Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 5, 2003, Pages 2363-2368

  Xiao, Bing ^a   Spencer, James ^a   Clements, Adrienne ^b   Ali Khan, Nadeem ^a   Mittnacht, Sibylle ^c   Broceño, Cristina ^c   Burghammer, Manfred ^d   Perrakis, Anastassis ^e   Marmorstein, Ronen ^b   Gamblin, Steven J ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^e NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN E; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ARTICLE; BINDING KINETICS; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

BLOTTING, WESTERN; CALORIMETRY; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ESCHERICHIA COLI; GLUTATHIONE TRANSFERASE; HUMANS; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS;

HUMAN PAPILLOMAVIRUS;

EID: 0037418175     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0436813100     Document Type: Article

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