Pocket protein p130/Rb2 is required for efficient herpes simplex virus type 1 gene expression and viral replication

Journal of Virology

Volumn 75, Issue 15, 2001, Pages 7149-7160

  Ehmann, G L ^a   Burnett, H A ^a   Bachenheimer, S L ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; PROTEIN P107; PROTEIN P130; PROTEIN RB2; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; CELL CYCLE; CELL STRAIN 3T3; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; VIRUS REPLICATION;

3T3 CELLS; ANIMALS; CDC2-CDC28 KINASES; CELL CYCLE; CERCOPITHECUS AETHIOPS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DNA REPLICATION; DNA, VIRAL; GENE EXPRESSION; HERPESVIRUS 1, HUMAN; HUMANS; MICE; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0034960351     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.15.7149-7160.2001     Document Type: Article

References (77)

1. E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1
2. Retinoblastoma protein recruits histone deacetylase to repress transcription
3. Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein
4. A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type 1
5. Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells
6. Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells
7. Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
8. Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB(-), p16INK4A(+) tumor cells
9. Requirement for a functional Rb-1 gene in murine development
10. Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control
11. Shared role of the pRB-related p130 and p107 proteins in limb development
12. Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides
13. Reversible phosphorylation of the C-terminal domain of RNA polymerase II
14. Ablation of the retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions
15. Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein
16. A unique domain of pRb2/p130 acts as an inhibitor of cdk2 kinase activity
17. The regulation of E2F by pRB-family proteins
18. Herpes simplex virus type 1 infection imposes a G(1)/S block in asynchronously growing cells and prevents G(1) entry in quiescent cells
19. A surprising role for the proteasome in the regulation of herpesvirus infection
20. HSV-1 IE protein Vmw110 causes redistribution of PML
21. The ability of herpes simplex virus type 1 immediate-early protein Vmw110 to bind to a ubiquitin-specific protease contributes to its roles in the activation of gene expression and stimulation of virus replication
22. Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb
23. Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis
24. RNA polymerase II holoenzyme and transcriptional regulation
25. The Rb/E2F pathway: Expanding roles and emerging paradigms
26. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
27. Induction by herpes simplex virus of free and heteromeric forms of E2F transcription factor
28. The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition
29. Effects of an Rb mutation in the mouse
30. Transactivation of herpes simplex virus type 1 immediate-early gene expression by virion-associated factors is blocked by an inhibitor of cyclin-dependent protein kinases
31. Nuclear organization of DNA replication in primary mammalian cells
32. Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor
33. Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4
34. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation
35. Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes
36. Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
37. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
38. Targeted disruption of p107: Functional overlap between p107 and Rb
39. Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures
40. Characterization of nuclear structures in cells infected with herpes simplex virus type 1 in the absence of viral DNA replication
41. Formation of herpes simplex virus type 1 replication compartments by transfection: Requirements and localization to nuclear domain 10
42. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
43. Rb interacts with histone deacetylase to repress transcription
44. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
45. The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0
46. Nuclear domain 10 as preexisting potential replication start sites of herpes simplex virus type-1
47. Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130
48. A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: Effects on DNA replication and late gene expression
49. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
50. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
51. Principles of CDK regulation
52. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
53. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
54. Herpes simplex virus induces intracellular redistribution of E2F4 and accumulation of E2F pocket protein complexes
55. Herpes simplex virus type 1 gene products required for DNA replication: Identification and overexpression
56. Nuclear sites of herpes simplex virus type 1 DNA replication and transcription colocalize at early times postinfection and are largely distinct from RNA processing factors
57. Cyclins, CDKs and cancer
58. Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments
59. The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication
60. Intranuclear localization of herpes simplex virus immediate-early and delayed-early proteins: Evidence that ICP 4 is associated with progeny virus DNA
61. RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection
62. Herpes simplex viruses and their replication
63. Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
64. Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins
65. The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27
66. Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription
67. Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins
68. Transcription of herpes simplex virus immediate-early and early genes is inhibited by Roscovitine, an inhibitor specific for cellular cyclin-dependent kinases
69. Mammalian G1 cyclins
70. 1 cell state
71. Herpes simplex virus infection blocks events in the G1 phase of the cell cycle
72. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
73. HBP1: A HMG box transcriptional repressor that is targeted by the retinoblastoma family
74. Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites
75. Target gene specificity of E2F and pocket protein family members in living cells
76. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
77. The pRB-related protein p107 contains two growth suppression domains: Independent interactions with E2F and cyclin/cdk complexes