Retinoblastoma protein recruits histone deacetylase to repress transcription

Nature

Volumn 391, Issue 6667, 1998, Pages 597-601

  Brehm, Alexander ^a   Miska, Eric A ^a   McCance, Dennis J ^a,b   Reid, Juliet L ^a   Bannister, Andrew J ^a   Kouzarides, Tony ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; GLUTATHIONE TRANSFERASE; HISTONE DEACETYLASE; ONCOPROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; TRICHOSTATIN A; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; WART VIRUS;

AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; CYCLIN E; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HELA CELLS; HISTONE DEACETYLASES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; HUMAN PAPILLOMA VIRUS; HUMAN PAPILLOMAVIRUS TYPES;

EID: 0032484989     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35404     Document Type: Article

References (25)

1. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995).
2. Weintraub, S. J., Prater, C. A. & Dean, D. C. Retinoblastoma protein switches the E2F site from positive to negative elements. Nature 358, 259-261 (1992).
3. Weintraub, S. J. et al. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375, 812-815 (1995).
4. Taunton, J., Hassig, C. A. & Schreiber, S. L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408-411 (1996).
5. Yang, W.-M., Inouye, C., Zeng, Y., Bearss, D. & Seto, E. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD2. Proc. Natl Acad. Sci. USA 93, 12845-12850 (1996).
6. Heinzel, T. et al. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387, 43-48 (1997).
7. Alland, L. et al. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387, 49-55 (1997).
8. Hassig, C. A., Fleischer, T. C., Billin, A. N., Schreiber, S. L. & Ayer, D. E. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89, 341-347 (1997).
9. Laherty, C. D. et al. Histone deacelylases associated with the mSin3 corepressor mediate Mad transcriptional repression. Cell 89, 349-356 (1997).
10. Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89, 357-364 (1997).
11. Nagy, L. et al. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89, 373-380 (1997).
12. Kadosh, D. & Struhl, K. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89, 365-371 (1997).
13. Qian, Y.-W. et al. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364, 648-652 (1993).
14. Huang, S., Lee, W.-H. & Lee, E. Y.-H. P. A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product. Nature 350, 160-162 (1991).
15. Hagemeier, C., Cook, A. & Kouzarides, T. The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res. 21, 4998-5004 (1993).
16. Martin, K. et al. Stimualtion of F2F1/DP1 transcriptional activity by Mdm2 oncoprotein. Nature 375, 691-694 (1995).
17. Botz, J. et al. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell Biol. 16, 3401-3409 (1996).
18. Hurford, R. K. Jr, Cobrinik, D., Lee, M. H. & Dyson, N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11, 1447-1463 (1997).
19. Alevizopoulos, A. et al. A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3. Genes Dev. 9, 3051-3066 (1995).
20. Bannister, A. J. & Kouzarides, T. The CBP co-activator is a histone aceryltransferase. Nature 384, 641-643 (1996).
21. Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H. & Nakatani, Y, The transcriptional coactivators p300 CBP are histone acetyltransferases. Cell 87, 953-959 (1996).
22. Gu, W. & Roeder, R. G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606 (1997).
23. Cavanaugh, A. H. et al. Activity of RNA polymerase 1 transcription factor UBF blocked by Rb gene product. Nature 374, 177-180 (1995).
24. White, R. J., Trouche, D., Martin, K., Jackson, S. P, & Kouzarides, T. Repression of RNA polymerase III transcription by the retinoblasioma protein. Nature 382, 88-90 (1996).
25. Larminie, C. G. et al. Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein. EMBO J. 16, 2061-2071 (1997).