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Angewandte Chemie - International Edition

Volumn 46, Issue 40, 2007, Pages 7697-7699

Saccharin inhibits carbonic anhydrases: Possible explanation for its unpleasant metallic aftertaste

(7) Köhler, Karen a Hillebrecht, Alexander a Schulze Wischeler, Johannes a Innocenti, Alessio b Heine, Andreas a Supuran, Claudiu T b Klebe, Gerhard a

a PHILIPPS UNIVERSITY MARBURG (Germany)

b UNIVERSITY OF FLORENCE (Italy)

Author keywords

Carbonic anhydrase; Homology models; Isoforms; Saccharin; Structure elucidation

Indexed keywords

BINDING SITES; METABOLISM; PLASMA (HUMAN);

CARBONIC ANHYDRASES; HOMOLOGY MODELS; ISOFORMS; SACCHARIN; STRUCTURE ELUCIDATION;

ENZYME INHIBITION;

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; ISOENZYME; METAL; SACCHARIN;

ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM; MOUSE; TASTE;

ANIMALS; BINDING SITES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; HUMANS; ISOENZYMES; METALS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SACCHARIN; TASTE;

EID: 35048900931 PISSN: 14337851 EISSN: None Source Type: Journal
DOI: 10.1002/anie.200701189 Document Type: Article

Times cited : (169)

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