Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Nature

Volumn 417, Issue 6892, 2002, Pages 975-978

  Hon, Wal Ching ^a   Wilson, Michael I ^a,c   Harlos, Karl ^a   Claridge, Timothy D W ^b   Schofield, Christopher J ^b   Pugh, Christopher W ^a   Maxwell, Patrick H ^a   Ratcliffe, Peter J ^a   Stuart, David I ^a   Jones, E Yvonne ^a  

^a Henry Wellcome Bldg of Genomic Med   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; GENES; HYDROGEN BONDS; HYDROXYLATION; OXYGEN; PROTEINS;

STRUCTURAL BASIS;

AMINO ACIDS;

ELONGATION FACTOR; HYDROXYPROLINE; HYPOXIA INDUCIBLE FACTOR 1; PROTEASOME;

CRYSTAL STRUCTURE; GENE; PEPTIDE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME PHOSPHORYLATION; HYDROXYLATION; MOLECULAR RECOGNITION; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANOXIA; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; HYDROXYLATION; HYDROXYPROLINE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KINETICS; LIGASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 18444368709     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00767     Document Type: Article

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