • 7
    • 2942597644 scopus 로고    scopus 로고
    • Vijayalaxmi, Reiter, R. J., Tan, D. X., Herman, T S. and Thomas, J. R. C. R. (2004) Melatonin As A Radioprotective Agent: A Review. Int. J. Radiation Oncology Biol. Phys. 59: 639-653.
    • Vijayalaxmi, Reiter, R. J., Tan, D. X., Herman, T S. and Thomas, J. R. C. R. (2004) Melatonin As A Radioprotective Agent: A Review. Int. J. Radiation Oncology Biol. Phys. 59: 639-653.
  • 8
    • 27744456655 scopus 로고    scopus 로고
    • Involvement of Peroxiredoxin I in Protecting Cells from Radiation-Induced Death
    • Zhang, B., Su, Y., Ai, G., Wang, Y., Wang, T. and Wang, F. (2005) Involvement of Peroxiredoxin I in Protecting Cells from Radiation-Induced Death. J. Radiat. Res. 46: 305-312.
    • (2005) J. Radiat. Res , vol.46 , pp. 305-312
    • Zhang, B.1    Su, Y.2    Ai, G.3    Wang, Y.4    Wang, T.5    Wang, F.6
  • 9
    • 0033798633 scopus 로고    scopus 로고
    • Antioxidative Effects of Melatonin in Protection Against Cellular Damage Caused by Ionizing Radiation
    • Karbownik, M. and Reiter, R. J. (2000) Antioxidative Effects of Melatonin in Protection Against Cellular Damage Caused by Ionizing Radiation. Proceedings of the Society for Experimental Biology and Medicine. 225: 9-22.
    • (2000) Proceedings of the Society for Experimental Biology and Medicine , vol.225 , pp. 9-22
    • Karbownik, M.1    Reiter, R.J.2
  • 11
    • 0022809670 scopus 로고
    • Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
    • Kasai, H., Crain, P. F., Kuchino, Y., Nishimura, S. A., Ootsuyama, and Tanooka, H. (1986) Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 7: 1849-1851.
    • (1986) Carcinogenesis , vol.7 , pp. 1849-1851
    • Kasai, H.1    Crain, P.F.2    Kuchino, Y.3    Nishimura, S.A.4    Ootsuyama5    Tanooka, H.6
  • 12
    • 0025160599 scopus 로고
    • Modification of DNA bases in mammalian chromatin by radiation-generated free radicals
    • Gajewski, E., Rao, G., Nackerdien, Z. and Dizdaroglu, M. (1990) Modification of DNA bases in mammalian chromatin by radiation-generated free radicals. Biochemistry. 29: 7876-7882.
    • (1990) Biochemistry , vol.29 , pp. 7876-7882
    • Gajewski, E.1    Rao, G.2    Nackerdien, Z.3    Dizdaroglu, M.4
  • 13
    • 0025334691 scopus 로고
    • Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome
    • Wood, ML., Dizdaroglu, M., Gajewski, E. and Essigmann, J. M. (1990) Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry. 29: 7024-7032.
    • (1990) Biochemistry , vol.29 , pp. 7024-7032
    • Wood, M.L.1    Dizdaroglu, M.2    Gajewski, E.3    Essigmann, J.M.4
  • 14
    • 0026592966 scopus 로고
    • 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and and A→X substitutions
    • Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S. and Loeb, L. A. (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and and A→X substitutions. J Biol Chem. 267: 166-172.
    • (1992) J Biol Chem , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 15
    • 0027528412 scopus 로고
    • Repair of DNA containing the oxidatively damaged base, 8-oxoguanine
    • Tchou, J. and Grollman, A. P. (1993) Repair of DNA containing the oxidatively damaged base, 8-oxoguanine. Mutat Res. 299: 277-287.
    • (1993) Mutat Res , vol.299 , pp. 277-287
    • Tchou, J.1    Grollman, A.P.2
  • 16
    • 0025045198 scopus 로고
    • The role of 8-hydroxydeoxyguanosine in carcinogenesis
    • Floyd, R. A. (1990) The role of 8-hydroxydeoxyguanosine in carcinogenesis. Carcinogenesis. 11: 1447-1450.
    • (1990) Carcinogenesis , vol.11 , pp. 1447-1450
    • Floyd, R.A.1
  • 17
    • 0028026878 scopus 로고
    • Radiation-induced formation of 8-hydroxy-2′-deoxyguanosine and its prevention by scavengers
    • Fischer-Nielsen, A., Jeding, I. B. and Loft, S. (1994) Radiation-induced formation of 8-hydroxy-2′-deoxyguanosine and its prevention by scavengers. Carcinogenesis. 15: 1609-1612.
    • (1994) Carcinogenesis , vol.15 , pp. 1609-1612
    • Fischer-Nielsen, A.1    Jeding, I.B.2    Loft, S.3
  • 18
    • 0031901226 scopus 로고    scopus 로고
    • X-radiation induces 8-hydroxy-2′-deoxyguanosine formation in vivo in rat mammary gland DNA
    • Haegele, A. D., Wolfe, P. and Thompson, H. J. (1998) X-radiation induces 8-hydroxy-2′-deoxyguanosine formation in vivo in rat mammary gland DNA. Carcinogenesis. 19: 1319-1321.
    • (1998) Carcinogenesis , vol.19 , pp. 1319-1321
    • Haegele, A.D.1    Wolfe, P.2    Thompson, H.J.3
  • 19
    • 0026347249 scopus 로고
    • Significance and measurement of DNA double strand breaks in mammalian cells
    • Elia, M. C., DeLuca, J. G. and Bradley, M. O. (1991) Significance and measurement of DNA double strand breaks in mammalian cells. Pharmacol Ther. 51: 291-327.
    • (1991) Pharmacol Ther , vol.51 , pp. 291-327
    • Elia, M.C.1    DeLuca, J.G.2    Bradley, M.O.3
  • 20
    • 0032856296 scopus 로고    scopus 로고
    • Ionizing radiation and genetic risks X. The potential "disease phenotypes" of radiation-induced genetic damage in humans: Perspectives from human molecular biology and radiation genetics
    • Sankaranarayanan, K. (1999) Ionizing radiation and genetic risks X. The potential "disease phenotypes" of radiation-induced genetic damage in humans: Perspectives from human molecular biology and radiation genetics. Mutat Res. 429: 45-83.
    • (1999) Mutat Res , vol.429 , pp. 45-83
    • Sankaranarayanan, K.1
  • 21
    • 0021354123 scopus 로고
    • Adaptive response of human lymphocytes to low concentrations of radioactive thymidine
    • Olivieri, G., Bodycote, J. and Wolff, S. (1984) Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science. 223: 594-597.
    • (1984) Science , vol.223 , pp. 594-597
    • Olivieri, G.1    Bodycote, J.2    Wolff, S.3
  • 22
    • 0028983511 scopus 로고
    • Melatonin protects human blood lymphocytes from radiation-induced chromosome damage
    • Vijayalaxmi, Reiter, R. J. and Meltz, M. L. (1995) Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat Res. 346: 23-31.
    • (1995) Mutat Res , vol.346 , pp. 23-31
    • Vijayalaxmi, R.R.J.1    Meltz, M.L.2
  • 23
    • 0029074197 scopus 로고    scopus 로고
    • Vijayalaxmi, Reiter, R. J., Sewerynek, E., Poeggeler, B., Leal, B. Z. and Meltz, M. L. (1995) Marked reduction of radiation-induced micronuclei in human blood lymphocytes pre-treated with melatonin. Radiat Res. 143: 102-106.
    • Vijayalaxmi, Reiter, R. J., Sewerynek, E., Poeggeler, B., Leal, B. Z. and Meltz, M. L. (1995) Marked reduction of radiation-induced micronuclei in human blood lymphocytes pre-treated with melatonin. Radiat Res. 143: 102-106.
  • 24
    • 0030596153 scopus 로고    scopus 로고
    • Vijayalaxmi, Reiter, R. J., Herman, T. S. and Meltz, M. L. (1996) Melatonin and radioprotection from genetic damage: In vivo/in vitro studies with human volunteers. Mutat Res. 371: 221-228.
    • Vijayalaxmi, Reiter, R. J., Herman, T. S. and Meltz, M. L. (1996) Melatonin and radioprotection from genetic damage: In vivo/in vitro studies with human volunteers. Mutat Res. 371: 221-228.
  • 25
    • 0032472921 scopus 로고    scopus 로고
    • Vijayalaxmi, Reiter, R. J., Herman, T. S. and Meltz, M. L. (1998) Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes. Mutat Res. 397: 203-208.
    • Vijayalaxmi, Reiter, R. J., Herman, T. S. and Meltz, M. L. (1998) Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes. Mutat Res. 397: 203-208.
  • 26
    • 0032480027 scopus 로고    scopus 로고
    • Vijayalaxmi, Reiter, R. J., Meltz, M. L. and Herman, T. S. (1998) Melatonin: Possible mechanisms involved in its 'radioprotective' effect. Mutat Res. 404: 187-189.
    • Vijayalaxmi, Reiter, R. J., Meltz, M. L. and Herman, T. S. (1998) Melatonin: Possible mechanisms involved in its 'radioprotective' effect. Mutat Res. 404: 187-189.
  • 27
    • 0021299068 scopus 로고
    • The effects of ionizing radiation on biomembrane structure and function
    • Edwards, J. C., Chapman, D., Cramp, W. A. and Yatvin, M. B. (1984) The effects of ionizing radiation on biomembrane structure and function. Prog Biophys Mol Biol. 43: 71-93.
    • (1984) Prog Biophys Mol Biol , vol.43 , pp. 71-93
    • Edwards, J.C.1    Chapman, D.2    Cramp, W.A.3    Yatvin, M.B.4
  • 28
    • 0025803728 scopus 로고
    • Structural changes in plasma membranes prepared from irradiated Chinese hamster V79 cells as revealed by Raman spectroscopy
    • Verma, S. P. and Sonwalker, N. (1991) Structural changes in plasma membranes prepared from irradiated Chinese hamster V79 cells as revealed by Raman spectroscopy. Radiat Res. 126: 27-35.
    • (1991) Radiat Res , vol.126 , pp. 27-35
    • Verma, S.P.1    Sonwalker, N.2
  • 29
    • 0042335708 scopus 로고    scopus 로고
    • Malondialdehyde and Nitric Oxide Levels in the Plasma of Patients with Advanced Laryngeal Cancer
    • Taysi, S., Uslu, C., Akcay, F. and Sutbeyaz, M. Y. (2003) Malondialdehyde and Nitric Oxide Levels in the Plasma of Patients with Advanced Laryngeal Cancer. Surg. Today. 33: 651-654.
    • (2003) Surg. Today , vol.33 , pp. 651-654
    • Taysi, S.1    Uslu, C.2    Akcay, F.3    Sutbeyaz, M.Y.4
  • 30
    • 0036561098 scopus 로고    scopus 로고
    • Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer
    • Bakan, E., Taysi, S., Polat, M. F., Dalga, S., Umudum, Z., Bakan, N. and Gumus, M. (2002) Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol. 32: 162-166.
    • (2002) Jpn J Clin Oncol , vol.32 , pp. 162-166
    • Bakan, E.1    Taysi, S.2    Polat, M.F.3    Dalga, S.4    Umudum, Z.5    Bakan, N.6    Gumus, M.7
  • 31
    • 34547098309 scopus 로고    scopus 로고
    • Dale, W. M., Gray, L. H. and Meredith, W. J. (1949) The inactivation of an enzyme (Carboxypeptidase) by X- and α-radiation. Philos Trans R Soc Lond A Math Phy Sci. 242: 33-62.
    • Dale, W. M., Gray, L. H. and Meredith, W. J. (1949) The inactivation of an enzyme (Carboxypeptidase) by X- and α-radiation. Philos Trans R Soc Lond A Math Phy Sci. 242: 33-62.
  • 32
    • 0000416892 scopus 로고
    • Cysteine protection against X irradiation
    • Patt, H. M., Tyree, E. B., Straube, R. L. and Smith, D. E. (1949) Cysteine protection against X irradiation. Science. 110: 213-214.
    • (1949) Science , vol.110 , pp. 213-214
    • Patt, H.M.1    Tyree, E.B.2    Straube, R.L.3    Smith, D.E.4
  • 33
    • 77951316832 scopus 로고
    • Protection contre le rayonnement X par la [graphic not provided] mercaptoethylamine
    • Becq, Z. M., Herve, A. and Lecomte, J. (1951) Protection contre le rayonnement X par la [graphic not provided] mercaptoethylamine. Arch Int Physiol. 59: 442-447.
    • (1951) Arch Int Physiol , vol.59 , pp. 442-447
    • Becq, Z.M.1    Herve, A.2    Lecomte, J.3
  • 35
    • 0019304979 scopus 로고
    • The role of WR-2721 in radiotherapy and/or chemotherapy
    • Yuhas, J. M., Spellman, J. M. and Culo, F. (1980) The role of WR-2721 in radiotherapy and/or chemotherapy. Cancer Clin Trials. 3: 211-216.
    • (1980) Cancer Clin Trials , vol.3 , pp. 211-216
    • Yuhas, J.M.1    Spellman, J.M.2    Culo, F.3
  • 38
    • 34547124525 scopus 로고    scopus 로고
    • Schuchter, L. M. and Glick, J. H. (1993) The current status of WR-2721 (amifostine): A chemotherapy and radiotherapy protector. In: Biologic therapy of cancer updates. EDs. DeVita, VT. Hellman, S. and Rosenberg, SA. pp. 1-10, Philadelphia, Lippincott.
    • Schuchter, L. M. and Glick, J. H. (1993) The current status of WR-2721 (amifostine): A chemotherapy and radiotherapy protector. In: Biologic therapy of cancer updates. EDs. DeVita, VT. Hellman, S. and Rosenberg, SA. pp. 1-10, Philadelphia, Lippincott.
  • 39
    • 0033035371 scopus 로고    scopus 로고
    • Vijayalaxmi, Meltz, M. L., Reiter, R. J., Herman, T. S. and Kumar, K. S. (1999) Melatonin and protection from whole-body irradiation: survival studies in mice. Mutation Research. 425: 21-27.
    • Vijayalaxmi, Meltz, M. L., Reiter, R. J., Herman, T. S. and Kumar, K. S. (1999) Melatonin and protection from whole-body irradiation: survival studies in mice. Mutation Research. 425: 21-27.
  • 40
    • 0022388062 scopus 로고
    • Pharmacokinetics of melatonin in man: First pass hepatic metabolism
    • Lane, E. A. and Moss, H. B. (1985) Pharmacokinetics of melatonin in man: First pass hepatic metabolism. J Clin Endocrinol Metab. 61: 1214-1216.
    • (1985) J Clin Endocrinol Metab , vol.61 , pp. 1214-1216
    • Lane, E.A.1    Moss, H.B.2
  • 41
    • 0033035371 scopus 로고    scopus 로고
    • Melatonin and protection from whole-body irradiation: Survival studies in mice
    • Vijayalaxmi, Meltz, M. L. and Reiter, R. J. (1999) Melatonin and protection from whole-body irradiation: Survival studies in mice. Mutat Res. 425: 21-27.
    • (1999) Mutat Res , vol.425 , pp. 21-27
    • Vijayalaxmi, M.M.L.1    Reiter, R.J.2
  • 42
    • 0032698584 scopus 로고    scopus 로고
    • Melatonin and protection from genetic damage in blood and bone marrow: Whole-body irradiation studies in mice
    • Vijayalaxmi, Meltz, M. L. and Reiter, R. J. (1999) Melatonin and protection from genetic damage in blood and bone marrow: Whole-body irradiation studies in mice. J Pineal Res. 27: 221-225.
    • (1999) J Pineal Res , vol.27 , pp. 221-225
    • Vijayalaxmi, M.M.L.1    Reiter, R.J.2
  • 43
    • 0344069780 scopus 로고    scopus 로고
    • Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague Dawley rats
    • Jahnke, G., Marr, M., Myers, C., Wilson, R., Travlos, G. and Price, C. (1999) Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague Dawley rats. Toxicol Sci. 50: 271-279.
    • (1999) Toxicol Sci , vol.50 , pp. 271-279
    • Jahnke, G.1    Marr, M.2    Myers, C.3    Wilson, R.4    Travlos, G.5    Price, C.6
  • 44
    • 0033002666 scopus 로고    scopus 로고
    • The effect of melatonin on lipid peroxidation during radiotherapy in female rats
    • Kaya, H., Delibas, N., Serteser, M., Ulukaya, E. and Ozkaya, O. (1999) The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlenther Onkol. 175: 285-288.
    • (1999) Strahlenther Onkol , vol.175 , pp. 285-288
    • Kaya, H.1    Delibas, N.2    Serteser, M.3    Ulukaya, E.4    Ozkaya, O.5
  • 46
    • 22844453014 scopus 로고    scopus 로고
    • A comparison of the action of amifostine and melatonin on DNA damaging effects and apoptosis induced by idarubicin in normal and cancer cells
    • Majsterek, I., Gloc, E., Blasiak, J. and Reiter, R. J. (2005) A comparison of the action of amifostine and melatonin on DNA damaging effects and apoptosis induced by idarubicin in normal and cancer cells. J. Pineal Res. 38: 254-263.
    • (2005) J. Pineal Res , vol.38 , pp. 254-263
    • Majsterek, I.1    Gloc, E.2    Blasiak, J.3    Reiter, R.J.4
  • 49
    • 34547125747 scopus 로고    scopus 로고
    • Arvind, L. and Bhatia. A. L. (2004) Melatonin: Anti-Aging Perception and Current Perspectives In: Aging Interventions and Therapies, EDs. Suresh, I. S. and Rattan, pp. 147-169.
    • Arvind, L. and Bhatia. A. L. (2004) Melatonin: Anti-Aging Perception and Current Perspectives In: Aging Interventions and Therapies, EDs. Suresh, I. S. and Rattan, pp. 147-169.
  • 50
    • 0028332850 scopus 로고
    • Potential radioprotective agents: 1. Homologs of melatonin
    • Blickenstaff, R. T., Brandstadter, S. M., Reddy, S. and Witt, R. (1994) Potential radioprotective agents: 1. Homologs of melatonin. J Pharm Sci. 83: 216-218.
    • (1994) J Pharm Sci , vol.83 , pp. 216-218
    • Blickenstaff, R.T.1    Brandstadter, S.M.2    Reddy, S.3    Witt, R.4
  • 51
    • 0032872264 scopus 로고    scopus 로고
    • Radioprotective effect of melatonin assessed by measuring chromosomal damage in mitotic and meiotic cells
    • Badr, F. M., Habit, O. H. E. and Harraz, M. M. (1999) Radioprotective effect of melatonin assessed by measuring chromosomal damage in mitotic and meiotic cells. Mutat Res. 444: 367-372.
    • (1999) Mutat Res , vol.444 , pp. 367-372
    • Badr, F.M.1    Habit, O.H.E.2    Harraz, M.M.3
  • 52
    • 1542651158 scopus 로고    scopus 로고
    • Taysi, S., Koc, M., Buyukokuroglu, M. E., Alt?nkaynak, K. and Sahin, Y. N. (2003) Melatonin protects rat liver against irradiation-induced oxidative injury. J Radiat Res. 44: 211-217.
    • Taysi, S., Koc, M., Buyukokuroglu, M. E., Alt?nkaynak, K. and Sahin, Y. N. (2003) Melatonin protects rat liver against irradiation-induced oxidative injury. J Radiat Res. 44: 211-217.
  • 53
    • 1342323925 scopus 로고    scopus 로고
    • Prophylactic action of melatonin against cyclophosphamide induced oxidative stress in mice
    • Manda, K. and Bhatia, A. L. (2003) Prophylactic action of melatonin against cyclophosphamide induced oxidative stress in mice. Cell Biol Toxicol. 19: 367-372.
    • (2003) Cell Biol Toxicol , vol.19 , pp. 367-372
    • Manda, K.1    Bhatia, A.L.2
  • 55
    • 0036479749 scopus 로고    scopus 로고
    • Melatonin as a Chronobiotic/Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy
    • Blask, D. E., Sauer, L. A. and Dauchy, R. T. (2002) Melatonin as a Chronobiotic/Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy. Current Topics in Medicinal Chemistry. 2: 113-132.
    • (2002) Current Topics in Medicinal Chemistry , vol.2 , pp. 113-132
    • Blask, D.E.1    Sauer, L.A.2    Dauchy, R.T.3
  • 56
    • 0033567891 scopus 로고    scopus 로고
    • Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events
    • Blask, D. E., Leonard, A., Sauer, R. T., Dauchy, E. W., Holowachuk, M. S. and Kopff, H. S. (1999) Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. Cancer Research. 59: 4693-4701.
    • (1999) Cancer Research , vol.59 , pp. 4693-4701
    • Blask, D.E.1    Leonard, A.2    Sauer, R.T.3    Dauchy, E.W.4    Holowachuk, M.S.5    Kopff, H.S.6
  • 58
    • 0038049828 scopus 로고    scopus 로고
    • Melatonin-induced reduction in age-related accumulation of oxidative damage in mice
    • Manda, K. and Bhatia, A. L. (2003a) Melatonin-induced reduction in age-related accumulation of oxidative damage in mice. Biogerontology. 4: 133-139.
    • (2003) Biogerontology , vol.4 , pp. 133-139
    • Manda, K.1    Bhatia, A.L.2
  • 59
    • 27744573253 scopus 로고    scopus 로고
    • Melatonin in the treatment of cancer: A systematic review of randomized controlled trials and meta-analysis
    • Mills, E., Wu, P., Seely, D. and Guyatt, G. (2005) Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J. Pineal Res. 31: 360-366.
    • (2005) J. Pineal Res , vol.31 , pp. 360-366
    • Mills, E.1    Wu, P.2    Seely, D.3    Guyatt, G.4
  • 60
    • 0037093071 scopus 로고    scopus 로고
    • Vijayalaxmi, Thomas, C. R., Reiter, R. J. and Herman, T. S. (2002) Melatonin: from basic research to cancer treatment clinics. J Clin Oncol. 20: 2575-2601.
    • Vijayalaxmi, Thomas, C. R., Reiter, R. J. and Herman, T. S. (2002) Melatonin: from basic research to cancer treatment clinics. J Clin Oncol. 20: 2575-2601.
  • 61
    • 0036479749 scopus 로고    scopus 로고
    • Melatonin as a chronobiotic/anticancer agent: Cellular, biochemical, and molecular mechanisms of action and their implications for circadianbased cancer therapy
    • Blask, D. E., Sauer, L. A. and Dauchy, R. T. (2002) Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadianbased cancer therapy. Curr Top Med Chem. 2: 113-132.
    • (2002) Curr Top Med Chem , vol.2 , pp. 113-132
    • Blask, D.E.1    Sauer, L.A.2    Dauchy, R.T.3
  • 63
    • 3042820946 scopus 로고    scopus 로고
    • Melatonin uptake and growth prevention in rat hepatoma 7288 CTC in response to dietary melatonin: Melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxydecadienoic acid and the potential role of phytomelatonin
    • Blask, D. E., Dauchy, R. T., Sauer, L. A. and Krause, J. A. (2004) Melatonin uptake and growth prevention in rat hepatoma 7288 CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxydecadienoic acid and the potential role of phytomelatonin. Carcinogenesis. 25: 951-960.
    • (2004) Carcinogenesis , vol.25 , pp. 951-960
    • Blask, D.E.1    Dauchy, R.T.2    Sauer, L.A.3    Krause, J.A.4
  • 64
    • 1342272917 scopus 로고    scopus 로고
    • Melatonin's anti-aging role: A study on LPO in mice tissues
    • Manda, K. and Bhatia, A. L. (2003b) Melatonin's anti-aging role: A study on LPO in mice tissues. Ind. J Gerontol. 6: 211-217.
    • (2003) Ind. J Gerontol , vol.6 , pp. 211-217
    • Manda, K.1    Bhatia, A.L.2
  • 65
    • 3843114361 scopus 로고    scopus 로고
    • Study on pre-treatment of melatonin against radiation-induced oxidative stress in mice
    • Bhatia, A. L. and Manda, K. (2004) Study on pre-treatment of melatonin against radiation-induced oxidative stress in mice. Environmental Toxicology and Pharmacology. 18: 13-20.
    • (2004) Environmental Toxicology and Pharmacology , vol.18 , pp. 13-20
    • Bhatia, A.L.1    Manda, K.2


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