Antioxidant role of N-acetyl cysteine isomers following high dose irradiation

Free Radical Biology and Medicine

Volumn 34, Issue 6, 2003, Pages 689-695

  Neal, Rachel ^a   Matthews, Richard H ^a,b,c   Lutz, Paula ^a   Ercal, Nuran ^a  

^a MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^b PCRMC   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

C57Bl 6; Free radicals; Gastrointestinal syndrome; NAC; Stereoisomers; Whole body irradiation

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; GLUTATHIONE; MALONALDEHYDE; RADIOPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CHIRALITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ERYTHROCYTE; GASTROINTESTINAL DISEASE; GLUTATHIONE METABOLISM; ISOMER; LIVER PROTECTION; LUNG INJURY; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; SPLEEN; TISSUE LEVEL; TISSUE REPAIR; WHOLE BODY RADIATION;

EID: 0037443718     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)01372-2     Document Type: Article

References (39)

1. Peters L.J. Radiation therapy tolerance limits. For one or for all? (Janeway lecture). Cancer. 77:1996;2379-2385.
2. Loprinzi C.L., Foote R.L., Michalak J. Alleviation of cytotoxic therapy-induced normal tissue damage. Semin. Oncol. 22:1995;95-97.
3. Otamiri T., Sjodahl R. Oxygen radicals their role in selected gastrointestinal disorders . Dig. Dis. 9:1991;133-141.
4. Hall E.J. Radiobiology for the radiologist. 4th ed:1994;Lippincott, Philadelphia.
5. Baranov A.E., Guskova A.K., Protasova T.G. Experience in treating the victims of the accident at Chernobyl atomic electric power station and the immediate disease outcomes. Meditsinskaia Radiologiia. 36:1991;29-32.
6. Yarilin A.A., Belyakov I.M., Kusmenok O.I., Arshinov V.Y., Simonova A.V., Nadezhina N.M., Gnezditskaya E.V. Late T cell deficiency in victims of the Chernobyl radiation accident possible mechanisms of induction . Int. J. Radiat. Biol. 63:1993;519-528.
7. Baranov A.E., Selidovkin G.D., Butturini A., Gale R.P. Hematopoetic recovery after 10 Gy acute total body radiation. Blood. 83:1994;596-599.
8. Dubois A., Walker R.I. Prospects for management of gastrointestinal injury associated with the acute radiation syndrome. Gastroenterology. 95:1988;500-507.
9. Kehrer J. Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol. 23:1993;21-48.
10. Tan K.H., Meyer D.J., Gillies N., Ketterer B. Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus. Biochem. J. 254:(3):1988;841-845.
11. Tatsumi Y., Kodama T., Kashima K., Ohkuma S. Inhibition of gastric glucosamine synthetase activity by oxygen radicals a possible cause of decreased mucosal protective capacity . Jpn. J. Pharmacol. 58:(4):1992;391-398.
12. Matthews W., Guido D., Fisher M., Jaeschke H. Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia. Free Radic. Biol. Med. 16:1994;763-770.
13. Logani M.K., Davies R.E. Lipid oxidation biologic effects and antioxidants - a review . Lipids. 15:1980;485-494.
14. Miura Y., Anzai K., Urano S., Ozawa T. In vivo electron paramagnetic resonance studies on oxidative stress caused by X-irradiation in whole mice. Free Radic. Biol. Med. 23:(4):1997;533-540.
15. Bump E.A., Brown J.M. Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacol. Ther. 47:1990;117-136.
16. 2, and the combination of both agents. Rad. Res. 111:1987;361-373.
17. Ozols R.F., Hamilton T.C., Young R.C. Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer. Prog. Clin. Biol. Res. 276:1988;287-293.
18. Hamilton T., Winker M.A., Louie K.G., Batist G., Behrens B.C., Tsuruo T., Grotzinger K.R., McKoy W.M., Young R.C., Ozols R.F. Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and sensitive human ovarian carcinoma cell lines by buthionine sulfoxime-mediated glutathione depletion. Biochem. Pharmacol. 34:1985;2583-2586.
19. Wanamarta A., Van Rijn J., Blank E., Haveman J., Van Zandwijk N., Joenje H. Effect of N-acetylcysteine on the antiproliferative action of x-rays or bleomycin in cultured human lung tumor cells. J. Cancer Res. Clin. Oncol. 115:1989;340-344.
20. Valles E., de Castro C., Castro J. N-acetylcysteine is an early but also a late preventive agent against carbon tetrachloride-induced liver necrosis. Toxicol. Lett. 71:1994;87-95.
21. Sjodin K., Nilsson E., Hallberg A., Tunek A. Metabolism of N-acetyl-L-cysteine. Biochem. Pharmacol. 38:1989;3981-3985.
22. Solen G. Radioprotective effect of N-acetylcysteine in vitro using the induction of DNA breaks as end-point. Int. J. Radiat. Biol. 64:1993;359-366.
23. Winters R., Zukowski J., Ercal N., Matthews R.H., Spitz D.R. Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization with N-(pyrenyl) maleimide. Anal. Biochem. 227:1995;14-21.
24. Ridnour L.A., Winters R.A., Ercal N., Spitz D.R. Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives. Methods Enzymol. 299:1999;258-267.
25. Draper H.H., Squires E.J., Mahmoodi H., Wu J., Agarwal S., Hadley M.S. Comparative evaluation of thiobarbituric acid methods for the determination of malonaldehyde in biological materials. Free Radic. Biol. Med. 15:1993;353-363.
26. Gutteridge J. The use of standards for malondialdehyde. Anal. Biochem. 69:1975;518-526.
27. Aebi H. Catalase in vitro. Methods Enzymol. 105:1984;121-126.
28. 2-induced cataract in cultured pig lens. Exp. Eye Res. 64:1997;693-700.
29. Bradford M. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-256.
30. Tietz N.W. Biochemical aspects of hematology. Tietz N.W. Textbook of clinical chemistry. 1986;691-698 W. B. Saunders, Philadelphia.
31. 2. Carcinogenesis. 13:1992;2003-2007.
32. Sarnstrand B., Tunek A., Sjodin K., Hallberg A. Effects of N-acetylcysteine stereoisomers on oxygen-induced lung injury in rats. Chem. Biol. Int. 94:1995;157-164.
33. Corcoran G., Wong B. Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo studies with N-acetyl-D-cysteine in mice . J. Pharmacol. Exp. Ther. 238:1986;54-61.
34. Holdiness M.R. Clinical pharmacokinetics of N-acetylcysteine. Clin. Pharmacokinet. 20:1991;123-134.
35. Meyer A., Buhl R., Magnussen H. The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis. Eur. Respir. J. 7:1994;431-436.
36. Burgunder J.M., Varriale A., Lauterburg B.H. Effect of n-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur. J. Clin. Pharmacol. 36:1989;127-131.
37. Fajardo L. Effects of ionizing radiation on lymph nodes. Front. Radiat. Ther. Oncol. 28:1994;37-45.
38. Anderson R.E., Warner N.L. Ionizing radiation and the immune response. Adv. Immun. 24:1976;215-335.
39. Adams J.D. Jr., Lauterburg B.H., Mitchell J.R. Plasma glutathione and glutathione disulfide in the rat regulation and response to oxidative stress . J. Pharmacol. Exp. Ther. 227:(3):1983;749-754.