p107 and p130: Versatile proteins with interesting pockets

Experimental Cell Research

Volumn 264, Issue 1, 2001, Pages 135-147

  Classon, Marie ^a   Dyson, Nicholas ^a  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; GENE PRODUCT; PROTEIN P107; PROTEIN P130; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

CARCINOGENESIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DNA TUMOR VIRUS; GENE FUNCTION; GENE INACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; VIRUS ONCOGENE;

ANIMALIA; TUMOR VIRUS;

EID: 0035835827     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5135     Document Type: Article

References (138)

1. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
2. Human retinoblastoma susceptibility gene: Cloning, identification, and sequence
3. Tumor suppressor genes
4. The retinoblastoma protein and cell cycle control
5. Cancer cell cycles
6. Association between an oncogene and an anti-oncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product
7. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
8. Cellular targets for transformation by the adenovirus E1A proteins
9. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
10. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120
11. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
12. Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides
13. Association of adenovirus early-region 1A proteins with cellular polypeptides
14. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus
15. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
16. Human cyclin A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product
17. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein
18. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins
19. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E
20. Cloning of a new member of the retinoblastoma gene family (pRb2), which binds to the E1A transforming domain
21. A maize cDNA encoding a member of the retinoblastoma protein family: Involvement in endoreduplication
22. Structure and expression of the chicken retinoblastoma gene
23. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila
24. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
25. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins
26. Interaction between human cyclin A and adenovirus E1A-associated p107 protein
27. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner
28. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
29. Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
30. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes
31. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases
32. The Rb2/p130 gene product is a nuclear protein whose phosphorylation is cell cycle regulated
33. Cell-cycle dependent phosphorylation of p130
34. G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4
35. Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells
36. PSK-J3/cdk4), for mammalian D type cyclins
37. The role of cyclin D3-dependent kinase in the phosphorylation of p130 in mouse BALB/c 3T3 fibroblasts
38. Regulatory interactions among E2Fs and cell cycle control proteins
39. E2Fs and the retinoblastoma protein family
40. Transcriptional repression by the Rb-related protein p107
41. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein
42. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response
43. E2F-4, a new member of the E2F transcription factor family, interacts with p107
44. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo
45. Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members
46. The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif
47. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase
48. The COOH-terminal region of pRb2/p130 binds to histone deacetylase 1 (HDAC 1)., enhancing transcriptional repression of the E2F-dependent cyclin A promoter
49. E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest
50. Nuclear organization of DNA replication in primary mammalian cells
51. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
52. Combinatorial roles for pRB, p107 and p130 in E2F-mediated cell cycle control
53. Cell cycle-specific association of E2F with the p130 E1A-binding domain
54. The accumulation of an E2F-p130 transcriptional repressor distinguishes a GO cell state from a G1 cell state
55. Multiple change in E2F function and regulation occur upon muscle differentiation
56. Expression and activity of the retinoblastoma protein (pRB).-family proteins, p107 and p130, during L6 myoblast differentiation
57. Retinoblastoma-related protein pRb2/p130 and its binding to the B-myb promoter increase during human neuroblastoma differentiation
58. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
59. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
60. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
61. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
62. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation
63. Cloning and expression of the Rb-related mouse p130 mRNA
64. E2F-5, a new E2F family member that interacts with p130 in vivo
65. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
66. The regulation of E2F by pRB-family proteins
67. E2F-4 and E2F-5, two novel members of the E2F family, are expressed in the early phases of the cell cycle
68. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
69. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
70. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity
71. Expression of the E2F1 transcription factor overcomes TGF-β mediated growth suppression
72. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
73. E2F-1 but not E2F4 can overcome p16-induced G1 cell cycle arrest
74. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F
75. Characterization of transcription factor E2F complexes during muscle and neuronal differentiation
76. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
77. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and other proteins
78. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
79. p130 is dispensable in peripheral T lymphocytes: Evidence for functional compensation by p107 and p130
80. Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex
81. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
82. Target gene specificity of E2F and pocket protein family members in living cells
83. p107 and p130 associated cyclin A has altered substrate specificity
84. CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
85. p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107
86. The pRB-related protein p107 contains two growth suppression domains: Independent interactions with E2F and cyclin/cdk complexes
87. The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2
88. Functional analysis of pRb2/p130 interaction with cyclins
89. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
90. Functional interactions between the hBrm/hBRG1 transcriptional activators and the pRB family of proteins
91. HBP1: A HMG box transcriptional repressor that is targeted by the retinoblastoma family
92. Interaction of the pRB-family proteins with factors containing paired-like homeodomains
93. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins
94. Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7
95. A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain
96. Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation
97. Binding and suppression of the Myc transcriptional activation domain by p107
98. Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells
99. Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription
100. RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130
101. Retinoblastoma protein partners
102. Requirement for a functional Rb-1 gene in murine development
103. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
104. Effects of an Rb mutation in the mouse
105. Shared role of the pRB-related p130 and p107 proteins in limb development
106. The retinoblastoma gene family in differentiation and development
107. Targeted disruption of p107: Functional overlap between p107 and Rb
108. p107 is a suppressor of retinoblastoma development in pRB-deficient mice
109. Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
110. Strain dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the pRB related p107 gene
111. New perspectives on retinoblastoma family functions in differentiation
112. Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
113. Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
114. Ablation of the retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions
115. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
116. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis
117. 2 phases of the cell cycle
118. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation
119. The retinoblastoma-like protein p130 is involved in the determination of reserve cells in myoblasts
120. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
121. Opposing roles for pRB and p107 in adipocyte differentiation
122. Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation
123. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
124. Differential expression of the retinoblastoma gene family members pRB/p105, p17 and pRB2/p130 in lung cancer
125. Differential expression of the retinoblastoma gene family members in choroidal melanoma: Prognostic significance
126. Immunohistochemical investigation of new suppressor oncogene p130 in oral squamous cell carcinoma
127. Expression of the retinoblastoma-related gene pRB2/p130 correlates with clinical outcome in endometrial cancer
128. The role of pRB2/p130 protein in diagnosing lung carcinoma on fine needle aspiration biopsies
129. Loss of retinoblastoma protein-related gene p130 in small cell lung carcinoma
130. Genetic alterations of the retinoblastoma-related gene RB2/p130 identify different mechanisms in and among BL subtypes
131. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer
132. Structure of the human retinoblastoma related p107 gene and its intragenic deletion in a B-cell lymphoma line
133. Retinoblastoma in transgenic mice
134. Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
135. Photoreceptor cell tumors in transgenic mice
136. cdkn2a, the cyclin dependent kinase inhibitor encoding p16 and p19, is a candidate for the plasmacytoma susceptibility locus, pctr1
137. Protein expression of the RB related gene family and SV40 large T antigen in mesothelioma and lung cancer