Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7

Journal of Virology

Volumn 75, Issue 16, 2001, Pages 7583-7591

  Gonzalez, S L ^a   Stremlau, M ^a   He, X ^a   Basile, J R ^a   Munger K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTEASOME; PROTEIN P107; PROTEIN P130; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; TUMOR SUPPRESSOR GENE;

CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MULTIENZYME COMPLEXES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PROTEASOME ENDOPEPTIDASE COMPLEX; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED; TUMOR VIRUS INFECTIONS; VIRUS REPLICATION;

EID: 0034899522     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.16.7583-7591.2001     Document Type: Article

References (55)

1. Induction of S phase and apoptosis by the human papillomavirus type 16 E7 protein are separable events in immortalized rodent fibroblasts
2. Cleavage of retinoblastoma protein during apoptosis: An interleukin 1 beta-converting enzyme-like protease as candidate
3. Suppression of human colorectal carcinoma cell growth by wild-type p53
4. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH 3T3 cells
5. The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26S proteasome
6. Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein
7. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
8. A mutational analysis of the amino terminal domain of the human papillomavirus type 16 E7 oncoprotein
9. ink4a
10. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between the transcription factor E2F and the retinoblastoma gene product
11. High-efficiency transformation of mammalian cells by plasmid DNA
12. Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding
13. Functional studies of E7 proteins from different HPV types
14. Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation
15. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
16. Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins
17. Adenovirus E1A makes two distinct contacts with the retinoblastoma protein
18. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
19. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
20. A point mutational analysis of human papillomavirus type 16 E7 protein
21. Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
22. Efficiency of binding to the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses
23. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
24. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
25. Papillomavirinae: The viruses and their replication
26. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells
27. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis
28. Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes
29. Cip1-mediated inhibition of cdk2
30. 1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein
31. Destabilization of the RB tumor suppressor and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis
32. The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone
33. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage
34. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
35. Structure-function analysis of the human papillomavirus E7 oncoprotein
36. Molecular chaperone function of the SV40 large T antigen
37. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: Targeting via ubiquitination of the N-terminal residue
38. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
39. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
40. Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high RB-binding activity for the E7 protein of the low-risk human papillomavirus type 1
41. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
42. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
43. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function
44. C-terminal truncation of the retinoblastoma gene product leads to functional inactivation
45. The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein
46. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
47. Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death
48. Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes
49. Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state
50. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-abl tyrosine kinase in the cell cycle
51. Association of human papillomavirus types 16 and 18 E6 proteins with p53
52. Association between an oncogene and an antioncogene: The adenovirus E1a proteins bind to the retinoblastoma gene product
53. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
54. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins
55. Papillomavirus infections - A major cause of human cancers