Carbonic anhydrase activators: Amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2915-2923

  Supuran, Claudiu T ^a   Scozzafava, Andrea ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Amino acid; Carbonic anhydrase; Dipeptide; Enzyme activators; Histamine; Proton shuttle

Indexed keywords

AMINO ACID; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE ACTIVATOR; DIAGNOSTIC AGENT; DIPEPTIDE; ENZYME ACTIVATOR; HISTAMINE; HISTAMINE DERIVATIVE; IMIDAZOLE; ISOENZYME; MEMBRANE ENZYME; REAGENT; TETRABROMOPHTHALIC ANHYDRIDE; TRITYLSULFENYL CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOSOL; DRUG SYNTHESIS; ENZYME DEFICIENCY; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; CARBONIC ANHYDRASES; CATTLE; ENZYME ACTIVATION; HISTAMINE; HUMANS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLISM, INBORN ERRORS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SYNDROME;

EID: 0033384171     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00227-8     Document Type: Article

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