Regulation of the retinoblastoma proteins by the human herpesviruses

Cell Division

Volumn 4, Issue , 2009, Pages

  Hume, Adam J ^a   Kalejta, Robert F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRIDAE; HERPESVIRIDAE; HUMAN PAPILLOMAVIRUS; SIMIAN VIRUS 40;

EID: 61349118084     PISSN: None     EISSN: 17471028     Source Type: Journal    
DOI: 10.1186/1747-1028-4-1     Document Type: Review

References (321)

1. Knudsen ES Knudsen KE Tailoring to RB: Tumour suppressor status and therapeutic response Nat Rev Cancer 2008, 8:714-724. 19143056
2. Weinberg RA The retinoblastoma protein and cell cycle control Cell 1995, 81:323-330. 7736585
3. Dick FA Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts? Cell Div 2007, 2:26. 17854503
4. Burkhart DL Sage J Cellular mechanisms of tumour suppression by the retinoblastoma gene Nat Rev Cancer 2008, 8:671-682. 18650841
5. Giacinti C Giordano A RB and cell cycle progression Oncogene 2006, 25:5220-5227. 16936740
6. Cobrinik D Pocket proteins and cell cycle control Oncogene 2005, 24:2796-2809. 15838516
7. Iaquinta PJ Lees JA Life and death decisions by the E2F transcription factors Curr Opin Cell Biol 2007, 19:649-657. 18032011
8. Polager S Ginsberg D E2F - at the crossroads of life and death Trends Cell Biol 2008, 18:528-535. 18805009
9. Blais A Dynlacht BD E2F-associated chromatin modifiers and cell cycle control Curr Opin Cell Biol 2007, 19:658-662. 18023996
10. Blais A Dynlacht BD Hitting their targets: An emerging picture of E2F and cell cycle control Curr Opin Genet Dev 2004, 14:527-532. 15380244
11. Ohtani K Implication of transcription factor E2F in regulation of DNA replication Front Biosci 1999, 4:D793-804. 10577392
12. Polager S Kalma Y Berkovich E Ginsberg D E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis Oncogene 2002, 21:437-446. 11821956
13. Stevens C Smith L La Thangue NB Chk2 activates E2F-1 in response to DNA damage Nat Cell Biol 2003, 5:401-409. 12717439
14. Phillips AC Ernst MK Bates S Rice NR Vousden KH E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways Mol Cell 1999, 4:771-781. 10619024
15. Phillips AC Bates S Ryan KM Helin K Vousden KH Induction of DNA synthesis and apoptosis are separable functions of E2F-1 Genes Dev 1997, 11:1853-1863. 9242492
16. Bell LA Ryan KM Life and death decisions by E2F-1 Cell Death Differ 2004, 11:137-142. 14526389
17. Kowalik TF DeGregori J Schwarz JK Nevins JR E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis J Virol 1995, 69:2491-2500. 7884898
18. Wu X Levine AJ p53 and E2F-1 cooperate to mediate apoptosis Proc Natl Acad Sci USA 1994, 91:3602-3606. 8170954
19. Skapek SX Pan YR Lee EY Regulation of cell lineage specification by the retinoblastoma tumor suppressor Oncogene 2006, 25:5268-5276. 16936747
20. Korenjak M Brehm A E2F-Rb complexes regulating transcription of genes important for differentiation and development Curr Opin Genet Dev 2005, 15:520-527. 16081278
21. Galderisi U Cipollaro M Giordano A The retinoblastoma gene is involved in multiple aspects of stem cell biology Oncogene 2006, 25:5250-5256. 16936744
22. Ben-Porath I Weinberg RA The signals and pathways activating cellular senescence Int J Biochem Cell Biol 2005, 37:961-976. 15743671
23. Gabellini C Del Bufalo D Zupi G Involvement of RB gene family in tumor angiogenesis Oncogene 2006, 25:5326-5332. 16936754
24. Shan B Chang CY Jones D Lee WH The transcription factor E2F-1 mediates the autoregulation of RB gene expression Mol Cell Biol 1994, 14:299-309. 8264596
25. Brehm A Miska EA McCance DJ Reid JL Bannister AJ Kouzarides T Retinoblastoma protein recruits histone deacetylase to repress transcription Nature 1998, 391:597-601. 9468139
26. Magnaghi-Jaulin L Groisman R Naguibneva I Robin P Lorain S Le Villain JP Troalen F Trouche D Harel-Bellan A Retinoblastoma protein represses transcription by recruiting a histone deacetylase Nature 1998, 391:601-605. 9468140
27. Luo RX Postigo AA Dean DC Rb interacts with histone deacetylase to repress transcription Cell 1998, 92:463-473. 9491888
28. Lai A Lee JM Yang WM DeCaprio JA Kaelin WG Jr Seto E Branton PE RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins Mol Cell Biol 1999, 19:6632-6641. 10490602
29. Dunaief JL Strober BE Guha S Khavari PA Alin K Luban J Begemann M Crabtree GR Goff SP The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest Cell 1994, 79:119-130. 7923370
30. Zhang HS Gavin M Dahiya A Postigo AA Ma D Luo RX Harbour JW Dean DC Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF Cell 2000, 101:79-89. 10778858
31. Strober BE Dunaief JL Guha Goff SP Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins Mol Cell Biol 1996, 16:1576-1583. 8657132
32. Xiao B Spencer J Clements A Ali-Khan N Mittnacht S Broceno C Burghammer M Perrakis A Marmorstein R Gamblin SJ Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation Proc Natl Acad Sci USA 2003, 100:2363-2368. 12598654
33. Chan HM Smith L La Thangue NB Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein Oncogene 2001, 20:6152-6163. 11593423
34. Dahiya A Gavin MR Luo RX Dean DC Role of the LXCXE binding site in Rb function Mol Cell Biol 2000, 20:6799-6805. 10958676
35. Singh M Krajewski M Mikolajka A Holak TA Molecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequences J Biol Chem 2005, 280:37868-37876. 16118215
36. Kim HY Ahn BY Cho Y Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen Embo J 2001, 20:295-304. 11226179
37. Lee JO Russo AA Pavletich NP Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7 Nature 1998, 391:859-865. 9495340
38. Bregman DB Pestell RG Kidd VJ Cell cycle regulation and RNA polymerase II Front Biosci 2000, 5:D244-257. 10704151
39. Hirose Y Ohkuma Y Phosphorylation of the C-terminal domain of RNA polymerase II plays central roles in the integrated events of eucaryotic gene expression J Biochem 2007, 141:601-608. 17405796
40. Canduri F Perez PC Caceres RA de Azevedo WF Jr CDK9 a potential target for drug development Med Chem 2008, 4:210-218. 18473913
41. Shapiro GI Cyclin-dependent kinase pathways as targets for cancer treatment J Clin Oncol 2006, 24:1770-1783. 16603719
42. Harbour JW Luo RX Dei Santi A Postigo AA Dean DC Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1 Cell 1999, 98:859-869. 10499802
43. Buchkovich K Duffy LA Harlow E The retinoblastoma protein is phosphorylated during specific phases of the cell cycle Cell 1989, 58:1097-1105. 2673543
44. Adams PD Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks Biochim Biophys Acta 2001, 1471:M123-133. 11250068
45. Lundberg AS Weinberg RA Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes Mol Cell Biol 1998, 18:753-761. 9447971
46. Dowdy SF Hinds PW Louie K Reed SI Arnold A Weinberg RA Physical interaction of the retinoblastoma protein with human D cyclins Cell 1993, 73:499-511. 8490963
47. Ewen ME Sluss HK Sherr CJ Matsushime H Kato J Livingston DM Functional interactions of the retinoblastoma protein with mammalian D-type cyclins Cell 1993, 73:487-497. 8343202
48. Kato J Matsushime H Hiebert SW Ewen ME Sherr CJ Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4 Genes Dev 1993, 7:331-342. 8449399
49. Adams PD Li X Sellers WR Baker KB Leng X Harper JW Taya Y Kaelin WG Jr Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes Mol Cell Biol 1999, 19:1068-1080. 9891042
50. Besson A Dowdy SF Roberts JM CDK inhibitors: Cell cycle regulators and beyond Dev Cell 2008, 14:159-169. 18267085
51. Sherr CJ Roberts JM CDK inhibitors: Positive and negative regulators of G1-phase progression Genes Dev 1999, 13:1501-1512. 10385618
52. Ludlow JW Shon J Pipas JM Livingston DM DeCaprio JA The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T Cell 1990, 60:387-396. 2154332
53. Ludlow JW Glendening CL Livingston DM DeCarprio JA Specific enzymatic dephosphorylation of the retinoblastoma protein Mol Cell Biol 1993, 13:367-372. 8380224
54. Vietri M Bianchi M Ludlow JW Mittnacht S Villa-Moruzzi E Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb Cancer Cell Int 2006, 6:3. 16466572
55. Higashitsuji H Itoh K Nagao T Dawson S Nonoguchi K Kido T Mayer RJ Arii S Fujita J Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas Nat Med 2000, 6:96-99. 10613832
56. Nakamura Y Nakano K Umehara T Kimura M Hayashizaki Y Tanaka A Horikoshi M Padmanabhan B Yokoyama S Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome Structure 2007, 15:179-189. 17292836
57. Sherr CJ Cancer cell cycles Science 1996, 274:1672-1677. 8939849
58. Santamaria D Ortega S Cyclins and CDKS in development and cancer: lessons from genetically modified mice Front Biosci 2006, 11:1164-1188. 16146805
59. Ortega S Malumbres M Barbacid M Cyclin D-dependent kinases, INK4 inhibitors and cancer Biochim Biophys Acta 2002, 1602:73-87. 11960696
60. Palmero I Peters G Perturbation of cell cycle regulators in human cancer Cancer Surv 1996, 27:351-367. 8909810
61. Malumbres M Barbacid M To cycle or not to cycle: A critical decision in cancer Nat Rev Cancer 2001, 1:222-231. 11902577
62. Munger K The role of human papillomaviruses in human cancers Front Biosci 2002, 7:d641-649. 11861215
63. Wolfel T Hauer M Schneider J Serrano M Wolfel C Klehmann-Hieb E De Plaen E Hankeln T Meyer zum Buschenfelde KH Beach D A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma Science 1995, 269:1281-1284. 7652577
64. Kefford R Bishop JN Tucker M Bressac-de Paillerets B Bianchi-Scarra G Bergman W Goldstein A Puig S Mackie R Elder D Hansson J Hayward N Hogg D Olsson H Genetic testing for melanoma Lancet Oncol 2002, 3:653-654. 12424065
65. Cavenee WK Dryja TP Phillips RA Benedict WF Godbout R Gallie BL Murphree AL Strong LC White RL Expression of recessive alleles by chromosomal mechanisms in retinoblastoma Nature 1983, 305:779-784. 6633649
66. Classon M Dyson N p107 and p130: Versatile proteins with interesting pockets Exp Cell Res 2001, 264:135-147. 11237530
67. Grana X Garriga J Mayol X Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth Oncogene 1998, 17:3365-3383. 9916999
68. Mayol X Garriga J Grana X Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130 Oncogene 1995, 11:801-808. 7651744
69. Tedesco D Lukas J Reed SI The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2) Genes Dev 2002, 16:2946-2957. 12435635
70. Mittnacht S Control of pRB phosphorylation Curr Opin Genet Dev 1998, 8:21-27. 9529601
71. Howard CM Claudio PP De Luca A Stiegler P Jori FP Safdar NM Caputi M Khalili K Giordano A Inducible pRb2/p130 expression and growth-suppressive mechanisms: Evidence of a pRb2/p130, p27Kip1, and cyclin E negative feedback regulatory loop Cancer Res 2000, 60:2737-2744. 10825149
72. Claudio PP Howard CM Fu Y Cinti C Califano L Micheli P Mercer EW Caputi M Giordano A Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma Cancer Res 2000, 60:8-12. 10646842
73. Claudio PP Caputi M Giordano A The RB2/p130 gene: The latest weapon in the war against lung cancer? Clin Cancer Res 2000, 6:754-764. 10741694
74. Claudio PP Howard CM Pacilio C Cinti C Romano G Minimo C Maraldi NM Minna JD Gelbert L Leoncini L Tosi GM Hicheli P Caputi M Giordano GG Giordano A Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer Cancer Res 2000, 60:372-382. 10667590
75. Yeung RS Bell DW Testa JR Mayol X Baldi A Grana X Klinga-Levan K Knudson AG Giordano A The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19 Oncogene 1993, 8:3465-3468. 8247552
76. Scambia G Lovergine S Masciullo V RB family members as predictive and prognostic factors in human cancer Oncogene 2006, 25:5302-5308. 16936751
77. Felsani A Mileo AM Paggi MG Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins Oncogene 2006, 25:5277-5285. 16936748
78. Helt AM Galloway DA Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins Carcinogenesis 2003, 24:159-169. 12584163
79. Lee C Cho Y Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor Rev Med Virol 2002, 12:81-92. 11921304
80. Raychaudhuri P Bagchi S Devoto SH Kraus VB Moran E Nevins JR Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes Genes Dev 1991, 5:1200-1211. 1829698
81. Liu X Marmorstein R Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor Genes Dev 2007, 21:2711-2716. 17974914
82. Ikeda MA Nevins JR Identification of distinct roles for separate E1A domains in disruption of E2F complexes Mol Cell Biol 1993, 13:7029-7035. 8413292
83. Gustafsson B Huang W Bogdanovic G Gauffin F Nordgren A Talekar G Ornelles DA Gooding LR Adenovirus DNA is detected at increased frequency in Guthrie cards from children who develop acute lymphoblastic leukaemia Br J Cancer 2007, 97:992-994. 17876329
84. Berezutskaya E Yu B Morozov A Raychaudhuri P Bagchi S Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein Cell Growth Differ 1997, 8:1277-1286. 9419416
85. Boyer SN Wazer DE Band V E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway Cancer Res 1996, 56:4620-4624. 8840974
86. Jones DL Munger K Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein J Virol 1997, 71:2905-2912. 9060648
87. Gonzalez SL Stremlau M He X Basile JR Munger K Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7 J Virol 2001, 75:7583-7591. 11462030
88. Helt AM Galloway DA Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes J Virol 2001, 75:6737-6747. 11435552
89. Vousden KH Interactions between papillomavirus proteins and tumor suppressor gene products Adv Cancer Res 1994, 64:1-24. 7879655
90. Berezutskaya E Bagchi S The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome J Biol Chem 1997, 272:30135-30140. 9374493
91. Huh K Zhou X Hayakawa H Cho JY Libermann TA Jin J Harper JW Munger K Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor J Virol 2007, 81:9737-9747. 17609271
92. Heck DV Yee CL Howley PM Munger K Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses Proc Natl Acad Sci USA 1992, 89:4442-4446. 1316608
93. DeCaprio JA Ludlow JW Figge J Shew JY Huang CM Lee WH Marsilio E Paucha E Livingston DM SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene Cell 1988, 54:275-283. 2839300
94. Zalvide J DeCaprio JA Stubdal H Binding of SV40 large T antigen to the retinoblastoma susceptibility gene product and related proteins Methods Mol Biol 2001, 165:213-218. 11217388
95. Zalvide J DeCaprio JA Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation Mol Cell Biol 1995, 15:5800-5810. 7565733
96. Zalvide J Stubdal H DeCaprio JA The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins Mol Cell Biol 1998, 18:1408-1415. 9488456
97. Sullivan CS Cantalupo P Pipas JM The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism Mol Cell Biol 2000, 20:6233-6243. 10938100
98. Stubdal H Zalvide J DeCaprio JA Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107 J Virol 1996, 70:2781-2788. 8627752
99. Leithner K Leithner A Clar H Weinhaeusel A Radl R Krippl P Rehak P Windhager R Haas OA Olschewski H Mesothelioma mortality in Europe: impact of asbestos consumption and simian virus 40 Orphanet J Rare Dis 2006, 1-44. 17090323
100. DeCaprio JA The role of the J domain of SV40 large T in cellular transformation Biologicals 1999, 27:23-28. 10441399
101. Lin JY DeCaprio JA SV40 large T antigen promotes dephosphorylation of p130 J Biol Chem 2003, 278:46482-46487. 12968030
102. Lundstig A Dejmek A Eklund C Filinic I Dillner J No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden Anticancer Res 2007, 27:4159-4161. 18225586
103. Saric M Curin K Varnai VM The role of polio-vaccine in pleural mesothelioma - an epidemiological observation Coll Antropol 2008, 32:479-483. 18756898
104. Pellett PE Roizman B The Family: Herpesviridae A Brief Introduction Fields Virology Philadelphia: Lippincott Williams & Wilkins 5 2007, II:2479-2499.
105. Grunewald K Desai P Winkler DC Heymann JB Belnap DM Baumeister W Steven AC Three-dimensional structure of herpes simplex virus from cryo-electron tomography Science 2003, 302:1396-1398. 14631040
106. Liu F Zhou ZH Comparative virion structures of human herpesviruses Human Herpesviruses New York: Cambridge University Press 2007, 27-43.
107. Kalejta RF Tegument proteins of human cytomegalovirus Microbiol Mol Biol Rev 2008, 72:249-265. 18535146
108. McGeoch DJ Rixon FJ Davison AJ Topics in herpesvirus genomics and evolution Virus Res 2006, 117:90-104. 16490275
109. Davison AJ Comparative analysis of the genomes Human Herpesviruses New York: Cambridge University Press 2007, 10-26.
110. Taylor TJ Brockman MA McNamee EE Knipe DM Herpes simplex virus Front Biosci 2002, 7:d752-764. 11861220
111. Mocarski ES Comparative analysis of herpesvirus-common proteins Human Herpesviruses New York: Cambridge University Press 2007, 44-58.
112. Mori I Nishiyama Y Herpes simplex virus and varicella-zoster virus: Why do these human alphaherpesviruses behave so differently from one another? Rev Med Virol 2005, 15:393-406. 16173110
113. Steiner I Kennedy PG Pachner AR The neurotropic herpes viruses: Herpes simplex and varicella-zoster Lancet Neurol 2007, 6:1015-1028. 17945155
114. Looker KJ Garnett GP Schmid GP An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection Bull World Health Organ 2008, 86:805-812. 18949218
115. Song B Liu JJ Yeh KC Knipe DM Herpes simplex virus infection blocks events in the G1 phase of the cell cycle Virology 2000, 267:326-334. 10662628
116. de Bruyn Kops A Knipe DM Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein Cell 1988, 55:857-868. 2847874
117. Ehmann GL McLean TI Bachenheimer SL Herpes simplex virus type 1 infection imposes a G(1)/S block in asynchronously growing cells and prevents G(1) entry in quiescent cells Virology 2000, 267:335-349. 10662629
118. Olgiate J Ehmann GL Vidyarthi S Hilton MJ Bachenheimer SL Herpes simplex virus induces intracellular redistribution of E2F4 and accumulation of E2F pocket protein complexes Virology 1999, 258:257-270. 10366563
119. Song B Yeh KC Liu J Knipe DM Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functions Virology 2001, 290:320-328. 11883196
120. Sandri-Goldin RM The many roles of the regulatory protein ICP27 during herpes simplex virus infection Front Biosci 2008, 13:5241-5256. 18508584
121. Smiley JR Elgadi MM Saffran HA Herpes simplex virus vhs protein Methods Enzymol 2001, 342:440-451. 11586916
122. Sandri-Goldin RM Mendoza GE A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing Genes Dev 1992, 6:848-863. 1315705
123. Sandri-Goldin RM Properties of an HSV-1 regulatory protein that appears to impair host cell splicing Infect Agents Dis 1994, 3:59-67. 7812656
124. Hardy WR Sandri-Goldin RM Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect J Virol 1994, 68:7790-7799. 7966568
125. Hobbs WE 2nd DeLuca NA Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0 J Virol 1999, 73:8245-8255. 10482575
126. Lomonte P Everett RD Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G(1) into S phase of the cell cycle J Virol 1999, 73:9456-9467. 10516054
127. Hossain A Holt T Ciacci-Zanella J Jones C Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection J Gen Virol 1997, 78(Pt 12):3341-3348. 9400986
128. Ehmann GL Burnett HA Bachenheimer SL Pocket protein p130/Rb2 is required for efficient herpes simplex virus type 1 gene expression and viral replication J Virol 2001, 75:7149-7160. 11435596
129. Hilton MJ Mounghane D McLean T Contractor NV O'Neil J Carpenter K Bachenheimer SL Induction by herpes simplex virus of free and heteromeric forms of E2F transcription factor Virology 1995, 213:624-638. 7491786
130. Sacks WR Schaffer PA Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture J Virol 1987, 61:829-839. 3027408
131. Stow ND Stow EC Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110 J Gen Virol 1986, 67(Pt 12):2571-2585. 3025339
132. Lacy S Whyte P Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes Oncogene 1997, 14:2395-2406. 9188854
133. Zhu L Enders G Lees JA Beijersbergen RL Bernards R Harlow E The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes Embo J 1995, 14:1904-1913. 7743997
134. Zhu L Harlow E Dynlacht BD p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F Genes Dev 1995, 9:1740-1752. 7622038
135. Shirodkar S Ewen M DeCaprio JA Morgan J Livingston DM Chittenden T The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner Cell 1992, 68:157-166. 1531040
136. Sage J Miller AL Perez-Mancera PA Wysocki JM Jacks T Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry Nature 2003, 424:223-228. 12853964
137. Schang LM Phillips J Schaffer PA Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription J Virol 1998, 72:5626-5637. 9621021
138. Diwan P Lacasse JJ Schang LM Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors J Virol 2004, 78:9352-9365. 15308730
139. Durand LO Roizman B Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1 J Virol 2008, 82:10591-10599. 18753202
140. Davido DJ Von Zagorski WF Maul GG Schaffer PA The differential requirement for cyclin-dependent kinase activities distinguishes two functions of herpes simplex virus type 1 ICP0 J Virol 2003, 77:12603-12616. 14610183
141. Advani SJ Weichselbaum RR Roizman B E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1 J Virol 2000, 74:7842-7850. 10933691
142. Leisenfelder SA Moffat JF Varicella-zoster virus infection of human foreskin fibroblast cells results in atypical cyclin expression and cyclin-dependent kinase activity J Virol 2006, 80:5577-5587. 16699039
143. Moffat JF McMichael MA Leisenfelder SA Taylor SL Viral and cellular kinases are potential antiviral targets and have a central role in varicella zoster virus pathogenesis Biochim Biophys Acta 2004, 1697:225-231. 15023363
144. Taylor SL Kinchington PR Brooks A Moffat JF Roscovitine, a cyclin-dependent kinase inhibitor, prevents replication of varicella-zoster virus J Virol 2004, 78:2853-2862. 14990704
145. Leisenfelder SA Kinchington PR Moffat JF Cyclin Dependent Kinase 1/ Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and is Incorporated into Virions J Virol 2008, 82:12116-12125. 18799590
146. De Bolle L Naesens L De Clercq E Update on human herpesvirus 6 biology, clinical features, and therapy Clin Microbiol Rev 2005, 18:217-245. 15653828
147. Caselli E Di Luca D Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7 New Microbiol 2007, 30:173-187. 17802896
148. Black JB Pellett PE Human herpesvirus 7 Rev Med Virol 1999, 9:245-262. 10578120
149. Braun DK Dominguez G Pellett PE Human herpesvirus 6 Clin Microbiol Rev 1997, 10:521-567. 9227865
150. Mori Y Yamanishi K HHV-6A, 6B, and 7: Pathogenesis, host response, and clinical disease Human Herpesviruses New York: Cambridge University Press 2007, 833-842.
151. Vancikova Z Dvorak P Cytomegalovirus infection in immunocompetent and immunocompromised individuals - a review Curr Drug Targets Immune Endocr Metabol Disord 2001, 1:179-187. 12476798
152. Boppana S Fowler K HCMV: Eersistence in the population: epidemiology and transmission Human Herpesviruses New York: Cambridge University Press 2007, 795-813.
153. Emery V Clark D HHV-6A, 6B, and 7: Persistence in the population: epidemiology, transmission Human Herpesviruses New York: Cambridge University Press 2007, 875-881.
154. Britt WJ HCMV: Pathogenesis and disease consequences Human Herpesviruses New York: Cambridge University Press 2007, 737-764.
155. Castillo JP Kowalik TF HCMV infection: Modulating the cell cycle and cell death Int Rev Immunol 2004, 23:113-139. 14690857
156. Jault FM Jault JM Ruchti F Fortunato EA Clark C Corbeil J Richman DD Spector DH Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest J Virol 1995, 69:6697-6704. 7474079
157. Sinclair J Baillie J Bryant L Caswell R Human cytomegalovirus mediates cell cycle progression through G(1) into early S phase in terminally differentiated cells J Gen Virol 2000, 81:1553-1565. 10811939
158. Kalejta RF Shenk T Manipulation of the cell cycle by human cytomegalovirus Front Biosci 2002, 7:d295-306. 11779699
159. Bresnahan WA Boldogh I Thompson EA Albrecht T Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1 Virology 1996, 224:150-160. 8862409
160. Dittmer D Mocarski ES Human cytomegalovirus infection inhibits G1/S transition J Virol 1997, 71:1629-1634. 8995690
161. Salvant BS Fortunato EA Spector DH Cell cycle dysregulation by human cytomegalovirus: Influence of the cell cycle phase at the time of infection and effects on cyclin transcription J Virol 1998, 72:3729-3741. 9557655
162. Lu M Shenk T Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S J Virol 1996, 70:8850-8857. 8971013
163. Hume AJ Finkel JS Kamil JP Coen DM Culbertson MR Kalejta RF Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function Science 2008, 320:797-799. 18467589
164. Kalejta RF Functions of human cytomegalovirus tegument proteins prior to immediate early gene expression Curr Top Microbiol Immunol 2008, 325:101-115. 18637502
165. Kalejta RF Shenk T Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein Proc Natl Acad Sci USA 2003, 100:3263-3268. 12626766
166. Kalejta RF Bechtel JT Shenk T Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors Mol Cell Biol 2003, 23:1885-1895. 12612064
167. Kalejta RF Shenk T The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle J Virol 2003, 77:3451-3459. 12610120
168. Kalejta RF Human cytomegalovirus pp71: A new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors J Cell Biochem 2004, 93:37-45. 15352160
169. Cantrell SR Bresnahan WA Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replication J Virol 2005, 79:7792-7802. 15919932
170. Saffert RT Kalejta RF Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression J Virol 2006, 80:3863-3871. 16571803
171. Cantrell SR Bresnahan WA Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication J Virol 2006, 80:6188-6191. 16731959
172. Preston CM Nicholl MJ Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression J Gen Virol 2006, 87:1113-1121. 16603511
173. Saffert RT Kalejta RF Promyelocytic leukemia-nuclear body proteins: herpesvirus enemies, accomplices or both? Future Virology 2008, 3:265-277.
174. Tavalai N Papior P Rechter S Leis M Stamminger T Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections J Virol 2006, 80:8006-8018. 16873257
175. Woodhall DL Groves IJ Reeves MB Wilkinson G Sinclair JH Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter J Biol Chem 2006, 281:37652-37660. 17035242
176. Saffert RT Kalejta RF Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro J Virol 2007, 81:9109-9120. 17596307
177. Hwang J Kalejta RF Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells Virology 2007, 367:334-338. 17590404
178. Prichard MN Gao N Jairath S Mulamba G Krosky P Coen DM Parker BO Pari GS A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency J Virol 1999, 73:5663-5670. 10364316
179. He Z He YS Kim Y Chu L Ohmstede C Biron KK Coen DM The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines J Virol 1997, 71:405-411. 8985364
180. Prichard MN Sztul E Daily SL Perry AL Frederick SL Gill RB Hartline CB Streblow DN Varnum SM Smith RD Kern ER Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes J Virol 2008, 82:5054-5067. 18321963
181. Wolf DG Courcelle CT Prichard MN Mocarski ES Distinct and separate roles
182. Prichard MN Britt WJ Daily SL Hartline CB Kern ER Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis J Virol 2005, 79:15494-15502. 16306620
183. Kamil JP Coen DM Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65 J Virol 2007, 81:10659-10668. 17634236
184. Marschall M Marzi A aus dem Siepen P Jochmann R Kalmer M Auerochs S Lischka P Leis M Stamminger T Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina J Biol Chem 2005, 280:33357-33367. 15975922
185. Littler E Stuart AD Chee MS Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir Nature 1992, 358:160-162. 1319559
186. Sullivan V Talarico CL Stanat SC Davis M Coen DM Biron KK A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells Nature 1992, 358:162-164. 1319560
187. Biron KK Harvey RJ Chamberlain SC Good SS Smith AA 3rd Davis MG Talarico CL Miller WH Ferris R Dornsife RE Stanat SC Drach JC Townsend LB Koszalka GW Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action Antimicrob Agents Chemother 2002, 46:2365-2372. 12121906
188. Biron KK Antiviral drugs for cytomegalovirus diseases Antiviral Res 2006, 71:154-163. 16765457
189. Trofe J Pote L Wade E Blumberg E Bloom RD Maribavir: A novel antiviral agent with activity against cytomegalovirus Ann Pharmacother 2008, 42:1447-1457. 18698013
190. Chou S Marousek GI Maribavir antagonizes the antiviral action of ganciclovir on human cytomegalovirus Antimicrob Agents Chemother 2006, 50:3470-3472. 17005835
191. Mocarski ES Kemble GW Lyle JM Greaves RF A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation Proc Natl Acad Sci USA 1996, 93:11321-11326. 8876134
192. Greaves RF Mocarski ES Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant J Virol 1998, 72:366-379. 9420235
193. Castillo JP Yurochko AD Kowalik TF Role of human cytomegalovirus immediate-early proteins in cell growth control J Virol 2000, 74:8028-8037. 10933712
194. Castillo JP Frame FM Rogoff HA Pickering MT Yurochko AD Kowalik TF Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response J Virol 2005, 79:11467-11475. 16103197
195. Poma EE Kowalik TF Zhu L Sinclair JH Huang ES The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter J Virol 1996, 70:7867-7877. 8892909
196. Zhang Z Huong SM Wang X Huang DY Huang ES Interactions between human cytomegalovirus IE1-72 and cellular p107: Functional domains and mechanisms of up-regulation of cyclin E/cdk2 kinase activity J Virol 2003, 77:12660-12670. 14610188
197. Chiou CJ Zong J Waheed I Hayward GS Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus J Virol 1993, 67:6201-6214. 8396676
198. Pajovic S Wong EL Black AR Azizkhan JC Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins Mol Cell Biol 1997, 17:6459-6464. 9343408
199. Marchini A Liu H Zhu H Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes J Virol 2001, 75:1870-1878. 11160686
200. Hagemeier C Caswell R Hayhurst G Sinclair J Kouzarides T Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein Embo J 1994, 13:2897-2903. 8026474
201. Fortunato EA Sommer MH Yoder K Spector DH Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other J Virol 1997, 71:8176-8185 9343168
202. Sommer MH Scully AL Spector DH Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein J Virol 1994, 68:6223-6231 8083962
203. Bresnahan WA Albrecht T Thompson EA The cyclin E promoter is activated by human cytomegalovirus 86-kDa immediate early protein J Biol Chem 1998, 273:22075-22082 9705351
204. Wiebusch L Asmar J Uecker R Hagemeier C Human cytomegalovirus immediate-early protein 2 (IE2)-mediated activation of cyclin E is cell-cycle-independent and forces S-phase entry in IE2-arrested cells J Gen Virol 2003, 84:51-60 12533700
205. White EA Spector DH Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation J Virol 2005, 79:7438-7452 15919900
206. Wiebusch L Hagemeier C Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1) J Virol 1999, 73:9274-9283 10516036
207. Murphy EA Streblow DN Nelson JA Stinski MF The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells J Virol 2000, 74:7108-7118 10888651
208. Song YJ Stinski MF Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: A DNA microarray analysis Proc Natl Acad Sci USA 2002, 99:2836-2841 11867723
209. McElroy AK Dwarakanath RS Spector DH Dysregulation of cyclin E gene expression in human cytomegalovirus-infected cells requires viral early gene expression and is associated with changes in the Rb-related protein p130 J Virol 2000, 74:4192-4206 10756032
210. Secchiero P Bertolaso L Casareto L Gibellini D Vitale M Bemis K Aleotti A Capitani S Franchini G Gallo RC Zauli G Human herpesvirus 7 infection induces profound cell cycle perturbations coupled to disregulation of cdc2 and cyclin B and polyploidization of CD4(+) T cells Blood 1998, 92:1685-1696 9716597
211. Oster B Bundgaard B Hollsberg P Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells J Virol 2005, 79:1961-1965 15650224
212. Oster B Kaspersen MD Kofod-Olsen E Bundgaard B Hollsberg P Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway J Clin Virol 2006, 37(Suppl 1):S63-68 17276372
213. Dietrich J Blumberg BM Roshal M Baker JV Hurley SD Mayer-Proschel M Mock DJ Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties J Neurosci 2004, 24:4875-4883 15152048
214. Kalejta RF Brideau AD Banfield BW Beavis AJ An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry Exp Cell Res 1999, 248:322-328 10094838
215. Kalejta RF Shenk T Beavis AJ Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry Cytometry 1997, 29:286-291 9415410
216. Oster B Kofod-Olsen E Bundgaard B Hollsberg P Restriction of human herpesvirus 6B replication by p53 J Gen Virol 2008, 89:1106-1113 18420787
217. De Bolle L Hatse S Verbeken E De Clercq E Naesens L Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle FEBS Lett 2004, 560:25-29 14987992
218. Bresnahan WA Boldogh I Chi P Thompson EA Albrecht T Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication Virology 1997, 231:239-247 9168886
219. Evers DL Breitenbach JM Borysko KZ Townsend LB Drach JC Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity Antimicrob Agents Chemother 2002, 46:2470-2476 12121920
220. Sanchez V McElroy AK Yen J Tamrakar S Clark CL Schwartz RA Spector DH Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production J Virol 2004, 78:11219-11232 15452241
221. Sanchez V Spector DH Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles J Virol 2006, 80:5886-5896 16731927
222. Soderberg-Naucler C Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J Intern Med 2006, 259:219-246 16476101
223. Goldmacher VS Cell death suppression by cytomegaloviruses Apoptosis 2005, 10:251-265 15843887
224. Michaelis M Kotchetkov R Vogel JU Doerr HW Cinatl J Jr Cytomegalovirus infection blocks apoptosis in cancer cells Cell Mol Life Sci 2004, 61:1307-1316 15170509
225. Shen Y Zhu H Shenk T Human cytomagalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteins Proc Natl Acad Sci USA 1997, 94:3341-3345 9096395
226. Hayashi ML Blankenship C Shenk T Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycle Proc Natl Acad Sci USA 2000, 97:2692-2696 10706637
227. Lu M Shenk T Human cytomegalovirus UL69 protein induces cells to accumulate in G1 phase of the cell cycle J Virol 1999, 73:676-683 9847373
228. Araujo JC Doniger J Kashanchi F Hermonat PL Thompson J Rosenthal LJ Human herpesvirus 6A ts suppresses both transformation by H-ras and transcription by the H-ras and human immunodeficiency virus type 1 promoters J Virol 1995, 69:4933-4940 7609062
229. Kutok JL Wang F Spectrum of Epstein-Barr virus-associated diseases Annu Rev Pathol 2006, 1:375-404 18039120
230. Kuppers R B cells under influence: Transformation of B cells by Epstein-Barr virus Nat Rev Immunol 2003, 3:801-812 14523386
231. Ambinder R Cesarman E Clinical and pathological aspects of EVB and KSHV infection Human Herpesviruses New York: Cambridge University Press 2007:885-903
232. Kieff ED Rickinson AB Epstein-Barr Virus and Its Replication Fields Virology Philadelphia: Lippincott Williams & Wilkins Fifth 2007, II:2603-2654
233. Rickinson AB Kieff ED Epstein-Barr Virus Fields Virology Philadelphia: Lippincott Williams & Wilkins Fifth 2007, II:2655-2700
234. Ganem D Kaposi's Sarcoma-Associated Herpesvirus Fields Virology Philadelphia: Lippincott Williams & Wilkins Fifth 2007, II:2847-2888
235. Ganem D KSHV infection and the pathogenesis of Kaposi's sarcoma Annu Rev Pathol 2006, 1:273-296 18039116
236. Thorley-Lawson DA Allday MJ The curious case of the tumour virus: 50 years of Burkitt's lymphoma Nat Rev Microbiol 2008, 6:913-924 19008891
237. Nicholas J Human herpesvirus 8-encoded proteins with potential roles in virus-associated neoplasia Front Biosci 2007, 12:265-281 17127298
238. Tao Q Young LS Woodman CB Murray PG Epstein-Barr virus (EBV) and its associated human cancers - genetics, epigenetics, pathobiology and novel therapeutics Front Biosci 2006, 11:2672-2713 16720343
239. Du MQ Bacon CM Isaacson PG Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders J Clin Pathol 2007, 60:1350-1357 18042691
240. Cannell EJ Farrell PJ Sinclair AJ Epstein-Barr virus exploits the normal cell pathway to regulate Rb activity during the immortalisation of primary B-cells Oncogene 1996, 13:1413-1421 8875979
241. Spender LC Cannell EJ Hollyoake M Wensing B Gawn JM Brimmell M Packham G Farrell PJ Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus J Virol 1999, 73:4678-4688 10233927
242. Yates JL Warren N Sugden B Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells Nature 1985, 313:812-815 2983224
243. Szekely L Selivanova G Magnusson KP Klein G Wiman KG EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins Proc Natl Acad Sci USA 1993, 90:5455-5459 8390666
244. Inman GJ Farrell PJ Epstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays J Gen Virol 1995, 76(Pt 9):2141-2149 7561751
245. Sinclair AJ Palmero I Peters G Farrell PJ EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus Embo J 1994, 13:3321-3328 8045261
246. Arvanitakis L Yaseen N Sharma S Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells J Immunol 1995, 155:1047-1056 7636179
247. Dirmeier U Hoffmann R Kilger E Schultheiss U Briseno C Gires O Kieser A Eick D Sugden B Hammerschmidt W Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis Oncogene 2005, 24:1711-1717 15674340
248. Yang X He Z Xin B Cao L LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression Oncogene 2000, 19:2002-2013 10803461
249. Ohtani N Brennan P Gaubatz S Sanij E Hertzog P Wolvetang E Ghysdael J Rowe M Hara E Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5 J Cell Biol 2003, 162:173-183 12860972
250. Parker GA Crook T Bain M Sara EA Farrell PJ Allday MJ Epstein-Barr virus nuclear antigen (EBNA)3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7 Oncogene 1996, 13:2541-2549 9000128
251. Maruo S Wu Y Ishikawa S Kanda T Iwakiri D Takada K Epstein-Barr virus nuclear protein EBNA3C is required for cell cycle progression and growth maintenance of lymphoblastoid cells Proc Natl Acad Sci USA 2006, 103:19500-19505 17159137
252. Kashuba E Yurchenko M Yenamandra SP Snopok B Isaguliants M Szekely L Klein G EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes Proc Natl Acad Sci USA 2008, 105:5489-5494 18391203
253. Knight JS Robertson ES Epstein-Barr virus nuclear antigen 3C regulates cyclin A/p27 complexes and enhances cyclin A-dependent kinase activity J Virol 2004, 78:1981-1991 14747563
254. Knight JS Sharma N Kalman DE Robertson ES A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells J Virol 2004, 78:12857-12867 15542638
255. Knight JS Sharma N Robertson ES SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen Mol Cell Biol 2005, 25:1749-1763 15713632
256. Knight JS Sharma N Robertson ES Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase Proc Natl Acad Sci USA 2005, 102:18562-18566 16352731
257. Ji P Jiang H Rekhtman K Bloom J Ichetovkin M Pagano M Zhu L An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant Mol Cell 2004, 16:47-58 15469821
258. Binne UK Classon MK Dick FA Wei W Rape M Kaelin WG Jr Naar AM Dyson NJ Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit Nat Cell Biol 2007, 9:225-232 17187060
259. Kudoh A Fujita M Kiyono T Kuzushima K Sugaya Y Izuta S Nishiyama Y Tsurumi T Reactivation of lytic replication from B cells latently infected with Epstein-Barr virus occurs with high S-phase cyclin-dependent kinase activity while inhibiting cellular DNA replication J Virol 2003, 77:851-861 12502801
260. Rodriguez A Jung EJ Flemington EK Cell cycle analysis of Epstein-Barr virus-infected cells following treatment with lytic cycle-inducing agents J Virol 2001, 75:4482-4489 11312318
261. Cayrol C Flemington EK The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors Embo J 1996, 15:2748-2759 8654372
262. Mauser A Holley-Guthrie E Zanation A Yarborough W Kaufmann W Klingelhutz A Seaman WT Kenney S The Epstein-Barr virus immediate-early protein BZLF1 induces expression of E2F-1 and other proteins involved in cell cycle progression in primary keratinocytes and gastric carcinoma cells J Virol 2002, 76:12543-12552 12438580
263. Mauser A Holley-Guthrie E Simpson D Kaufmann W Kenney S The Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic block J Virol 2002, 76:10030-10037 12208981
264. Zacny VL Wilson J Pagano JS The Epstein-Barr virus immediate-early gene product, BRLF1, interacts with the retinoblastoma protein during the viral lytic cycle J Virol 1998, 72:8043-8051 9733844
265. Swenson JJ Mauser AE Kaufmann WK Kenney SC The Epstein-Barr virus protein BRLF1 activates S phase entry through E2F1 induction J Virol 1999, 73:6540-6550 10400750
266. Liu C Sista ND Pagano JS Activation of the Epstein-Barr virus DNA polymerase promoter by the BRLF1 immediate-early protein is mediated through USF and E2F J Virol 1996, 70:2545-2555 8642684
267. Kudoh A Daikoku T Sugaya Y Isomura H Fujita M Kiyono T Nishiyama Y Tsurumi T Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication J Virol 2004, 78:104-115 14671092
268. Dourmishev LA Dourmishev AL Palmeri D Schwartz RA Lukac DM Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis Microbiol Mol Biol Rev 2003, 67:175-212 table of contents 12794189
269. Radkov SA Kellam P Boshoff C The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells Nat Med 2000, 6:1121-1127 11017143
270. Fakhari FD Jeong JH Kanan Y Dittmer DP The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma J Clin Invest 2006, 116:735-742 16498502
271. Fujimuro M Wu FY ApRhys C Kajumbula H Young DB Hayward GS Hayward SD A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency Nat Med 2003, 9:300-306 12592400
272. Tang J Gordon GM Muller MG Dahiya M Foreman KE Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces expression of the helix-loop-helix protein Id-1 in human endothelial cells J Virol 2003, 77:5975-5984 12719589
273. Sikder HA Devlin MK Dunlap S Ryu B Alani RM Id proteins in cell growth and tumorigenesis Cancer Cell 2003, 3:525-530 12842081
274. An FQ Compitello N Horwitz E Sramkoski M Knudsen ES Renne R The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest J Biol Chem 2005, 280:3862-3874 15525642
275. Cesarman E Nador RG Bai F Bohenzky RA Russo JJ Moore PS Chang Y Knowles DM Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma J Virol 1996, 70:8218-8223 8892957
276. Li M Lee H Yoon DW Albrecht JC Fleckenstein B Neipel F Jung JU Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin J Virol 1997, 71:1984-1991 9032330
277. Ojala PM Tiainen M Salven P Veikkola T Castanos-Velez E Sarid R Biberfeld P Makela TP Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6 Cancer Res 1999, 59:4984-4989 10519412
278. Platt GM Cannell E Cuomo ME Singh S Mittnacht S Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines Virology 2000, 272:257-266 10873769
279. Davis MA Sturzl MA Blasig C Schreier A Guo HG Reitz M Opalenik SR Browning PJ Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells J Natl Cancer Inst 1997, 89:1868-1874 9414174
280. Ascherl G Hohenadl C Monini P Zietz C Browning PJ Ensoli B Sturzl M Expression of human herpesvirus-8 (HHV-8) encoded pathogenic genes in Kaposi's sarcoma (KS) primary lesions Adv Enzyme Regul 1999, 39:331-339 10470382
281. Godden-Kent D Talbot SJ Boshoff C Chang Y Moore P Weiss RA Mittnacht S The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1 J Virol 1997, 71:4193-4198 9151805
282. Jung JU Stager M Desrosiers RC Virus-encoded cyclin Mol Cell Biol 1994, 14:7235-7244 7935438
283. Chang Y Moore PS Talbot SJ Boshoff CH Zarkowska T Godden K Paterson H Weiss RA Mittnacht S Cyclin encoded by KS herpesvirus Nature 1996, 382:410 8684480
284. Laman H Mann DJ Jones NC Viral-encoded cyclins Curr Opin Genet Dev 2000, 10:70-74 10679390
285. Mann DJ Child ES Swanton C Laman H Jones N Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus Embo J 1999, 18:654-663 9927425
286. Ellis M Chew YP Fallis L Freddersdorf S Boshoff C Weiss RA Lu X Mittnacht S Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex Embo J 1999, 18:644-653 9927424
287. Sarek G Jarviluoma A Ojala PM KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas Blood 2006, 107:725-732 16160006
288. Van Dross R Yao S Asad S Westlake G Mays DJ Barquero L Duell S Pietenpol JA Browning PJ Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells J Natl Cancer Inst 2005, 97:656-666 15870436
289. Laman H Coverley D Krude T Laskey R Jones N Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication Mol Cell Biol 2001, 21:624-635 11134348
290. Verschuren EW Jones N Evan GI The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin J Gen Virol 2004, 85:1347-1361 15166416
291. Moore P KSHV manipulation of the cell cycle and programmed cell death pathways Human Herpesviruses New York: Cambridge University Press 2007:540-558
292. Swanton C Mann DJ Fleckenstein B Neipel F Peters G Jones N Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins Nature 1997, 390:184-187 9367157
293. Child ES Mann DJ Novel properties of the cyclin encoded by Human Herpesvirus 8 that facilitate exit from quiescence Oncogene 2001, 20:3311-3322 11423981
294. Kaldis P Ojala PM Tong L Makela TP Solomon MJ CAK-independent activation of CDK6 by a viral cyclin Mol Biol Cell 2001, 12:3987-3999 11739795
295. Sugaya M Watanabe T Yang A Starost MF Kobayashi H Atkins AM Borris DL Hanan EA Schimel D Bryant MA Roberts N Skobe M Staskus KA Kaldis P Blauvelt A Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter Blood 2005, 105:2356-2363 15536152
296. Chang PC Li M Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor J Virol 2008, 82:278-290 17942552
297. Friborg J Jr Kong W Hottiger MO Nabel GJ p53 inhibition by the LANA protein of KSHV protects against cell death Nature 1999, 402:889-894 10622254
298. Wu FY Tang QQ Chen H ApRhys C Farrell C Chen J Fujimuro M Lane MD Hayward GS Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha Proc Natl Acad Sci USA 2002, 99:10683-10688 12145325
299. Izumiya Y Lin SF Ellison TJ Levy AM Mayeur GL Izumiya C Kung HJ Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest J Virol 2003, 77:9652-9661 12915577
300. Park J Seo T Hwang S Lee D Gwack Y Choe J The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity J Virol 2000, 74:11977-11982 11090200
301. Polson AG Huang L Lukac DM Blethrow JD Morgan DO Burlingame AL Ganem D Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases J Virol 2001, 75:3175-3184 11238844
302. Lukac DM Renne R Kirshner JR Ganem D Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein Virology 1998, 252:304-312 9878608
303. Sun R Lin SF Gradoville L Yuan Y Zhu F Miller G A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus Proc Natl Acad Sci USA 1998, 95:10866-10871 9724796
304. Cannon M Cesarman E Boshoff C KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2 Blood 2006, 107:277-284 16150942
305. Bais C Van Geelen A Eroles P Mutlu A Chiozzini C Dias S Silverstein RL Rafii S Mesri EA Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/KDR Cancer Cell 2003, 3:131-143 12620408
306. Sodhi A Chaisuparat R Hu J Ramsdell AK Manning BD Sausville EA Sawai ET Molinolo A Gutkind JS Montaner S The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor Cancer Cell 2006, 10:133-143 16904612
307. Montaner S Sodhi A Ramsdell AK Martin D Hu J Sawai ET Gutkind JS The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma Cancer Res 2006, 66:168-174 16397229
308. Sodhi A Montaner S Gutkind JS Viral hijacking of G-protein-coupled-receptor signalling networks Nat Rev Mol Cell Biol 2004, 5:998-1012 15573137
309. Montaner S Sodhi A Molinolo A Bugge TH Sawai ET He Y Li Y Ray PE Gutkind JS Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes Cancer Cell 2003, 3:23-36 12559173
310. van Dyk LF Virgin HWt Speck SH The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency J Virol 2000, 74:7451-7461 10906198
311. Platt G Carbone A Mittnacht S p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma Oncogene 2002, 21:1823-1831 11896614
312. Glaunsinger B Chavez L Ganem D The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable J Virol 2005, 79:7396-7401 15919895
313. Glaunsinger B Ganem D Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover Mol Cell 2004, 13:713-723 15023341
314. Glaunsinger B Ganem D Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis J Exp Med 2004, 200:391-398 15289507
315. Chandriani S Ganem D Host transcript accumulation during lytic KSHV infection reveals several classes of host responses PLoS ONE 2007, 2:e811 17726541
316. Browne EP Wing B Coleman D Shenk T Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: Viral block to the accumulation of antiviral mRNAs J Virol 2001, 75:12319-12330 11711622
317. Ray N Enquist LW Transcriptional response of a common permissive cell type to infection by two diverse alphaherpesviruses J Virol 2004, 78:3489-3501 15016872
318. Carter KL Cahir-McFarland E Kieff E Epstein-barr virus-induced changes in B-lymphocyte gene expression J Virol 2002, 76:10427-10436 12239319
319. Wade M Kowalik TF Mudryj M Huang ES Azizkhan JC E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection Mol Cell Biol 1992, 12:4364-4374. 1328853
320. Lembo D Gribaudo G Cavallo R Riera L Angeretti A Hertel L Landolfo S Human cytomegalovirus stimulates cellular dihydrofolate reductase activity in quiescent cells Intervirology 1999, 42:30-36. 10393501
321. Petrik DT Schmitt KP Stinski MF Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication J Virol 2006, 80:3872-3883. 16571804