Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 8218-8223

  Cesarman, Ethel ^a   Nador, Roland G ^a   Bai, Feng ^a   Bohenzky, Roy A ^b   Russo, James J ^b   Moore, Patrick S ^b   Chang, Yuan ^b   Knowles, Daniel M ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b Department of Orthopaedic Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYCLIN D; CYCLINE; GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DNA LIBRARY; EPSTEIN BARR VIRUS; HERPES SIMPLEX VIRUS; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; KAPOSI SARCOMA; LYMPHOMA; OPEN READING FRAME; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; VIRUS GENOME;

EID: 0029798249     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.8218-8223.1996     Document Type: Article

References (76)

1. Ahuja, S. K., and P. M. Murphy. 1993. Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri. J. Biol. Chem. 268: 20691-20694.
2. Albrecht, J.-C., J. Nicholas, D. Biller, K. R. Cameron, B. Biesinger, C. Newman, S. Wittmann, M. A. Craxton, H. Coleman, B. Fleckenstein, and R. W. Honess. 1992. Primary structure of the herpesvirus saimiri genome. J. Virol. 66:5047-5058.
3. Allen, L. F., R. J. Lefkowitz, M. G. Caron, and S. Cotecchia. 1991. G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc. Natl. Acad. Sci. USA 88:11354-11358.
4. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
5. Ambroziak, J. A., D. J. Blackbourn, B. G. Herndier, R. G. Glogau, J. H. Gullett, A. R. McDonald, E. T. Lennette, and J. A. Levy. 1995. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268:582-583.
6. Arnold, A., H. G. Kim, R. D. Gaz, R. L. Eddy, Y. Fukushima, M. G. Byers, T. B. Shows, and H. M. Kronenberg. 1989. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J. Clin. Invest. 83:2034-2040.
7. Arvanitakis, L., E. A. Mesri, R. Nador. J. W. Said, A. S. Asch, D. M. Knowles, and E. Cesarman. Establishment and characterization of a body cavity-based lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus in the absence of EBV. Blood, in press.
8. Arvanitakis, L., N. Yaseen, and S. Sharma. 1995. Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1 -mediated growth inhibition in EBV-positive B cells. J. Immunol. 155:1047-1056.
9. Baer, R., A. T. Bankier, M. D. Biggin, P. L. Deininger, P. J. Farrell, T. J. Gibson, G. Hatfull, G. S. Hudson, S. C. Satchwell, C. Séguin, P. S. Tuffnell, and B. G. Barrell. 1984. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature (London) 310:207-211.
10. Biesinger, B., I. Müller-Fleckenstein, B. Simmer, G. Lang, S. Wittman, E. Platzer, R. C. Desrosiers, and B. Fleckenstein. 1992. Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proc. Natl. Acad. Sci. USA 89:3116-3119.
11. Birkenbach, M., K. Josefsen, R. Yalamanchili, G. Lenoir, and E. Kieff. 1993. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Viral. 67:2209-2220.
12. Bodenteich, A., S. Chissoe, Y.-F. Wang, and B. A. Roe. 1994. Shotgun cloning as the strategy of choice to generate templates for high-throughput dideoxynucleotide sequencing, p. 42-50. In M. D. Adams, and C. Fields, and J. C. Venter (ed.), Automated DNA sequencing and analysis. Academic Press, Inc., San Diego.
13. Bohenzky, R., J. Russo, P. S. Moore, and Y. Chang. Unpublished observation.
14. Boshoff, C., D. Whitby, T. Hatziionnou, C. Fisher, J. van der Walt, A. Hatzakis, R. Weiss, and T. Schulz. 1995. Kaposi's sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet 345:1043-1044.
15. r membrane antigen encoded at the left end of the Epstein-Barr virus genome. J. Virol. 61:2063-2070.
16. Cesarman, E., Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences are present in AIDS-related body cavity based lymphomas. N. Engl. J. Med. 332:1186-1191.
17. Cesarman, E., P. S. Moore, P. Rao, G. Inghirami, D.M. Knowles, and Y. Chang. 1995. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86:2708-2714.
18. Chang, Y., E. Cesarman, M. S. Pessin, F. Lee, J. Culpepper, D. M. Knowles, and P. S. Moore. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associaled Kaposi's sarcoma. Science 266:1865-1869.
19. Chang, Y., P. S. Moore, S. J. Talbot, C. Boschoff, T. Zarkowska, D. Godden-Kent, R. Weiss, and S. Mittnacht. 1996. Cyclin encoded by herpesvirus KS Nature (London), 382:410.
20. Chang, Y., J. Ziegler, H. Wabinga, E. Katangole-Mbidde, C. Boshoff, T. Schulz, D. Whitby, D. Maddalena, H. W. Jaffe, R. A. Weiss, P. S. Moore, and the Uganda Kaposi's Sarcoma Study Group. 1996. Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Arch. Intern. Med. 156:202-204.
21. di Celle, P. F., A. Carbone, D. Marchis, D. Zhou, S. Sozzani, S. Zupo, M. Pini, A. Mantovani, and R. Foa. 1994. Cytokine gene expression in B-cell chronic lymphocytic leukemia: evidence of constitutive interleukin-8 (IL-8) mRNA expression and secretion of biologically active IL-8 protein. Blood 84:220-228.
22. di Celle, P. F., S. Mariani, L. Riera, A. Stacchini, G. Reato, and R. Foa. 1996. Interleukin-8 induces the accumulation of B-cell chronic lymphocytic leukemia by prolonging survival in an autocrine fashion. Blood 87:4382-4389.
23. Dobner, T., I. Wolf, T. Emrich, and M. Lipp. 1992. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. Eur. J. Immunol. 22:2795-2799.
24. Dupin, N., I. Gorin, J. Deleuze, H. Agut, J.-M. Huraux, and J.-P. Escande. 1995. Herpes-like DNA sequences, AIDS-related tumors, and Castleman's disease. N. Engl. J. Med. 333:798. (Letter.)
25. Dupin, N., M. Grandadam, V. Calvez, I. Gorin, J. T. Aubin, S. Havard, F. Lamy, M. Leibowitch, J. M. Huraux, J. P. Escande, and H. Augut. 1995. Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma. Lancet 345:761-762.
26. Ensser, A., and B. Fleckenstein. 1995. The alcelaphine herpesvirus type 1 has a semaphorin-like gene. J. Gen. Virol. 75:1063-1067.
27. Federsppiel, B., I. G. Melhado, A. M. Duncan, A. Delaney, K. Schappert, I. Clark-Lewis, and F. R. Jirik. 1993. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Genomies 16:707-712.
28. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877.
29. Fiore, O., and P. Moore. Submitted for publication.
30. Fleckenstein, B., and R. C. Desrosiers. 1982. Herpesvirus saimiri and herpesvirus ateles. p. 253-332. In B. Roizman (ed.), The herpesviruses. Plenum Press, New York.
31. Frank, D., E. Cesarman, Y. F. Liu, R. E. Michler, and D. M. Knowles. 1995. Post-transplantation lymphoproliferative disorders frequently contain type A and not type B Epstein-Barr virus. Blood 85:1396-1403.
32. Gessain, A., A. Sudaka, J. Brière, N. Fouchard, M.-A. Nicola, B. Rio, M. Arborio, X. Troussard, J. Ausouin, J. Diebold, and G. de Thé. 1995. Kaposi sarcoma-associated herpes-like virus (human herpesvirus type 8) DNA sequences in multicentric Castleman's disease: is there any relevant association in non-human immunodeficiency virus-infected patients? Blood 87:414-416. (Letter.)
33. Gutkind, J. S., E. A. Novotny, M. R. Brann, and K. C. Robbins. 1991. Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc. Natl. Acad. Sci. USA 88:4703-4707.
34. Herzog, H., Y. J. Hort, J. Shine, and L. A. Selbie. 1993. Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. DNA Cell Biol. 12:465-471.
35. Hofmann, K., and W. Stoffel. 1993. TMbase - a database of membrane spanning protein segments. Biol. Chem. Hoppe-Seyler 347:166.
36. Honess, R. W., U. A. Gompels, B. G. Barrell, M. Craxton, K. R. Cameron, R. Staden, Y.-N. Chang, and G. S. Hayward. 1989. Deviations from expected frequencies of CpG dinucleotides in herpesvirus DNAs may be diagnostic of differences in the states of their latent genomes. J. Gen. Virol. 70:837-855.
37. Jackson, T. R., L. A. Blair, J. Marshall, M. Goedert, and M. R. Hanley. 1988. The mas oncogene encodes an angiotensin receptor. Nature (London) 335: 437-440.
38. Jazin, E. E., H. Yoo, A. G. Blomqvist, F. Yee, G. Weng, M. W. Walker, J. Salon, D. Larhammar, and C. Wahlestedt. 1993. A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regul. Pept. 47:247-258.
39. Julius, D., T. J. Livelli, T. M. Jessell, and R. Axel. 1989. Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science 244:1057-1062.
40. Jung, J. U., M. Släger, and R. G. Desrosiers. 1994. Virus-encoded cyclin. Mol. Cell. Biol. 14:7235-7244.
41. Karcher, D. S., and S. Alkan. 1995. Herpes-like DNA sequences, AIDS-related tumors, and Castleman's disease. N. Engl. J. Med. 333:797-798. (Letter.)
42. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
43. Martin-Gallardo, A., J. Lamerdin, and A. Carrano. 1994. Shotgun sequencing, p. 37-41. In M. D. Adams, C. Fields, and J. C. Venter (ed.), Automated DNA sequencing and analysis. Academic Press, Inc., San Diego.
44. Merico, F., L. Bergui, M. G. Gregoretti, P. Ghia, G. Aimo, I. J. Lindley, and F. Caligatis-Cappio. 1993. Cytokines involved in the progression of multiple myeloma. Clin. Exp. Immunol. 92:27-31.
45. Mesri, E. A., E. Cesarman, L. Arvanitakis, S. Rafii, M. A. S. Moore, D. N. Posnett, D. M. Knowles, and A. S. Asch. 1996. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J. Exp. Med. 183:2385-2390.
46. Miller, G. 1990. Epstein-Barr virus. Biology, pathogenesis and medical aspects, p. 1021-1058. In B. N. Fields, D. M. Knipe, R. M. Chanock, M. S. Hirsch, J. L. Melnick, T. P. Monath, and B. Roizman (ed.), Virology, 2nd ed. Raven Press, Ltd., New York.
47. Miller, G., M. O. Rigsby, L. Heston, E. Grogan, R. Sun, C. Metroka, J. A. Levy, S.-J. Gao, Y. Chang, and P. Moore. 1996. Antibodies to butyrateinducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. N. Engl. J. Med. 334:1292-1297.
48. Moore, P. S., and Y. Chang. 1995. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma lesions from persons with and without HIV infection. N. Engl. J. Med. 332:1181-1185.
49. Moore, P. S., S.-J. Gao, G. Dominguez, E. Cesarman, O. Lungu, D. M. Knowles, R. Garber, P. E. Pellett, D. J. McGeogh, and Y. Chang. 1996. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma. J. Virol. 70:549-558.
50. Moore, P. S., A. Kingsley, S. D. Holmberg, T. Spira, P. Gupta, D. R. Hoover, J. P. Parry, L. J. Conley, H. W. Jaffe, and Y. Chang. 1996. Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcoma. AIDS 10:175-180.
51. Motokura, T., T. Bloom, H. G. Kim, H. Juppner, J. V. Ruderman, H. M. Kronenberg, and A. Arnold. 1991. A novel cyclin encoded by a bell-linked candidate oncogene. Nature (London) 350:512-515.
52. Murphy, P. M., and H. L. Tiffany. 1991. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 253:1280-1283.
53. Nicholas, J., K. R. Cameron, and R. W. Honess. 1992. Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. Nature (London) 355:362-365.
54. Noel, J. C. 1995. Kaposi's sarcoma and KSHV. Lancet 346:1359. (Letter.)
55. Nomura, H., B. W. Nielsen, and K. Matsushima. 1993. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotaetic peptide receptors. Int. Immunol. 5:1239-1249.
56. Parma, J., L. Duprez, J. Van Sande, P. Cochaux, C. Gervy, J. Mortel, J. Dumont, and G. Vassart. 1993. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature (London) 365: 649-651.
57. Peters, G. 1994. The D-type cyclins and their role in tumorigenesis. J. Cell Sci. 18:89-96.
58. Renne, R., W. Zhong, B. Herndier, M. McGrath, N. Abbey, D. Kedes, and D. Ganem. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 2:342-346.
59. Russo, D., F. Arturi, M. Schlumberger, B. Caillou, R. Monier, S. Filleti, and H. G. Suarez. 1995. Activating mutations of the TSH receptor in differentiated thyroid carcinomas. Oncogene 11:1907-1911.
60. Said, J. W., K. Chien, S. Takeuchi, H. Asou, S. K. Cho, S. de Vos, E. Cesarman, and D. M. Knowles. Kaposi's sarcoma associated herpesvirus (KSHV of HHV 8) in body cavity based primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. Blood, in press.
61. Sampei, G., and K. Mizobuchi. 1989. The organization of the purL gene encoding 5′-phosphoribosylformylglycinamide amidotransferase of Escherichia coli. J. Biol. Chem. 264:21230-21238.
62. Schalling, M., M. Ekman, E. E. Kaaya, A. Linde, and P. Biberfeld. 1995. A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nat. Med. 1:707-708.
63. Sciacca, F. L., M. Stürzl, F. Bussolino, M. Sironi, H. Brandstetter, C. Zietz, D. Zhou, C. Matteucci, G. Peri, S. Sozzani, R. Benelli, M. Arese, A. Albini, F. Colotta, and A. Mantovani. 1994. Expression of adhesion molecules, platelet-activation factor, and chemokines by Kaposi's sarcoma cells. J. Immunol. 153:4816-4825.
64. Shigandia, D., M. R. Howard, N. S. Brink, D. Gibb, N. Klein, R. Tedder, and V. Novelli. 1995. Kaposi's sarcoma and KSHV. Lancet 346:1359-1360. (Letter.)
65. Soulier, J., L. Grollet, E. Oksenhendler, P. Cacoub, D. Cazals-Hatem, P. Babinet, M.-F. d'Agay, J.-P. Clauvel, M. Raphael, L. Degos, and F. Sigaux. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86:1275-1280.
66. Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503-517.
67. Strader, C. D., T. M. Fong, M. R. Tota, and D. Underwood. 1994. Structure and function of G protein-coupled receptors. Annu. Rev. Biochem. 63:101-132.
68. Telford, E. A., M. S. Watson, H. C. Aird, J. Perry, and A. J. Davison. 1995. The DNA sequence of equine herpesvirus 2. J. Mol. Biol. 249:520-528.
69. Tiong, S. Y., and D. Nash. 1993. The adenosine2 gene of Drosophila melanogaster encodes a formylglycineamide ribotide amidotransferase. Genome 36:924-934.
70. Tsujimoto, Y., L. R. Finger, J. Yunis, P. C. Nowell, and C. M. Croce. 1984. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14; 18) chromosome translocation. Science 226:1097-1099.
71. Whitby, D., M. R. Howard, M. Tenant-Flowers, N. S. Brink, A. Copas, C. Boshoff, T. Hatzioannou, F. E. A. Suffett, D. M. Aldam, A. S. Denton, R. F. Miller, I. V. D. Weller, R. A. Weiss, R. S. Tedder, and T. F. Schulz. 1995. Detection of Kaposi's sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 346: 799-802.
72. Wilson, R., R. Ainscough, K. Anderson, C. Baynes, M. Berks, J. Bonfield, J. Burton, M. Connell, T. Copsey, J. Cooper, A. Coulson, M. Craxton, S. Dear, Z. Du, R. Durbin, A. Favello, L. Fulton, A. Gardner, P. Green, T. Hawkins, L. Hillier, M. Jier, L. Johnston, M. Jones, J. Kershaw, J. Kirste, N. Laister, P. Latreille, J. Lightning, C. Lloyd, A. McMurray, B. Mortimore, M. O'Callaghan, J. Parsons, C. Percy, L. Rifken, A. Roopra, D. Saunders, R. Shownkeen, N. Smaldon, A. Smith, E. Sonnhannerm, R. Staden, J. Sulston, J. Thierry-Mieg, K. Thomas, M. Vaudin, K. Vaughan, R. Waterston, A. Watson, L. Weinstock, J. Wilkinson-Sproat, and P. Wohlman. 1994. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature (London) 368:32-38.
73. Wolf, J., A. Draube, A. Bohlen, H. Jox, E. Mucke, M. Pawlita, P. Moller, and V. Diehl. 1995. Suppression of Burkitt's lymphoma tumorigenicity in nude mice by co-inoculation of EBV-immortalized lymphoblastoid cells. Int. J. Cancer 60:5227-5253.
74. Young, D., G. Waitches, C. Birchmeier, O. Fasano, and M. Wigler. 1986. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell 45:711-719.
75. Zhang, Y. J., W. Jiang, C. J. Chen, C. S. Lee, S. M. Kahn, R. M. Santella, and I. B. Weinstein. 1993. Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 196: 1010-1016.
76. Zhong, W., H. Wang, B. Herndier, and D. Ganem. 1996. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc. Natl. Acad. Sci. USA 93:6641-6646.