Amelioration of the pathological changes induced by radiotherapy in normal tissues

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 8, 2008, Pages 1037-1048

  Rezvani, Mohi ^a  

^a Systems Biology Laboratory   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIFOSTINE; ANTICOAGULANT AGENT; ANTIOXIDANT; ASCORBIC ACID; BETAMETHASONE; CAPTOPRIL; COPPER ZINC SUPEROXIDE DISMUTASE; CORTICOSTEROID; CORTISONE; CURCUMIN; DEXAMETHASONE; DEXCHLORPHENIRAMINE; DICLOFENAC; ENALAPRIL; ENPROSTIL; FLURBIPROFEN; INDOMETACIN; LOSARTAN; MECLOFENAMATE SODIUM; METHOTREXATE; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; OXYTETRACYCLINE; PENTOXIFYLLINE; PREDNISOLONE; RADIOPROTECTIVE AGENT; RAMIPRIL; SALICYLATE SODIUM; TRIMETAZIDINE; UNINDEXED DRUG;

BRAIN NECROSIS; CORTICOSTEROID THERAPY; DESQUAMATION; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LOW DRUG DOSE; LUNG ALVEOLITIS; LUNG EDEMA; NEPHROSCLEROSIS; NONHUMAN; OPTIC NERVE INJURY; OXIDATIVE STRESS; RADIATION DOSE; RADIATION ENTEROPATHY; RADIATION EXPOSURE; RADIATION INDUCED CYSTITIS; RADIATION INDUCED DIARRHEA; RADIATION INDUCED ENDOTHELIAL DYSFUNCTION; RADIATION INDUCED ESOPHAGITIS; RADIATION INJURY; RADIATION NECROSIS; RADIATION PNEUMONIA; RADIATION PROCTITIS; RADIOTHERAPY; REVIEW; X RAY;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; NEOPLASMS; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; RADIOTHERAPY; RADIOTHERAPY DOSAGE; TREATMENT OUTCOME;

EID: 47949107554     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.8.0010     Document Type: Review

References (131)

1. Abdelaal, A. S., Barker, D. S., Fergusson, M. M. (1989) Treatment for radiation-induced mucositis [Letter]. Lancet 1(8629): 97
2. Abramsson-Zetterberg, L. (1996) Ascorbic acid is not clastogenic and does not modify the effect of extended low-dose-rate γ-irradiation in mouse bone marrow. Int. J. Radiat. Biol. 70: 77-81
3. Abramson, S. B., Weissmann, G. (1989) The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis Rheum. 32:1-9
4. Ambrus, J. L., Ambrus, C. M., Lillie, D. B., Johnson, R. J., Gastpar, H., Kishel, S. (1984) Effect of sodium meclofenamate on radiation induced esophagitis and cystitis. J. Med. 15: 81-92
5. Ammon, H. P. T., Wahi, M. A. (1990) Pharmacology of Curcuma longa. Planta Medica 57: 1-7
6. Babior, B. M., Woodman, R. C. (1990) Chronic granulomatous disease. Semin. Hematol. 27: 247-259
7. Bachwich, P. R., Chensue, S. W., Larrick, J. W., Kunkel, S. L. (1986) Tumour necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. Biochem. Biophys. Res. Commun. 136: 94-101
8. Baillet, F., Housset, M., Michelson, A. M., Puget, K. (1986) Treatment of radiofibrosis with liposomal superoxide dismutase. Preliminary results of 50 cases. Free Rad. Res. Comm. 1: 387-394
9. Baum, C. A., Biddle, W. L., Miner, P. B. (1989) Failure of 5-aminosalicylic acid enemas to improve chronic radiation proctitis. Dig. Dis. Sci. 34: 758-760
10. Berdjis, C. C. (1960) Cortisone and radiation. III. Histopathology of the effect of cortisone on the irradiated rat kidney. Arch. Pathol. 69: 431-439
11. Bertho, J. M., Frick, J., Demarquay, C., Lauby, A., Mathieu, E., Dudoignon, N., Jacquet, N., Trompier, F., Chapel, A., Joubert, C., Lopez, M., Aigueperse, J., Gorin, N. C., Gourmelon, P., Thierry, D. (2002) Reinjection of ex vivo-expanded primate bone marrow mononuclear cells strongly reduces radiation-induced aplasia. J. Hematother. Stem Cell Res. 11: 549-564
12. Bianco, J. A., Appelbaum, F. R., Nemunaitis, J. (1991) Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood 78: 1205-1211
13. Blomstrand, C., Johansson, B., Rosengren, B. (1975) Dexamethasone effect on blood-brain barrier damage caused by acute hypertension in X-irradiated rabbits. Acta Neurol. Stand. 52: 331-334
14. Boys, F., Harris, I. D. (1943)The effect of heparinization on experimental post-irradiation tissue changes in the lung. Am. J. Roentg. Radium Ther. 50: 1-8
15. Brizel, D. M., Wasserman, T. H., Henke, M., Strnad, V., Rudat, V., Monnier, A., Eschwege, F., Zhang, J., Russell, L., Oster, W., Sauer, R. (2000) Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J. Clin. Oncol. 18: 3339-3345
16. Brown, R. F. (1956) Effect of cortisone on the radiation reaction of the rat lung. Am. J. Roentgenol. 75: 796-806
17. Cameron, E., Pauling, L. (1976) Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc. Natl Acad. Sci. USA 73: 3685-3689
18. Chance, B., Sia, H., Hoveria, A. (1979) Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59: 527-605
19. Chapel, A., Bertho, J. M., Bensidhoum, M., Fouillard, L., Young, R. G., Frick, J., Demarquay, C., Cuvelier, F., Mathieu, E., Trompier, F., Dudoignon, N., Germain, C., Mazurier, C., Aigueperse, J., Borneman, J., Gorin, N. C., Gourmelon, P., Thierry, D. (2003) Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome. J. Gene Med. 5: 1028-1038
20. Chatterjee, I. B. (1970) Biosynthesis of ascorbic acid in animals. Methods Enzymol. 18A: 28-34
21. Chen, Y.-R., Tan, T.-H. (1998) Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 17: 173-178
22. Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Sen, T. S., Ko, J. Y., Lin, J.T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C.A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., Hsieh, C. Y. (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21: 2895-2900
23. Cladwell, W. (1971) The effect of prednisolone on fatal postirradiation nephritis in rabbits. Radiology 98: 431-433
24. Cohen, E. P., Fish, B. L., Moulder, J. E. (1992) Treatment of radiation nephropathy with Captopril. Radiat. Res. 132: 346-350
25. Cohen, E. P., Irving, A. A., Drobyski, W. R., Klein, J. P., Passweg, J., Talano, J.-A. M., Juckett, M. B., Moulder, J. E. (2008) Captropril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int. J. Radiat. Biol. Phys. 70: 1546-1551
26. Delanian, S. (1998) Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol. Br. J. Radiol. 71: 892-894
27. Delanian, S., Baillet, F., Hurat, J., Lefaix, J.-L., Maulard, C., Housset, M. (1994) Successful treatment of radiation fibrosis using liposomal Cu/Zn superoxide dismutase: clinical trial. Radiother. Oncol. 32: 12-20
28. Delanian, S., Porcher, R., Balla-Mekias, S., Lefaix, J. L. (2003) Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis. J. Clin. Oncol. 21: 2545-2550
29. Delanian, S., Porcher, R., Rudant, J., Lefaix, J. L. (2005) Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis. J. Clin. Oncol. 23: 8570-8579
30. Dion, M. W., Hussey, D. H., Osborne, J. W. (1989) The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. Int. J. Radiat. Oncol. Biol. Phys. 17: 101-107
31. Dion, W., Hussey, D. H., Doornbos, J. F., Vigliotti, A. P., Wen, B. C., Anderson, B. (1990) Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. Int. J. Radiat. Oncol. Biol. Phys. 19: 401-407
32. Epstein, J. B., Stevenson-Moore, P., Jackson, S., Mahomed, J. H., Spinelli, J. J. (1989) Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse. Int. J. Radiat. Oncol. Biol. Phys. 16: 1571-1575
33. Estrov, Z., Resnitzky, P. (1983) Enhancement of hemopoietic stem cell proliferation by prostaglandin inhibitor drugs. Exp. Hematol. 11: 802-809
34. Fantone, J. C., Schrier, D., Weingarten, B. (1982) Inhibition of vascular permeability changes in rats by Captopril. J. Clin. Invest. 69: 1207-1211
35. Fleming, W. H., Szakacz, J. E., King, E. R., Martin, M. L., Roche, J. J. (1962) The effect of gamma radiation on the fibrinolytic system of dog lung and its modification by certain drugs: relationship to radiation pnuemonitis and hyaline membrane formation in lung. J. Nucl. Med. 3: 341-351
36. Futran, N. D., Trotti, A., Gwede, C. (1997) Pentoxifylline in the treatment of radiation-related soft tissue injury: preliminary observations. Laryngoscope 107: 391-395
37. Glantz, M. J., Burger, P. C., Friedman, A. H., Radtke, R. A., Massey, E. W., Schold Jr, S. C. (1994) Treatment of radiation-induced nervous system injury with heparin and warfarin. Am. Acad. Neurol. 44: 2020-2027
38. Godwin-Austin, R. B., Howell, D. A., Worthington, B. (1975) Observations of radiation myelopathy. Brain 98: 577-568
39. Goreckie, M., Beck, Y., Hartman, J. R., Fischer, M., Weiss, L., Tochner, Z., Slavin, Z., Nimrod, R. (1991) Recombinant human superoxide dismutases: production and potential therapeutical uses. Free Radic. Res. Commun. 12-13: 401-410
40. Gottlöber, P., Korting, H., Stock, W., Peter, R. (1996) Behandlung der kautanen Strahlenfibrose mit Pentoxifyllin und Vitamin E. Strahlenter Onkol 172: 34-38
41. Govindarajan, V. S. (1980) Turmeric chemistry, technology and quality. CRC Review. Food Sci. Nutr. 12: 199-301
42. Halliwell, B. (1994) Free radicals, antioxidants and human disease: curiosity, cause or consequence. Lancet 344: 721-724
43. Hainan, K. E. (1962) The effect of corticosteroids on the radiation skin reaction. A random trial to assess the value of local application of prednisolone and neomycin ointment after X ray treatment of basal carcinoma. Br. J. Radiol. 35: 403-408
44. Higgs, G., Vane, J. (1989) Inhibitors of enzymes of the arachidonic acid metabolic pathways. In: Sandler, M., Smith, H. J. (eds) Design of enzyme inhibitors as drugs, Oxford University Press, Oxford, pp 314-342
45. Hodges, R. E. (1980) Ascorbic acid. In: Goodhart, R. S., Shils, M. E. (eds) Modern nutrition in health and disease. 6th edn. Philadelphia. Lea & Febiger, pp 259-273
46. Hodges, R. E., Hood, J., Canham, J. E., Sauberlich, H. E., Baker, E. M. (1971) Clinical manifestations of ascorbic acid deficiency in man. Am. J. Clin. Nutr. 24: 432-443
47. Hofer, M., Pospisil, M., Tkadlecek, L., Viklicha, S., Pipalova, I., Hola, J. (1992) Low survival of mice following lethal gamma-irradiation after administration of inhibitors of prostaglandin synthesis. Physiol. Res. 41:157-161
48. Huang, M.-T., Robertson, F. M., Lysz, T., Ferraro, T., Wang, Z. Y., Georgiadis, C. A., Laskin, J. D., Conney, A. H. (1992) Inhibitory effects of curcumin on carcinogenesis in mouse epidermis. In: Huang, M.-T., Ho, C.-T., Lee, C. Y. (eds). Phenolic compounds in food and their effects on health it: antioxidants and cancer prevention. Washington, DC: American Chemical Society, pp 339-349
49. Huang, M.-T., Lou, Y.-R., Ma, W., Newmark, H. L., Reuhl, K. R., Conney, A. H. (1994) Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res. 54: 5841-5847
50. Jacob, C. O., Hercberg, A., Brenner, H. (1984) Effect of dexamethasone on the survival of whole-body irradiated mice. Isr. J. Med. Sci. 20: 639-640
51. Joe, B., Lokesh, B. R. (1994) Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim. Biophys. Acta 1224: 255-263
52. Kasama, T., Kobayashi, K., Fukushima, T., Tabata, M., Ohno, I., Negishi, M., Ide, H., Takahashi, T., Niwa, Y. (1989) Production of interleukin-1 like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: the role of interleukin-1 and reactive oxygen species in inflamed sites. Clin. Immunol. Immunopathol. 53: 439-448
53. Keelan, M., Walker, K., Cheeseman, C. I., Thomson, A. B. R. (1992) Two weeks of oral synthetic E2 prostaglandin (Enprostil) improves the intestinal morphological but not the absorptive response in the rat to abdominal irradiation. Digestion 53:101-107
54. Kim, J. H., Chu, F. Ch., Lakshmi, V., Houde, R. (1986) Benzydamine HCl, a new agent for the treatment of radiation mucositis of the oropharynx. Am. J. Clin. Oncol. 9:132-134
55. Kim, J. H., Brown, S. L., Kolozsvary, A., Jenrow, K. A., Ryu, S., Rosenblum, M. L., Carretero, O. A. (2004) Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat. Radiat. Res. 161: 137-142
56. Kitsis, E. A., Weissmann, G., Abramson, S. B. (1991) The prostaglandin paradox: additive inhibition of neutrophil function by aspirin-like drugs and the prostaglandin E1 analog misoprostol. J. Rheumatol. 18: 1461-1465
57. Kunchandy, E., Rao, M. N. A. (1990) Oxygen radical scavenging activity of curcumin. Int. J. Pharm. 58: 237-240
58. Kunkel, S. L., Spengler, M., May, M., Spengler, R., Larrick, J., Remick, D. (1988) Prostaglandin E2 regulates macrophage derived tumour necrosis factor gene expression. J. Biol. Chem. 263: 5380-5389
59. Kwon, H. C., Kim, S. K., Chung, W. K. (2000) Effect of pentoxifylline on radiation response of non-small cell lung cancer: a phase III randomised multicenter trial. Radiother. Oncol. 56: 175-179
60. Lefaix, J. L., Daburon, F., Tricaud, Y. (1992) Evolution radiopathologique spontanee et apres traitement medical dans deux modeles d'accident d'irradiation localisee. Bull. Cancer Radiother. 79:189-198
61. Lefaix, J. L., Delanian, S., Leplat, J. J., Tricaud, Y., Martin, M., Nimrod, A., Baillet, F., Daburon, F. (1996) Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study. Int. J. Radiat. Oncol. Biol. Phys. 35: 305-312
62. Lefaix, J. L., Delanian, S., Vozenin, M. C., Leplat, J. J., Tricaud, Y., Martin, M. (1999) Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study. Int. J. Radiat. Oncol. Biol. Phys. 43: 839-847
63. Levine, M. (1986) New concepts in the biology and biochemistry of ascorbic acid. N. Engl. J. Med. 314: 892-902
64. Lombaert, I. M., Wierenga, P. K., Kok, T., Kampinga, H. H., De Haan, G., Coppes, R. P. (2006) Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands. Clin. Cancer Res. 12: 1804-1812
65. Lu, Y. P., Chang, R. L., Lou, Y. R., Huang, M.-T., Newmark, H. L., Reuhl, K. R., Conney, A. H. (1994) Effect of curcumin on 12-tetradecanoylphorbol-13- acetate- and untraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis. Carcinogenesis 15: 2363-2370
66. Ludgate, C. M. (1985) Preliminary report: acetylsalicylic acid therapy in the treatment of complications following abdominal radiation. J. Can. Assoc. Radiol. 36: 138-140
67. Lurie, A. G., Casarett, G. W. (1975) Influence of adrenalectomy on radiation hypertension and nephrosclerosis. Radiat. Res. 61: 80-99
68. Macht, S. H., Perlberg, H. (1950) Use of anticoagulant (Dicumarol) in preventing post-irradiation tissue changes in the human lung. Am. J. Roentgenol. 63: 335-341
69. Malaker, K., Das, R. M. (1988) The effect of superoxide dismutase on the pathogenesis of radiation-induced pulmonary damage in the rat. Pharmac. Ther. 39: 327-330
70. Marshall, A. H. E. (1953) The action of cortisone on experimental acute roentgen dermatitis. Acta Radiol. Stockh. 39: 73-77
71. Martins, A. N., Johnston, J. S., Hendry, J. M., Stoffel, T. J., DiChiro, G. (1977) Delayed radiation necrosis of the brain. J. Neurosurg. 47: 135-150
72. Mennie, A. T., Dalley, V. (1973) Aspirin in radiation-induced diarrhoea. Lancet 1(7812): 1131
73. Mennie, A. T., Dalley, V. M., Dinneen, L. C., Collier, H. O. (1975) Treatment of radiation-induced gastrointestinal distress with acetylsalicylate. Lancet 2(7942): 942-943
74. Michalowski, A. S. (1992) Post irradiation modification of normal tissue injury: lessons from the clinic. Br. J. Radiol. (Suppl.) 24: 183-186
75. Moss, W. T., Haddy, F. J., Sweany, S. K. (1960) Some factors altering the severity of acute radiation pneumonitis variation with cortisone, heparin, and antibiotics. Radiology 75: 50-54
76. Moulder, J. E., Fish, B. L., Cohen, E. P. (1993) Treatment of radiation nephropathy with ACE inhibitors. Int. J. Radiat. Oncol. Biol. Phys. 27: 93-99
77. Moulder, J. E., Fish, B. L., Cohen, E. P., Bonsib, S. M. (1996) Angiotensin II receptor antagonists in the prevention of radiation nephropathy. Radiat. Res. 146: 106-110
78. Moulder, J. E., Fish, B. L., Cohen, E. P. (1998) Angiotensin II receptor antagonists in the treatment and prevention of radiation nephropathy. Int. J. Radiat. Biol. 73: 415-421
79. Mullenix, P. J., Kernan, W. J., Schunior, A., Howes, A., Waber, D. P., Sallan, S. E., Tarbell N. J. (1994) Interactions of steroid, methotrexate, and radiation determine neurotoxicity in an animal model to study therapy for childhood leukemia. Pediatr. Res. 35: 171-178
80. Mussini, E., Hutton, J. J. Jr, Udenfriend, S. (1967) Collagen proline hydroxylase in wound healing, granuloma formation, scurvy and growth. Science 157: 927-929
81. Narra, V. R., Howell, R. W., Sastry, K. S. R., Rao, D. V. (1993) Vitamin C as a radioprotector against 1311 in vivo. J. Nucl. Med. 34: 637-640
82. Narra, V. R., Harapanhalli, R. S., Howell, R. W., Sastry, K. S., Rao, D. V. (1994) Vitamins as radioprotectors in vivo. I. Protection by vitamin C against internal radionuclides in mouse testes: implications to the mechanism of damage caused by the Auger effect. Radiat. Res. 137: 394-399
83. Nicolopoulos, N., Mantidis, A., Stathopoulos, E., Papaodysseas, S., Kouvaris, J., Varveris, H., Papavasiliou, C. (1985) Prophylactic administration of indomethacin for irradiation esophagitis. Radiother. Oncol. 3: 23-25
84. Northway, M. G., Libshitz, H. I., Osborne, M. B., Feldman, M. S., Mamel, J. J., West, J. H, Szwarc, I. A. (1980) Radiation oesaphagitis in the opossum: radioprotection with indomethacin. Gastroenterology 78: 883-892
85. Northway, M. G., Scobey, M. W., Geisinger, K. R. (1988) Radiation proctitis in the rat. Sequential changes and effects of anti-inflammatory agents. Cancer 62: 1962-1969
86. Parizada, B., Werber, M. M., Nimrod, R. (1991) Protective effects of human recombinant Mn-SOD in adjuvant arthritis and bleomycin-induced lung fibrosis. Free Radic. Res. Commun. 15: 297-301
87. Petrini, B., Wolk, G., Wasserman, J., Vedin, I., Strannegard, O., Blomgren, H., Eposti P. L. (1991) Indomethacin modulation of monocyte cytokine release following pelvic irradiation for cancer. Eur. J. Cancer 27: 591-594
88. Phillips, T. L., Wharam, M. D., Margolis, L. W. (1975) Modification of radiation injury to normal tissues by chemotherapeutic agents. Cancer 35: 1678-1684
89. Pospisil, M., Netikova, J., Kozubik, A. (1986) Enhancement of hemopoietic recovery by indomethacin after sublethal whole-body gamma irradiation. Acta Radiol. Oncol. 25: 195-198
90. Pospisil, M., Netikova, J., Kozubik, A., Pipalova, I. (1989) Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice. Strahlenther Onkol. 165: 627-631
91. Puistola, U., Turpeenniemi-Hujanen, T. M., Myllyla, R., Kiviikko, K. I. (1980) Studies on the lysyl hydroxylase reacton. I. Initial velocity kinetics and related aspects. Biochem. Biophys. Acta 611: 40-50
92. Rao, T. S., Basu, N., Siddiqui, H. H. (1982) Anti-inflammatory activity of curcumin analogues. Ind. J. Med. Res. 75: 574-578
93. Rao, C. V., Simi, B., Reddy, B. S. (1993) Inhibitory effect by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 14: 2219-2225
94. Ravindranath, V., Chandrasekhara, N. (1980) Absorption and tissue distribution of curcumin in rats. Toxicology 16: 259-265
95. Ravindranath, V., Chandrasekhara, N. (1982) Metabolism of curcumin - studies with [3H]curcumin. Toxicology 22: 337-344
96. Rezvani, M., Ross, G. (2004) Modification of radiation-induced acute oral mucositis in the rat. Int. J. Radiat. Biol. 80: 177-182
97. Rezvani, M., Birds, D. A., Hodges, H., Hopewell, J. W., Milledew, K., Wilkinson, J. H. (2001) Modification of radiation myelopathy by the transplantation of neural stem cells in the rat. Radiat. Res. 156: 408-412
98. Robbins, M. E., Hopewell, J. W. (1986) Physiological factors effecting renal radiation tolerance: a guide to the treatment of late effects. Br. J. Cancer 53: 265-267
99. Rose, P. G., Halter, S. A., Su, C. M. (1992) The effect of indomethacin on acute radiation induced gastrointestinal injury: a morphologic study. J. Surg. Oncol. 49: 231-238
100. Samaranayake, L. P., Robertson, A. G., MacFarlane, T. W., Hunter, I. P., MacFarlane, G., Soutar, D. S., Ferguson, M. M. (1988) The effect of chlorohexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clin. Radiol. 39: 291-294
101. Serushago, B. A., Tanaka, K., Koga, Y., Taniguchi, K., Nomoto, K. (1987) Positive effects of indomethacin on restoration of splenic nucleated cell populations in mice given sublethal irradiation. Immunopharmacology 14: 21-26
102. Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., Marczylo, T. H., Morgan, B., Hemingway, D., Plummer, S. M., Pirmohamed, M., Gescher, A. J., Steward, W. P. (2004) Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin. Cancer Res. 10: 6847-6854
103. Shaw, P. J., Bates, D. (1984) Conservative treatment of delayed cerebral radiation necrosis. J. Neurol. Neurosurg. Psychiatry 47: 1338-1341
104. Smith, W. W., Smith, F., Thompson, E. C. (1950) Failure of cortisone or ACTH to reduce mortality in irradiated mice. Proc. Soc. Exp. Biol. Med. 73: 529-531
105. Sreejayan, N., Rao, M. N. A. (1994) Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol. 46: 1013-1016
106. Sreejayan, N., Rao, M. N. A., Priyadarsini, K. I., Devasagayan, T. P. A. (1997) Inhibition of radiation-induced lipid peroxidation by curcumin. Int. J. Pharm. 151: 127-130
107. Steeves, R. A., Robins, H. I. (1998) Pentoxifylline treatment of radiation mastitis [Letter]. Int. J. Radiat. Oncol. Biol. Phys. 42: 1177
108. Stelzer, K. J., Koh, W.-J., Kurtz, H., Greer, B. E., Griffin, T. W. (1994) Caffeine consumption is associated with decreased severe late toxicity after radiation to the pelvis. Int. J. Radiat. Oncol. Biol. Phys. 30: 411-417
109. Stoner, G. D., Mukhtar, H. (1995) Polyphenols as cancer chemopreventive agents. J. Cell. Biochem. 22 (Suppl.): 169-180
110. Stryker, J. A., Abt, A. B., Allegra, J. C., Mortel, R., Uhlin, S., Hepner, G. W. (1976) The effect of prednisone and irradiation on the rectum in dogs. Radiology 121: 183-187
111. Subramanian, M., Sreejayan, N., Rao, M. N. A., Devasagayam, T. P., Singh, B. B. (1994) Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants. Mutat. Res. 311: 249-255
112. Tada, E., Matsumoto, K., Kinoshita, K. (1997) The protective effect of dexamethasone against radiation damage induced by interstitial irradiation in normal monkey brain. Neurosurgery 41: 217-219
113. Tanner, N. S. B., Stamford, I. F., Bennett, A. (1981) Plasma prostaglandins in mucositis due to radiotherapy and chemotherapy for head and neck cancer. Br. J. Cancer 43: 767-771
114. Tochner, Z., Barnes, M., Mitchell, J. B., Orr, K., Glatstein, E., Russo, A. (1990) Protection by indomethacin against acute radiation esophagitis. Digestion 47: 81-87
115. Tofilon, P. J., Fike, J. R. (2000) The radioresponse of the central nervous system: a dynamic process. Radiat. Res. 153: 357-370
116. Tonnesen, H. H. (1988) Chemistry, stability and analysis of curcumin, a naturally occurring drug molecule. PhD Dissertation, The Institute of Pharmacy, University of Oslo, Norway
117. Triantafillidis, J. K., Dadioti, P., Nicolakis, D., Mericas, E. (1990) High doses of 5-aminosalicylic acid enemas in chronic radiation proctitis: comparison with betamethasone enemas [letter]. Am. J. Gastroenterol. 85: 1537-1538
118. Twomey, B. M., Dale, M. M. (1992) Cyclooxygenase-independent effects of non-steroidal anti-inflammatory drugs on the neutrophil respiratory burst. Biochem. Pharmacol. 43: 413-418
119. Umeki, S. (1990) Effects of non-steroidal anti-inflammatory drugs on human neutrophil NADPH oxidase in both whole cell and cell-free systems. Biochem. Pharmacol. 40: 559-564
120. Vane, J. R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 231: 232-235
121. Vujaskovic, Z., Feng, Q. F., Rabbani, Z. N., Anscher, M. S., Samulski, T. V., Brizel, D. M. (2002) Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. Radiat. Res. 157: 656-660
122. Wachholz, B. W., Casarett, G. W. (1970) Radiation hypertension and nephrosclerosis. Radiat. Res. 41: 39-56
123. Wahlstrom, B., Blennow, G. (1980) A study on the fate of curcumin in the rat. Acta Pharmacol. Toxicol. 43: 86-92
124. Wang, L. W., Fu, X. L., Clough, R. (2000) Can angiotensin-convering enzyme inhibitors protect against symptomatic radiation pneumonitis? Radiat. Res. 153: 405-410
125. Ward, W. F., Kim, Y. T., Molteni, A., Solliday, N. H. (1988) Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme. Int. J. Radiat. Oncol. Biol. Phys. 15: 135-140
126. Ward, W. F., Kim, Y. T. (1989) Radiation-induced pulmonary fibrosis. In: Cantor, J. O. (ed). Handbook of animal models of pulmonary disease. Boca Raton, FL: CRC Press, pp 165-182
127. Ward, W. F., Molteni, A., Ts'ao, C. H., Kim, Y. T., Hinz, J. M. (1992a) Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme. Int. J. Radiat. Oncol. Biol. Phys. 22: 623-625
128. Ward, W. F., Kim, Y. T., Molteni, A., Ts'ao, C., Hinz, J. M. (1992b) Pentoxifylline does not spare acute radiation reactions in rat lung and skin. Radiat. Res. 129: 107-111
129. Ward, H. E., Kemsley, L., Davies, L., Holecek, M., Berend, N. (1993) The effect of steroids on radiation-induced lung disease in the rat. Radiat. Res. 136: 22-28
130. Werner-Wasik, M., Madoc-Jones, H. (1993) Trental (pentoxifylline) relieves pain from postradiation fibrosis [letter]. Int. J. Radiat. Oncol. Biol. Phys. 25: 757-758
131. Yarom, R., Harper, I. S., Wynchunk, S., van Schalkwyk, D., Madhoo, J., Williams, K., Salie, R., Genade, S., Lochiners, A. (1993) Effects of Captopril on changes in rats' hearts induced by long-term irradiation. Radiat. Res. 133:187-197