Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor

Genes and Development

Volumn 21, Issue 21, 2007, Pages 2711-2716

  Liu, Xin ^a   Marmorstein, Ronen ^a  

^a NONE

Author keywords

Adenovirus e1a; Prb e1a complex; Retinoblastoma protein; Tumor suppressor; Viral oncoprotein

Indexed keywords

CYCLIN A; CYCLIN B; E1A PROTEIN; ONCOPROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; GENE INACTIVATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE; VIRUS CARCINOGENESIS;

ADENOVIRUS E1A PROTEINS; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; E2F TRANSCRIPTION FACTORS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ONCOGENE PROTEINS, VIRAL; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RETINOBLASTOMA PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR SUPPRESSOR PROTEINS;

ADENOVIRIDAE;

EID: 35948959373     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1590607     Document Type: Article

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