메뉴 건너뛰기




Volumn 11, Issue 14, 1997, Pages 1853-1863

Induction of DNA synthesis and apoptosis are separable functions of E2F- 1

Author keywords

Apoptosis; Cell cycle; E2F; p53

Indexed keywords

TRANSCRIPTION FACTOR E2F;

EID: 0030739355     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.14.1853     Document Type: Article
Times cited : (242)

References (49)
  • 2
    • 0029050533 scopus 로고
    • Deficiency of retinohlastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    • Almasan, A., Y. Yin, R.E. Kelly, E.Y.-H.P. Lee, A. Bradley, W. Li, J.R. Bertino, and G.M. Wahl. 1995. Deficiency of retinohlastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. 92: 5436-5440.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.-H.P.4    Bradley, A.5    Li, W.6    Bertino, J.R.7    Wahl, G.M.8
  • 4
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • Chen, X., L.J. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes & Dev. 10:2438-2451.
    • (1996) Genes & Dev. , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 5
    • 0028347587 scopus 로고
    • Modulation of transcriptional regulatory properties of p53 by HPV E6
    • Crook, T., C. Fisher, P.J. Masterson, and K.H. Vousden. 1994a. Modulation of transcriptional regulatory properties of p53 by HPV E6. Oncogene 9: 1225-1230.
    • (1994) Oncogene , vol.9 , pp. 1225-1230
    • Crook, T.1    Fisher, C.2    Masterson, P.J.3    Vousden, K.H.4
  • 6
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • Crook, T., N.J. Marston, E.A. Sara, and K.H. Vousden. 1994b. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79: 817-827.
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 9
    • 0028263811 scopus 로고
    • c-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
    • Harrington, E.A., M.R. Bennett, A. Fanidi, and G.I. Evan. 1994. c-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13: 3286-3295.
    • (1994) EMBO J. , vol.13 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fanidi, A.3    Evan, G.I.4
  • 10
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L.H. and M.B. Kastan. 1994. Cell cycle control and cancer. Science 266: 1821-1828.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 11
    • 0028338653 scopus 로고
    • Heterodimerization of the transcription factors E2F-1 and DP-I is required for binding to the adenovirus E4 (ORF6/7) protein
    • Helin, K. and E. Harlow. 1994. Heterodimerization of the transcription factors E2F-1 and DP-I is required for binding to the adenovirus E4 (ORF6/7) protein, J. Virol. 68: 5027-5035.
    • (1994) J. Virol. , vol.68 , pp. 5027-5035
    • Helin, K.1    Harlow, E.2
  • 12
    • 15644364779 scopus 로고
    • Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation
    • Helin, K., C. Wu, A. Fattaey, J. Lees, B. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation. Genes & Dev. 6: 177-185.
    • (1993) Genes & Dev. , vol.6 , pp. 177-185
    • Helin, K.1    Wu, C.2    Fattaey, A.3    Lees, J.4    Dynlacht, B.5    Ngwu, C.6    Harlow, E.7
  • 13
    • 0029820095 scopus 로고    scopus 로고
    • The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
    • Hoffmann, F., F. Martelli, D.M. Livingston, and Z. Wang. 1996. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes & Dev. 10: 2949-2959.
    • (1996) Genes & Dev. , vol.10 , pp. 2949-2959
    • Hoffmann, F.1    Martelli, F.2    Livingston, D.M.3    Wang, Z.4
  • 14
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D.G., J.K. Schwarz, J.D. Cress, and J.R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, J.D.3    Nevins, J.R.4
  • 15
    • 0028364529 scopus 로고
    • Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
    • Johnson, D.G., D. Ohtani, and J.R. Nevins. 1994. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes & Dev. 8: 1514-1525.
    • (1994) Genes & Dev. , vol.8 , pp. 1514-1525
    • Johnson, D.G.1    Ohtani, D.2    Nevins, J.R.3
  • 17
    • 0028960617 scopus 로고    scopus 로고
    • E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
    • Kowalik, T.F., J. Degregori, J.K. Schwarz, and J.R. Nevins. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69: 2491-2500.
    • J. Virol. , vol.69 , pp. 2491-2500
    • Kowalik, T.F.1    Degregori, J.2    Schwarz, J.K.3    Nevins, J.R.4
  • 18
    • 0028362359 scopus 로고
    • Negative regulation of the growthpromoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
    • Krek, W., M.E. Ewen, S. Shirodkar, Z. Arany, W.G. Kaelin, and D.M. Livingston. 1994. Negative regulation of the growthpromoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78: 161-172.
    • (1994) Cell , vol.78 , pp. 161-172
    • Krek, W.1    Ewen, M.E.2    Shirodkar, S.3    Arany, Z.4    Kaelin, W.G.5    Livingston, D.M.6
  • 19
    • 0029559027 scopus 로고
    • Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S-phase checkpoint
    • Krek, W., G. Xu, and D.M. Livingston. 1995. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S-phase checkpoint. Cell 83: 1149-1158.
    • (1995) Cell , vol.83 , pp. 1149-1158
    • Krek, W.1    Xu, G.2    Livingston, D.M.3
  • 20
    • 0027316813 scopus 로고
    • An E2F-binding site mediates cell-cycle regulation repression of mouse B-myb transcription
    • Lam, E.W.F. and R.J. Waston. 1993. An E2F-binding site mediates cell-cycle regulation repression of mouse B-myb transcription. EMBO J. 12: 2705-2713.
    • (1993) EMBO J. , vol.12 , pp. 2705-2713
    • Lam, E.W.F.1    Waston, R.J.2
  • 21
    • 0028040299 scopus 로고
    • HPV16 E7 oncoprotein deregulates b-myb expression - Correlation with targeting of p107/E2F complexes
    • Lam, E.W.F., J.D.H. Morris, R. Davies, T. Crook, R.J. Waston, and K.H. Vousden. 1994. HPV16 E7 oncoprotein deregulates b-myb expression - correlation with targeting of p107/E2F complexes. EMBO J. 13: 871-878.
    • (1994) EMBO J. , vol.13 , pp. 871-878
    • Lam, E.W.F.1    Morris, J.D.H.2    Davies, R.3    Crook, T.4    Waston, R.J.5    Vousden, K.H.6
  • 22
    • 0028267869 scopus 로고
    • DRTF1/E2F - An expanding family of heterodimeric transcription factors implicated in cell-cycle control
    • LaThangue, N.B. 1994. DRTF1/E2F - an expanding family of heterodimeric transcription factors implicated in cell-cycle control Trends Biochem. Sci. 19: 108-114.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 108-114
    • LaThangue, N.B.1
  • 24
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod, K.F., Y. Hu, and T. Jacks. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15: 6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 25
    • 0028109692 scopus 로고
    • Positive and negative regulation of cell proliferation by E2F-1: Influence of protein level and human papillomavirus oncoproteins
    • Melillo, R.M., K. Helin, D.R. Lowy, and J.T. Schiller. 1994. Positive and negative regulation of cell proliferation by E2F-1: Influence of protein level and human papillomavirus oncoproteins. Mol Cell. Biol. 14: 8241-8249.
    • (1994) Mol Cell. Biol. , vol.14 , pp. 8241-8249
    • Melillo, R.M.1    Helin, K.2    Lowy, D.R.3    Schiller, J.T.4
  • 26
    • 0027934570 scopus 로고
    • p53-dependent apoptisis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser, S.D., B.O. Williams, T. Jacks, and R.A. Depinho. 1994. p53-dependent apoptisis produced by Rb-deficiency in the developing mouse lens. Nature 371: 72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    Depinho, R.A.4
  • 27
    • 0028136903 scopus 로고
    • Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
    • Neuman, E., E.K. Flemington, W.R. Sellers, and W.G. Kaelin. 1994. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol Cell. Biol. 14:6607-6615.
    • (1994) Mol Cell. Biol. , vol.14 , pp. 6607-6615
    • Neuman, E.1    Flemington, E.K.2    Sellers, W.R.3    Kaelin, W.G.4
  • 28
    • 0029583648 scopus 로고
    • Regulation of the cyclin e gene by transcription factor E2F1
    • Ohtani, K., J. DeGregori, and J.R. Nevins. 1995. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. 92: 12146-12150.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 12146-12150
    • Ohtani, K.1    DeGregori, J.2    Nevins, J.R.3
  • 29
    • 0029840701 scopus 로고    scopus 로고
    • c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways
    • Packham, G., C. Porter, and J.L. Cleveland. 1996. c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways. Oncogene 13: 461-469.
    • (1996) Oncogene , vol.13 , pp. 461-469
    • Packham, G.1    Porter, C.2    Cleveland, J.L.3
  • 30
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • Pan, H.C. and A.E. Griep. 1994. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development. Genes & Dev. 8: 1285-1299.
    • (1994) Genes & Dev. , vol.8 , pp. 1285-1299
    • Pan, H.C.1    Griep, A.E.2
  • 31
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X.-Q., D.M. Livingston, W.G. Kaelin, and P.D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. 91: 10918-10922.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 10918-10922
    • Qin, X.-Q.1    Livingston, D.M.2    Kaelin, W.G.3    Adams, P.D.4
  • 33
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant
    • Rowan, S., R.L. Ludwig, Y. Haupt, S. Bates, X. Lu, M. Oren, and K.H. Vousden. 1996. Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant. EMBO J. 15: 827-838.
    • (1996) EMBO J. , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 34
    • 0029888119 scopus 로고    scopus 로고
    • Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis
    • Rudolph, B., R. Saffrich, J. Zwicker, B, Henglein, R. Müller, W. Ansorge, and M. Eilers. 1996. Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis, EMBO J. 15: 3065-3076.
    • (1996) EMBO J. , vol.15 , pp. 3065-3076
    • Rudolph, B.1    Saffrich, R.2    Zwicker, J.3    Henglein, B.4    Müller, R.5    Ansorge, W.6    Eilers, M.7
  • 36
    • 0029612231 scopus 로고
    • A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
    • Sellers, W.R., J.W. Rodgers, and W.G. Kaelin. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. 92: 11544-11548.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 11544-11548
    • Sellers, W.R.1    Rodgers, J.W.2    Kaelin, W.G.3
  • 37
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B. and W.H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell. Biol. 14:8166-8173.
    • (1994) Mol Cell. Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 38
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C.J. 1996. Cancer cell cycles. Science 274: 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 39
    • 0027403342 scopus 로고
    • A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the DHFR promoter. mol
    • Slansky, J.E., Y. Li, W.G. Kaelin, and P.J. Farnham. 1993. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the DHFR promoter. mol. Cell. Biol. 13: 1610-1618.
    • (1993) Cell. Biol. , vol.13 , pp. 1610-1618
    • Slansky, J.E.1    Li, Y.2    Kaelin, W.G.3    Farnham, P.J.4
  • 40
    • 0026769713 scopus 로고
    • An immunochemical analysis of the human nuclear phosphoprotein p53
    • Vojtesek, B., J. Bartek. C.A. Midgley, and D.P. Lane. 1992. An immunochemical analysis of the human nuclear phosphoprotein p53. J. Immunol. Methods 151: 237-244.
    • (1992) J. Immunol. Methods , vol.151 , pp. 237-244
    • Vojtesek, B.1    Bartek, J.2    Midgley, C.A.3    Lane, D.P.4
  • 41
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 42
    • 0026636908 scopus 로고
    • Retinoblastoma protein switches the E2F site from positive to negative element
    • Weintraub, S.J., C.A. Prater, and D.C. Dean. 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358: 259-261.
    • (1992) Nature , vol.358 , pp. 259-261
    • Weintraub, S.J.1    Prater, C.A.2    Dean, D.C.3
  • 43
    • 0029043782 scopus 로고
    • Mechanism of active transcriptional repression by the retinoblastoma protein
    • Weintraub, S.J., K.N.B. Chow, R.X. Luo, S.H. Zhang, S. He, and D.C. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
    • (1995) Nature , vol.375 , pp. 812-815
    • Weintraub, S.J.1    Chow, K.N.B.2    Luo, R.X.3    Zhang, S.H.4    He, S.5    Dean, D.C.6
  • 45
    • 0030008768 scopus 로고    scopus 로고
    • Expression of dominant-negative mutant DP-1 blocks cell cycle progression in Gl
    • Wu, C.-L., M. Classon, N. Dyson, and E. Harlow. 1996. Expression of dominant-negative mutant DP-1 blocks cell cycle progression in Gl. Mol. Cell Biol 16:3698-3706.
    • (1996) Mol. Cell Biol , vol.16 , pp. 3698-3706
    • Wu, C.-L.1    Classon, M.2    Dyson, N.3    Harlow, E.4
  • 46
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X.W. and A.J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. 91: 3602-3606.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 3602-3606
    • Wu, X.W.1    Levine, A.J.2
  • 48
    • 0026645529 scopus 로고
    • Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor
    • Zamanian, M. and N.B. La Thangue. 1992. Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor. EMBO J. 11: 2603-2610.
    • (1992) EMBO J. , vol.11 , pp. 2603-2610
    • Zamanian, M.1    La Thangue, N.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.