Carbonic anhydrase activators, activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: Stereospecific recognition within the active site of an enzyme and its consequences for the drug design

Journal of Medicinal Chemistry

Volumn 49, Issue 10, 2006, Pages 3019-3027

  Temperini, Claudia ^a   Scozzafava, Andrea ^a   Vullo, Daniela ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; PHENYLALANINE;

ARTICLE; DRUG DESIGN; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; HYDROPHOBICITY; LEARNING; MOLECULAR RECOGNITION; MULTIGENE FAMILY; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTON TRANSPORT; STEREOSPECIFICITY; STRUCTURE ANALYSIS; SYNAPTIC TRANSMISSION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BRAIN CHEMISTRY; CARBONIC ANHYDRASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME ACTIVATORS; HUMANS; ISOENZYMES; KINETICS; MODELS, MOLECULAR; PHENYLALANINE; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 33646751543     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0603320     Document Type: Article

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