Oral glutamine to alleviate radiation-induced oral mucositis: A pilot randomized trial

International Journal of Radiation Oncology Biology Physics

Volumn 46, Issue 3, 2000, Pages 535-539

  Huang, Eng Yen ^a   Leung, Stephen Wan ^a   Wang, Chong Jong ^a   Chen, Hui Chun ^a   Sun, Li Min ^a   Fang, Fu Min ^a   Yeh, Shyh An ^a   Hsu, Hsuan Chih ^a   Hsiung, Ching Yeh ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Glutamine; Oral mucositis; Radiation

Indexed keywords

GLUTAMINE; PLACEBO;

ADULT; ANALGESIA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; FEMALE; HEAD CANCER; HUMAN; MALE; MUCOSA INFLAMMATION; NECK CANCER; PRIORITY JOURNAL; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; BODY WEIGHT; FEMALE; GLUTAMINE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; RADIATION INJURIES; STOMATITIS;

EID: 0033956296     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00402-2     Document Type: Article

References (27)

1. Rothwell B.R. Prevention and treatment of the orofacial complications of radiotherapy. J Am Dent Assoc. 114:1987;316-322.
2. Budihna M., Skrk J., Smid L., et al. Tumor cell repopulation in the rest interval of split course radiation treatment. Strahlenther Onkol. 156:1980;402-408.
3. Okuno S.H., Foote R.L., Loprinzi C.L., et al. A randomized trial of a nonabsorbable antibiotic lozenge given to alleviate radiation-induced mucositis. Cancer. 79:1997;2193-2199.
4. Meredith R., Salter M., Kim R., et al. Sucralfate for radiation mucositis Results of a double-blind randomized trial . Int J Radiat Oncol Biol Phys. 37:1997;275-279.
5. Lievens Y., Haustermans K., Van den Weyngaert D., et al. Does sucralfate reduce the acute side-effects in head and neck cancer treated with radiotherapy? A double-blind randomized trial. Radiother Oncol. 47:1998;149-153.
6. Symonds R.P., McIlroy P., Khorrami J., et al. The reduction of radiation mucositis by selective decontamination antibiotic pastilles A placebo-controlled double-blind trial . Br J Cancer. 74:1996;312-317.
7. Leborgne J.H., Leborgne F., Zubizarreta E., et al. Corticosteroids and radiation mucositis in head and neck cancer A double-blind placebo-controlled randomized trial . Radiother Oncol. 47:1998;145-148.
8. Rosso M., Blasi G., Gherlone E., et al. Effect of granulocyte-macrophage colony-stimulating factor on prevention of mucositis in head and neck cancer patients treated with chemo-radiotherapy. J Chemother. 9:1997;382-385.
9. Kannan V., Bapsy P.P., Anantha N., et al. Efficacy and safety of granulocyte macrophage-colony stimulating factor (GM-CSF) on the frequency and severity of radiation mucositis in patients with head and neck carcinoma. Int J Radiat Oncol Biol Phys. 37:1997;1005-1010.
10. Abitbol A.A., Sridhar K.S., Lewin A.A., et al. Hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and mitomycin-C (+/- granulocyte-colony stimulating factor) in the treatment of patients with locally advanced head and neck carcinoma. Cancer. 80:1997;266-276.
11. Van der Hulst R.R.W.J., Deutz N.E.P., Von Meyenfeld M.F., et al. Decrease in mucosal glutamine concentration in nutritionally depleted patient. Clin Nutr. 13:1994;228-233.
12. Klimberg V.S., Souba W.W., Salloum R.M., et al. Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth. J Surg Res. 48:1990;319-323.
13. Klimberg V.S., Souba W.W., Dolson D.J., et al. Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer. 66:1990;62-68.
14. Souba W.W., Klimberg V.S., Copeland E.M. Glutamine nutrition in the management of radiation enteritis. J Parenter Enteral Nutr. 14:1990;106S-108S.
15. Shou J., Lieberman M.D., Hofmann K., et al. Dietary manipulation of methotrexate-induced enterocolitis. J Parenter Enteral Nutr. 15:1991;307-312.
16. Fox A.D., Kripke S.A., De Paula J., et al. Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis. J Parenter Enteral Nutr. 12:1988;325-331.
17. Skubitz K.M., Anderson P.M. Oral glutamine to prevent chemotherapy induced stomatitis A pilot study . J Lab Clin Med. 127:1996;223-228.
18. Anderson P.M., Schroeder G., Skubitz K.M. Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer. 83:1998;1433-1439.
19. Cox J.D., Stetz J., Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 31:1995;1341-1346.
20. McCaffery M. Pain control barriers to the use of available information. World Health Organization expert committee on cancer pain relief and active supportive care. Cancer. 70:1992;1438-1449.
21. Martin M.V., van Saene H.K. The role of oral microorganisms in cancer therapy. Curr Opin Dent. 2:1992;81-84.
22. Lowe D.K., Benfell K., Smith R.J., et al. Safety and metabolic effects of L-glutamine administration in humans. Am J Clin Nutr. 52:1990;1101-1106.
23. Ziegler T.R., Benfell K., Smith R.J., et al. Safety and metabolic effects of L-glutamine administration in humans. J Parenter Enteral Nutr. 14:1990;137S-146S.
24. Klimberg V.S., Nwokedi E., Hutchins L.F., et al. Glutamine facilitates chemotherapy while reducing toxicity. J Parenter Enteral Nutr. 16:1992;83S-87S.
25. van der Hulst R.R., van Kreel B.K., von Meyenfeldt M.F., et al. Glutamine and the preservation of gut integrity. Lancet. 341:1993;1363-1365.
26. Alverdy J.C. Effects of glutamine-supplemented diets on immunology of the gut. J Parenter Enteral Nutr. 14:1990;109S-113S.
27. Jebb S.A., Osborne R.J., Maughan T.S., et al. 5-fluorouracil and folinic acid-induced mucositis No effect of oral glutamine supplementation . Br J Cancer. 70:1994;732-735.