Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice

Radiation Research

Volumn 166, Issue 3, 2006, Pages 556-560

  Hofer, M ^a,d   Pospisil M ^a   Znojil, V ^c   Hola J ^a   Vacek, A ^a   Weiterova L ^a   Streitova D ^a   Kozubik A ^b  

^a Laboratory of Experimental Hematology   (Czech Republic)

^b Laboratory of Cytokinetics   (Czech Republic)

^c MASARYK UNIVERSITY   (Czech Republic)

^d INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; CYCLOOXYGENASE 2 INHIBITOR; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ERYTHROID CELL; GAMMA IRRADIATION; GASTROINTESTINAL TOXICITY; GRANULOCYTE; HEMATOLOGIC DISEASE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IONIZING RADIATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY;

ANIMALS; BONE MARROW; CELLS, CULTURED; CYCLOOXYGENASE 2 INHIBITORS; GAMMA RAYS; HEMATOPOIESIS; MALE; MICE; RADIATION DOSAGE; RADIATION-PROTECTIVE AGENTS; THIAZINES; THIAZOLES; WHOLE-BODY IRRADIATION;

ANIMALIA;

EID: 33748449242     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3598.1     Document Type: Article

References (23)

1. T. C. Pellmar, S. Rockwell and the Radiological/Nuclear Counter-measures Working Group, Priority list of research areas for radiological nuclear threat countermeasures. Radiat. Res. 163, 115-123 (2005).
2. M. Pospíšil, J. Netíková and A. Kozubík, Enhancement of hematopoietic recovery by indomethacin after sublethal whole-body gamma irradiation. Acta Radiol. Oncol. 25, 195-198 (1986).
3. B. A. Serushago, K. Tanaka, Y. Koga, K. Taniguchi and K. Nomoto, Positive effects of indomethacin on restoration of splenic nucleated cell populations in mice given sublethal irradiation. Immunopharmacology 14, 21-26 (1987).
4. M. Pospíšil, J. Netíková, A. Kozubík and I. Pipalová, Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice. Strahlenther. Onkol. 165, 627-631 (1989).
5. A. Kozubík, M. Pospíšil and J. Netí ková, Enhancement of haemopoietic recovery in sublethally gamma-irradiated mice by the joint use of indomethacin and cystamine. Folia Biol. (Praha) 36, 291-300 (1990).
6. I. Nishiguchi, Y. Furuta, N. Hunter, D. Murray and L. Milas, Radioprotection of hematopoietic tissues in mice by indomethacin. Radiat. Res. 122, 188-192 (1990).
7. A. Kozubík, M. Pospíšil and J. Netí ková, Possibilities of the combined use of non-steioidal anti-inflammatory drugs and sulfhydryl compounds in radioprotection. Strahlenther. Onkol. 167, 186-190 (1991).
8. M. Pospíšil, M. Hofer, I. Pipalová, S. Viklická, J. Netíková and J. Šandula, Enhancement of hematopoietic recovery in gamma-irradiated mice by the joint use of diclofenac, an inhibitor of prostaglandin production, and glucan, a macrophage activator. Exp. Hematol. 20, 891-895 (1992).
9. M. Hofer, M. Pospíšil, S. Viklická, A. Vacek, I. Pipalová and A. Bartoníčková, Hematopoietic recovery in repeatedly irradiated mice can be enhanced by a repeatedly administered combination of diclofenac and glucan. J. Leukoc. Biol. 53, 185-189 (1993).
10. A. Kozubík, J. Hofmanová, M. Pospíšil, J. Netíková, J. Holá and A. Lojek, Effects of drugs inhibiting prostaglandin or leukotriene biosynthesis on postirradiation haematopoiesis in mouse. Int. J. Radiat. Biol. 65, 369-377 (1994).
11. P. Fedoročko and N. O. Macková, Combined modality radioprotection: Enhancement of survival and hematopoietic recovery in gamma-irradiated mice by the joint use of liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) and indomethacin. Int. J. Immunopharmac. 18, 329-337 (1996).
12. M. Hofer, M. Pospíšil and I. Pipalová, Radioprotective effects of flurbiprofen. Folia Biol. (Praha) 42, 267-269 (1996).
13. M. Hofer, M. Pospíšil, I. Pipalová and J. Holá, Modulation of haemopoietic radiation damage by diclofenac in fractionated treatment. Physiol. Res. 45, 213-220 (1996).
14. L. Juchelková, M. Hofer, M. Pospíšil and I. Pipalová, Radioprotective properties of flurbiprofen and its nitroderivative. Physiol. Res. 47, 73-80 (1998).
15. Y. Furuta, N. Hunter, T. Barkley, E. Hall and L. Milas, Increase in radioresponse of murine tumors by treatment with indomethacin. Cancer Res. 48, 3008-3013 (1988).
16. J. Kurland and M. A. S. Moore, Modulation of hemopoiesis by prostaglandins. Exp. Hematol. 5, 357-373 (1977).
17. J. Fontagné, M. Adolphe, M. Semichon, L. Zizine and P. Léchat, Effect of in vivo treatment with indomethacin on mouse granulocyte-macrophage colony-forming cells in culture (CFUc). Possible role of prostaglandins. Exp. Hematol. 8, 1157-1164 (1980).
18. 2: Demonstration of novel mechanism of action in vivo. Immunol. Res. 8, 176-184 (1989).
19. J. C. Frölich, A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol. Sci. 18, 30-34 (1997).
20. M. Donlon, L. Steel, E. A. Helgeson, A. Shipp and G. N. Catravas, Radiation-induced alterations in prostaglandin secretion in the rat. Life Sci. 32, 2631-2639 (1983).
21. M. Hofer, M. Pospíšil, L. Tkadleček, S. Viklická, I. Pipalová and J. Holá, Low survival of mice following lethal irradiation after administration of inhibitors of prostaglandin synthesis. Physiol. Res. 41, 157-161 (1992).
22. A. Lanas, J. Panés and J. M. Piqué, Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract. Curr. Pharm. Des. 9, 2253-2266 (2003).
23. M. Pospíšil, Pharmacological radiation protection. In Fundamentals for the Assessment of Risks from Environmental Radiation (C. Baumstark-Khan, G. Horneck and S. Kozubek, Eds.), pp. 411-420. Kluwer Academic Publishers, Amsterdam, 1999.