The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism

Molecular and Cellular Biology

Volumn 20, Issue 17, 2000, Pages 6233-6243

  Sullivan, C S ^a   Cantalupo, P ^a   Pipas, J M ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHAPERONE; PROTEIN DNAK; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CELL IMMORTALIZATION; CELL TRANSFORMATION; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; GENE DISRUPTION; GENE INACTIVATION; INSECT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; SIMIAN VIRUS 40;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, VIRAL, TUMOR; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HYDROLYSIS; INSECTS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; PHOSPHOPROTEINS; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P130; SIMIAN VIRUS 40; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS;

ANIMALIA; INSECTA; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0033842443     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.17.6233-6243.2000     Document Type: Article

References (50)

1. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo
2. Polyomavirus T antigens: Molecular chaperones for multiprotein complexes
3. SV40-induced immortalization of human cells
4. The Hsp70 and Hsp60 chaperone machines
5. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication
6. Expression of SV40 large T antigen in baculovirus systems and purification by immuno-affinity chromatography
7. trans-Dominant and non-trans-dominant mutant simian virus 40 large T antigens show distinct responses to ATP
8. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product
9. The E2F transcription factor is a cellular target for the RB protein
10. T-antigen mutant activities in vivo: Roles of p53 and pRB binding in tumorigenesis of the choroid plexus
11. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
12. 1/S-regulatory genes
13. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
14. The regulation of E2F by pRB-family proteins
15. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
16. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes
17. HSP70 binding sites in the tumor suppressor protein p53
18. Creation of human tumour cells with defined genetic elements
19. Monoclonal antibodies specific for simian virus 40 tumor antigens
20. Novel mechanisms of E2F induction by BK virus large-T antigen: Requirement of both the pRb-binding and the J domains
21. Molecular chaperones in cellular protein folding
22. 15N magnetic resonance assignments, secondary structure, and tertiary fold of Escherichia coli DnaJ(1-78)
23. Human lens epithehal cell line
24. Identification of distinct roles for separate E1A domains in the disruption of E2F complexes
25. 70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb: Identification of a novel region of pRb-mediating protein interaction
26. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
27. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product
28. The N-terminal 178-amino-acid domain only of the SV40 large T antigen acts as a transforming suppressor of the HER-2/neu oncogene
29. Expression of simian virus 40 T antigen in insect cells using a baculovirus expression vector
30. p53, the cellular gatekeeper for growth and division
31. Human Hsp70 and Hsp40 chaperone proteins facilitate human papillomavirus-11 E1 protein binding to the origin and stimulate cell-free DNA replication
32. HSP binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines
33. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
34. Simian virus 40 mutants with amino-acid substitutions near the amino terminus of large T antigen
35. Common and unique features of T antigens encoded by the polyomavirus group
36. The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells
37. Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53
38. Replication and transformation functions of in vitro-generated simian virus 40 large T antigen mutants
39. Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells
40. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein
41. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function
42. Simian virus 40 large T antigen J domain and Rb-binding motif are sufficient to block apoptosis induced by growth factor withdrawal in a neural stem cell line
43. The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP
44. The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain
45. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
46. TID1, a human homolog of the Drosophila tumor suppressor 1(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions
47. 2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication
48. The retinoblastoma protein and cell cycle control
49. The J domain of simian virus 40 large T antigen is required to functionally inactivate Rb family proteins
50. Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen