메뉴 건너뛰기




Volumn 11, Issue 1 P.889-1198, 2006, Pages 1164-1188

Cyclins and CDKS in development and cancer: Lessons from genetically modified mice

Author keywords

Cancer; Cdks; Cell Cycle; Cyclins; Gene targeting; Genetically Modified Mouse; Model; Neoplasia; Review; Tumor

Indexed keywords

MAMMALIA;

EID: 27144458683     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1871     Document Type: Review
Times cited : (163)

References (180)
  • 1
    • 0026693966 scopus 로고
    • Animal cell cycles and their control
    • Norbury C & P. Nurse: Animal cell cycles and their control. Annu Rev Biochem 61, 441-70 (1992)
    • (1992) Annu Rev Biochem , vol.61 , pp. 441-470
    • Norbury, C.1    Nurse, P.2
  • 2
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81: 323-30 (1995)
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 4
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ: Cancer cell cycles. Science 274, 1672-77 (1996)
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 5
    • 0842324788 scopus 로고    scopus 로고
    • Recycling the cell cycle: Cyclins revisited
    • 5
    • Murray AW: Recycling the cell cycle: cyclins revisited. Cell 116: 221-234 (2004)5.
    • (2004) Cell , vol.116 , pp. 221-234
    • Murray, A.W.1
  • 6
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ & J.M. Roberts: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes & Dev 13, 1501-12 (1999)
    • (1999) Genes & Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 7
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks and microprocessors
    • Morgan DO: Cyclin-dependent kinases: engines, clocks and microprocessors. Annu Rev Cell Dev Biol 13, 261-91 (1997)
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 8
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two cyclin-cdk complexes
    • Lundberg AS, & R.A. Weinberg: Functional inactivation of the retinoblastoma protein requires sequential modification by at least two cyclin-cdk complexes. Mol Cell Biol 18, 753-61 (1998)
    • (1998) Mol Cell Biol , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 10
    • 0035852699 scopus 로고    scopus 로고
    • A premature termination mutation in the Mus musculus cyclin dependent kinase 3 gene
    • Ye X, C. Zhu & J.W. Harper: A premature termination mutation in the Mus musculus cyclin dependent kinase 3 gene. Proc Natl Acad Sci USA 98:1682-6 (2001)
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1682-1686
    • Ye, X.1    Zhu, C.2    Harper, J.W.3
  • 11
    • 25444483052 scopus 로고    scopus 로고
    • Revisiting the "Cdk-centric" view of the mammalian cell cycle
    • Malumbres M: Revisiting the "Cdk-centric" view of the mammalian cell cycle. Cell Cycle 4, e19-e23 (2005)
    • (2005) Cell Cycle , vol.4
    • Malumbres, M.1
  • 13
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin dependent kinases
    • Sherr CJ & J.M. Roberts: Living with or without cyclins and cyclin dependent kinases. Genes & Dev 18, 2699-711 (2004)
    • (2004) Genes & Dev , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 14
    • 1342272916 scopus 로고    scopus 로고
    • How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
    • Koepp DM, J.W. Harper & S.J. Elledge: How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell 97, 431-4 (1999)
    • (1999) Cell , vol.97 , pp. 431-434
    • Koepp, D.M.1    Harper, J.W.2    Elledge, S.J.3
  • 15
    • 0035150990 scopus 로고    scopus 로고
    • Growth-factor-dependent mitogenesis requires two distinct phases of signalling
    • Jones SM & A. Kazlauskas: Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol 3, 165-72 (2001)
    • (2001) Nat Cell Biol , vol.3 , pp. 165-172
    • Jones, S.M.1    Kazlauskas, A.2
  • 16
    • 0033574614 scopus 로고    scopus 로고
    • Mechanisms of cyclin-dependent kinase regulation: Structures of cdks, their cyclin activators and Cip and INK inhibitors
    • Pavletich NP: Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators and Cip and INK inhibitors. J Mol Biol 287, 821-8 (1999)
    • (1999) J Mol Biol , vol.287 , pp. 821-828
    • Pavletich, N.P.1
  • 17
    • 2942722811 scopus 로고    scopus 로고
    • Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
    • Frolov MV & N.J. Dyson: Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci 17: 2173-81 (2004)
    • (2004) J Cell Sci , vol.17 , pp. 2173-2181
    • Frolov, M.V.1    Dyson, N.J.2
  • 18
    • 0032899038 scopus 로고    scopus 로고
    • Retinoblastoma protein meets chromatin
    • Brehm A & T. Kouzarides: Retinoblastoma protein meets chromatin. Trends Biochem Sci 24, 142-5 (1999)
    • (1999) Trends Biochem Sci , vol.24 , pp. 142-145
    • Brehm, A.1    Kouzarides, T.2
  • 20
    • 0003418645 scopus 로고
    • A restriction point for control of normal animal cell proliferation
    • Pardee AB: A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci USA 71, 1286-90 (1974)
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 1286-1290
    • Pardee, A.B.1
  • 23
    • 85047680672 scopus 로고    scopus 로고
    • Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice
    • Geng Y, Q. Yu, E. Sicinska, M. Das, R.T. Bronson & P. Sicinski: Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci USA 98, 194-9 (2001)
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 194-199
    • Geng, Y.1    Yu, Q.2    Sicinska, E.3    Das, M.4    Bronson, R.T.5    Sicinski, P.6
  • 24
    • 0033559264 scopus 로고    scopus 로고
    • The p21Cip1 and p27Kip1 CDK inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M, P. Olivier, J.A. Diehl, M. Fero, M.F. Roussel, J.M. Roberts & C.J. Sherr: The p21Cip1 and p27Kip1 CDK inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 18, 1571-83 (1999)
    • (1999) EMBO J , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 25
  • 27
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura I, N.G. Denissova, G. Wang, D. He, J. Long & F. Liu: Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430, 226-31 (2004)
    • (2004) Nature , vol.430 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 28
    • 0037121081 scopus 로고    scopus 로고
    • Linking cyclins to transcriptional control
    • Coqueret O: Linking cyclins to transcriptional control. Gene 299, 35-55 (2002)
    • (2002) Gene , vol.299 , pp. 35-55
    • Coqueret, O.1
  • 30
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • Vlach J, S. Henneke & B. Amati: Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 16, 5334-44 (1997)
    • (1997) EMBO J , vol.16 , pp. 5334-5344
    • Vlach, J.1    Henneke, S.2    Amati, B.3
  • 33
    • 0031957450 scopus 로고    scopus 로고
    • G1-phase regulators, cyclin D1, cyclin D2 and cyclin D3: Up-regulation at gastrulation and dynamic expression during neurulation
    • Wianny F, F.X. Real, C.L. Mummery, M. Van Rooijen, J. Lahti, J. Samarut & P. Savatier: G1-phase regulators, cyclin D1, cyclin D2 and cyclin D3: up-regulation at gastrulation and dynamic expression during neurulation. Dev. Dyn 212, 49-62 (1998)
    • (1998) Dev Dyn , vol.212 , pp. 49-62
    • Wianny, F.1    Real, F.X.2    Mummery, C.L.3    Van Rooijen, M.4    Lahti, J.5    Samarut, J.6    Savatier, P.7
  • 34
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl V, G. Stamp, A. Andrews, I. Rosewell & C. Dickson: Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes & Dev 9, 2364-72 (1995)
    • (1995) Genes & Dev , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 38
    • 18344381110 scopus 로고    scopus 로고
    • Cell cycle in mouse development
    • Ciemerych MA & P. Sicinski: Cell cycle in mouse development. Oncogene 24, 2877-2898 (2005)
    • (2005) Oncogene , vol.24 , pp. 2877-2898
    • Ciemerych, M.A.1    Sicinski, P.2
  • 39
    • 4444350468 scopus 로고    scopus 로고
    • Wagging the dogma: Tissue-specific cell cycle control in the mouse embryo
    • Pagano M & P.K. Jackson: Wagging the dogma: tissue-specific cell cycle control in the mouse embryo. Cell 118, 535-8 (2004)
    • (2004) Cell , vol.118 , pp. 535-538
    • Pagano, M.1    Jackson, P.K.2
  • 42
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficiente diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    • Rane SG, P. Dubus, R.V. Mettus, E.J. Galbreath, G. Boden, E.P. Reddy & M. Barbacid: Loss of Cdk4 expression causes insulin-deficiente diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 22, 44-52 (1999)
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 44
    • 0036327961 scopus 로고    scopus 로고
    • Pituitary hypoplasia and lactotroph dysfuntcion in mice deficient for cyclin-dependent kinase 4
    • Moons DS, S. Jirawatnotai, A.F. Parlow, G. Gibori, R.D. Kineman & H. Kiyokawa: Pituitary hypoplasia and lactotroph dysfuntcion in mice deficient for cyclin-dependent kinase 4. Endocrinology 143, 3001-8 (2002)
    • (2002) Endocrinology , vol.143 , pp. 3001-3008
    • Moons, D.S.1    Jirawatnotai, S.2    Parlow, A.F.3    Gibori, G.4    Kineman, R.D.5    Kiyokawa, H.6
  • 46
    • 0035803395 scopus 로고    scopus 로고
    • Wide spectrum of tumors in knockin mice carrying a Cdk4 protein insensitive to INK4 inhibitors
    • Sotillo R, P. Dubus, J. Martín , E. de la Cueva, S. Ortega, M. Malumbres & M. Barbacid: Wide spectrum of tumors in knockin mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J 20, 6637-47 (2001)
    • (2001) EMBO J , vol.20 , pp. 6637-6647
    • Sotillo, R.1    Dubus, P.2    Martín, J.3    De La Cueva, E.4    Ortega, S.5    Malumbres, M.6    Barbacid, M.7
  • 47
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia S & A. Bhushan: Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114, 963-8 (2004)
    • (2004) J Clin Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 49
    • 0037117412 scopus 로고    scopus 로고
    • Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos
    • Meyer CA, H.W. Jacobs & C.F. Lehner: Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos. Curr Biol 12, 661-6 (2002)
    • (2002) Curr Biol , vol.12 , pp. 661-666
    • Meyer, C.A.1    Jacobs, H.W.2    Lehner, C.F.3
  • 53
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • Sherr C J: Principles of tumor suppression. Cell 116, 235-46 (2004)
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 54
    • 0030918714 scopus 로고    scopus 로고
    • Differential phosphorylation of the retinoblastoms protein by G1/S cyclin-dependent kinases
    • Zarkowska T & S. Mittnacht: Differential phosphorylation of the retinoblastoms protein by G1/S cyclin-dependent kinases. J Biol Chem 272, 12738-46 (1997)
    • (1997) J Biol Chem , vol.272 , pp. 12738-12746
    • Zarkowska, T.1    Mittnacht, S.2
  • 55
    • 0026547060 scopus 로고
    • Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins
    • Ewen ME, B. Faha, E. Harlow & D.M. Livingston: Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science 255, 85-7 (1992)
    • (1992) Science , vol.255 , pp. 85-87
    • Ewen, M.E.1    Faha, B.2    Harlow, E.3    Livingston, D.M.4
  • 56
    • 0034014307 scopus 로고    scopus 로고
    • Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway
    • Santoni-Rugiu E, J. Falck, N. Mailand, J. Bartek & J. Lukas: Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway. Mol Cell Biol 20, 3497-509 (2000)
    • (2000) Mol Cell Biol , vol.20 , pp. 3497-3509
    • Santoni-Rugiu, E.1    Falck, J.2    Mailand, N.3    Bartek, J.4    Lukas, J.5
  • 57
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel SJL & E. Harlow: Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050-4 (1993)
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.J.L.1    Harlow, E.2
  • 58
    • 0041327168 scopus 로고    scopus 로고
    • Proliferation of cancer cells despite CDK2 inhibition
    • Tetsu O & F. McCormick: Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 3, 233-45 (2003)
    • (2003) Cancer Cell , vol.3 , pp. 233-245
    • Tetsu, O.1    McCormick, F.2
  • 59
    • 0042856400 scopus 로고    scopus 로고
    • Bared essentials of CDK2 and cyclin E
    • Roberts JM & C.J. Sherr: Bared essentials of CDK2 and cyclin E. Nat Genet 35, 9-10 (2003)
    • (2003) Nat Genet , vol.35 , pp. 9-10
    • Roberts, J.M.1    Sherr, C.J.2
  • 62
    • 0141569038 scopus 로고    scopus 로고
    • Cell cycle progression without cyclin E/CDK2: Breaking down the walls of dogma
    • Gladden AB & J.A. Diehl: Cell cycle progression without cyclin E/CDK2: breaking down the walls of dogma. Cancer Cell 4, 160-2 (2003)
    • (2003) Cancer Cell , vol.4 , pp. 160-162
    • Gladden, A.B.1    Diehl, J.A.2
  • 64
    • 0037322744 scopus 로고    scopus 로고
    • Active cyclin B1-Cdk1 first appears on centrosomes in prophase
    • Jackman M, C. Lindon, E.A. Nigg & J. Pines: Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 5, 143-8 (2003)
    • (2003) Nat Cell Biol , vol.5 , pp. 143-148
    • Jackman, M.1    Lindon, C.2    Nigg, E.A.3    Pines, J.4
  • 65
    • 0037655970 scopus 로고    scopus 로고
    • Unmasking the S-phase-promoting potential of cyclin B1
    • Moore JD, J.A. Kirk & T. Hunt: Unmasking the S-phase-promoting potential of cyclin B1. Science 300, 987-90 (2003)
    • (2003) Science , vol.300 , pp. 987-990
    • Moore, J.D.1    Kirk, J.A.2    Hunt, T.3
  • 66
    • 0029670828 scopus 로고    scopus 로고
    • A single fission yeast mitotic cyclin B-p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins
    • Fisher DL & P. Nurse: A single fission yeast mitotic cyclin B-p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J 15, 850-60 (1996)
    • (1996) EMBO J , vol.15 , pp. 850-860
    • Fisher, D.L.1    Nurse, P.2
  • 67
    • 0034574613 scopus 로고    scopus 로고
    • The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing
    • Donaldson AD: The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing. EMBO Rep 1, 507-12 (2000)
    • (2000) EMBO Rep , vol.1 , pp. 507-512
    • Donaldson, A.D.1
  • 68
    • 0037071899 scopus 로고    scopus 로고
    • Physical interaction between pRb and cdk9/cyclin T2 complex
    • Simone C, L. Bagella, C. Bellan & A. Giordano: Physical interaction between pRb and cdk9/cyclin T2 complex. Oncogene 21, 4158-65 (2002)
    • (2002) Oncogene , vol.21 , pp. 4158-4165
    • Simone, C.1    Bagella, L.2    Bellan, C.3    Giordano, A.4
  • 72
    • 0034663209 scopus 로고    scopus 로고
    • A role for Cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice
    • Liu D, C. Liao & D.J. Wolgemuth: A role for Cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. Dev Biol 224, 388-400 (2000)
    • (2000) Dev Biol , vol.224 , pp. 388-400
    • Liao, L.D.C.1    Wolgemuth, D.J.2
  • 74
    • 4043162062 scopus 로고    scopus 로고
    • Identification of interaction partners and substrates of the Cyclin A1-CDK2 complex
    • Diederichs S, N. Bäumer, P. Ji, S.K. Metzelder, G.E. Idos, T. Cauvet et al.: Identification of interaction partners and substrates of the Cyclin A1-CDK2 complex. J Biol Chem 279, 33727-41 (2004)
    • (2004) J Biol Chem , vol.279 , pp. 33727-33741
    • Diederichs, S.1    Bäumer, N.2    Ji, P.3    Metzelder, S.K.4    Idos, G.E.5    Cauvet, T.6
  • 75
    • 15844373362 scopus 로고    scopus 로고
    • CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombination and repair
    • Esashi F, N. Christ, J. Gannon, Y. Liu, T. Hunt, M. Jasin & S. West: CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombination and repair. Nature 434, 598-604 (2005)
    • (2005) Nature , vol.434 , pp. 598-604
    • Esashi, F.1    Christ, N.2    Gannon, J.3    Liu, Y.4    Hunt, T.5    Jasin, M.6    West, S.7
  • 77
    • 0141737069 scopus 로고    scopus 로고
    • Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells
    • Parisi T, A.R. Beck, N. Rougier, T. McNeil, L. Lucian, Z. Werb & B. Amati: Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO 718, 4794-803 (2003)
    • (2003) EMBO , vol.718 , pp. 4794-4803
    • Parisi, T.1    Beck, A.R.2    Rougier, N.3    McNeil, T.4    Lucian, L.5    Werb, Z.6    Amati, B.7
  • 79
    • 0031260028 scopus 로고    scopus 로고
    • Mash2 acts cell autonomously in mouse spongiotrophoblast development
    • Tanaka M, M. Gertsenstein, J. Rossant, & A. Nagy: Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev Biol 190, 55-65 (1997)
    • (1997) Dev Biol , vol.190 , pp. 55-65
    • Tanaka, M.1    Gertsenstein, M.2    Rossant, J.3    Nagy, A.4
  • 81
    • 0038245246 scopus 로고    scopus 로고
    • Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological and neurological characteristics
    • Schwenk F, B. Zevnik, J. Bruning, M. Rohl, A. Willuweit, A. Rode, T. Hennek, G. Kauselmann, R. Jaenisch & R. Kuhn: Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological and neurological characteristics. Mol Biol Cell 23, 3982-9 (2003)
    • (2003) Mol Biol Cell , vol.23 , pp. 3982-3989
    • Schwenk, F.1    Zevnik, B.2    Bruning, J.3    Rohl, M.4    Willuweit, A.5    Rode, A.6    Hennek, T.7    Kauselmann, G.8    Jaenisch, R.9    Kuhn, R.10
  • 82
    • 0031795548 scopus 로고    scopus 로고
    • Translational inhibition of cyclin B1 and appearance of cyclin D1 very early in the differentiation of mouse trophoblast giant cells
    • Palazón LS, T.J. Davies & R.L. Gardner: Translational inhibition of cyclin B1 and appearance of cyclin D1 very early in the differentiation of mouse trophoblast giant cells. Mol Hum Reprod 4, 1013-20 (1998)
    • (1998) Mol Hum Reprod , vol.4 , pp. 1013-1020
    • Palazón, L.S.1    Davies, T.J.2    Gardner, R.L.3
  • 83
    • 0009677457 scopus 로고    scopus 로고
    • Chromosome association of minichromosome maintenance proteins in Drosophila endoreplicative cycles
    • Su TT & P.H. O'Farrel: Chromosome association of minichromosome maintenance proteins in Drosophila endoreplicative cycles. J Cell Biol 140, 451-60 (1998)
    • (1998) J Cell Biol , vol.140 , pp. 451-460
    • Su, T.T.1    O'Farrel, P.H.2
  • 84
    • 4544221279 scopus 로고    scopus 로고
    • Regulation of early events in chromosome replication
    • Diffley JF: Regulation of early events in chromosome replication. Curr Biol 21, 778-86 (2004)
    • (2004) Curr Biol , vol.21 , pp. 778-786
    • Diffley, J.F.1
  • 85
    • 1542467403 scopus 로고    scopus 로고
    • Metazoan origin selection: Origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis
    • Harvey KJ & J. Newport: Metazoan origin selection: origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis. J Biol Chem 278, 48524-8 (2003)
    • (2003) J Biol Chem , vol.278 , pp. 48524-48528
    • Harvey, K.J.1    Newport, J.2
  • 86
    • 0033940513 scopus 로고    scopus 로고
    • The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells
    • Madine MA, M. Swietlik, C. Pelizon, P. Romanowski, A.D. Mills & R.A. Laskey: The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells. J Struc Biol 129, 198-210 (2000)
    • (2000) J Struc Biol , vol.129 , pp. 198-210
    • Madine, M.A.1    Swietlik, M.2    Pelizon, C.3    Romanowski, P.4    Mills, A.D.5    Laskey, R.A.6
  • 87
    • 0036305474 scopus 로고    scopus 로고
    • Distinct roles for cyclins e and a during DNA replication complex assembly and activation
    • Coverley D, H. Laman & R.A. Laskey: Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 4, 523-8 (2002)
    • (2002) Nat Cell Biol , vol.4 , pp. 523-528
    • Coverley, D.1    Laman, H.2    Laskey, R.A.3
  • 88
    • 7444229923 scopus 로고    scopus 로고
    • A centrosomal localization signal in cyclin E is required for Cdk2-independent S phase entry
    • Matsumoto Y & J.L. Maller: A centrosomal localization signal in cyclin E is required for Cdk2-independent S phase entry. Nature 306, 885-8 (2004)
    • (2004) Nature , vol.306 , pp. 885-888
    • Matsumoto, Y.1    Maller, J.L.2
  • 89
    • 0037131309 scopus 로고    scopus 로고
    • The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein
    • Geisen G and T. Möröy: The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. J Biol Chem 277, 39909-18 (2002)
    • (2002) J Biol Chem , vol.277 , pp. 39909-39918
    • Geisen, G.1    Möröy, T.2
  • 93
    • 0032728975 scopus 로고    scopus 로고
    • Human cyclin A is required for mitosis until mid prophase
    • Furuno N, N. den Elzen & J. Pines: Human cyclin A is required for mitosis until mid prophase. J Cell Sci 147, 295-306 (1999)
    • (1999) J Cell Sci , vol.147 , pp. 295-306
    • Furuno, N.1    Den Elzen, N.2    Pines, J.3
  • 94
    • 0033145508 scopus 로고    scopus 로고
    • Temporal and spatial control of Cyclin B1 destruction in metaphase
    • Clute P & J. Pines: Temporal and spatial control of Cyclin B1 destruction in metaphase. Nat Cell Biol 1, 82-7 (1999)
    • (1999) Nat Cell Biol , vol.1 , pp. 82-87
    • Clute, P.1    Pines, J.2
  • 95
    • 0035809921 scopus 로고    scopus 로고
    • The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus
    • Draviam VM, S. Orrechia, M. Lowe, R. Pardi & J. Pines: The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus. J Cell Biol 152, 945-58 (2001)
    • (2001) J Cell Biol , vol.152 , pp. 945-958
    • Draviam, V.M.1    Orrechia, S.2    Lowe, M.3    Pardi, R.4    Pines, J.5
  • 98
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres M & M. Barbacid: To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 1, 222-31 (2001)
    • (2001) Nat Rev Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 99
    • 18344372831 scopus 로고    scopus 로고
    • Cyclins and cdks in development and cancer: A perspective
    • Deshpande A, P. Sicinski & P.W. Hinds: Cyclins and cdks in development and cancer: a perspective. Oncogene 24, 2909-15 (2005)
    • (2005) Oncogene , vol.24 , pp. 2909-2915
    • Deshpande, A.1    Sicinski, P.2    Hinds, P.W.3
  • 101
    • 0037126387 scopus 로고    scopus 로고
    • Functional analysis of cyclin D2 and p27Kip1 in cyclin D2 transgenic mouse mammary gland during development
    • Kong G, S.S. Chua, Y. Yijun, F. Kittrell, R.C. Moraes, D. Medina & T.K. Said: Functional analysis of cyclin D2 and p27Kip1 in cyclin D2 transgenic mouse mammary gland during development. Oncogene 21, 7214-25 (2002)
    • (2002) Oncogene , vol.21 , pp. 7214-7225
    • Kong, G.1    Chua, S.S.2    Yijun, Y.3    Kittrell, F.4    Moraes, R.C.5    Medina, D.6    Said, T.K.7
  • 102
    • 0028274940 scopus 로고
    • Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
    • Bodrug SE, B.J. Warner, M.L. Bath, G.J. Lindeman, A.W. Harris & J.M. Adams: Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J 13, 2124-30 (1994)
    • (1994) EMBO J , vol.13 , pp. 2124-2130
    • Bodrug, S.E.1    Warner, B.J.2    Bath, M.L.3    Lindeman, G.J.4    Harris, A.W.5    Adams, J.M.6
  • 103
    • 1842370870 scopus 로고    scopus 로고
    • Cyclin D1 overexpression promotes cardyomyocite DNA synthesis and multinucleation in transgenic mice
    • Soonpaa MH, G.Y. Koh, L. Pajak, S. Jing, H. Wang, M.T. Franklin, K.K. Kim & L.J. Field: Cyclin D1 overexpression promotes cardyomyocite DNA synthesis and multinucleation in transgenic mice. J Clin Invest 99, 2644-54 (1997)
    • (1997) J Clin Invest , vol.99 , pp. 2644-2654
    • Soonpaa, M.H.1    Koh, G.Y.2    Pajak, L.3    Jing, S.4    Wang, H.5    Franklin, M.T.6    Kim, K.K.7    Field, L.J.8
  • 105
    • 0036302434 scopus 로고    scopus 로고
    • Cell Cycle and cancer: The G1 restriction point and the G1/S transition
    • Ortega S, M. Malumbres & M. Barbacid: Cell Cycle and cancer: the G1 restriction point and the G1/S transition. Current Genomics 3, 245-263 (2002)
    • (2002) Current Genomics , vol.3 , pp. 245-263
    • Ortega, S.1    Malumbres, M.2    Barbacid, M.3
  • 106
    • 0035404133 scopus 로고    scopus 로고
    • Transgenic expression of Cyclin-dependent kinase 4 results in epidermal hiperplasya, hipertrophy and severe dermal fibiosis
    • Miliani de Marval P, I. Giménez-Conti, M. La Cava, L. Martínez, C. Conti & M. Rodríguez-Puebla: Transgenic expression of Cyclin-dependent kinase 4 results in epidermal hiperplasya, hipertrophy and severe dermal fibiosis. Am J Pathol 159, 369-79 (2001)
    • (2001) Am J Pathol , vol.159 , pp. 369-379
    • Miliani De Marval, P.1    Giménez-Conti, I.2    La Cava, M.3    Martínez, L.4    Conti, C.5    Rodríguez-Puebla, M.6
  • 107
    • 0032789831 scopus 로고    scopus 로고
    • Cyclin D1 overexpression in mouse epidermis increases Cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development
    • Rodríguez-Puebla ML, M. LaCava & C. Conti: Cyclin D1 overexpression in mouse epidermis increases Cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development. Cell Growth Diff 10, 467-472 (1999)
    • (1999) Cell Growth Diff , vol.10 , pp. 467-472
    • Rodríguez-Puebla, M.L.1    LaCava, M.2    Conti, C.3
  • 108
    • 0027530449 scopus 로고
    • Redundant cyclin overexpression and gene amplification in breast cancer cells
    • Keyomarsi K & A.B. Pardee: Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci USA 90, 1112-16 (1993)
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1112-1116
    • Keyomarsi, K.1    Pardee, A.B.2
  • 109
    • 0035726627 scopus 로고    scopus 로고
    • Tumor-specific proteolytic processing of Cyclin E generates hyperactive lower-molecular-weight forms
    • Porter DC, N. Zhang, C. Danes, M.J. McGrehan, R.M. Harwell, S. Faruki & K. Keyomarsi: Tumor-specific proteolytic processing of Cyclin E generates hyperactive lower-molecular-weight forms. Mol Cell Biol 21, 6254-69 (2001)
    • (2001) Mol Cell Biol , vol.21 , pp. 6254-6269
    • Porter, D.C.1    Zhang, N.2    Danes, C.3    Mcgrehan, M.J.4    Harwell, R.M.5    Faruki, S.6    Keyomarsi, K.7
  • 110
    • 17644407081 scopus 로고    scopus 로고
    • The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27
    • Wingate H, N. Zhang, M.J. McGarhen, I. Bedrosian, J.W. Harper & K. Keyomarsi: The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27. J Biol Chem 280, 15148-57 (2005)
    • (2005) J Biol Chem , vol.280 , pp. 15148-15157
    • Wingate, H.1    Zhang, N.2    McGarhen, M.J.3    Bedrosian, I.4    Harper, J.W.5    Keyomarsi, K.6
  • 112
    • 0031028246 scopus 로고    scopus 로고
    • Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human Cyclin E
    • Bortner DM & M.P. Rosenberg: Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human Cyclin E. Mol Cell Biol 17, 453-59 (1997)
    • (1997) Mol Cell Biol , vol.17 , pp. 453-459
    • Bortner, D.M.1    Rosenberg, M.P.2
  • 114
    • 0033576570 scopus 로고    scopus 로고
    • Oncogenic potential of Cyclin E in T-cell lymphomagenesis in transgenic mice: Evidence for the cooperation between Cyclin E and Ras but not Myc
    • Karsunky H, C. Geisen, T. Schmidt, K. Haas, B. Zevnik, E. Gau et al.: Oncogenic potential of Cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for the cooperation between Cyclin E and Ras but not Myc. Oncogens 18, 7816-24 (1999)
    • (1999) Oncogens , vol.18 , pp. 7816-7824
    • Karsunky, H.1    Geisen, C.2    Schmidt, T.3    Haas, K.4    Zevnik, B.5    Gau, E.6
  • 115
    • 0037456996 scopus 로고    scopus 로고
    • Loss of p27(kip1) cooperates with Cyclin E in T-cell lymphomagenesis
    • Geisen C, H. Karsunky, R. Yucel & T. Möröy: Loss of p27(kip1) cooperates with Cyclin E in T-cell lymphomagenesis. Oncogene 22, 1724-29 (2003)
    • (2003) Oncogene , vol.22 , pp. 1724-1729
    • Geisen, C.1    Karsunky, H.2    Yucel, R.3    Möröy, T.4
  • 116
    • 0028785885 scopus 로고
    • Overexpression of cyclin a in the mammary glands of transgenic mice results in the induction of nuclear abnormalities and increased apoptosis
    • Bortner DM & M.P. Rosenberg: Overexpression of cyclin A in the mammary glands of transgenic mice results in the induction of nuclear abnormalities and increased apoptosis. Cell Growth Differ 6, 1579-89 (1995)
    • (1995) Cell Growth Differ , vol.6 , pp. 1579-1589
    • Bortner, D.M.1    Rosenberg, M.P.2
  • 117
    • 0032517341 scopus 로고    scopus 로고
    • The p16INK4a/CDKN2A tumor suppressor and its relatives
    • Ruas M & G. Peters: The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1378, F115-77 (1998)
    • (1998) Biochim Biophys Acta , vol.1378
    • Ruas, M.1    Peters, G.2
  • 123
    • 0032587495 scopus 로고    scopus 로고
    • p27Kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
    • Lloyd RV, L.A. Erickson, L. Jin, E. Kulig, X. Qian, J.C. Cheville & B.W. Scheithauer: p27Kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 154, 313-23 (1999)
    • (1999) Am J Pathol , vol.154 , pp. 313-323
    • Lloyd, R.V.1    Erickson, L.A.2    Jin, L.3    Kulig, E.4    Qian, X.5    Cheville, J.C.6    Scheithauer, B.W.7
  • 124
    • 0032980308 scopus 로고    scopus 로고
    • The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
    • Tsihlias J, L. Kapusta & J. Slingerland: The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Anna Rev Med 50, 401-23 (1999)
    • (1999) Anna Rev Med , vol.50 , pp. 401-423
    • Kapusta, T.J.L.1    Slingerland, J.2
  • 125
    • 0037112178 scopus 로고    scopus 로고
    • Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence
    • Zou X, D. Ray, A. Aziyu, K. Christov, A.D. Boiko, A.V. Gudkov & H. Kiyokawa: Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev 16, 2923-34 (2002)
    • (2002) Genes Dev , vol.16 , pp. 2923-2934
    • Zou, X.1    Ray, D.2    Aziyu, A.3    Christov, K.4    Boiko, A.D.5    Gudkov, A.V.6    Kiyokawa, H.7
  • 128
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu Q & P. Sicinski: Specific protection against breast cancers by cyclin D1 ablation. Nature 411, 1017-21 (2001)
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Sicinski, P.2
  • 129
    • 0142024939 scopus 로고    scopus 로고
    • Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice
    • Burns KH, J.E. Agno, P. Sicinski & M.M. Matzuk: Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice. Mol Endocrinol 10, 2053-69 (2003)
    • (2003) Mol Endocrinol , vol.10 , pp. 2053-2069
    • Burns, K.H.1    Agno, J.E.2    Sicinski, P.3    Matzuk, M.M.4
  • 133
    • 20444410393 scopus 로고    scopus 로고
    • Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1
    • Martín A, J. Odajima, S.L. Hunt, P. Dubus, S. Ortega, M. Malumbres, & M. Barbacid: Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1. Cancer Cell 7, 1-8 (2005)
    • (2005) Cancer Cell , vol.7 , pp. 1-8
    • Martín, A.1    Odajima, J.2    Hunt, S.L.3    Dubus, P.4    Ortega, S.5    Malumbres, M.6    Barbacid, M.7
  • 134
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
    • Toyoshima H & T. Hunter: p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78, 67-74 (1994)
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 136
    • 0032829687 scopus 로고    scopus 로고
    • CDK-independent activities of D type cyclins
    • Bernards R: CDK-independent activities of D type cyclins. Biochim Biophys Acta 1424, M17-22 (1999)
    • (1999) Biochim Biophys Acta , vol.1424
    • Bernards, R.1
  • 137
    • 1642603438 scopus 로고    scopus 로고
    • The activities of cyclin D1 that drive tumorigenesis
    • Ewen ME & J. Lamb: The activities of cyclin D1 that drive tumorigenesis. TRENDS Mol Med 10, 158-62 (2004)
    • (2004) TRENDS Mol Med , vol.10 , pp. 158-162
    • Ewen, M.E.1    Lamb, J.2
  • 139
    • 0035687780 scopus 로고    scopus 로고
    • Differential cyclin D1 requirements of proliferating Schwann cells during development and after injury
    • Atanasoski S, S. Shumas, C. Dickson, S.S. Scherer & U. Suter: Differential cyclin D1 requirements of proliferating Schwann cells during development and after injury. Mol Cell Neurosci 18, 581-92 (2001)
    • (2001) Mol Cell Neurosci , vol.18 , pp. 581-592
    • Atanasoski, S.1    Shumas, S.2    Dickson, C.3    Scherer, S.S.4    Suter, U.5
  • 141
    • 0034603064 scopus 로고    scopus 로고
    • Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40
    • Lam EW, J. Glassford, L. Banerji, N.S. Thomas, P. Sicinski & G.G. Klaus: Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. J Biol Chem 275, 3479-84 (2000)
    • (2000) J Biol Chem , vol.275 , pp. 3479-3484
    • Lam, E.W.1    Glassford, J.2    Banerji, L.3    Thomas, N.S.4    Sicinski, P.5    Klaus, G.G.6
  • 144
    • 0035817687 scopus 로고    scopus 로고
    • Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
    • Krimpenfort P, K.C. Quon, W.J. Mooi, A. Loonstra & A. Berns: Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 413, 83-6 (2001)
    • (2001) Nature , vol.413 , pp. 83-86
    • Krimpenfort, P.1    Quon, K.C.2    Mooi, W.J.3    Loonstra, A.4    Berns, A.5
  • 147
    • 0032530112 scopus 로고    scopus 로고
    • Cdk inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
    • Franklin DS, V.L. Godfrey, H. Lee, G.I. Kovalev, R. Schoonhoven, S. Chen-Kiang, L. Su & Y. Xiong: Cdk inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev 12, 2899-911 (1998)
    • (1998) Genes Dev , vol.12 , pp. 2899-2911
    • Franklin, D.S.1    Godfrey, V.L.2    Lee, H.3    Kovalev, G.I.4    Schoonhoven, R.5    Chen-Kiang, S.6    Su, L.7    Xiong, Y.8
  • 149
    • 0037317415 scopus 로고    scopus 로고
    • Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis
    • Bai F, X.H. Pei, V.L. Godfrey & Y. Xiong: Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol 23, 1269-77 (2003)
    • (2003) Mol Cell Biol , vol.23 , pp. 1269-1277
    • Bai, F.1    Pei, X.H.2    Godfrey, V.L.3    Xiong, Y.4
  • 151
    • 0037936843 scopus 로고    scopus 로고
    • Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    • Chen P, F. Zindy, C. Abdala, F. Liu, X. Li, M.F. Roussel & N. Segil: Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol 5, 385-7 (2003)
    • (2003) Nat Cell Biol , vol.5 , pp. 385-387
    • Chen, P.1    Zindy, F.2    Abdala, C.3    Liu, F.4    Li, X.5    Roussel, M.F.6    Segil, N.7
  • 153
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-84 (1995)
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 156
    • 0035863515 scopus 로고    scopus 로고
    • WAF1/CIP1 enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosa
    • WAF1/CIP1 enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosa. Cancer Res 61, 565-9 (2001)
    • (2001) Cancer Res , vol.61 , pp. 565-569
    • Yang, K.1    Mathew, J.2    Velcich, A.3    Edelmann, W.4    Kucherlapati, R.5    Lipkin, M.6    Yang, K.7    Augenlicht, L.H.8
  • 157
    • 0032550224 scopus 로고    scopus 로고
    • p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells
    • Brugarolas J, R.T. Bronson & T. Jacks: p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J Cell Biol 141, 503-14 (1998)
    • (1998) J Cell Biol , vol.141 , pp. 503-514
    • Brugarolas, J.1    Bronson, R.T.2    Jacks, T.3
  • 159
    • 0036532056 scopus 로고    scopus 로고
    • Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties
    • Bearss DJ, R.J. Lee, D.A. Troyer, R.G. Pestell & J.J. Windle: Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties. Cancer Res 62, 2077-84 (2002)
    • (2002) Cancer Res , vol.62 , pp. 2077-2084
    • Bearss, D.J.1    Lee, R.J.2    Troyer, D.A.3    Pestell, R.G.4    Windle, J.J.5
  • 163
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama K, N. Ishida, M. Shirane, A. Inomata, T. Inoue, N. Shishido, I. Horii & D. Y. Loh: Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-20 (1996)
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3    Inomata, A.4    Inoue, T.5    Shishido, N.6    Horii, I.7    Loh, D.Y.8
  • 166
    • 0036124467 scopus 로고    scopus 로고
    • ErbB2/Neu-induced, Cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
    • Muraoka RS, A.E. Lenferink, B. Law, E. Hamilton, D.M. Brantley, L.R. Roebuck & C.L. Arteaga: ErbB2/Neu-induced, Cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol 22, 2204-19 (2002)
    • (2002) Mol Cell Biol , vol.22 , pp. 2204-2219
    • Muraoka, R.S.1    Lenferink, A.E.2    Law, B.3    Hamilton, E.4    Brantley, D.M.5    Roebuck, L.R.6    Arteaga, C.L.7
  • 167
    • 0037456996 scopus 로고    scopus 로고
    • Loos of p27Kip1 cooperates with Cyclin E in T-cell lymphomagenesis
    • Geisen C, H. Karsunky, R. Yucel & T. Moroy: Loos of p27Kip1 cooperates with Cyclin E in T-cell lymphomagenesis. Oncogene 22, 1724-9 (2003)
    • (2003) Oncogene , vol.22 , pp. 1724-1729
    • Geisen, C.1    Karsunky, H.2    Yucel, R.3    Moroy, T.4
  • 168
    • 8844258062 scopus 로고    scopus 로고
    • Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice
    • Martin-Caballero J, J.M. Flores, P. García-Palencia, M. Collado & M. Serrano: Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice. Oncogene 23, 8231-7 (2004)
    • (2004) Oncogene , vol.23 , pp. 8231-8237
    • Martin-Caballero, J.1    Flores, J.M.2    García-Palencia, P.3    Collado, M.4    Serrano, M.5
  • 169
    • 0037099496 scopus 로고    scopus 로고
    • Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis
    • Martins CP & A. Berns: Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J 21, 3739-48 (2002)
    • (2002) EMBO J , vol.21 , pp. 3739-3748
    • Martins, C.P.1    Berns, A.2
  • 170
    • 0030955563 scopus 로고    scopus 로고
    • Ablation of the Cdk inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
    • Yan Y, J. Frisen, M.H. Lee, J. Massagué & M. Barbacid: Ablation of the Cdk inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev 11, 973-83 (1997)
    • (1997) Genes Dev , vol.11 , pp. 973-983
    • Yan, Y.1    Frisen, J.2    Lee, M.H.3    Massagué, J.4    Barbacid, M.5
  • 172
    • 0037593890 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 cooperate to restrict proliferative life span in differentiating ovarian cells
    • Jirawatnotai S, D.S. Moons, C.O. Stocco, R. Franks, D.B. Hales, G. Gibori & H. Kiyokawa: The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 cooperate to restrict proliferative life span in differentiating ovarian cells. J Biol Chem 278, 17021-7 (2003)
    • (2003) J Biol Chem , vol.278 , pp. 17021-17027
    • Jirawatnotai, S.1    Moons, D.S.2    Stocco, C.O.3    Franks, R.4    Hales, D.B.5    Gibori, G.6    Kiyokawa, H.7
  • 173
    • 4344622055 scopus 로고    scopus 로고
    • p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naïve
    • Wolfraim LA, T.M. Walz, Z. James, T. Fernàndez & J. Letterio: p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naïve T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness. J Immunol 3093-102 (2004)
    • (2004) J Immunol , pp. 3093-3102
    • Wolfraim, L.A.1    Walz, T.M.2    James, Z.3    Fernàndez, T.4    Letterio, J.5
  • 176
    • 0033864297 scopus 로고    scopus 로고
    • Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity
    • Franklin DS, V.L. Godfrey, D.A. O'Brien, C. Deng, & Y. Xiong: Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol Cell Biol 20, 6147-58 (2000)
    • (2000) Mol Cell Biol , vol.20 , pp. 6147-6158
    • Franklin, D.S.1    Godfrey, V.L.2    O'Brien, D.A.3    Deng, C.4    Xiong, Y.5
  • 177
    • 0033539696 scopus 로고    scopus 로고
    • Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases
    • Zindy F, J.J. Cunningham, C.J. Sherr, S. Jogal, R.J. Smeyne & M.F. Roussel: Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. Proc Natl Acad Sci USA 96, 13462-7 (1999)
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13462-13467
    • Zindy, F.1    Cunningham, J.J.2    Sherr, C.J.3    Jogal, S.4    Smeyne, R.J.5    Roussel, M.F.6
  • 178
    • 3242720392 scopus 로고    scopus 로고
    • Genetic evidence for functional dependency of p18Ink4c on Cdk4
    • Pei XH, F. Bai, T. Tsutsui, H. Kiyokawa & Y. Xiong: Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol Cell Biol 24, 6653-64 (2004)
    • (2004) Mol Cell Biol , vol.24 , pp. 6653-6664
    • Pei, X.H.1    Bai, F.2    Tsutsui, T.3    Kiyokawa, H.4    Xiong, Y.5
  • 179
    • 18144424779 scopus 로고    scopus 로고
    • Cooperation between Cdk4 and p27Kip1 in tumor development: A preclinical model to evaluate cell cycle inhibitors with therapeutic activity
    • Sotillo R, O. Renner, P. Dubus, J. Ruiz-Cabello, J. Martin-Caballero, M. Barbacid, A. Carnero & M. Malumbres: Cooperation between Cdk4 and p27Kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Res 65, 3846-52 (2005)
    • (2005) Cancer Res , vol.65 , pp. 3846-3852
    • Sotillo, R.1    Renner, O.2    Dubus, P.3    Ruiz-Cabello, J.4    Martin-Caballero, J.5    Barbacid, M.6    Carnero, A.7    Malumbres, M.8
  • 180
    • 0035142831 scopus 로고    scopus 로고
    • Genetic evidence for the interactions of Cyclin D1 and p27 (Kip1) in mice
    • Tong W & J.W. Pollard: Genetic evidence for the interactions of Cyclin D1 and p27 (Kip1) in mice. Mol Cell Biol 21, 1319-28 (2001)
    • (2001) Mol Cell Biol , vol.21 , pp. 1319-1328
    • Tong, W.1    Pollard, J.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.