Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation

Free Radical Biology and Medicine

Volumn 31, Issue 1, 2001, Pages 10-19

  Limoli, Charles L ^a   Kaplan, Mark I ^b   Giedzinski, Erich ^a   Morgan, William F ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Deltagen Inc   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Chromosomal instability; DNA damage; DNA repair; Free radicals; Genomic instability; Scavengers

Indexed keywords

DIMETHYL SULFOXIDE; GLYCEROL; MERCAPTAMINE; SCAVENGER;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPAIR; FREEZING; HUMAN; HUMAN CELL; KARYOTYPE; METAPHASE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY REPAIR; STEM CELL; TEMPERATURE SENSITIVITY;

NON-PROGRAMMATIC;

ANIMALS; CELL CYCLE; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CRICETINAE; CYSTEAMINE; DIMETHYL SULFOXIDE; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; GLYCEROL; HUMANS; HYBRID CELLS; IN SITU HYBRIDIZATION, FLUORESCENCE; RADIATION-PROTECTIVE AGENTS;

LETHRINIDAE;

EID: 0035399786     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00542-1     Document Type: Article

References (45)

1. Genomic instability induced by ionizing radiation
2. Perpetuating radiation-induced chromosomal instability
3. The clonal evolution of tumor cell populations
4. Mutator phenotype may be required for multistage carcinogenesis
5. Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
6. Transmission of chromosomal instability after plutonium alpha-particle irradiation
7. Delayed chromosomal instability induced by DNA damage
8. Specific chromosome instability induced by heavy ions: A step towards transformation of human fibroblasts?
9. Clonal chromosome aberrations and genomic instability in x-irradiated human T-lymphocyte cultures
10. Differential induction of chromosomal instability by DNA strand-breaking agents
11. Chromosomal breakage syndromes
12. DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability
13. Variation of single-strand break yield with scavenger concentration for plasmid DNA irradiated in aqueous solution
14. Variation of single-strand break yield with scavenger concentration for the Sv40 minichromosome irradiated in aqueous solution
15. The nucleus is the target for radiation-induced chromosomal instability
16. A proposed system for scoring structural aberrations detected by chromosome painting
17. Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma-radiation
18. Radiation protection of in vitro mammalian cells: Effects of hydroxyl radical scavengers on the slopes and shoulders of survival curves
19. Influence of intracellular thiol and polyamine levels on radioprotection by aminothiols
20. Radioprotection by antioxidants
21. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts
22. Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant
23. Molecular mechanism of potentially lethal damage repair. I. Enhanced fidelity of DNA double-strand break rejoining under conditions allowing potentially lethal damage repair
24. Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation
25. Chromosomal instability induced by heavy ion irradiation
26. Radioprotection of DNA by thiols: Relationship between the net charge on a thiol and its ability to protect DNA
27. Aerobic radioprotection of pBR322 by thiols: Effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals
28. Thiol uptake by chinese hamster V79-cells and aerobic radioprotection as a function of the net charge on the thiol
29. DNA repair by thiols in air shows two radicals make a double-strand break
30. Effect of hydroxyl radical scavenging capacity on clustering of DNA damage
31. Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals
32. Weiss lecture. Effects of radiations of different qualities on cells: Molecular mechanisms of damage and repair
33. Studies on the chemical basis of cellular radiosensitization by 5-bromouracil substitution in DNA. II. Pulse- and steadystate radiolysis of bromouracil-substituted and unsubstituted DNA
34. Range of radiochemical damage to DNA with decay of iodine-125
35. Induction of chromosome aberrations and delayed genomic instability by photochemical processes
36. Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures
37. α Particles initiate production of superoxide anions and hydrogen peroxide in human cells
38. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells
39. Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity
40. Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress
41. Alpha particles induce the production of interleukin-8 by human cells
42. Factors underlying the cell growth-related bystander responses to alpha particles