Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II

Journal of Medicinal Chemistry

Volumn 48, Issue 18, 2005, Pages 5721-5727

  Menchise, Valeria ^a,b   De Simone, Giuseppina ^a   Alterio, Vincenzo ^a   Di Fiore, Anna ^a   Pedone, Carlo ^a,c   Scozzafava, Andrea ^d   Supuran, Claudiu T ^d  

^a CNR   (Italy)

^b Bioindustry Park del Canavese   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 N (4 SULFAMOYLPHENYLETHYL) 2,4,6 TRIMETHYLPYRIDINIUM PERCHLORATE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; GLUTAMINE; ISOENZYME; LEUCINE; PHENYLALANINE; SULFONAMIDE; THREONINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG STRUCTURE; HYDROPHILICITY; HYDROPHOBICITY; PROTEIN EXPRESSION; PROTEIN TARGETING; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BINDING SITES; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASES; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIDINIUM COMPOUNDS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS; SULFONAMIDES; TUMOR MARKERS, BIOLOGICAL;

EID: 24744467784     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050333c     Document Type: Article

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