Medical countermeasures against nuclear threats: Radionuclide decorporation agents

Radiation Research

Volumn 170, Issue 4, 2008, Pages 540-548

  Cassatt, David R ^a   Kaminski, Joseph M ^a   Hatchett, Richard J ^a   DiCarlo, Andrea L ^a   Benjamin, Jessica M ^a   Maidment, Bert W ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINIDE; ANTIDOTE; CALCIUM DIETHYLENETRIAMINEPENTAACETIC ACID; CESIUM; CHELATING AGENT; CHITOSAN; COBALT; DEFERRIFERRITHIOCIN; DEFERRIFERRITHIOCIN DERIVATIVE; DIMERCAPROL; FERRIC FERROCYANIDE; IODINE; IRON CHELATING AGENT; LANTHANIDE; METAL; NANOPARTICLE; PENICILLAMINE; PENTETIC ACID; PENTETIC ACID DERIVATIVE; PLUTONIUM; PYRIDINE DERIVATIVE; RADIOISOTOPE; SIDEROPHORE; SUCCIMER; THORIUM; TRIENTINE; TRIETHYLENETETRAMINEHEXAACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNITHIOL; URANIUM; ZINC DIETHYLENETRIAMINEPENTAACETIC ACID;

ATOMIC BOMB; CANCER RISK; CONFERENCE PAPER; CYSTINURIA; DRUG BIOAVAILABILITY; FALLOUT; FOOD AND DRUG ADMINISTRATION; GOOD LABORATORY PRACTICE; GOOD MANUFACTURING PRACTICE; HEALTH CARE; HEALTH CARE POLICY; HEALTH PROGRAM; HUMAN; INTOXICATION; LEAD POISONING; MERCURIALISM; NONHUMAN; NUCLEAR ACCIDENT; PRIORITY JOURNAL; RADIATION INJURY; RADIATION SICKNESS; RHEUMATOID ARTHRITIS; RISK FACTOR; WILSON DISEASE;

CHELATING AGENTS; HUMANS; NUCLEAR WEAPONS; RADIATION INJURIES; RADIOACTIVE FALLOUT; RADIOACTIVE HAZARD RELEASE; RADIOISOTOPES;

EID: 55349084049     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1485.1     Document Type: Conference Paper

References (47)

1. HHS Public Health Emergency Medical Countermeasure Enterprise Implementation Plan for Chemical, Biological, Radiological and Nuclear Threats. Office of Public Health Emergency Medical Countermeasures, U.S. Department of Health and Human Services, Washington, DC, 2007.
2. NCRP, Management of Persons Accidentally Contaminated with Radionuclides: Recommendations of the National Council on Radiation Protection and Measurements. Report No. 65, National Council on Radiation Protection and Measurements, Bethesda, MD, 1980.
3. 137Cs internal contamination involving a Brazilian accident, and the efficacy of Prussian Blue treatment. Health Phys. 66, 245-252 (1994).
4. 137Cs decorporation: the Goiania radiological accident. Health Phys. 60, 63-66 (1991).
5. F. T. Harper, S. V. Musolino and W. B. Wente, Realistic radiological dispersal device hazard boundaries and ramifications for early consequence management decisions. Health Phys. 93, 1-16 (2007).
6. Guidance for Industry, Internal Radioactive Contamination - Development of decorporation Agents. U.S. Food and Drug Administration, Washington, DC, 2006. [Available online at http://www.fda.gov/CDER/guidance/ 6983fnl.htm]
7. 237Np: Oxidation state in vivo and chelation by multidentate catecholate and hydroxypyridinonate ligands. Health Phys. 75, 34-50 (1998).
8. R. A. Guilmette and B. A. Muggenburg, Reducing the radiation dose from inhaled americium-241 using continuously administered DTPA therapy. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 53, 261-271 (1988).
9. 144Ce in dogs. Radiat. Res. 124, 147-155 (1990).
10. 239Pu by chelation therapy. Radiat. Res. 107, 296-306 (1986).
11. M. W. Rosenthal and A. Lindenbaum, Osteosarcomas as Related to Tissue Distribution of Monomeric and Polymeric Plutonium in Mice. Report ANL-7409, Argonne National Laboratory, Argonne, IL, 1967.
12. 241Am removal by DTPA vs. occurrence of skeletal malignancy. Health Phys. 75, 640-645 (1998).
13. M. Blanusa, V. M. Varnai, M. Piasek and K. Kostial, Chelators as antidotes of metal toxicity: Therapeutic and experimental aspects. Curr. Med. Chem. 12, 2771-2794 (2005).
14. J. Rencova, V. Volf, M. M. Jones and P. K. Singh, Decorporation of polonium from rats by new chelating agents. Radiat. Prot. Dosimetry 53, 311-313 (1994).
15. J. B. Hursh, The effect of BAL on the excretion and tissue distribution of polonium in rats. J. Pharmacol. Exp. Ther. 103, 450-459 (1951).
16. J. B. Hursh, Effect of BAL on survival of rats after lethal doses of polonium. Proc. Soc. Exp. Biol. Med. 79, 210-212 (1952).
17. J. Rencova, V. Volf, M. M. Jones and P. K. Singh, Relative effectiveness of dithiol and dithiocarbamate chelating agents in reducing retention of polonium-210 in rats. Int. J. Radiat. Biol. 63, 223-232 (1993).
18. H. V. Aposhian, R. C. Dart, M. M. Aposhian and B. V. Dawson, Tissue decorporation of polonium-210 in rats by DMPA. Res. Commun. Chem. Pathol. Pharmacol. 58, 157-171 (1987).
19. H. V. Aposhian, R. M. Maiorino, D. Gonzalez-Ramirez, M. Zuniga-Charles, Z. Xu, K. M. Hurlbut, P. Junco-Munoz, R. C. Dart and M. M. Aposhian, Mobilization of heavy metals by newer, therapeutically useful chelating agents. Toxicology 97, 23-38 (1995).
20. J. Rencova, V. Volf, M. M. Jones, P. K. Singh and R. Filgas, Bisdithiocarbamates: effective chelating agents for mobilization of polonium-210 from rat. Int. J. Radiat. Biol. 67, 229-234 (1995).
21. G. M. Bogdan and H. V. Aposhian, N-(2,3-dimercaptopropyl) phthalamidic acid (DMPA) increases polonium-210 excretion. Biol. Met. 3, 232-236 (1990).
22. T. Pincus, S. B. Marcum and L. F. Callahan, Longterm drug therapy for rheumatoid arthritis in seven rheumatology private practices: II. Second line drugs and prednisone. J. Rheumatol. 19, 1885-1894 (1992).
23. J. Christensen and R. Izat, Handbook of Metal Ligand Heats. Marcel Dekker, New York, 1983.
24. P. Bohme and A. Catsch, Comparative studies on the decorporation efficacy of D-penicillamine, penicillic acid and penillic acid. Arzneimittelforschung 17, 19-22 (1967).
25. D. K. Le, Distribution of cobalt-60 in the rat as influenced by chelating agents. Nature 204, 696-697 (1964).
26. K. Bibow, B. Salbu, K. M. Strand and E. Munthe, The influence of D-penicillamine on trace element excretion. Acta Pharmacol. Toxicol. (Copenhagen) 59 (Suppl. 7), 374-377 (1986).
27. A. Ala, A. P. Walker, K. Ashkan, J. S. Dooley and M. L. Schilsky, Wilson's disease. Lancet 369, 397-408 (2007).
28. S. Fukuda, Chelating agents used for plutonium and uranium removal in radiation emergency medicine. Curr. Med. Chem. 12, 2765-2770 (2005).
29. A. E. Gorden, J. Xu, K. N. Raymond and P. Durbin, Rational design of sequestering agents for plutonium and other actinides. Chem. Rev. 103, 4207-4282 (2003).
30. P. V. Bernhardt, Coordination chemistry and biology of chelators for the treatment of iron overload disorders. Dalton Trans. 3214-3220 (2007).
31. 241Am in the rat: comparison of 3,4,3-LIHOPO, DFO-HOPO, DTPA-DX, DTPA and DFOA. Int. J. Radiat. Biol. 63, 785-793 (1993).
32. 241Am in the rat: Effect of dosage, time and mode of chelate administration. Int. J. Radiat. Biol. 70, 765-772 (1996).
33. P. Fritsch, D. Herbreteau, K. Moutairou, G. Lantenois, H. Richard-le Naour, G. Grillon, D. Hoffschir, J. L. Poncy, A. Laurent and R. Masse, Comparative Toxicity of 3,4,3-LIHOPO and DTPA in baboons: Preliminary results. Radiat. Prot. Dosimetry 53, 315-318 (1994).
34. G. Liu, P. Men, G. H. Kenner and S. C. Miller, Age-associated iron accumulation in bone: implications for postmenopausal osteoporosis and a new target for prevention and treatment by chelation. Biometals 19, 245-251 (2006).
35. M. Sonoda, I. Yoshida and I. Murase, Synthesis and determination of metal chelate stabilities of n-alkyltriethylenetetraaminepentaacetic acid. J. Coord. Chem. 54, 153-165 (2001).
36. S. C. Miller, G. Liu, F. W. Bruenger and R. D. Lloyd, Efficacy of orally administered amphipathic polyaminocarboxylic acid chelators for the removal of plutonium and americium: comparison with injected Zn-DTPA in the rat. Radiat. Prot. Dosimetry 118, 412-420 (2006).
37. Y. Nishimura, I. Kakuta, H. Takeda, J. Inaba, K. Imai, K. Watari and N. Matsusaka, Effect of natural chelating agents on the intestinal absorption of radiostrontium in rats. Radiat. Prot. Dosimetry 53, 331-334 (1994).
38. 14C-chitosan in rats. Chitin. Chitosan. Res. 3, 55-61 (1997).
39. Y. Nishimura, H. S. Kim, N. Ikota, H. Arima, H. S. Bom, Y. H. Kim, Y. Watanabe, M. Yukawa and T. Ozawa, Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice. J. Radiat. Res. (Tokyo) 44, 53-58 (2003).
40. W. Yantasee, Y. Lin, G. E. Fryxell, B. J. Busche and J. C. Birbaum, Removal of heavy metals from the aqueous solution using novel nanoengineered sorbents: self-assembled carbamoylphosphonic acids on mesoporous silica. Sep. Sci. Technol. 38, 3809-3825 (2003).
41. W. Yantasee, G. E. Fryxell, M. M. Conner and Y. Lin, Nanostructured electrochemical sensors based on functionalized nanoporous silica for voltammetric analysis of lead, mercury, and copper. J. Nanosci. Nanotechnol. 5, 1537-1540 (2005).
42. X. B. Chen, X. D. Feng, J. Liu, G. E. Fryxell and M. Gong, Mercury separation and immobilization using self-assembled monolayers on mesoporous supports (SAMMS). Sep. Sci. Technol. 34, 1121-1132 (1993).
43. X. Feng, G. E. Fryxell, L. Q. Wang, A. Y. Kim, J. Liu and K. M. Kemner, Functionalized monolayers on ordered mesoporous supports. Science 276, 923-926 (1997).
44. Y. Lin, G. E. Fryxell, H. Wu and M. Engelhard, Selective sorption of cesium using self-assembled monolayers on mesoporous supports. Environ. Sci. Technol. 35, 3962-3966 (2001).
45. S. V. Mattigod, G. E. Fryxell, R. J. Serne, K. E. Parker and F. M. Mann, Evaluation of novel getters for adsorption of radioiodine from groundwater and waste glass leachates. Radiochim. Acta 91, 539-545 (2003).
46. C. N. Coleman, C. Hrdina, J. L. Bader, A. Norwood, R. Hayhurst, J. Forsha, K. Yeskey and A. Knebel, Medical response to a radiologic/nuclear event: integrated plan from the office of the assistant secretary for preparedness and response, department of health and human services. Ann. Emerg. Med., in press.
47. J. Rencova, A. Vikova, R. Curik, R. Holusa and G. Vesela, Influence of heavy metals upon the retention and mobilization of polonium-210 in rats. Int. J. Radiat. Biol. 80, 769-776 (2004).