Human cytomegalovirus pp71: A new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors

Journal of Cellular Biochemistry

Volumn 93, Issue 1, 2004, Pages 37-45

  Kalejta, Robert F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cell cycle; Cytomegalovirus; E2F; p107; p130; pp71; Rb; Retinoblastoma

Indexed keywords

DNA; E1A PROTEIN; PROTEIN PP71; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS T ANTIGEN; CELL CYCLE PROTEIN; CYTOMEGALOVIRUS PHOSPHOPROTEIN 71KDA; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL TRANSFORMATION; DNA SYNTHESIS; DNA TUMOR VIRUS; HUMAN CYTOMEGALOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RETINOBLASTOMA; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; ANIMAL; CELL CYCLE; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ADENOVIRIDAE; CANCER VIRUS; CYTOMEGALOVIRUS; HERPESVIRIDAE; HUMAN HERPESVIRUS 5; PAPILLOMAVIRIDAE; SIMIAN VIRUS 40;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEINS; VIRAL PROTEINS;

EID: 16644392462     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20177     Document Type: Article

References (57)

1. Berezutskaya E, Yu B, Morozov A, Raychaudhuri P, Bagchi S. 1997. Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoproteins. Cell Growth Diff 8:1277-1286.
2. Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601.
3. Castillo JP, Kowalik TF. 2004. HCMV infection: Modulating the cell cycle and cell death. Int Rev Immunol 23:113-139.
4. Castillo JP, Yurochko AD, Kowalik TF. 2000. Role of human cytomegalovirus immediate-early proteins in cell growth control. J Virol 74:8028-8037.
5. Chan HM, Krstic-Demonacos M, Smith L, Demonacos C, La Thangue NB. 2001. Acetylation control of the retinoblastoma tumor-suppressor protein. Nat Cell Biol 3:667-674.
6. Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, Nevins JR. 1992. Adenovirus E1A, simian virus 40 tumor antigen and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci USA 89:4549-4553.
7. Chinnadurai G. 2004. Modulation of oncogenic transformation by the human adenovirus E1A C-terminal region. Curr Top Microbiol Immunol 273:139-161.
8. Corbeil HB, Branton PE. 1994. Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2. J Virol 68:6697-6709.
9. Debbas M, White E. 1993. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev 7:535-545.
10. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR. 1997. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci USA 94:7245-7250.
11. Dick FA, Dyson N. 2003. pRb contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol Cell 12:639-649.
12. Duensing S, Munger K. 2003. Mechanisms of genomic instability in human cancers: Insights from studies with human papillomavirus oncoproteins. Int J Cancer 109:157-162.
13. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D. 1998. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc Natl Acad Sci USA 95:10493-10498.
14. Flemington EK, Speck SH, Kaelin WG. 1993. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc Natl Acad Sci 90:6914-6918.
15. Ginsberg D. 2002. E2F1 pathways to apoptosis. FEBS Lett 529:122-125.
16. Gonzalez SL, Stremlau M, He X, Basile JR, Munger K. 2001. Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J Virol 75:7583-7591.
17. Goodman RH, Smolik S. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev 14:1553-1577.
18. Grana X, Garriga J, Mayol X. 1998. Role of the retinoblastoma protein family, pRb, p107 and p130 in the negative control of cell growth. Oncogene 17:3365-3383.
19. Heck DV, Yee CL, Howley PM, Munger K. 1992. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc Natl Acad Sci USA 89:4442-4446.
20. Helin K, Harlow E, Fattaey A. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol 13:6501-6508.
21. Helt A-M, Galloway DA. 2003. Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis 24:159-169.
22. Kalejta RF, Shenk T. 2002. Manipulation of the cell cycle by human cytomegalovirus. Front Biosci 7:295-306.
23. Kalejta RF, Shenk T. 2003a. The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle. J Virol 77:3451-3459.
24. Kalejta RF, Shenk T. 2003b. Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein. Proc Natl Acad Sci USA 100:3263-3268.
25. Kalejta RF, Bechtel JT, Shenk T. 2003. Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors. Mol Cell Biol 23:1885-1895.
26. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K. 1993. The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol 13:7813-7825.
27. Liu B, Stinski MF. 1992. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements. J Virol 66:4434-4444.
28. Lu M, Shenk T. 1999. Human cytomegalovirus UL69 protein induces cells to accumulate in G1 phase of the cell cycle. J Virol 73:676-683.
29. Luo RX, Postigo AA, Dean DC. 1998. Rb interacts with histone deacetylase to repress transcription. Cell 20:463-473.
30. Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, LeVillain JP, Troalen F, Trouche D, Harel-Bellan A. 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-605.
31. Mei Y-F, Skog J, Lindman K, Wadell G. 2003. Comparative analysis of the genome organization of human adenovirus 11, a member of the human adenovirus species B, and the commonly used human adenovirus 5 vector, a member of species C. J Gen Virol 84:2061-2071.
32. Mietz JA, Unger T, Huibregtse JM, Howley PM. 1992. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J 11:5013-5020.
33. Moberg K, Starz JA, Lees JA. 1996. E2F-4 switches from 130 to p107 and Rb in response to cell cycle reentry. Mol Cell Biol 16:1436-1449.
34. Moroni MC, Hickman ES, Denchi EL, Caprara G, Colli E, Cecconi F, Muller H, Helin K. 2001. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol 3:552-558.
35. Morris EJ, Dyson NJ. 2001. Retinoblastoma protein partners. Adv Cancer Res 82:1-54.
36. Muller H, Moroni MC, Vigo E, Petersen BO, Bartek J, Helin K. 1997. Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol 17:5508-5520.
37. Muratani M, Tansey WP. 2003. How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 4:192-201.
38. Murphy EA, Streblow DN, Nelson JA, Stinski MF. 2000. The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells. J Virol 74:7108-7118.
39. Murphy E, Rigoutsos I, Shibuya T, Shenk TE. 2003. Reevaluation of human cytomegalovirus coding potential. Proc Natl Acad Sci USA 100:13585-13590.
40. Nahle Z, Polakoff J, Davuluri RV, McCurrach ME, Jacobson MD, Narita M, Zhang MQ, Lazebnik Y, Bar-Sagi D, Lowe SW. 2002. Direct coupling of the cell cycle and cell death machinery by E2F. Nat cell Biol 4:859-864.
41. Nevins J. 1998. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ 9:585-593.
42. Orlowski M, Wilk S. 2003. Ubiquitin-independent proteolytic functions of the proteasome. Arch Biochem Biophys 415:1-5.
43. Qin XQ, Livingston DM, Kaelin WG, Adams PD. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA 91:10918-10922.
44. Rogoff HA, Pickering MT, France FM, Debatis ME, Sanchez Y, Jones S, Kowalik TF. 2004. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol 24:2968-2977.
45. Saenz-Robles MT, Sullivan CS, Pipas JM. 2001. Transforming functions of simian virus 40. Oncogene 20:7899-7907.
46. Salghetti SE, Muratani M, Wijnen H, Futcher B, Tansey WP. 2000. Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc Natl Acad Sci USA 97:3118-3123.
47. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
48. Shan B, Lee WH. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol 14:8166-8173.
49. Spector DJ, Tevethia MJ. 1986. Identification of a human cytomegalovirus DNA segment that compliments and adenovirus 5 immediate early mutant. Virology 151:329-338.
50. Stubdal H, Zalvide J, Campbell KS, Schweitzer C, Roberts TM, DeCaprio JA. 1997. Inactivation of pRb-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol 17:4979-4990.
51. Trimarchi JM, Lees JA. 2001. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 3:11-20.
52. Vigo E, Muller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K. 1999. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol 19:6379-6395.
53. Weinberg RA. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
54. Wiebusch L, Hagemeier C. 1999. Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1). J Virol 73:9274-9283.
55. Wu X, Levine AJ. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 91:3602-3606.
56. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. 2001. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 22:457-462.
57. Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht S, Broceno C, Burghammer M, Perrakis A, Marmorstein R, Gamblin SJ. 2003. Crystal Structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc Natl Acad Sci USA 100:2363-2368.