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Volumn 5, Issue 5, 2003, Pages 401-409

Chk2 activates E2F-1 in response to DNA damage

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 2; ETOPOSIDE; MUTANT PROTEIN; PROTEIN KINASE; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 0038752083     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb974     Document Type: Article
Times cited : (333)

References (46)
  • 1
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 2
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C. J. Cancer cell cycles. Science 274, 1672-1677 (1996).
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 4
    • 0029949784 scopus 로고    scopus 로고
    • E2F-1 functions in mice to promote apoptosis and suppress proliferation
    • Field, S. J. et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561 (1996).
    • (1996) Cell , vol.85 , pp. 549-561
    • Field, S.J.1
  • 5
    • 0029888359 scopus 로고    scopus 로고
    • Tumour induction and tissue atrophy in mice lacking E2F-1
    • Yamasaki, L. et al. Tumour induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537-547 (1996).
    • (1996) Cell , vol.85 , pp. 537-547
    • Yamasaki, L.1
  • 6
    • 0028945789 scopus 로고
    • Multiple members of the E2F transcription factor family are the products of oncogenes
    • Xu, G., Livingston, D. M. & Krek, W. Multiple members of the E2F transcription factor family are the products of oncogenes. Proc. Natl Acad. Sci. USA 92, 357-1361 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 357-1361
    • Xu, G.1    Livingston, D.M.2    Krek, W.3
  • 7
    • 0035936113 scopus 로고    scopus 로고
    • The E2F1-3 transcription factors are essential for cellular proliferation
    • Wu., L. et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414, 457-462 (2001).
    • (2001) Nature , vol.414 , pp. 457-462
    • Wu., L.1
  • 8
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X. Q., Livingston, D. M., Kaelin, W. G. Jr & Adams, P. D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl Acad. Sci. USA 91, 10918-10922 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin W.G., Jr.3    Adams, P.D.4
  • 9
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B. & Lee, W. H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell Biol. 14, 8166-8173 (1994).
    • (1994) Mol. Cell Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 10
    • 0028222124 scopus 로고
    • P53 and E2F-1 co-operate to mediate apoptosis
    • Wu, X. & Levine, A. J. P53 and E2F-1 co-operate to mediate apoptosis. Proc. Natl Acad. Sci. USA 91, 3602-3606 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 12
    • 0032504783 scopus 로고    scopus 로고
    • p14ARF links the tumour suppressor RB and p53
    • Bates, S. et al. p14ARF links the tumour suppressor RB and p53. Nature 395, 124-125 (1998).
    • (1998) Nature , vol.395 , pp. 124-125
    • Bates, S.1
  • 13
    • 0032191393 scopus 로고    scopus 로고
    • Tumour surveillance via the ARF-p53 pathway
    • Sherr, C. J. Tumour surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 14
    • 0034609798 scopus 로고    scopus 로고
    • Role for the p53 homologue p73 in E2F-1-induced apoptosis
    • Irwin, M. et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407, 645-648 (2000).
    • (2000) Nature , vol.407 , pp. 645-648
    • Irwin, M.1
  • 15
    • 0034609864 scopus 로고    scopus 로고
    • A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
    • Lissy, N. A., Davis, P. K., Irwin, M., Kaelin, W. G. & Dowdy, S. F. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 407, 642-644 (2000).
    • (2000) Nature , vol.407 , pp. 642-644
    • Lissy, N.A.1    Davis, P.K.2    Irwin, M.3    Kaelin, W.G.4    Dowdy, S.F.5
  • 16
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53 homologue p73 in E2F-1-induced apoptosis
    • Stiewe, T. & Putzer, B. M. Role of the p53 homologue p73 in E2F-1-induced apoptosis. Nature Genet. 26, 464-469 (2000).
    • (2000) Nature Genet. , vol.26 , pp. 464-469
    • Stiewe, T.1    Putzer, B.M.2
  • 17
    • 0034977277 scopus 로고    scopus 로고
    • Apaf-1 is a transcriptional target for E2F and p53
    • Moroni, M. C. et al. Apaf-1 is a transcriptional target for E2F and p53. Nature Cell Biol. 3, 552-558 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 552-558
    • Moroni, M.C.1
  • 18
    • 0033998439 scopus 로고    scopus 로고
    • Apoptotic and growth-promoting activity of E2F modulated by MDM2
    • Loughran, Ö. & La Thangue, N. B. Apoptotic and growth-promoting activity of E2F modulated by MDM2. Mol. Cell. Biol. 20, 2186-2197 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2186-2197
    • Loughran, Ö.1    La Thangue, N.B.2
  • 19
    • 0032939925 scopus 로고    scopus 로고
    • Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
    • Blattner, C., Sparks, A., & Lane, D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol. Cell Biol. 19, 3704-3713 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 3704-3713
    • Blattner, C.1    Sparks, A.2    Lane, D.3
  • 20
    • 0035878122 scopus 로고    scopus 로고
    • Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
    • Lin, W. C., Lin, F. T. & Nevins, J. R. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 15, 1833-1844 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1833-1844
    • Lin, W.C.1    Lin, F.T.2    Nevins, J.R.3
  • 21
    • 0035313706 scopus 로고    scopus 로고
    • DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
    • Durocher, D. & Jackson, S. P. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13, 225-231 (2001).
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 225-231
    • Durocher, D.1    Jackson, S.P.2
  • 22
    • 0034142325 scopus 로고    scopus 로고
    • Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53
    • Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D. Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53. Genes Dev.14, 278-288 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 278-288
    • Chehab, N.H.1    Malikzay, A.2    Appel, M.3    Halazonetis, T.D.4
  • 23
    • 0034629072 scopus 로고    scopus 로고
    • DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    • Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 1824-1827 (2000).
    • (2000) Science , vol.287 , pp. 1824-1827
    • Hirao, A.1
  • 24
    • 0034142034 scopus 로고    scopus 로고
    • The human homologues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylates p53 at multiple DNA damage-inducible sites
    • Sheih, S. Y., Ahn, J., Tamai, K., Taya, Y. & Prives, C. The human homologues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylates p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 289-300
    • Sheih, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 25
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • Falck, J., Maitland, N., Syljuåsen, R. G., Bartek, J. & Lukas, J. The ATM-chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
    • (2001) Nature , vol.410 , pp. 842-847
    • Falck, J.1    Maitland, N.2    Syljuåsen, R.G.3    Bartek, J.4    Lukas, J.5
  • 26
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S. & Piwnica-Worms, H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505 (1997).
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.-Y.1    Graves, P.R.2    Thoma, R.S.3    Wu, Z.4    Shaw, A.S.5    Piwnica-Worms, H.6
  • 27
    • 0034624718 scopus 로고    scopus 로고
    • HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • Lee, J.-S., Collins, K. M., Brown, A. L., Lee, C.-H. & Chung, J. H. HCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000).
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.-S.1    Collins, K.M.2    Brown, A.L.3    Lee, C.-H.4    Chung, J.H.5
  • 28
    • 0036847998 scopus 로고    scopus 로고
    • PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
    • Yang, S., Kuo, C., Bisi, J. E. & Kim, M. K. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nature Cell Biol. 4, 865-870 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 865-870
    • Yang, S.1    Kuo, C.2    Bisi, J.E.3    Kim, M.K.4
  • 29
    • 18644375649 scopus 로고    scopus 로고
    • Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
    • Takai, H. et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO. J. 21, 5195-5205 (2002).
    • (2002) EMBO. J. , vol.21 , pp. 5195-5205
    • Takai, H.1
  • 30
    • 0029942908 scopus 로고    scopus 로고
    • Cell cycle regulation of the murine cyclinE gene depends on an E2F binding site in the promoter
    • Botz, J. et al. Cell cycle regulation of the murine cyclinE gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16, 3401-3409 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3401-3409
    • Botz, J.1
  • 31
    • 0033601346 scopus 로고    scopus 로고
    • Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
    • Bell, D. W. et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286, 2528-2531 (1999).
    • (1999) Science , vol.286 , pp. 2528-2531
    • Bell, D.W.1
  • 32
    • 0035817764 scopus 로고    scopus 로고
    • Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
    • Falck, J. et al. Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Oncogene 20, 5505-5510 (2001).
    • (2001) Oncogene , vol.20 , pp. 5505-5510
    • Falck, J.1
  • 33
    • 0034641724 scopus 로고    scopus 로고
    • Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
    • Matsuoka, S. et al. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl Acad. Sci. 97, 10389-10394 (2000).
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 10389-10394
    • Matsuoka, S.1
  • 34
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D. G., Schwartz, J. K., Cress, W. D. & Nevins, J. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349-352 (1993).
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwartz, J.K.2    Cress, W.D.3    Nevins, J.4
  • 36
    • 0030053130 scopus 로고    scopus 로고
    • Deregulated expression of E2F family members induces S-phase entry and overcome p16INK4A-mediated growth suppression
    • Lucas, J., Petersen, B. O., Holm, K., Bartek, J. & Helin, K. Deregulated expression of E2F family members induces S-phase entry and overcome p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16, 1047-1057 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1047-1057
    • Lucas, J.1    Petersen, B.O.2    Holm, K.3    Bartek, J.4    Helin, K.5
  • 37
    • 0031897273 scopus 로고    scopus 로고
    • Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice
    • Yamasaki, L. et al. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice. Nature Genet. 18, 360-364 (1998).
    • (1998) Nature Genet. , vol.18 , pp. 360-364
    • Yamasaki, L.1
  • 38
    • 0033552595 scopus 로고    scopus 로고
    • Regulation of p53 in response to DNA damage
    • Lakin, N. D. & Jackson, S. P. Regulation of p53 in response to DNA damage. Oncogene 18, 7644-7655 (1999).
    • (1999) Oncogene , vol.18 , pp. 7644-7655
    • Lakin, N.D.1    Jackson, S.P.2
  • 39
    • 0034644274 scopus 로고    scopus 로고
    • PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    • Pearson, M. et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-210 (2000).
    • (2000) Nature , vol.406 , pp. 207-210
    • Pearson, M.1
  • 40
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Koh, L. & Prives, C. P53: puzzle and paradigm. Genes Dev. 10, 1054-1072 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Koh, L.1    Prives, C.2
  • 41
    • 0034616913 scopus 로고    scopus 로고
    • Distinct initiation and maintenance mechanisms co-operate to induce G1 cell cycle arrest in response to DNA damage
    • Agami, R. & Bernards, R. Distinct initiation and maintenance mechanisms co-operate to induce G1 cell cycle arrest in response to DNA damage. Cell 102, 55-66 (2000).
    • (2000) Cell , vol.102 , pp. 55-66
    • Agami, R.1    Bernards, R.2
  • 42
    • 0030774301 scopus 로고    scopus 로고
    • Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors
    • Allen, K. E., de la Luna, S., Kerkhoven, R. M., Bernards, R. & La Thangue, N. B. Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors. J. Cell Sci. 110, 2819-2831 (1997).
    • (1997) J. Cell Sci. , vol.110 , pp. 2819-2831
    • Allen, K.E.1    de la Luna, S.2    Kerkhoven, R.M.3    Bernards, R.4    La Thangue, N.B.5
  • 43
    • 0027434084 scopus 로고
    • Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF/E2F
    • Bandara, L. R., Buck, V. M., Zamanian, M., Johnston, L. H. & La Thangue, N. B. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF/E2F. EMBO J. 12, 4317-4324 (1993).
    • (1993) EMBO J. , vol.12 , pp. 4317-4324
    • Bandara, L.R.1    Buck, V.M.2    Zamanian, M.3    Johnston, L.H.4    La Thangue, N.B.5
  • 44
    • 0033783177 scopus 로고    scopus 로고
    • Regulation of E2F transcription by cyclinE/cdk2 kinase mediated through p300/CBP co-activators
    • Morris, L., Allen, K. E. & La Thangue, N. B. Regulation of E2F transcription by cyclinE/cdk2 kinase mediated through p300/CBP co-activators. Nature Cell Biol. 12, 232-239 (2000).
    • (2000) Nature Cell Biol. , vol.12 , pp. 232-239
    • Morris, L.1    Allen, K.E.2    La Thangue, N.B.3
  • 45
    • 0033521615 scopus 로고    scopus 로고
    • Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor
    • de la Luna, S., Allen, K. E., Mason, S. M. & La Thangue, N. B. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J. 18, 212-228 (1999).
    • (1999) EMBO J. , vol.18 , pp. 212-228
    • de la Luna, S.1    Allen, K.E.2    Mason, S.M.3    La Thangue, N.B.4


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