Targeting tumors through the HIF system

Nature Medicine

Volumn 6, Issue 12, 2000, Pages 1315-1316

  Ratcliffe, Peter J ^a   Pugh, Christopher W ^a   Maxwell, Patrick H ^a  

^a The Henry Wellcome Building of Genomic Medicine ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HEMOPOIETIC GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1;

ANIMAL CELL; APOPTOSIS; CANCER CELL; CELL PROLIFERATION; CHEMOTHERAPY; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SHORT SURVEY; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; CELL HYPOXIA; DNA-BINDING PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MODELS, GENETIC; NUCLEAR PROTEINS; RESPONSE ELEMENTS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0034533143     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/82113     Document Type: Article

References (13)

1. Suppression of tumor growth through disruption of hypoxia-inducible transcription
2. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
3. Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: Evidence for a widespread oxygen sensing mechanism
4. HIF-1 and human disease: One highly involved factor
5. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
6. HIF-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
7. HIF-1α is required for solid tumor formation and embryonic vascularization
8. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
9. Mammalian oxygen sensing, signalling and gene regulation
10. Functional role of p35srj, a novel p300/CBP-binding protein, during transactivation by HIF-1
11. Overexpression of HIF-1α in common human cancers and their metastases
12. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
13. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis