HHV-6A, 6B, and 7: Pathogenesis, host response, and clinical disease

Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis

Volumn 9780521827140, Issue , 2007, Pages 833-842

  Mori, Yasuko ^a   Yamanishi, Koichi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 61349177840     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511545313.047     Document Type: Chapter

References (85)

1. Akashi, K., Eizuru, Y., Sumiyoshi, Y. et al. (1993). Brief report: Severe infectious mononucleosis-like syndrome and primary human herpesvirus 6 infection in an adult [see comments]. N. Engl. J. Med., 329(3), 168-171.
2. Appleton, A. L., Sviland, L., Peiris, J. S. et al. (1995). Human herpes virus-6 infection in marrow graft recipients: Role in pathogen-esis of graft-versus-host disease. Newcastle upon Tyne Bone Marrow Transport Group. Bone Marrow Transpl, 16(6), 777-782.
3. Asano, Y., Yoshikawa, T., Kajita, Y. et al. (1992). Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection. Arch. Dis. Child., 67(12), 1484-1485.
4. Asano, Y., Yoshikawa, T., Suga, S. et al. (1990). Fatal fulminant hep-atitis in an infant with human herpesvirus-6 infection [letter]. Lancet, 335(8693), 862-863.
5. Atedzoe, B. N., Ahmad, A., and Menezes, J. (1997). Enhancement of natural killer cell cytotoxicity by the human herpesvirus-7 via IL-15 induction. J. Immunol., 159(10), 4966-4972.
6. Black, J. B., Inoue, N., Kite-Powel, K. et al. (1993). Frequent isolation of human herpesvirus 7 from saliva. Virus Res., 29(1), 91-98.
7. Cardinali, G., Gentile, M., Cirone, M. et al. (1998). Viral glycopro-teins accumulate in newly formed annulate lamellae following infection of lymphoid cells by human herpesvirus 6. J. Virol., 72(12), 9738-9746.
8. Carrigan, D. R. and Knox, K. K. (1995). Bone marrow suppres-sion by human herpesvirus-6: Comparison of the A and B variants of the virus [letter; comment]. Blood, 86(2), 835-836.
9. Caruso, A., Favilli, F., Rotola, A. et al. (2003). Human herpesvirus-6 modulates RANTES production in primary human endothelial cell cultures. J. Med. Virol., 70(3), 451-458.
10. Cermelli, C., Pietrosemoli, P., Meacci, M. et al. (1997). SupT-1: A cell system suitable for an efficient propagation of both HHV-7 and HHV-6 variants A and B. New Microbiol., 20(3), 187-196.
11. Challoner, P. B., Smith, K. T., Parker, J. D. et al. (1995). Plaque-associated expression of human herpesvirus 6 in multiple scle-rosis. Proc. Natl Acad. Sci. USA, 92(16), 7440-7444.
12. Cirone, M., Campadelli Fiume, G., Foa-Tomasi, L. et al. (1994). Human herpesvirus 6 envelope glycoproteins B and H-L complex are undetectable on the plasma membrane of infected lymphocytes. AIDS Res. Hum. Retroviruses, 10(2), 175-179.
13. Coates, A. R. and Bell, J. (1998). HHV-6 and multiple sclerosis. Nat. Med., 4(5), 537-538.
14. Cone, R. W., Hackman, R. C., Huang, M. L. et al. (1993). Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation [see comments]. N. Engl. J. Med., 329(3), 156-161.
15. Cone, R. W., Huang, M. L., Corey, L. et al. (1999). Human herpesvirus 6 infections after bone marrow transplantation: Clinical and virologic manifestations [In Process Citation]. J. Infect. Dis., 179(2), 311-318.
16. Dockrell, D. H. (2003). Human herpesvirus 6: Molecular biology and clinical features. J. Med. Microbiol., 52(Pt 1), 5-18.
17. Dominguez, G., Dambaugh, T. R., Stamey, F. R. et al. (1999). Human herpesvirus 6B genome sequence: Coding content and com-parison with human herpesvirus 6A. J. Virol., 73(10), 8040-8052.
18. Drobyski, W. R., Dunne, W. M., Burd, E. M. et al. (1993). Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: Evidence of a marrow-suppressive role for HHV-6 in vivo. J. Infect. Dis., 167(3), 735-739.
19. Drobyski, W. R., Knox, K. K., Majewski, D. et al. (1994). Brief report: Fatal encephalitis due to variant B human herpesvirus-6 infec-tion in a bone marrow-transplant recipient. N. Engl. J. Med., 330(19), 1356-1360.
20. Flamand, L., Gosselin, J., and Petlett, P. E. (1991). Human her-pesvirus 6 induces interleukin-1 beta and tumor necrosis fac-tor alpha, but not interleukin-6, in peripheral blood mononu-clear cell cultures. J. Virol., 65(9), 5105-5110.
21. Flamand, L., Stefanescu, I., and Menezes, J. (1996). Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Invest., 97(6), 1373-1381.
22. Foa Tomasi, L., Boscaro, A., di Eaeta, S. et al. (1991). Monoclonal antibodies to gp100 inhibit penetration of human herpesvirus 6 and polykaryocyte formation in susceptible cells. J. Virol., 65(8), 4124-4129.
23. Fox, J. D., Briggs, M., Ward, P. A. et al. (1990). Human herpesvirus 6 in salivary glands [see comments]. Lancet, 336(8715), 590-593.
24. Frenkel, N., Schirmer, E. C., Wyatt, L. S. et al. (1990). Isolation of a new herpesvirus from human CD4+ T cells. Proc. Natl Acad. Sci. USA, 87(2), 748-752.
25. Furukawa, M., Yasukawa, M., Yakushijin, Y. et al. (1994). Distinct effects of human herpesvirus 6 and human herpesvirus 7 on surface molecule expression and function of CD4+ T cells. J. Immunol., 152(12), 5768-5775.
26. Gompels, U. A., Nicholas, J., Lawrence, G. et al. (1995). The DNA sequence of human herpesvirus-6: Structure, coding content, and genome evolution. Virology, 209(1), 29-51.
27. Gosselin, J., TomoIu, A., Gallo, R. C. et al. (1999). Interleukin-15 as an activator of natural killer cell-mediated antiviral response. Blood, 94(12), 4210-4219.
28. Greenstone, H. L., Santoro, F., Lusso, P, et al. (2002). Human her-pesvirus 6 and measles virus employ distinct CD46 domains for receptor function. J. Biol. Chem., 277(42), 39112-39118.
29. Griffiths, P. D., Ait-Khaled, M., Bearcroft, C. P. et al. (1999). Human herpesviruses 6 and 7 as potential pathogens after liver transplant: Prospective comparison with the effect of cytomegalovirus. J. Med. Virol., 59(4), 496-501.
30. Griffiths, P. D., Clark, D. A., and Emery, V. C. (2000). Beta-herpesviruses in transplant recipients [In Process Citation]. J. Antimicrob. Chemother., 45(Suppl T3), 29-34.
31. Grivel, J. C., Ito, Y., Faga, G. et al. (2001). Suppression of CCR5-but not CXCR4-tropic HIV-1 in lymphoid tissue by human her-pesvirus 6. Nat. Med., 7(11), 1232-1235.
32. Grivel, J. C., Santoro, F., Chen, S. et al. (2003). Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. J. Virol., 77(15), 8280-8289.
33. Hall, C. B., Caserta, M. T., Schnabel, K. C. et al. (1998). Persistence of human herpesvirus 6 according to site and variant: Possible greater neurotropism of variant A. Clin. Infect. Dis., 26(1), 132-137.
34. Ichimi, R., Jin-no, T., and Ito, M. (1999). Induction of apoptosis in cord blood lymphocytes by HHV-6 [In Process Citation]. J. Med. Virol., 58(1), 63-68.
35. Inoue, Y., Yasukawa, M., and Fugita, S. (1997). Induction of T-cell apoptosis by human herpesvirus 6. J. Virol., 71(5), 3751-3759.
36. Isegawa, Y., Mukai, T., Nakano, K. et al. (1999). Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J. Virol., 73(10), 8053-8063.
37. Isomura, H., Yamada, M., Namba, H. et al. (1997). Suppressive effects of human herpesvirus 6 on in vitro colony formation of hematopoietic progenitor cells. J. Med. Virol., 52(4), 406-412.
38. Isomura, H., Yoshida, M., Namba, H. et al. (2000). Suppressive effects of human herpesvirus-6 on thrombopoietin-inducible megakaryocytic colony formation in vitro. J. Gen. Virol., 81(Pt 3), 663-673.
39. Isomura, H., Yoshida, M., Namba, H. et al. (2003). Interaction of human herpesvirus 6 with human CD34 positive cells. J. Med. Virol., 70(3), 444-450.
40. Kempf, W., Adams, V., Mirandola, P. et al. (1998). Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen. J. Infect. Dis., 178(3), 841-845.
41. Kikuta, H., Nakane, A., Lu, H. et al. (1990). Interferon induction by human herpesvirus 6 in human mononuclear cells. J. Infect. Dis., 162(1), 35-38.
42. Kurata, T., Iwasaki, T., Sata, T. et al. (1990). Viral pathology of human herpesvirus 6 infection. Adv. Exp. Med. Biol., 278, 39-47.
43. Leahy, M. A., Krejci, S. M., Friednash, M. et al. (1993). Human her-pesvirus 6 is present in lesions of Langerhans cell histiocytosis. J. Invest. Dermatol., 101(5), 642-645.
44. Levine, P. H., Jahan, N., Murari, P. et al. (1992). Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). J. Infect. Dis., 166(2), 291-295.
45. Liu, D. X., Gompels, U. A., Nicholas, J. et al. (1993). Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein. J. Gen. Virol., 74(Pt 9), 1847-1857.
46. Luppi, M., Barozzi, P., Maiorana, A. et al. (1994). Human herpesvirus 6 infection in normal human brain tissue [letter]. J. Infect. Dis., 169(4), 943-944.
47. Lusso, P., Malnati, M., de Mania, A. et al. (1991a). Productive infec-tion of CD4+ and CD8+ mature human T cells populations and clones by human herpesvirus 6. Transcriptional down-regulation of CD3. J. Immunol., 147(2), 685-691.
48. Lusso, P., De Maria, A., Malnati, M. et al. (1991a). Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lym-phocytes by human herpesvirus 6. Nature, 349(6309), 533-535.
49. Lusso, P., Secchiero, P., Crowley, R. W. et al. (1994). CD4 is a critical component of the receptor for human herpesvirus 7: Interfer-ence with human immunodeficiency virus. Proc. Natl Acad. Sci. USA, 91(9), 3872-3876.
50. Lusso, P., Garzino-Demo, A., Crowley, R. W. et al. (1995). Infection of gamma/delta T lymphocytes by human herpesvirus 6: Tran-scriptional induction of CD4 and susceptibility to HIV infec-tion. J. Exp. Med., 181(4), 1303-1310.
51. Mori, Y., Seya, T., Huang, H. L. et al. (2002). Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J. Virol., 76(13), 6750-6761.
52. Mori, Y., Akkapaiboon, P., Yang, X. et al. (2003a). The human her-pesvirus 6 U100 gene product is the third component of the gH-gL glycoprotein complex on the viral envelope. J. Virol., 77(4), 2452-2458.
53. Mori, Y., Yang, X., Akkapaiboon, P. et al. (2003b). Human herpesvirus 6 variant Aglycoprotein H-glycoprotein L-glycoprotein Qcom-plex associates with human CD46. J. Virol., 77(8), 4992-4999.
54. Pfeiffer, B., Thomson, B., and Chadran, B. (1995). Identification and characterization of a cDNA derived from multiple splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6. J. Virol., 69(6), 3490-3500.
55. Rodrigues, G. A. (1999). Human herpes virus 6 fatal encephalitis in a bone marrow recipient. Scand. J. Infect. Dis., 31, 313-315.
56. Salahuddin, S. Z., Ablashi, D. V., Maskham, P. D. et al. (1986). Isola-tion of a new virus, HBLV, in patients with lymphoproliferative disorders. Science, 234(4776), Transplantation, 60(11), 1355-1357.
57. Santoro, F., Greenstone, H. L., Insinga, A. et al. (2003). Inter-action of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46. J. Biol. Chem., 278(28), 25964-25969.
58. Santoro, F. M., Kennedy, P. E., Locatelli, G. et al. (1999). CD46 is a cellular receptor for human herpesvirus 6 [In process citation]. Cell, 99(7), 817-827.
59. Schirmer, E. C., Wyatt, L. S., Yamanishi, K. et al. (1991). Differenti-ation between two distinct classes of viruses now classified as human herpesvirus 6. Proc. Natl Acad. Sci. USA, 88(13), 5922-5926.
60. Secchiero, P., Flamand, L., Gibellini, D. et al. (1997a). Human herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: Necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells. Blood, 90(11), 4502-4512.
61. Secchiero, P., Sun, D., De Vico, A. L. et al. (1997b). Role of the extra-cellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans. J. Virol., 71(6), 4571-4580.
62. Secchiero, P., Bertolaso, L., Casareto, L. et al. (1998a). Human her-pesvirus 7 infection induces profound cell cycle perturbations coupled to disregulation of cdc2 and cyclin B and polyploidiza-tion of CD4(+) T-cells. Blood, 92(5), 1685-1696.
63. Secchiero, P., Zella, D., Barabitsskaja, O. et al. (1998b). Progressive and persistent downregulation of surface CXCR4 in CD4(+)T cells infected with human herpesvirus 7. Blood, 92(12), 4521-4528.
64. Secchiero, P., Mirandola, P., Zella, D. et al. (2001). Human her-pesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4(+) T cells. Blood, 98(8), 2474-24781.
65. Seya, T., Hara, T., Matsumoto, M. et al. (1990). Complement-mediated tumor cell damage induced by antibodies against membrane cofactor protein (MCP, CD46). J. Exp. Med., 172(6), 1673-1680.
66. Singh, N., Carrigan, D. R., Gayowski, T. et al. (1995). Vari-ant B human herpesvirus-6 associated febrile dermatosis with thrombocytopenia and encephalopathy in a liver trans-plant recipient [published erratum appears in Transplanta-tion1996 Feb 27;61(4):677].
67. Singh, N., Bentlejewski, C., Carrigan, D. R. et al. (2002a). Persistent lack of human herpesvirus-6 specific T-helper cell response in liver transplant recipients. Transpl. Infect. Dis., 4(2), 59-63.
68. Singh, N., Husain, S., Carrigan, D. R. et al. (2002b). Impact of human herpesvirus-6 on the frequency and severity of recur-rent hepatitis C virus hepatitis in liver transplant recipients. Clin. Transpl., 16(2), 92-96.
69. Skrincosky, D., Hocknell, P., Whetter, L. et al. (2001). Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7 [in process citation]. J. Virol., 74(10), 4530-4540.
70. Smith, A., Santoro, F., Di Lullo, G. et al. (2003). Selective suppression of IL-12 production by human herpesvirus 6. Blood.
71. Soldan, S. S., Berti, R., Salem, N. et al. (1997). Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat. Med., 3(12), 1394-1397.
72. Suzuki, Y., Inagi, R., Acono, T. et al. (1998). Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch. Dermatol., 134(9), 1108-1112.
73. Tajiri, H., Nose, O., Baba, K. et al. (1990). Human herpesvirus-6 infection with liver injury in neonatal hepatitis [letter]. Lancet, 335(8693), 863.
74. Takahashi, K., Sonoda, S., Higashi, K. et al. (1989). Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J. Virol., 63(7), 3161-3163.
75. Takahashi, K., Segal, E., Kondo, T. et al. (1992). Interferon and natu-ral killer cell activity in patients with exanthem subitum. Pedi-atr. Infect. Dis. J., 11(5), 369-373.
76. Tanaka, K., Kondo, T., Torigoe, S. et al. (1994). Human herpesvirus 7: Another causal agent for roseola (exanthem subitum). J. Pedi-atr., 125(1), 1-5.
77. Tohyama, M., Yahata, Y., Yasukawa, M. et al. (1998). Severe hyper-sensitivity syndrome due to sulfasalazine associated with reac-tivationofhumanherpesvirus 6. Arch. Dermatol., 134(9), 1113-1117.
78. Torigoe, S., Koide, W., Yamada, M. et al. (1996). Human herpesvirus 7 infection associated with central nervous system manifesta-tions. J. Pediatr., 129(2), 301-305.
79. Tsujimura, H., Iseki, T., Date, Y. et al. (1998). Human herpesvirus-6 encephalitis after bone marrow transplantation: Magnetic res-onance imaging could identify the involved sites of encephali-tis [letter]. Eur. J. Haematol., 61(4), 284-285.
80. Wyatt, L. S. and Frenkel, N. (1992). Human herpesvirus 7 is a consti-tutive inhabitant of adult human saliva. J. Virol., 66(5), 3206-3209.
81. Yamanishi, K., Okuno, T. et al. (1988). Identification of human herpesvirus-6 as a causal agent for exanthem subitum [see comments]. Lancet, 1(8594), 1065-1067.
82. Yasukawa, M., Inoue, Y., Ohminami, H. et al. (1998). Apoptosis of CD4+ T lymphocytes in human herpesvirus-6 infection. J. Gen. Virol., 79(Pt 1), 143-147.
83. Yasukawa, M., Hasegawa, A., Sakai, I. et al. (1999). Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7. J. Immunol., 162(9), 5417-5422.
84. Yoshikawa, T., Asano, Y., Kobayashi, I. et al. (1993). Exacerbation of idiopathic thrombocytopenic purpura by primary human herpesvirus 6 infection. Pediatr. Infect. Dis. J., 12(5), 409-410.
85. Zhang, Y., Hatse, S., De Clerq, E. et al. (2000). CXC-chemokine recep-tor 4 is not a coreceptor for human herpesvirus 7 entry into CD4(+) T cells. J. Virol., 74(4), 2011-2016.