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Volumn 19, Issue 2, 1999, Pages 1068-1080

Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; RETINOBLASTOMA PROTEIN;

EID: 0032929012     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.2.1068     Document Type: Article
Times cited : (165)

References (100)
  • 1
  • 2
    • 0029973557 scopus 로고    scopus 로고
    • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cdk inhibitors
    • Adams, P. D., W. R. Sellers, S. K. Sharma, A. D. Wu, C. M. Nalin, and W. G. Kaelin. 1996. Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cdk inhibitors. Mol. Cell. Biol. 16:6623-6633.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6623-6633
    • Adams, P.D.1    Sellers, W.R.2    Sharma, S.K.3    Wu, A.D.4    Nalin, C.M.5    Kaelin, W.G.6
  • 6
    • 0023392945 scopus 로고
    • High-efficiency transformation of mammalian cells by plasmid DNA
    • Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 2745-2752
    • Chen, C.1    Okayama, H.2
  • 7
    • 0029784513 scopus 로고    scopus 로고
    • Cyclin binding motifs are essential tor the function of p21cip1
    • Chen, J., P. Saha, S. Kornbluth, B. D. Dynlacht, and A. Dutta. 1996. Cyclin binding motifs are essential tor the function of p21cip1. Mol. Cell. Biol. 16:4673-4682.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4673-4682
    • Chen, J.1    Saha, P.2    Kornbluth, S.3    Dynlacht, B.D.4    Dutta, A.5
  • 8
    • 0027140404 scopus 로고
    • Cell cycle-specific association of E2F with the p130 E1A-binding protein
    • Cobrinik, D., P. Whyte, D. S. Peeper, T. Jacks, and R. A. Weinberg. 1993. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 7:2392-2404.
    • (1993) Genes Dev. , vol.7 , pp. 2392-2404
    • Cobrinik, D.1    Whyte, P.2    Peeper, D.S.3    Jacks, T.4    Weinberg, R.A.5
  • 9
    • 0031019197 scopus 로고    scopus 로고
    • Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
    • Connell-Crowley, L., J. W. Harper, and D. W. Goodrich. 1997. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol. Biol. Cell 8:287-301.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 287-301
    • Connell-Crowley, L.1    Harper, J.W.2    Goodrich, D.W.3
  • 10
    • 0026567432 scopus 로고
    • The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression
    • DeCaprio, J. A., Y. Furukawa, F. Ajchenbaum, J. Griffen, and D. M. Livingston. 1992. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc. Natl. Acad. Sci. USA 89:1795-1798.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1795-1798
    • DeCaprio, J.A.1    Furukawa, Y.2    Ajchenbaum, F.3    Griffen, J.4    Livingston, D.M.5
  • 11
    • 0028826881 scopus 로고
    • E2F1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity
    • DeGregori, J., G. Leone, K. Ohtani, A. Miron, and J. R. Nevins. 1995. E2F1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9:2873-2887.
    • (1995) Genes Dev. , vol.9 , pp. 2873-2887
    • DeGregori, J.1    Leone, G.2    Ohtani, K.3    Miron, A.4    Nevins, J.R.5
  • 12
    • 0027204555 scopus 로고
    • Physical interaction of the retinoblastoma protein with human D cyclins
    • Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg. 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73:499-511.
    • (1993) Cell , vol.73 , pp. 499-511
    • Dowdy, S.F.1    Hinds, P.W.2    Louie, K.3    Reed, S.I.4    Arnold, A.5    Weinberg, R.A.6
  • 14
    • 0028980858 scopus 로고
    • Developmental control of the G1 to S transition in drosophila: Cyclin E is a limiting downstream target of E2F
    • Duronio, R. J., and P. H. O'Farrell. 1995. Developmental control of the G1 to S transition in Drosophila: cyclin E is a limiting downstream target of E2F. Genes Dev. 9:1456-1468.
    • (1995) Genes Dev. , vol.9 , pp. 1456-1468
    • Duronio, R.J.1    O'Farrell, P.H.2
  • 15
    • 0027936686 scopus 로고
    • Differential regulation of E2F transactivation by cyclin/cdk complexes
    • Dynlacht, B. D., Flores, O., Lees, J. A. Harlow, E. 1994. Differential regulation of E2F transactivation by cyclin/cdk complexes. Genes Dev. 8:1772-1786.
    • (1994) Genes Dev. , vol.8 , pp. 1772-1786
    • Dynlacht, B.D.1    Flores, O.2    Lees, J.A.3    Harlow, E.4
  • 16
    • 0030990095 scopus 로고    scopus 로고
    • Specific regulation of E2F family members by cyclin-dependent kinases
    • Dynlacht, B. D., K. Moberg, J. A. Lees, E. Harlow, and L. Zhu. 1997. Specific Regulation of E2F family members by cyclin-dependent kinases. Mol. Cell. Biol. 17:3867-3875.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3867-3875
    • Dynlacht, B.D.1    Moberg, K.2    Lees, J.A.3    Harlow, E.4    Zhu, L.5
  • 17
    • 0026547060 scopus 로고
    • Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins
    • Ewen, M. E., B. Faha, E. Harlow, and D. M. Livingston. 1992. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science 255:85-87.
    • (1992) Science , vol.255 , pp. 85-87
    • Ewen, M.E.1    Faha, B.2    Harlow, E.3    Livingston, D.M.4
  • 18
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
    • Ewen, M. E., H. K. Sluss, C. J. Sherr, H. Matsushime, J.-Y. Kato, and D. M. Livingston. 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487-497.
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.-Y.5    Livingston, D.M.6
  • 20
    • 0027936238 scopus 로고
    • Phosphorylation of E2F1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19kD protein
    • Fagan, R., Flint, K. J., Jones, N. 1994. Phosphorylation of E2F1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19kD protein. Cell 78:799-811.
    • (1994) Cell , vol.78 , pp. 799-811
    • Fagan, R.1    Flint, K.J.2    Jones, N.3
  • 21
    • 0027110048 scopus 로고
    • Interaction between human cyclin A and adenovirus E1A-associated p107 protein
    • Faha, B., M. Ewen, L. Tsai, D. M. Livingston, and E. Harlow. 1992. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 255:87-90.
    • (1992) Science , vol.255 , pp. 87-90
    • Faha, B.1    Ewen, M.2    Tsai, L.3    Livingston, D.M.4    Harlow, E.5
  • 22
    • 0027212498 scopus 로고
    • Solubilisation and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins
    • Frangioni, J., and B. G. Neel. 1993. Solubilisation and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem. 210:179-187.
    • (1993) Anal. Biochem. , vol.210 , pp. 179-187
    • Frangioni, J.1    Neel, B.G.2
  • 24
    • 0027731971 scopus 로고
    • Inhibition of cdk2 activity in vivo by an associated 20K regulatory subunit
    • Gu, Y., C. W. Turek, and D. O. Morgan. 1993. Inhibition of cdk2 activity in vivo by an associated 20K regulatory subunit. Nature 366:707-710.
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turek, C.W.2    Morgan, D.O.3
  • 25
    • 0028582034 scopus 로고
    • Growth suppression by p18, a p16 INK4/MTS1 and p14 INK4B/MTS1-relaled CDK6 inhibitor, correlates with wild-type pRb function
    • Guan, K.-L., C. W. Jenkins, Y. Li, M. A. Nichols, X. Wu, C. L. O'Keefe, A. G. Matera, and Y. Xiong. 1994. Growth suppression by p18, a p16 INK4/MTS1 and p14 INK4B/MTS1-relaled CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8:2939-2952.
    • (1994) Genes Dev. , vol.8 , pp. 2939-2952
    • Guan, K.-L.1    Jenkins, C.W.2    Li, Y.3    Nichols, M.A.4    Wu, X.5    O'Keefe, C.L.6    Matera, A.G.7    Xiong, Y.8
  • 27
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin dependent kinases, and Ddk inhibitors in human cancer
    • Hall, M., and G. Peters. 1996. Genetic alterations of cyclins, cyclin dependent kinases, and Ddk inhibitors in human cancer. Adv. Cancer Res. 68: 67-108.
    • (1996) Adv. Cancer Res. , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 28
    • 0025223150 scopus 로고
    • Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions
    • Hamel, P. A., B. L. Cohen, L. M. Sorce, B. L. Gallie, and R. A. Phillips. 1990. Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions. Mol. Cell. Biol. 10:6586-6595.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6586-6595
    • Hamel, P.A.1    Cohen, B.L.2    Sorce, L.M.3    Gallie, B.L.4    Phillips, R.A.5
  • 29
    • 0026569054 scopus 로고
    • Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression
    • Hamel, P. A., R. M. Gill, R. A. Phillips, and B. L. Gallie. 1992. Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression. Oncogene 7:693-701.
    • (1992) Oncogene , vol.7 , pp. 693-701
    • Hamel, P.A.1    Gill, R.M.2    Phillips, R.A.3    Gallie, B.L.4
  • 30
    • 0027496935 scopus 로고
    • The p21 cdk-interacting protein CIP1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 cdk-interacting protein CIP1 is a potent inhibitor of G1 Cyclin-dependent kinases. Cell 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 31
    • 0028169237 scopus 로고
    • Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein
    • Hatakeyama, M., J. Brill, G. Fink, and R. Weinberg. 1994. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 8:1759-1771.
    • (1994) Genes Dev. , vol.8 , pp. 1759-1771
    • Hatakeyama, M.1    Brill, J.2    Fink, G.3    Weinberg, R.4
  • 33
    • 0027212380 scopus 로고
    • Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression
    • Hiebert, S. W. 1993. Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol. Cell. Biol. 13:3384-3391.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3384-3391
    • Hiebert, S.W.1
  • 34
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006.
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1    Mittnacht, S.2    Dulic, V.3    Arnold, A.4    Reed, S.I.5    Weinberg, R.A.6
  • 35
    • 0029001787 scopus 로고
    • A link between increased transforming activity of lymphoma derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-myc transactivation domain
    • Hoang, A., B. Lutterbach, B. C. Lewis, T. Yano, T. Y. Chou, J. F. Barrett, M. Raffeld, S. R. Hann, and C. V. Dang. 1995. A link between increased transforming activity of lymphoma derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-myc transactivation domain. Mol. Cell. Biol. 15:4031-4042.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4031-4042
    • Hoang, A.1    Lutterbach, B.2    Lewis, B.C.3    Yano, T.4    Chou, T.Y.5    Barrett, J.F.6    Raffeld, M.7    Hann, S.R.8    Dang, C.V.9
  • 36
    • 0029819179 scopus 로고    scopus 로고
    • A predictive scale for evaluating cyclin-dependent kinase substrates
    • Holmes, J. K., and M. J. Solomon. 1996. A predictive scale for evaluating cyclin-dependent kinase substrates. J. Biol. Chem. 41:25240-25246.
    • (1996) J. Biol. Chem. , vol.41 , pp. 25240-25246
    • Holmes, J.K.1    Solomon, M.J.2
  • 37
    • 0028935698 scopus 로고
    • G1 cyclins control the retinoblastoma gene product growth regulation activity via upstream mechanisms
    • Horton, L. E., Y. Qian, and D. J. Templeton. 1995. G1 cyclins control the retinoblastoma gene product growth regulation activity via upstream mechanisms. Cell Growth Differ. 6:395-407.
    • (1995) Cell Growth Differ. , vol.6 , pp. 395-407
    • Horton, L.E.1    Qian, Y.2    Templeton, D.J.3
  • 38
    • 0025773123 scopus 로고
    • Cyclins and cancer
    • Hunter, T., and J. Pines. 1991. Cyclins and cancer. Cell 66:1071-1074.
    • (1991) Cell , vol.66 , pp. 1071-1074
    • Hunter, T.1    Pines, J.2
  • 39
    • 0027938209 scopus 로고
    • Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
    • Hunter, T., and J. Pines. 1994. Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79:573-582.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 40
    • 15444353328 scopus 로고    scopus 로고
    • PRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
    • Hurford, R. K., D. Cobrinik, M.-H. Lee, and N. Dyson. 1997. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11:1447-1463.
    • (1997) Genes Dev. , vol.11 , pp. 1447-1463
    • Hurford, R.K.1    Cobrinik, D.2    Lee, M.-H.3    Dyson, N.4
  • 41
    • 1842289794 scopus 로고    scopus 로고
    • Recent insights into the functions of the retinoblastoma gene product
    • Kaelin, W. G. 1997. Recent insights into the functions of the retinoblastoma gene product. Cancer Investig. 15:243-254.
    • (1997) Cancer Investig. , vol.15 , pp. 243-254
    • Kaelin, W.G.1
  • 42
    • 0030606319 scopus 로고    scopus 로고
    • C-jun can recruit JNK to phosphorylate dimerisation partners via specific docking interactions
    • Kallunki, T., T. Deng, M. Hibi, and M. Karin. 1996. c-jun can recruit JNK to phosphorylate dimerisation partners via specific docking interactions. Cell 87:929-39.
    • (1996) Cell , vol.87 , pp. 929-939
    • Kallunki, T.1    Deng, T.2    Hibi, M.3    Karin, M.4
  • 43
    • 0027288908 scopus 로고
    • Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase cdk4
    • Kato, J.-Y., H. Matsushime, S. W. Hiebert, M. E. Ewen, and C. J. Sherr. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase cdk4. Genes Dev. 7:331-342.
    • (1993) Genes Dev. , vol.7 , pp. 331-342
    • Kato, J.-Y.1    Matsushime, H.2    Hiebert, S.W.3    Ewen, M.E.4    Sherr, C.J.5
  • 44
    • 0025009110 scopus 로고
    • A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding
    • Kaye, F. J., R. A. Kratzke, J. L. Gerster, and J. M. Horowitz. 1990. A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc. Natl. Acad. Sci. USA 87: 6922-6926.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6922-6926
    • Kaye, F.J.1    Kratzke, R.A.2    Gerster, J.L.3    Horowitz, J.M.4
  • 45
    • 0032478177 scopus 로고    scopus 로고
    • Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein
    • Kelly, B., K. Wolfe, and J. Roberts. 1998. Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein. Proc. Natl. Acad. Sci. USA 95:2535-2540.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2535-2540
    • Kelly, B.1    Wolfe, K.2    Roberts, J.3
  • 47
    • 0032146267 scopus 로고    scopus 로고
    • Inhibition of DNA synthesis by RB: Effects on G1/S transition and S-phase progression
    • Knudsen, E. S., C. Buckmaster, T.-T. Chen, J. R. Feramisco, and J. Y. J. Wang. 1998. Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12:2278-2821.
    • (1998) Genes Dev. , vol.12 , pp. 2278-2821
    • Knudsen, E.S.1    Buckmaster, C.2    Chen, T.-T.3    Feramisco, J.R.4    Wang, J.Y.J.5
  • 48
    • 0029924241 scopus 로고    scopus 로고
    • Differential regulation of retinoblastoma function by specific cdk phosphorylation sites
    • Knudsen, E. S., and J. Y. Wang. 1996. Differential regulation of retinoblastoma function by specific cdk phosphorylation sites. J. Biol. Chem. 271: 8313-20.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8313-8320
    • Knudsen, E.S.1    Wang, J.Y.2
  • 49
    • 0030849455 scopus 로고    scopus 로고
    • Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation
    • Knudsen, E. S., and J. Y. J. Wang. 1997. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol. 17:5771-5783.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5771-5783
    • Knudsen, E.S.1    Wang, J.Y.J.2
  • 50
    • 0029052951 scopus 로고
    • Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
    • Koh, J., G. Enders, B. Dynlacht, and E. Harlow. 1995. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375:506-510.
    • (1995) Nature , vol.375 , pp. 506-510
    • Koh, J.1    Enders, G.2    Dynlacht, B.3    Harlow, E.4
  • 51
    • 0028362359 scopus 로고
    • Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
    • Krek, W., M. Ewen, S. Shirodkar, Z. Arany, W. G. Kaelin, and D. M. Livingston. 1994. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78:1-20.
    • (1994) Cell , vol.78 , pp. 1-20
    • Krek, W.1    Ewen, M.2    Shirodkar, S.3    Arany, Z.4    Kaelin, W.G.5    Livingston, D.M.6
  • 53
    • 0026701339 scopus 로고
    • Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner
    • Lees, E., B. Faha, V. Dulic, S. I. Reed, and E. Harlow. 1992. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 6:1874-1885.
    • (1992) Genes Dev. , vol.6 , pp. 1874-1885
    • Lees, E.1    Faha, B.2    Dulic, V.3    Reed, S.I.4    Harlow, E.5
  • 54
    • 0026039676 scopus 로고
    • The retinoblastoma protein is phosphorylated on multiple sites by human cdc2
    • Lees, J. A., K. J. Buchkovich, D. R. Marshak, C. W. Anderson, and E. Harlow. 1991. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J. 10:4279-4290.
    • (1991) EMBO J. , vol.10 , pp. 4279-4290
    • Lees, J.A.1    Buchkovich, K.J.2    Marshak, D.R.3    Anderson, C.W.4    Harlow, E.5
  • 55
    • 0031239985 scopus 로고    scopus 로고
    • S-phase entry upon ectopic production of G1 cyclin-dependent kinases in the absence of retinoblastoma phosphorylation
    • Leng, X., L. Connell-Crowley, D. Goodrich, and J. W. Harper. 1997. S-phase entry upon ectopic production of G1 cyclin-dependent kinases in the absence of retinoblastoma phosphorylation. Curr. Biol. 7:709-712.
    • (1997) Curr. Biol. , vol.7 , pp. 709-712
    • Leng, X.1    Connell-Crowley, L.2    Goodrich, D.3    Harper, J.W.4
  • 56
    • 0030995824 scopus 로고    scopus 로고
    • Myc and ras collaborate in inducing accumulation of active cyclin E/cdk2 and E2F
    • Leone, G., J. DeGregori, R. Sears, L. Jakoi, and J. R. Nevins. 1997. Myc and Ras collaborate in inducing accumulation of active cyclin E/cdk2 and E2F. Nature 387:422-426.
    • (1997) Nature , vol.387 , pp. 422-426
    • Leone, G.1    DeGregori, J.2    Sears, R.3    Jakoi, L.4    Nevins, J.R.5
  • 57
    • 0027135209 scopus 로고
    • The adenovirus E1A-associated 130-kd protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E
    • Li, Y., C. Graham, S. Lacy, A. M. V. Duncan, and P. Whyte. 1993. The adenovirus E1A-associated 130-kd protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev. 7:2366-2377.
    • (1993) Genes Dev. , vol.7 , pp. 2366-2377
    • Li, Y.1    Graham, C.2    Lacy, S.3    Duncan, A.M.V.4    Whyte, P.5
  • 58
    • 0026034418 scopus 로고
    • Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase
    • Lin, B. T.-Y., S. Gruenwald, A. O. Moria, W.-H. Lee, and J. Y. J. Wang. 1991. Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J. 10:857-864.
    • (1991) EMBO J. , vol.10 , pp. 857-864
    • Lin, B.T.-Y.1    Gruenwald, S.2    Moria, A.O.3    Lee, W.-H.4    Wang, J.Y.J.5
  • 59
    • 0032518828 scopus 로고    scopus 로고
    • Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): Evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway
    • Lisztwan, J., A. Marti, H. Sutterluty, M. Gstaiger, C. Wirbelauer, and W. Krek. 1998. Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO 17:368-383.
    • (1998) EMBO , vol.17 , pp. 368-383
    • Lisztwan, J.1    Marti, A.2    Sutterluty, H.3    Gstaiger, M.4    Wirbelauer, C.5    Krek, W.6
  • 62
    • 0028925360 scopus 로고
    • Cyclin D1 is dispensable for G1 control in retinoblastoma gene deficient cells independently of cdk4 activity
    • Lukas, J. B., J. Rohde, M. Strauss, and J. Bartek. 1995. Cyclin D1 is dispensable for G1 control in retinoblastoma gene deficient cells independently of cdk4 activity. Mol. Cell. Biol. 15:2600-2611.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2600-2611
    • Lukas, J.B.1    Rohde, J.2    Strauss, M.3    Bartek, J.4
  • 63
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg, A., and R. Weinberg. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18:743-761.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 743-761
    • Lundberg, A.1    Weinberg, R.2
  • 64
    • 0026014956 scopus 로고
    • The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence
    • Marsilio, E., S. H. Cheng, B. Schaffhausen, E. Paucha, and D. M. Livingston. 1991. The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence. J. Virol. 65:5647-5652.
    • (1991) J. Virol. , vol.65 , pp. 5647-5652
    • Marsilio, E.1    Cheng, S.H.2    Schaffhausen, B.3    Paucha, E.4    Livingston, D.M.5
  • 66
    • 0031935648 scopus 로고    scopus 로고
    • Control of pRb phosphorylation
    • Mittnacht, S. 1998. Control of pRB phosphorylation. Curr. Opin. Genet. Dev. 8:21-27.
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 21-27
    • Mittnacht, S.1
  • 67
    • 0025193506 scopus 로고
    • Substrates for p34cdc2: In vivo veritas
    • Moreno, S., and P. Nurse. 1990. Substrates for p34cdc2: in vivo veritas. Cell 61:549-551.
    • (1990) Cell , vol.61 , pp. 549-551
    • Moreno, S.1    Nurse, P.2
  • 69
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 70
    • 0026207389 scopus 로고
    • The substrates of the cdc2 kinase
    • Nigg, E. 1991. The substrates of the cdc2 kinase. Semin. Cell. Biol. 2:261-270.
    • (1991) Semin. Cell. Biol. , vol.2 , pp. 261-270
    • Nigg, E.1
  • 71
    • 0026693966 scopus 로고
    • Animal cell cycles and their control
    • Norbury, C., and P. Nurse. 1992. Animal cell cycles and their control. Annu. Rev. Biochem. 61:441-470.
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 441-470
    • Norbury, C.1    Nurse, P.2
  • 72
    • 0029583648 scopus 로고
    • Regulation of the cyclin E gene by transcription factor E2F1
    • Ohtani, K., J. DeGregori, and J. R. Nevins. 1995. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA 92:12146-12150.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12146-12150
    • Ohtani, K.1    Degregori, J.2    Nevins, J.R.3
  • 74
    • 0031844197 scopus 로고    scopus 로고
    • Defining the minimal portion of the retinoblastoma protein that serves as an efficient substrate for cdk4 kinase/cyclin D1 complex
    • Pan, W., T. Sun, R. Hoess, and R. Grafstrom. 1998. Defining the minimal portion of the retinoblastoma protein that serves as an efficient substrate for cdk4 kinase/cyclin D1 complex. Carcinogenesis 19:765-769.
    • (1998) Carcinogenesis , vol.19 , pp. 765-769
    • Pan, W.1    Sun, T.2    Hoess, R.3    Grafstrom, R.4
  • 75
    • 0028801689 scopus 로고
    • Phosphorylation of a specific site in E2F1 affects its electrophoretic mobility and promotes pRB binding in vitro
    • Peeper, D. S., P. Keblusek, K. Helin, M. Toebes, A. J. van der Eb, and A. Zantema. 1995. Phosphorylation of a specific site in E2F1 affects its electrophoretic mobility and promotes pRB binding in vitro. Oncogene 10:39-48.
    • (1995) Oncogene , vol.10 , pp. 39-48
    • Peeper, D.S.1    Keblusek, P.2    Helin, K.3    Toebes, M.4    Van Der Eb, A.J.5    Zantema, A.6
  • 77
    • 0028176483 scopus 로고
    • Cloning of p27kip1, a cyclin dependent kinase inhibitor and a potential mediator of extracellular mitogenic signals
    • Polyak, K., M. Lee, H. Erdjument-Bromage, A. Koff, J. Roberts, P. Tempst, and J. Massague. 1994. Cloning of p27kip1, a cyclin dependent kinase inhibitor and a potential mediator of extracellular mitogenic signals. Cell 78:59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.5    Tempst, P.6    Massague, J.7
  • 78
    • 0026648086 scopus 로고
    • Identification of a growth suppression domain within the retinoblastoma gene product
    • Qin, X.-Q., T. Chittenden, D. M. Livingston, and W. G. Kaelin. 1992. Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 6:953-964.
    • (1992) Genes Dev. , vol.6 , pp. 953-964
    • Qin, X.-Q.1    Chittenden, T.2    Livingston, D.M.3    Kaelin, W.G.4
  • 79
    • 0029665852 scopus 로고    scopus 로고
    • Crystal structure of the p27kip1 cyclin dependent kinase inhibitor bound to the cyclin A-cdk2 complex
    • Russo, A. A., P. D. Jeffrey, A. K. Patten, J. Massague, and N. P. Pavletich. 1996. Crystal structure of the p27kip1 cyclin dependent kinase inhibitor bound to the cyclin A-cdk2 complex. Nature 382:325-331.
    • (1996) Nature , vol.382 , pp. 325-331
    • Russo, A.A.1    Jeffrey, P.D.2    Patten, A.K.3    Massague, J.4    Pavletich, N.P.5
  • 80
    • 0032167631 scopus 로고    scopus 로고
    • Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
    • Schulman, B., D. Lindstrom, and E. Harlow. 1998. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc. Natl. Acad. Sci. USA 95:10453-10458.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10453-10458
    • Schulman, B.1    Lindstrom, D.2    Harlow, E.3
  • 81
    • 0031930466 scopus 로고    scopus 로고
    • Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
    • Sellers, W. R., B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. Lassar, and W. G. Kaelin. 1998. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 12:95-106.
    • (1998) Genes Dev. , vol.12 , pp. 95-106
    • Sellers, W.R.1    Novitch, B.G.2    Miyake, S.3    Heith, A.4    Otterson, G.A.5    Kaye, F.J.6    Lassar, A.7    Kaelin, W.G.8
  • 82
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr, C. 1993. Mammalian G1 cyclins. Cell 73:1059-1065.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.1
  • 84
    • 0030988293 scopus 로고    scopus 로고
    • Deregulated expression of E2F1 induces cyclin A- and E-associated kinase activities independently from cell cycle position
    • Soucek, T., O. Pusch, E. Hengstschlager-Ottnad, P. D. Adams, and M. Hengstschlager. 1997. Deregulated Expression of E2F1 induces cyclin A- and E-associated kinase activities independently from cell cycle position. Oncogene 14:2251-2257.
    • (1997) Oncogene , vol.14 , pp. 2251-2257
    • Soucek, T.1    Pusch, O.2    Hengstschlager-Ottnad, E.3    Adams, P.D.4    Hengstschlager, M.5
  • 86
    • 85038201185 scopus 로고    scopus 로고
    • Unpublished data
    • Taya, Y. Unpublished data.
    • Taya, Y.1
  • 87
    • 0026329868 scopus 로고
    • Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering
    • Templeton, D. J., S. H. Park, L. Lanier, and R. Weinberg. 1991. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sci. USA 88:3033-3037.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3033-3037
    • Templeton, D.J.1    Park, S.H.2    Lanier, L.3    Weinberg, R.4
  • 88
    • 0028363519 scopus 로고
    • P27, a novel inhibitor of G1 cyclin/cdk protein kinase activity is related to p21
    • Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin/cdk protein kinase activity is related to p21. Cell 78:67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 89
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel, S., and E. Harlow. 1993. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262:2050-2053.
    • (1993) Science , vol.262 , pp. 2050-2053
    • Van Den Heuvel, S.1    Harlow, E.2
  • 90
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 91
    • 0026610958 scopus 로고
    • Co-purification of p34 cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: Interaction of an oncogenic serinethreonine protein kinase with a tumor-suppressor protein
    • Williams, R. T., D. A. Carbonaro-Hall, and F. L. Hall. 1992. Co-purification of p34 cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serinethreonine protein kinase with a tumor-suppressor protein. Oncogene 7:423-432.
    • (1992) Oncogene , vol.7 , pp. 423-432
    • Williams, R.T.1    Carbonaro-Hall, D.A.2    Hall, F.L.3
  • 92
    • 0347262257 scopus 로고
    • Identical short peptide sequences in unrelated proteins can have different confirmations: A testing ground for theories of immune recognition
    • Wilson, I. A., D. H. Haft, E. D. Getzoff, J. A. Tainer, R. A. Lerner, and S. Brenner. 1985. Identical short peptide sequences in unrelated proteins can have different confirmations: a testing ground for theories of immune recognition. Proc. Natl. Acad. Sci. USA 82:5255-5259.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 5255-5259
    • Wilson, I.A.1    Haft, D.H.2    Getzoff, E.D.3    Tainer, J.A.4    Lerner, R.A.5    Brenner, S.6
  • 93
    • 0027301324 scopus 로고
    • Subunit rearrangement of the cyclin dependent kinases is associated with cellular transformation
    • Xiong, Y., H. Zhang, and D. Beach. 1993. Subunit rearrangement of the cyclin dependent kinases is associated with cellular transformation. Genes Dev. 7:1572-1583.
    • (1993) Genes Dev. , vol.7 , pp. 1572-1583
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 95
    • 0028019279 scopus 로고
    • Cyclin A/cdk2 binds directly to E2F1 and inhibits the DNA-binding activity of E2F1/DP1 by phosphorylation
    • Xu, M., K. A. Sheppard, C.-Y. Peng, A. S. Yee, and H. Piwnica-Worms. 1994. Cyclin A/cdk2 binds directly to E2F1 and inhibits the DNA-binding activity of E2F1/DP1 by phosphorylation. Mol. Cell. Biol. 14:8420-8431.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8420-8431
    • Xu, M.1    Sheppard, K.A.2    Peng, C.-Y.3    Yee, A.S.4    Piwnica-Worms, H.5
  • 96
    • 0030918714 scopus 로고    scopus 로고
    • Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
    • Zarkowska, T., and S. Mittnacht. 1997. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272:12738-12746.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12738-12746
    • Zarkowska, T.1    Mittnacht, S.2
  • 97
    • 0028169236 scopus 로고
    • P21-containing cyclin kinases exist in both active and inactive states
    • Zhang, H., G. J. Hannon, and D. Beach. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750-1758.
    • (1994) Genes Dev. , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 98
    • 0028021003 scopus 로고
    • Substrate specificity of cdc2 kinase from human HeLa cells as determined with synthetic peptides and molecular modelling
    • Zhang, J., R. J. Sanchez, S. Wang, C. Guarnaccia, A. Tossi, S. Zahariev, and S. Pongor. 1994. Substrate specificity of cdc2 kinase from human HeLa cells as determined with synthetic peptides and molecular modelling. Arch. Biochem. Biophys. 315:415-424.
    • (1994) Arch. Biochem. Biophys. , vol.315 , pp. 415-424
    • Zhang, J.1    Sanchez, R.J.2    Wang, S.3    Guarnaccia, C.4    Tossi, A.5    Zahariev, S.6    Pongor, S.7
  • 99
    • 0029860520 scopus 로고    scopus 로고
    • Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases
    • Zhao, Y., C. Bjorbaek, and D. E. Moller. 1996. Regulation and Interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. J. Biol. Chem. 271:29773-29779.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29773-29779
    • Zhao, Y.1    Bjorbaek, C.2    Moller, D.E.3
  • 100
    • 0028983384 scopus 로고
    • P107 uses a p21/CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
    • Zhu, L., E. Harlow, and B. D. Dynlacht. 1995. p107 uses a p21/CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9:1740-1752.
    • (1995) Genes Dev. , vol.9 , pp. 1740-1752
    • Zhu, L.1    Harlow, E.2    Dynlacht, B.D.3


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