Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5152-5156

  Temperini, Claudia ^a   Scozzafava, Andrea ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Activator; Amino acid; Carbonic anhydrase; Enzyme mechanism; l Histidine; X ray crystallography

Indexed keywords

CARBONIC ANHYDRASE ACTIVATOR; CARBOXYLIC ACID; ENZYME ACTIVATOR; HISTIDINE; HYDROGEN; IMIDAZOLE; THREONINE; UNCLASSIFIED DRUG; WATER; ZINC;

ARTICLE; ENZYME ACTIVE SITE; ENZYME BINDING; HYDROGEN BOND; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; BINDING SITES; CARBONIC ANHYDRASE I; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HISTIDINE; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747520016     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.021     Document Type: Article

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