Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: Engineering proton-transfer processes within the active site of an enzyme

Chemistry - A European Journal

Volumn 12, Issue 27, 2006, Pages 7057-7066

  Temperini, Claudia ^a   Scozzafava, Andrea ^a   Vullo, Daniela ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase; D histidine; Enzyme catalysis; Kinetics; L histidine; Proton transfer

Indexed keywords

CARBONIC ANHYDRASE ACTIVATORS; D HISTIDINE; ENZYME CATALYSIS; ISOFORM II; L HISTIDINE; PROTON TRANSFER;

AMINO ACIDS; CATALYSIS; DISEASES; ENZYME KINETICS; HYDROGEN BONDS; REACTION KINETICS; X RAY CRYSTALLOGRAPHY;

CHEMICAL ACTIVATION;

CARBONATE DEHYDRATASE; ENZYME ACTIVATOR; HISTIDINE; ISOENZYME;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; KINETICS; METABOLISM; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARBONIC ANHYDRASES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATORS; HISTIDINE; HUMANS; ISOENZYMES; KINETICS; MODELS, MOLECULAR; STEREOISOMERISM;

EID: 33749039202     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200600159     Document Type: Article

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