Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides - A new zinc-binding function in the design of inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2353-2358

  Winum, Jean Yves ^a,b   Innocenti, Alessio ^a   Nasr, Jihane ^b   Montero, Jean Louis ^b   Scozzafava, Andrea ^a   Vullo, Daniela ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; ISOENZYME; MEMBRANE PROTEIN; N HYDROXYSULFAMIDE; SULFAMIC ACID; SULFAMIDE DERIVATIVE; SULFANILAMIDE; SULFONAMIDE; SULFUR DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; X RAY CRYSTALLOGRAPHY;

EID: 17244376080     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.091     Document Type: Article

References (30)

1. S. Pastorekova, S. Parkkila, J. Pastorek, and C.T. Supuran J. Enzyme Inhib. Med. Chem. 19 2004 199 229
2. C.T. Supuran, A. Scozzafava, and A. Casini Med. Res. Rev. 23 2003 146 189
3. A. Scozzafava, T. Owa, A. Mastrolorenzo, and C.T. Supuran Curr. Med. Chem. 10 2003 925 953
4. A. Casini, J.Y. Winum, J.L. Montero, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett. 13 2003 837 840
5. C.T. Supuran, and A. Scozzafava Eur. J. Med. Chem. 35 2000 867 874
6. C.T. Supuran, and A. Scozzafava J. Enzyme Inhib. 15 2000 597 610
7. E. Svastova, A. Hulikova, M. Rafajova, M. Zat'ovicova, A. Gibadulinova, A. Casini, A. Cecchi, A. Scozzafava, C.T. Supuran, J. Pastorek, and S. Pastorekova FEBS Lett. 577 2004 439 445
8. F. Mincione, L. Menabuoni, F. Briganti, G. Mincione, A. Scozzafava, and C.T. Supuran J. Enzyme Inhib. 13 1998 267 284
9. I. Fenesan, R. Popescu, A. Scozzafava, V. Crucin, E. Mateiciuc, R. Bauer, M.A. Ilies, and C.T. Supuran J. Enzyme Inhib. 15 2000 297 310
10. I. Fenesan, R. Popescu, C.T. Supuran, S. Nicoara, M. Culea, N. Palibroda, Z. Moldovan, and O. Cozar Rapid Commun. Mass Spectrom. 15 2001 721 729
11. L. Bonnac, A. Innocenti, J.Y. Winum, A. Casini, J.L. Montero, A. Scozzafava, V. Barragan, and C.T. Supuran J. Enzyme Inhib. Med. Chem. 19 2004 275 278
12. F. Abbate, C.T. Supuran, A. Scozzafava, P. Orioli, M.T. Stubbs, and G. Klebe J. Med. Chem. 45 2002 3583 3587
13. F. Briganti, S. Mangani, A. Scozzafava, G. Vernaglione, and C.T. Supuran J. Biol. Inorg. Chem. 4 1999 528 536
14. A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. 11 2003 2241 2246
15. Maryanoff, B. E.; McComsey, D. F.; Costanzo, M. J.; Hochman, C.; Smith-Swintowsky, V.; Shank, R. P. J. Med. Chem. 2005, 48, in press
16. J.Y. Winum, D. Vullo, A. Casini, J.L. Montero, A. Scozzafava, and C.T. Supuran J. Med. Chem. 46 2003 2197 2204
17. J.-Y. Winum, L. Toupet, V. Barragan, G. Dewynter, and J.-L. Montero Org. Lett. 3 2001 2241 2243
18. A.-H.D.G. Hajri, M. Criton, P. Dilda, and J.-L. Montero Heteroatom. Chem. 12 2001 1 5
19. +.
20. 4-7
21. A. Innocenti, D. Vullo, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett. 15 2005 567 571
22. J.-Y. Winum, D. Vullo, A. Casini, J.-L. Montero, A. Scozzafava, and C.T. Supuran J. Med. Chem. 46 2003 2197 2204
23. A. Casini, J. Antel, F. Abbate, A. Scozzafava, S. David, H. Waldeck, S. Schäfer, and C.T. Supuran Bioorg. Med. Chem. Lett. 13 2003 841 845
24. F. Abbate, A. Casini, T. Owa, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett. 14 2004 217 223
25. F. Abbate, J.-Y. Winum, B.V.L. Potter, A. Casini, J.-L. Montero, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett. 14 2004 231 234
26. A. Weber, A. Casini, A. Heine, D. Kuhn, C.T. Supuran, A. Scozzafava, and G. Klebe J. Med. Chem. 47 2004 550 557
27. F. Abbate, A. Casini, A. Scozzafava, and C.T. Supuran J. Enzyme Inhib. Med. Chem. 18 2003 303 308
28. A. Casini, F. Abbate, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett 13 2003 2763 2769
29. F. Abbate, A. Coetzee, A. Casini, S. Ciattini, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett. 14 2004 337 341
30. F. Abbate, A. Casini, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett. 14 2004 2357 2361