Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 6, 2003, Pages 1005-1009

  Vullo, Daniela ^a   Franchi, Marco ^a   Gallori, Enzo ^a   Pastorek, Jaromir ^b   Scozzafava, Andrea ^a   Pastorekova, Silvia ^b   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHALENESULFONAMIDE; 1,3 BENZENEDISULFONAMIDE; 1,3,4 THIADIZOLE 2 SULFONAMIDE; ACETAZOLAMIDE; ANTINEOPLASTIC AGENT; AROMATIC AMIDE; BRINZOLAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; CARBONIC ANHYDRATE IX; CARZENIDE; DICLOFENAMIDE; DORZOLAMIDE; ETHOXZOLAMIDE; HETEROCYCLIC AMINE; HOMOSULFONILAMIDE; METHAZOLAMIDE; ORTHANILAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION;

EID: 0037463790     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00091-X     Document Type: Article

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41. 25.
42. 2 solutions in water at 20°C were used as substrate. Stock solutions of inhibitors were prepared at a concentration of 1-3 mM (in DMSO-water 1:1, v/v) and dilutions up to 0.1 nM done with the assay buffer mentioned above.
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