Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX

Journal of Medicinal Chemistry

Volumn 49, Issue 9, 2006, Pages 2743-2749

  Thiry, Anne ^a   Ledecq, Marie ^a   Cecchi, Alessandro ^b   Dogné, Jean Michel ^a   Wouters, Johan ^a   Supuran, Claudiu T ^b   Masereel, Bernard ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 PENTAFLUOROPHENYLAMIDO 5 SULFONAMIDOINDANE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX INHIBITOR; INDANESULFONAMIDE DERIVATIVE; ISOENZYME; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ARTICLE; CALCIFICATION; CANCER DIAGNOSIS; CANCER INHIBITION; CELL RESPIRATION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; MOLECULAR MODEL; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DRUG DESIGN; HUMANS; ISOENZYMES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33646446585     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0600287     Document Type: Article

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