The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity

Journal of Virology

Volumn 74, Issue 24, 2000, Pages 11977-11982

  Park, J ^a   Seo, T ^a   Hwang, S ^a   Lee, D ^a   Gwack, Y ^a   Choe, J ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE ZIPPER PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE REPRESSION; GENETIC TRANSCRIPTION; HOST CELL; HUMAN HERPESVIRUS 8; MULTIGENE FAMILY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 8, HUMAN; HUMANS; NUCLEAR PROTEINS; RNA-BINDING PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0034467970     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.24.11977-11982.2000     Document Type: Article

References (32)

1. The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors
2. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
3. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
4. Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA
5. Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency
6. Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos
7. Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1
8. Transformation of rat cells by DNA of human adenovirus 5
9. Transfection of a rearranged viral DNA fragment, WZhet, stably converts latent Epstein-Barr viral infection to productive infection in lymphoid cells
10. Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1
11. Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease
12. The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators
13. Oligomerization of oncoprotein p53
14. CBP binds to human papillomavirus E2 protein and activates E2-dependent transcription
15. The Zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions
16. Responsiveness of the Epstein-Barr virus NotI repeat promoter to the Z transactivator is mediated in a cell-type-specific manner by two independent signal regions
17. Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus
18. Epstein-Barr virus bicistronic mRNAs generated by facultative splicing code for two transcriptional trans-activators
19. Twenty years of p53 research: Structural and functional aspects of the p53 protein
20. Tumor suppressor p53 is a regulator of bcl-2 and bax in gene expression in vitro and in vivo
21. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection
22. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma
23. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expresson
24. Sequence-specific transcriptional activation is essential for growth suppression by p53
25. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture
26. Genetic dissection of cell growth arrest functions mediated by the Epstein-Barr virus lyric gene product, Zta
27. Negative regulation of Rb expression by the p53 gene product
28. Structural aspects of the p53 protein in relation to gene evolution: A second look
29. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
30. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression
31. The Epstein-Barr virus early protein EB1 activates transcription from different responsive elements including AP-1 binding sites
32. Functional and physical interaction between p53 and BZLF1: Implications for Epstein-Barr virus latency