Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

Cell

Volumn 98, Issue 6, 1999, Pages 859-869

  Harbour, J William ^a   Luo, Robin X ^a   Dei Santi, Angeline ^a   Postigo, Antonio A ^a   Dean, Douglas C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; HISTONE DEACETYLASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G1 PHASE; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE REPRESSION; GENE TARGETING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION TERMINATION;

EID: 0033578816     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81519-6     Document Type: Article

References (49)

1. Adams, P.D., and Kaelin, W.G., Jr. (1996). The cellular effects of E2F overexpression. Curr. Top. Microbiol. Immunol. 208, 79-93.
2. Adams, P.D., Li, X., Sellers, W.R., Baker, K.B., Leng, X., Harper, J.W., Taya, Y., and Kaelin, W.G., Jr. (1999). Retinoblastoma protein contains a C-terminal motif that targets It for phosphorylation by cyclin-cdk complexes. Mol. Cell. Biol. 19, 1068-1080.
3. Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J., and Kouzarides, T. (1998). Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391, 597-601.
4. Chellappan, S.P., Hiebert, S., Mudryj, M., Horowitz, J.M., and Nevins, J.R. (1991). The E2F transcription factor is a cellular target for the RB protein. Cell 65, 1053-1061.
5. Chew, Y.P., Ellis, M., Wilkie, S., and Mittnacht, S. (1998). pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F. Oncogene 17, 2177-2186.
6. Chow, K.N., and Dean, D.C. (1996). Domains A and B in the Rb pocket interact to form a transcriptional represser motif. Mol. Cell. Biol. 16, 4862-4868.
7. Chow, K.N., Starostik, P., and Dean, D.C. (1996). The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional represser motif. Mol. Cell. Biol. 16, 7173-7181.
8. Dowdy, S.F., Hinds, P.W., Louie, K., Reed, S.I., Arnold, A., and Weinberg, R.A. (1993). Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73, 499-511.
9. Dyson, N. (1998). The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262.
10. Ewen, M.E. (1994). The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev. 13, 45-66.
11. Ewen, M.E., Sluss, H.K., Sherr, C.J., Matsushime, H., Kato, J., and Livingston, D.M. (1993). Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487-497.
12. Ezhevsky, S.A., Nagahara, H., Vocero-Akbani, A.M., Gius, D.R., Wei, M.C., and Dowdy, S.F. (1997). Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. USA 20, 699-704.
13. Geng, Y., Eaton, E.N., Picon, M., Roberts, J.M., Lundberg, A.S., Gifford, A., Sardet, C., and Weinberg, R.A. (1996). Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12, 1173-1180.
14. Geng, Y., Whoriskey, W., Park, M.Y., Bronson, R.T., Medema, R.H., Li, T., Weinberg, R.A., and Sicinski, P. (1999). Rescue of cyclin D1 deficiency by knockin cyclin E. Cell 97, 767-777.
15. Hassig, C.A., Fleischer, T.C., Billin, A.N., Schreiber, S.L, and Ayer, D.E. (1997). Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89, 341-347.
16. Hatakeyama, M., Brill, J.A., Fink, G.R., and Weinberg, R.A. (1994). Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 8, 1759-1771.
17. Hinds, P.W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S.I., and Weinberg, R.A. (1992). Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993-1006.
18. Holmes, J.K., and Solomon, M. J. (1996). A predictive scale for evaluating cyclin-dependent kinase substrates. J. Biol. Chem. 41, 25240-25246.
19. Hua, X.H., and Newport, J. (1998). Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. J. Cell Biol. 140, 271-281.
20. Kato, J., Matsushime, H., Hiebert, S.W., Ewen, M.E., and Sherr, C.J. (1993). Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7, 331-342.
21. Knudsen, E.S., and Wang, J.Y. (1996). Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 271, 8313-8320.
22. Knudsen, E.S., and Wang, J.Y. (1997). Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol. 17, 5771-5783.
23. Knudsen, E.S., Buckmaster, C., Chen, T.T., Feramisco, J.R., and Wang, J.Y. (1998). Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12, 2278-2292.
24. La Thangue, N.B. (1994). DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sei. 19, 108-114.
25. Lam, E.W., and La Thangue, N.B. (1994). DP and E2F proteins: coordinating transcription with cell cycle progression. Curr. Opin. Cell Biol. 6, 859-866.
26. Lee, J.O., Russo, A.A., and Pavletich, N.P. (1998). Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 397, 859-865.
27. Lundberg, A.S., and Weinberg, R.A. (1998). Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18,753-761.
28. Luo, R.X., Postigo, A.A., and Dean, D.C. (1998). Rb interacts with histone deacetylase to repress transcription. Cell 92, 463-473.
29. Magnaghi, J.L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Le, V.J., Troalen, F., Trouche, D., and Harel, B.A. (1998). Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391, 601-605.
30. Mittnacht, S., Lees, U.A., Desai, D., Harlow, E., Morgan, D.O., and Weinberg, R.A. (1994). Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J. 13, 118-127.
31. Morgan, D.O. (1995). Principles of CDK regulation. Nature 374, 131-134.
32. Nasmyth, K. (1993). Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol. 5, 166-179.
33. Nevins, U.R. (1992). E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258, 424-429.
34. Norbury, C., and Nurse, P. (1992). Animal cell cycles and their control. Annu. Rev. Biochem. 61, 441-470.
35. Ohtsubo, M., Theodoras, A.M., Schumacher, J., Roberts, J.M., and Pagano, M. (1995). Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15, 2612-2624.
36. Reed, S.I. (1992). The role of p34 kinases in the G1 to S-phase transition. Annu. Rev. Cell Biol. 8, 529-561.
37. Roberts, J.M., Koff, A., Polyak, K., Firpo, E., Collins, S., Ohtsubo, M., and Massague, J. (1994). Cyclins, Cdks, and cyclin kinase inhibitors. Cold Spring Harbor Symp. Quant. Biol. 59, 31-38.
38. Sherr, C.J. (1996). Cancer cell cycles. Science 274, 1672-1677.
39. Slansky, J.E., and Farnham, P.J. (1996). Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208, 1-30.
40. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M.F., Piwnica-Worms, H., and Cantley, L.C. (1994). Use of an orientated peptide library to determine the optimal substrates of protein kinases. Curr. Biol. 4, 973-982.
41. Templeton, D.J., Park, S.H., Lanier, L., and Weinberg, R.A. (1991). Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sei. USA 88, 3033-3037.
42. van den Heuvel, S., and Harlow, E. (1993). Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050-2054.
43. Weinberg, R.A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
44. Weintraub, S.u., Prater, C.A., and Dean, D.C. (1992). Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358, 259-261.
45. Weintraub, S.J., Chow, K.N., Luo, R.X., Zhang, S.H., He, S., and Dean, D.C. (1995). Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375, 812-815.
46. Whitaker, L.L., Su, H., Baskaran, R., Knudsen, E.S., and Wang, J.Y.J. (1998). Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. Mol. Cell. Biol. 18, 4032-4042.
47. Xu, M., Sheppard, K.A., Peng, C.Y., Yee, A.S., and Piwnica-Worms, H. (1994). Cyclin A/cdk2 binds directly to E2F1 and inhibits the DNA-binding activity of E2F1/DP1 by phosphorylation. Mol. Cell. Biol. 14, 8420-8431.
48. Zarkowska, T., and Mittnacht, S. (1997). Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272, 12738-12746.
49. Zhang, H.S., Postigo, A.A., and Dean, D.C. (1999). Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFβ, and contact inhibition. Cell 97, 53-61.