Carbonic anhydrase activators: Design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 504-510

  Ilies, Monica ^a   Banciu, Mircea D ^b   Ilies, Marc A ^a   Scozzafava, Andrea ^c   Caproiu, Miron T ^d   Supuran, Claudiu T ^c  

^a UNIVERSITY OF AGRONOMIC SCIENCES AND VETERINARY MEDICINE OF BUCHAREST   (Romania)

^b UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

^c UNIVERSITY OF FLORENCE   (Italy)

^d INSTITUTE OF ORGANIC CHEMISTRY   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE INHIBITOR; ISOENZYME; PYRIDINIUM DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; DERIVATIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; MEMBRANE BINDING; MEMBRANE PERMEABILITY; RECEPTOR AFFINITY; SYNAPTIC TRANSMISSION; X RAY CRYSTALLOGRAPHY;

ANIMALS; AZOLES; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE IV; CATTLE; ENZYME ACTIVATORS; ERYTHROCYTES; HUMANS; IMIDAZOLES; KINETICS; PHENYLACETATES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0037122755     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011031n     Document Type: Article

References (41)

1. Activation of carbonic anhydrase isozymes
2. Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine
3. A ternary complex of carbonic anhydrase: X-ray crystallographic structure of the adduct of human carbonic anhydrase II with the activator phenylalanine and the inhibitor azide
4. Carbonic anhydrase inhibitors
5. Carbonic anhydrase inhibitors and their therapeutic potential
6. Pharmacological enhancement of synaptic efficacy, spatial learning and memory through carbonic anhydrase activation in rats
7. Neurochemical enzyme changes in Alzheimer's and Pick's disease
8. Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties
9. Carbonic anhydrase activators. Amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators
10. Carbonic anhydrase activators. Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4-chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole
11. Carbonic anhydrase activators. Synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(4-tosylureido-amino acyl)ethyl-1H-imidazole (histamine derivatives)
12. Carbonic anhydrase activators. Part 21. Novel activators of isozymes I, II and IV incorporating carboxamido- and ureido histamine moieties
13. Carbonic anhydrase activators. Synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole
14. Carbonic anhydrase activators: High affinity isozymes I, II and IV activators, incorporating a beta-alanyl-histidine scaffold
15. Carbonic anhydrase activators. VII. Isozyme II activation by bis-azolylmethanes, -ethanes and related azoles
16. Carbonic anhydrase activators. XV. A kinetic study of the interaction of bovine isozyme with pyrazoles, bis- and tris-azolyl methanes
17. Carbonic anhydrase activators. Part 3. Structure-activity correlations for a series of isozyme II activators
18. Carbonic anhydrase activators. Part 14. Synthesis of mono and bis pyridinium salt derivatives of 2-amino-5-(2-aminoethyl)- and 2-amino-5-(3-aminopropyl)-1,3,4-thiadiazole and their interaction with isozyme II
19. Carbonic anhydrase activators. Part 17. Synthesis and activation studies of a series of 1-(1,2,4-triazole-1H-3-yl)-2,4,6-trisubstituted-pyridinium salts against isozymes I, II and IV
20. a-activation relationship for amino acid derivatives, activators of isozyme II
21. Pyrylium salts: Syntheses, reactions and physical properties
22. Reaction of pyrylium salts with nucleophiles. XIV. New pyridinium salts with potential biological activity
23. Reaction of pyrylium salts with amino acid derivatives. Part 3. Ribonuclease A inactivation by trisubstituted pyrylium salts
24. Carbonic anhydrase inhibitors. Part 5. Pyrylium salts in the synthesis of isozymespecific inhibitors
25. Reaction of pyrylium salts with nucleophiles. IV. Isolation of an intermediate in the conversion of 2,4,6-triphenylpyrylium perchlorate into 2,4,6-triphenylpyridine by amonia
26. Kinetics and mechanism of the reactions of primary amines with pyrylium cations
27. The preparation of pyridinium from pyryliums
28. Carbonic anhydrase inhibitors. Part 53. Synthesis of substituted-pyridinium derivatives of aromatic sulfonamides: The first non polymeric membrane-impermeable inhibitors with selectivity for isozyme IV
29. Carbonic anhydrase inhibitors. Synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus the cytosolic isozymes
30. Design of carbonic anhydrase inhibitors and the relationship between the pharmacodynamics and pharmacokinetics of acetazolamide
31. The catalytic versatility of erythrocyte carbonic anhydrase. III. Kinetic studies of the enzyme-catalyzed hydrolysis of p-nitrophenyl acetate
32. Carbonic anhydrase II deficiency syndrome: Clinical delineation, interpretation and implications
33. Human carbonic anhydrases and carbonic anhydrase deficiencies
34. Fine-tuning of the catalytic properties of carbonic anhydrase. Studies of a Thr200-His variant of human isoenzyme II
35. Structure-function relations in human carbonic anhydrase II as studied by site-directed mutagenesis
36. Carbon-13 nuclear magnetic resonance probe of active site ionization of human carbonic anhydrase B
37. The catalytic mechanism of carbonic anhydrase. Hydrogen-isotope effects on the kinetic parameters of the human C isoenzyme
38. Chemical properties of carbonic anhydrase IV, the membrane-bound enzyme
39. Catalysis and inhibition of human carbonic anhydrase IV