An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

Science

Volumn 320, Issue 5873, 2008, Pages 226-230

  Burdelya, Lyudmila G ^a   Krivokrysenko, Vadim I ^b   Tallant, Thomas C ^c   Strom, Evguenia ^b   Gleiberman, Anatoly S ^b   Gupta, Damodar ^a   Kurnasov, Oleg V ^d   Fort, Farrel L ^b   Osterman, Andrei L ^d   DiDonato, Joseph A ^c   Feinstein, Elena ^b   Gudkov, Andrei V ^a,b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b CLEVELAND BIOLABS INC   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIFOSTINE; BACTERIAL PROTEIN; CBLB 502; CYTOKINE; FLAGELLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYPEPTIDE; TOLL LIKE RECEPTOR 5 AGONIST; UNCLASSIFIED DRUG;

AGONISTIC BEHAVIOR; BACTERIUM; CANCER; IRRADIATION; MODELING; PRIMATE; RODENT; SIGNALING; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL PROTECTION; CONTROLLED STUDY; DISEASE MODEL; GASTROINTESTINAL RADIOGRAPHY; GENE ACTIVATION; HEMATOPOIETIC SYSTEM; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PROTECTION; RADIATION SICKNESS; RADIOSENSITIVITY; RHESUS MONKEY; SALMONELLA; SURVIVAL; TUMOR CELL; WHOLE BODY RADIATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CHEMOTHERAPY, ADJUVANT; FLAGELLIN; GAMMA RAYS; HEMATOPOIETIC SYSTEM; INTESTINE, SMALL; MACACA MULATTA; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; NEOPLASMS, EXPERIMENTAL; NF-KAPPA B; PEPTIDES; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; SALMONELLA ENTERICA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; WHOLE-BODY IRRADIATION;

MACACA MULATTA; MUS; PRIMATES; SALMONELLA;

EID: 42049095095     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1154986     Document Type: Article

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37. We thank P. Baker for help with manuscript preparation and editing. Supported by grants CA75179 and AI066497 from NIH and grants from NASA (U.S. National Aeronuautics and Space Administration), the Defense Advanced Research Projects Agency (DARPA) and Cleveland BioLabs, Inc., to A.V.G. and grant CA84406 from NIH to J.A.D. A.V.G., E.F., L.G.B., and J.A.D. have a paid consulting relationship with Cleveland BioLabs, Inc. We dedicate this paper to the memory of our friend and colleague Alexander (Shurik) Neyfakh.