-
1
-
-
0032146274
-
The regulation of E2F by pRB-family proteins
-
Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 2245-2262
-
-
Dyson, N.1
-
2
-
-
0029849620
-
Cancer cell cycles
-
Sherr, C. J. Cancer cell cycles. Science 274, 1672-1677 (1996).
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
4
-
-
0029949784
-
E2F-1 functions in mice to promote apoptosis and suppress proliferation
-
Field, S. J. et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561 (1996).
-
(1996)
Cell
, vol.85
, pp. 549-561
-
-
Field, S.J.1
-
5
-
-
0029888359
-
Tumour induction and tissue atrophy in mice lacking E2F-1
-
Yamasaki, L. et al. Tumour induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537-547 (1996).
-
(1996)
Cell
, vol.85
, pp. 537-547
-
-
Yamasaki, L.1
-
6
-
-
0028945789
-
Multiple members of the E2F transcription factor family are the products of oncogenes
-
Xu, G., Livingston, D. M. & Krek, W. Multiple members of the E2F transcription factor family are the products of oncogenes. Proc. Natl Acad. Sci. USA 92, 357-1361 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 357-1361
-
-
Xu, G.1
Livingston, D.M.2
Krek, W.3
-
7
-
-
0035936113
-
The E2F1-3 transcription factors are essential for cellular proliferation
-
Wu., L. et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414, 457-462 (2001).
-
(2001)
Nature
, vol.414
, pp. 457-462
-
-
Wu., L.1
-
8
-
-
0027947383
-
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
-
Qin, X. Q., Livingston, D. M., Kaelin, W. G. Jr & Adams, P. D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl Acad. Sci. USA 91, 10918-10922 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 10918-10922
-
-
Qin, X.Q.1
Livingston, D.M.2
Kaelin W.G., Jr.3
Adams, P.D.4
-
9
-
-
0028061670
-
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
-
Shan, B. & Lee, W. H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell Biol. 14, 8166-8173 (1994).
-
(1994)
Mol. Cell Biol.
, vol.14
, pp. 8166-8173
-
-
Shan, B.1
Lee, W.H.2
-
10
-
-
0028222124
-
P53 and E2F-1 co-operate to mediate apoptosis
-
Wu, X. & Levine, A. J. P53 and E2F-1 co-operate to mediate apoptosis. Proc. Natl Acad. Sci. USA 91, 3602-3606 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3602-3606
-
-
Wu, X.1
Levine, A.J.2
-
11
-
-
0030738479
-
Distinct roles for E2F proteins in cell growth control and apoptosis
-
DeGregori, J., Leone, G., Miron, A., Jakoi, L. & Nevins, J. R. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl Acad. Sci. USA 94, 7245-7250 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 7245-7250
-
-
DeGregori, J.1
Leone, G.2
Miron, A.3
Jakoi, L.4
Nevins, J.R.5
-
12
-
-
0032504783
-
p14ARF links the tumour suppressor RB and p53
-
Bates, S. et al. p14ARF links the tumour suppressor RB and p53. Nature 395, 124-125 (1998).
-
(1998)
Nature
, vol.395
, pp. 124-125
-
-
Bates, S.1
-
13
-
-
0032191393
-
Tumour surveillance via the ARF-p53 pathway
-
Sherr, C. J. Tumour surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 2984-2991
-
-
Sherr, C.J.1
-
14
-
-
0034609798
-
Role for the p53 homologue p73 in E2F-1-induced apoptosis
-
Irwin, M. et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407, 645-648 (2000).
-
(2000)
Nature
, vol.407
, pp. 645-648
-
-
Irwin, M.1
-
15
-
-
0034609864
-
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
-
Lissy, N. A., Davis, P. K., Irwin, M., Kaelin, W. G. & Dowdy, S. F. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 407, 642-644 (2000).
-
(2000)
Nature
, vol.407
, pp. 642-644
-
-
Lissy, N.A.1
Davis, P.K.2
Irwin, M.3
Kaelin, W.G.4
Dowdy, S.F.5
-
16
-
-
0033666776
-
Role of the p53 homologue p73 in E2F-1-induced apoptosis
-
Stiewe, T. & Putzer, B. M. Role of the p53 homologue p73 in E2F-1-induced apoptosis. Nature Genet. 26, 464-469 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 464-469
-
-
Stiewe, T.1
Putzer, B.M.2
-
17
-
-
0034977277
-
Apaf-1 is a transcriptional target for E2F and p53
-
Moroni, M. C. et al. Apaf-1 is a transcriptional target for E2F and p53. Nature Cell Biol. 3, 552-558 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 552-558
-
-
Moroni, M.C.1
-
18
-
-
0033998439
-
Apoptotic and growth-promoting activity of E2F modulated by MDM2
-
Loughran, Ö. & La Thangue, N. B. Apoptotic and growth-promoting activity of E2F modulated by MDM2. Mol. Cell. Biol. 20, 2186-2197 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2186-2197
-
-
Loughran, Ö.1
La Thangue, N.B.2
-
19
-
-
0032939925
-
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
-
Blattner, C., Sparks, A., & Lane, D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol. Cell Biol. 19, 3704-3713 (1999).
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 3704-3713
-
-
Blattner, C.1
Sparks, A.2
Lane, D.3
-
20
-
-
0035878122
-
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
-
Lin, W. C., Lin, F. T. & Nevins, J. R. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 15, 1833-1844 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 1833-1844
-
-
Lin, W.C.1
Lin, F.T.2
Nevins, J.R.3
-
21
-
-
0035313706
-
DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
-
Durocher, D. & Jackson, S. P. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13, 225-231 (2001).
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 225-231
-
-
Durocher, D.1
Jackson, S.P.2
-
22
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53
-
Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D. Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53. Genes Dev.14, 278-288 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
23
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 1824-1827 (2000).
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
-
24
-
-
0034142034
-
The human homologues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylates p53 at multiple DNA damage-inducible sites
-
Sheih, S. Y., Ahn, J., Tamai, K., Taya, Y. & Prives, C. The human homologues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylates p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 289-300
-
-
Sheih, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
25
-
-
0035848819
-
The ATM-chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
Falck, J., Maitland, N., Syljuåsen, R. G., Bartek, J. & Lukas, J. The ATM-chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Maitland, N.2
Syljuåsen, R.G.3
Bartek, J.4
Lukas, J.5
-
26
-
-
0030611095
-
Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
-
Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S. & Piwnica-Worms, H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505 (1997).
-
(1997)
Science
, vol.277
, pp. 1501-1505
-
-
Peng, C.-Y.1
Graves, P.R.2
Thoma, R.S.3
Wu, Z.4
Shaw, A.S.5
Piwnica-Worms, H.6
-
27
-
-
0034624718
-
HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
-
Lee, J.-S., Collins, K. M., Brown, A. L., Lee, C.-H. & Chung, J. H. HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000).
-
(2000)
Nature
, vol.404
, pp. 201-204
-
-
Lee, J.-S.1
Collins, K.M.2
Brown, A.L.3
Lee, C.-H.4
Chung, J.H.5
-
28
-
-
0036847998
-
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
-
Yang, S., Kuo, C., Bisi, J. E. & Kim, M. K. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nature Cell Biol. 4, 865-870 (2002).
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 865-870
-
-
Yang, S.1
Kuo, C.2
Bisi, J.E.3
Kim, M.K.4
-
29
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai, H. et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO. J. 21, 5195-5205 (2002).
-
(2002)
EMBO. J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
-
30
-
-
0029942908
-
Cell cycle regulation of the murine cyclinE gene depends on an E2F binding site in the promoter
-
Botz, J. et al. Cell cycle regulation of the murine cyclinE gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16, 3401-3409 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 3401-3409
-
-
Botz, J.1
-
31
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
Bell, D. W. et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286, 2528-2531 (1999).
-
(1999)
Science
, vol.286
, pp. 2528-2531
-
-
Bell, D.W.1
-
32
-
-
0035817764
-
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
-
Falck, J. et al. Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Oncogene 20, 5505-5510 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 5505-5510
-
-
Falck, J.1
-
33
-
-
0034641724
-
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
-
Matsuoka, S. et al. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl Acad. Sci. 97, 10389-10394 (2000).
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
-
34
-
-
0027491775
-
Expression of transcription factor E2F1 induces quiescent cells to enter S phase
-
Johnson, D. G., Schwartz, J. K., Cress, W. D. & Nevins, J. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349-352 (1993).
-
(1993)
Nature
, vol.365
, pp. 349-352
-
-
Johnson, D.G.1
Schwartz, J.K.2
Cress, W.D.3
Nevins, J.4
-
35
-
-
0028577731
-
Oncogenic capacity of the E2F1 gene
-
Johnson, D. G., Cress, W. D., Jakol, L. & Nevins, J. R. Oncogenic capacity of the E2F1 gene. Proc. Natl Acad. Sci. USA. 91, 12823-12827 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA.
, vol.91
, pp. 12823-12827
-
-
Johnson, D.G.1
Cress, W.D.2
Jakol, L.3
Nevins, J.R.4
-
36
-
-
0030053130
-
Deregulated expression of E2F family members induces S-phase entry and overcome p16INK4A-mediated growth suppression
-
Lucas, J., Petersen, B. O., Holm, K., Bartek, J. & Helin, K. Deregulated expression of E2F family members induces S-phase entry and overcome p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16, 1047-1057 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1047-1057
-
-
Lucas, J.1
Petersen, B.O.2
Holm, K.3
Bartek, J.4
Helin, K.5
-
37
-
-
0031897273
-
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice
-
Yamasaki, L. et al. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice. Nature Genet. 18, 360-364 (1998).
-
(1998)
Nature Genet.
, vol.18
, pp. 360-364
-
-
Yamasaki, L.1
-
38
-
-
0033552595
-
Regulation of p53 in response to DNA damage
-
Lakin, N. D. & Jackson, S. P. Regulation of p53 in response to DNA damage. Oncogene 18, 7644-7655 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7644-7655
-
-
Lakin, N.D.1
Jackson, S.P.2
-
39
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
Pearson, M. et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-210 (2000).
-
(2000)
Nature
, vol.406
, pp. 207-210
-
-
Pearson, M.1
-
40
-
-
0029972806
-
P53: Puzzle and paradigm
-
Koh, L. & Prives, C. P53: puzzle and paradigm. Genes Dev. 10, 1054-1072 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 1054-1072
-
-
Koh, L.1
Prives, C.2
-
41
-
-
0034616913
-
Distinct initiation and maintenance mechanisms co-operate to induce G1 cell cycle arrest in response to DNA damage
-
Agami, R. & Bernards, R. Distinct initiation and maintenance mechanisms co-operate to induce G1 cell cycle arrest in response to DNA damage. Cell 102, 55-66 (2000).
-
(2000)
Cell
, vol.102
, pp. 55-66
-
-
Agami, R.1
Bernards, R.2
-
42
-
-
0030774301
-
Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors
-
Allen, K. E., de la Luna, S., Kerkhoven, R. M., Bernards, R. & La Thangue, N. B. Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors. J. Cell Sci. 110, 2819-2831 (1997).
-
(1997)
J. Cell Sci.
, vol.110
, pp. 2819-2831
-
-
Allen, K.E.1
de la Luna, S.2
Kerkhoven, R.M.3
Bernards, R.4
La Thangue, N.B.5
-
43
-
-
0027434084
-
Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF/E2F
-
Bandara, L. R., Buck, V. M., Zamanian, M., Johnston, L. H. & La Thangue, N. B. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF/E2F. EMBO J. 12, 4317-4324 (1993).
-
(1993)
EMBO J.
, vol.12
, pp. 4317-4324
-
-
Bandara, L.R.1
Buck, V.M.2
Zamanian, M.3
Johnston, L.H.4
La Thangue, N.B.5
-
44
-
-
0033783177
-
Regulation of E2F transcription by cyclinE/cdk2 kinase mediated through p300/CBP co-activators
-
Morris, L., Allen, K. E. & La Thangue, N. B. Regulation of E2F transcription by cyclinE/cdk2 kinase mediated through p300/CBP co-activators. Nature Cell Biol. 12, 232-239 (2000).
-
(2000)
Nature Cell Biol.
, vol.12
, pp. 232-239
-
-
Morris, L.1
Allen, K.E.2
La Thangue, N.B.3
-
45
-
-
0033521615
-
Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor
-
de la Luna, S., Allen, K. E., Mason, S. M. & La Thangue, N. B. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J. 18, 212-228 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 212-228
-
-
de la Luna, S.1
Allen, K.E.2
Mason, S.M.3
La Thangue, N.B.4
-
46
-
-
0034944423
-
Acetylation control of the retinoblastoma tumour-suppressor protein
-
Chan, H.-M., Kristic-Demonacos, M., Smith, L., Demonacos, C. & La Thangue, N. B. Acetylation control of the retinoblastoma tumour-suppressor protein. Nature Cell Biol. 3, 667-674 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 667-674
-
-
Chan, H.-M.1
Kristic-Demonacos, M.2
Smith, L.3
Demonacos, C.4
La Thangue, N.B.5
|