Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and X-ray crystallographic studies

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2315-2320

  De Simone, Giuseppina ^a   Di Fiore, Anna ^a   Menchise, Valeria ^a   Pedone, Carlo ^a   Antel, Jochen ^b   Casini, Angela ^c   Scozzafava, Andrea ^c   Wurl, Michael ^b   Supuran, Claudiu T ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Solvay Pharmaceuticals GmbH   (Germany)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE V; ETHOXZOLAMIDE; GLUTAMIC ACID; METHAZOLAMIDE; MITOCHONDRIAL ENZYME; SULFONAMIDE; THREONINE; TOPIRAMATE; ZINC ION; ZONISAMIDE;

ARTICLE; CRYSTAL STRUCTURE; CYTOSOL; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; INCUBATION TIME; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 17144375722     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.032     Document Type: Article

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