Comparison of autologous cell therapy and granulocyte-colony stimulating factor (G-CSF) injection vs. G-CSF injection alone for the treatment of acute radiation syndrome in a non-human primate model

International Journal of Radiation Oncology Biology Physics

Volumn 63, Issue 3, 2005, Pages 911-920

  Bertho, Jean Marc ^a,c   Frick, Johanna ^a,c   Prat, Marie ^a,c   Demarquay, Christelle ^a,c   Dudoignon, Nicolas ^a   Trompier, François ^b   Gorin, Norbert Claude ^c   Thierry, Dominique ^a,c   Gourmelon, Patrick ^a,c  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^b Service de Dosimétrie Externe   (France)

^c HÔPITAL SAINT ANTOINE   (France)

Author keywords

Acute radiation syndrome; Cell therapy; G CSF; Heterogeneous irradiation; Non human primates

Indexed keywords

CELLS; IRRADIATION; PATIENT TREATMENT;

ACUTE RADIATION SYNDROME; CELL THERAPY; GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF); HETEROGENEOUS IRRADIATION; NON-HUMAN PRIMATES;

RADIOTHERAPY;

GRANULOCYTE COLONY STIMULATING FACTOR;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BONE MARROW CELL; FOLLOW UP; HEMATOPOIETIC CELL; LEUKOCYTE; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RADIATION INJURY; STEM CELL; THROMBOCYTE; TREATMENT OUTCOME;

ANIMALS; COMBINED MODALITY THERAPY; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MACACA FASCICULARIS; MALE; RADIATION INJURIES, EXPERIMENTAL; RECOMBINANT PROTEINS; SYNDROME; TREATMENT OUTCOME;

EID: 25844497528     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2005.03.045     Document Type: Article

References (43)

1. R.P. Gale, A. Butturini, A.E. Baranov Radiation accidents Primum non nocere Bone Marrow Transplant 11 1993 421 424
2. A.E. Baranov Is allogeneic bone marrow transplantation needed in case of severe uniform whole-body irradiation Experience from a recent accident (Nextwish, Belarus) and previous accidents T.J. Macvittie Advances in the treatment of radiation injuries Proceedings of the 2nd Consensus Development Conference on the Treatment of Radiation Injuries 1996 Elsevier New York
3. M.R. Bishop Potential use of hematopoietic stem cells after radiation injury Stem Cells 15 Suppl. 2 1997 305 310
4. H. Nagayama, K. Misawa, H. Tanaka Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim Bone Marrow Transplant 29 2002 197 204
5. T. Hirama, S. Tanosaki, S. Kandatsu Initial medical management of patients severely irradiated in the Tokaimura criticality accident Br J Radiol 76 2003 246 253
6. D. Thierry, P. Gourmelon, C. Parmentier Haematopoietic growth factors in the treatment of therapeutic and accidental irradiation-induced bone marrow aplasia Int J Radiat Biol Phys 67 1995 103 117
7. D. Densow, H. Kindler, A.E. Baranov Criteria for the selection of radiation accident victims for stem cell transplantation Stem Cells 15 Suppl. 2 1997 287 297
8. A.E. Baranov, G.D. Selidovkin, A.E. Butturini Hematopoietic recovery after 10-Gy acute total body radiation Blood 83 1994 596 599
9. J.P. Jouet, N.C. Gorin, P. Gourmelon Gestion médicale des victimes d'irradiation lors d'un accident nucléaire ou d'un acte de malveillance de grande ampleur Les entretiens de Bichat 2003 ESF Paris, France 144 147 [in French]
10. K. Atkinson, K. Fay, I. Nivison-Smith Lenograstim administration to HLA-identical donor-recipient pairs to accelerate marrow recovery post-transplant Bone Marrow Transplant 19 1997 15 21
11. N. Thatcher, D.J. Girling, P. Hopwood Improving survival without reducing quality of life in small-cell lung cancer patients by increasing the dose-intensity of chemotherapy with granulocyte colony stimulating factor support Results of a British medical research council multicenter randomized trial J Clin Oncol 18 2000 395 404
12. D.R. Barreda, P.C. Hanington, M. Belosevic Regulation of myeloid development and function by colony stimulating factors Dev Comp Immunol 28 2004 509 554
13. + cell proliferation and differentiation Stem Cells 17 1999 273 285
14. F. Herodin, P. Bourin, J.F. Mayol Short-term injection of antiapoptotic cytokine combination soon after lethal γ-irradiation promotes survival Blood 101 2003 2609 2616
15. J.E. Moulder Molecular and cellular biology of moderate (1-10 Sv) radiation and potential mechanisms of radiation protection Report on an interagency workshop on the radiobiology of nuclear terrorism Radiat Res 158 2002 118 124
16. J.E. Brandt, A.H.M. Galy, K.M. Luens Bone marrow repopulation by human marrow stem cells after long-term expansion culture on a porcine endothelial cell line Exp Hematol 26 1998 950 961
17. + cells accelerate haematological recovery in a baboon model of autologous transplantation Br J Haematol 109 2000 162 172
18. W. Brugger, S. Heimfeld, R.J. Berenson Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo New Engl J Med 333 1995 283 287
19. J. Reiffers, C. Caillot, B. Dazey Abrogation of post-myeloablative chemotherapy neutropenia by ex-vivo expansion autologous CD34-positive cells Lancet 354 1999 1092 1093
20. R.L. Paquette, S.T. Dergham, E. Karpf Ex vivo expanded unselected peripheral blood Progenitor cells reduce posttransplantation neutropenia, thrombocytopenia, and anemia in patients with breast cancer Blood 96 2000 2385 2390
21. J.M. Bertho, J. Frick, C. Demarquay Reinjection of ex vivo expanded primate bone marrow mononuclear cells strongly reduces radiation-induced aplasia J Hematother Stem Cell Res 11 2002 549 564
22. L.J. Cole, H.M. Haire, E.L. Alpen Partial shielding of dogs Effectiveness of small external epicondylar lead cuffs against lethal irradiation Radiat Res 32 1967 54 63
23. K. Baltschukat, W. Nothdurft Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays Radiat Res 123 1990 7 16
24. N.C. Parmentier, J.C. Nénot, H.J. Jammet A dosimetric study of the Belgian (1965) and Italian (1975) accidents K.F. Hübner S.A. Fry The medical basis for radiation accident preparedness 1980 Elsevier Amsterdam 105 112
25. Y. Belkacemi, S. Bouchet, J. Frick Monitoring of residual hematopoiesis after total body irradiation in humans as a model for accidental X-ray exposure Dose-effect and failure of ex vivo expansion of residual stem cells in view of autografting Int J Radiat Oncol Biol Phys 57 2003 500 507
26. J.M. Bertho, E. Mathieu, A. Lauby Feasibility and limits of bone marrow mononuclear cell expansion following irradiation Int J Radiat Biol 80 2004 73 81
27. J.P. Chute, J. Fung, G. Muramoto Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice Exp Hematol 32 2004 308 317
28. + progenitor cells Folia Biol (Praha) 48 2002 51 57
29. J.M. Bertho, M. Prat, J. Frick Application of autologous cell therapy to a non human primate model of heterogeneous high dose irradiation Radiat Res 163 2005 557 570
30. S.T. Taketa, V.P. Bond Active bone marrow distribution in the monkey Life Sci 9 1970 169 174
31. J. Zoetelief, G. Wagemaker, J.J. Broerse Dosimetry for total body irradiation of rhesus monkeys with 300 kV X-rays Int J Radiat Biol 74 1998 265 272
32. Burger H, Van Leen RW, Dorsser LC, et al. Species specificity of human interleukin-3 demonstrated by cloning and expression of homologous rhesus monkey (Macaca Mulatta) gene. Blood 76:2229-2234.
33. H. Castro-Malaspina, R.E. Gay, G. Resnick Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny Blood 56 1980 289 301
34. T. Lapidot, I. Petit Current understanding of stem cell mobilization the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells Exp Hematol 30 2002 973 981
35. A. Woldnar-Filipowicz, S.D. Lyman, A. Gratwohl Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia Blood 88 1996 4493 4499
36. J.M. Bertho, C. Demarquay, J. Frick Level of Flt3-ligand in plasma A possible new bio-indicator for radiation-induced aplasia Int J Radiat Biol 77 2001 703 712
37. A. Huchet, Y. Belkacemi, J. Frick Plasma Flt-3 ligand concentration is correlated with radiation-induced bone marrow damage during local fractionated radiotherapy Int J Radiat Oncol Biol Phys 57 2003 508 515
38. F. Herodin, M. Drouet Autologous cell therapy as a new approach to treatment of radiation induced bone marrow aplasia Preliminary study in a baboon model Can J Physiol Pharmacol 80 2003 710 716
39. M.A. Mouthon, A. Van Der Meeren, M. Vandamme Thrombopoietin protects mice from mortality and myelosuppression following high-dose irradiation Importance of time scheduling Can J Physiol Pharmacol 80 2002 717 721
40. T. Grande, J.A. Bueren A new approach to evaluate the total reserve of hematopoietic progenitors after acute irradiation Radiat Res 162 2004 397 404
41. W. Nothdurft, L. Kreja, C. Selig Acceleration of hemopoietic recovery in dogs after extended-field partial-body irradiation by treatment with colony-stimulating factors rhG-CSF and rhGM-CSF Int J Radiat Oncol Biol Phys 37 1997 1145 1154
42. N. Dainiak Hematological consequences of exposure to ionizing radiation Exp Hematol 30 2003 513 528
43. M.A. Mouthon, M.H. Gaugler, A. Van Der Meeren Single administration of thrombopoietin to lethally irradiated mice prevents infectious and thrombotic events leading to mortality Exp Hematol 29 2001 30 40