Transcriptome analysis of human hepatic and pancreatic stellate cells: Organ-specific variations of a common transcriptional phenotype

Journal of Molecular Medicine

Volumn 83, Issue 10, 2005, Pages 795-805

  Buchholz, Malte ^a   Kestler, Hans A ^a,b   Holzmann, Karlheinz ^a   Ellenrieder, Volker ^a   Schneiderhan, Wilhelm ^a   Siech, Marco ^c   Adler, Guido ^a   Bachem, Max G ^a   Gress, Thomas M ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c Ostalb Klinikum   (Germany)

Author keywords

Expression profiling; Fibrosis; Stellate cell biology

Indexed keywords

CELL SURFACE MARKER; CELL SURFACE PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL CULTURE; CELL FUNCTION; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; CYTOLOGY; CYTOPATHOGENIC EFFECT; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER FIBROSIS; NUCLEOTIDE SEQUENCE; PANCREAS CELL; PHENOTYPIC VARIATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; STELLATE CELL; STEM CELL; TRANSCRIPTOMICS; UNINDEXED SEQUENCE;

CELL LINEAGE; FIBROBLASTS; GENE EXPRESSION PROFILING; HUMANS; LIVER; ORGAN SPECIFICITY; PANCREAS; PHENOTYPE; SKIN; TRANSCRIPTION, GENETIC;

EID: 26044431888     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-005-0680-2     Document Type: Article

References (43)

1. Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M, Adler G (1995) Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Int J Cancer 62:407-413
2. Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1998) Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43:128-133
3. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G (1998) Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115:421-432
4. Blomhoff R, Wake K (1991) Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J 5:271-277
5. Friedman SL (1993) Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 328:1828-1835
6. Friedman SL (1990) Cellular sources of collagen and regulation of collagen production in liver. Semin Liver Dis 10:20-29
7. McGee JO, Patrick RS (1972) The role of perisinusoidal cells in experimental hepatic fibrogenesis. J Pathol 106:vi
8. Gressner AM, Bachem MG (1995) Molecular mechanisms of liver fibrogenesis - a homage to the role of activated fat-storing cells. Digestion 56:335-346
9. Geerts A (2001) History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis 21:311-335
10. Ballardini G, Fallani M, Biagini G, Blanchi FB, Pisi E (1988) Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Arch B Cell Pathol Incl Mol Pathol 56:45-49
11. Bachem MG, Meyer D, Schafer W, Riess U, Melchior R, Sell KM, Gressner AM (1993) The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture. J Hepatol 18:40-52
12. Bachem MG, Sell KM, Melchior R, Kropf J, Eller T, Gressner AM (1993) Tumor necrosis factor alpha (TNF alpha) and transforming growth factor beta 1 (TGF beta 1) stimulate fibronectin synthesis and the transdifferentiation of fat-storing cells in the rat liver into myofibroblasts. Virchows Arch B Cell Pathol Incl Mol Pathol 63:123-130
13. Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1999) Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 44:534-541
14. Luttenberger T, Schmid-Kotsas A, Menke A, Siech M, Beger H, Adler G, Grunert A, Bachem MG (2000) Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab Invest 80:47-55
15. Ramadori G (1991) The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insights into pathophysiology of an intriguing cell. Virchows Arch B Cell Pathol Incl Mol Pathol 61:147-158
16. Gressner AM (1991) Time-related distribution profiles of sulfated glycosaminoglycans in cells, cell surfaces, and media of cultured rat liver fat-storing cells. Proc Soc Exp Biol Med 196:307-315
17. Pinzani M (2002) PDGF and signal transduction in hepatic stellate cells. Front Biosci 7:d1720-d1726
18. Pinzani M, Marra F (2001) Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 21:397-416
19. Pinzani M, Gesualdo L, Sabbah GM, Abboud HE (1989) Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 84:1786-1793
20. Mews P, Phillips P, Fahmy R, Korsten M, Pirola R, Wilson J, Apte M (2002) Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 50:535-541
21. Niki T, Pekny M, Hellemans K, Bleser PD, Berg KV, Vaeyens F, Quartier E, Schuit F, Geerts A (1999) Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Hepatology 29:520-527
22. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G (1998) Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115:421-432
23. Schneiderhan W, Schmid-Kotsas A, Zhao J, Grunert A, Nussler A, Weidenbach H, Menke A, Schmid RM, Adler G, Bachem MG (2001) Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis. Hepatology 34:729-737
24. Smyth GK (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical applications in genetics and molecular biology 3. http://www.bepress.com/sagmb/vol3/iss1/art3
25. Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, Bussey KJ, Riss J, Barrett JC, Weinstein JN (2003) GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 4:R28
26. Eisen MB, Spellman PT, Brown PO, Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 95:14863-14868
27. Ross AC (1993) Cellular metabolism and activation of retinoids: roles of cellular retinoid-binding proteins. FASEB J 7:317-327
28. Napoli JL (1996) Retinoic acid biosynthesis and metabolism. FASEB J 10:993-1001
29. Tolwinski NS, Wieschaus E (2004) Rethinking WNT signaling. Trends Genet 20:177-181
30. Wodarz A, Nusse R (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88
31. Hari L, Brault V, Kleber M, Lee HY, Ille F, Leimeroth R, Paratore C, Suter U, Kemler R, Sommer L (2002) Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol 159:867-880
32. Hirabayashi Y, Itoh Y, Tabata H, Nakajima K, Akiyama T, Masuyama N, Gotoh Y (2004) The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 131:2791-2801
33. Satoh K, Kasai M, Ishidao T, Tago K, Ohwada S, Hasegawa Y, Senda T, Takada S, Nada S, Nakamura T, Akiyama T (2004) Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc Natl Acad Sci U S A 101:8017-8021
34. 2+ signaling. Mech Dev 106:61-76
35. Espinosa L, Ingles-Esteve J, Aguilera C, Bigas A (2003) Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. J Biol Chem 278:32227-32235
36. Yao J, Lai E, Stifani S (2001) The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. Mol Cell Biol 21:1962-1972
37. Cassiman D, Denef C, Desmet VJ, Roskams T (2001) Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology 33:148-158
38. Knittel T, Aurisch S, Neubauer K, Eichhorst S, Ramadori G (1996) Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair. Am J Pathol 149:449-462
39. Niki T, Pekny M, Hellemans K, Bleser PD, Berg KV, Vaeyens F, Quartier E, Schuit F, Geerts A (1999) Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Hepatology 29:520-527
40. Lardon J, Rooman I, Bouwens L (2002) Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem Cell Biol 117:535-540
41. Tsai RY, McKay RD (2000) Cell contact regulates fate choice by cortical stem cells. J Neurosci 20:3725-3735
42. Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, Korbutt G, van der Kooy D (2004) Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol 22:1115-1124
43. Shinji T, Ujike K, Ochi K, Kusano N, Kikui T, Matsumura N, Emori Y, Seno T, Koide N (2002) Establishment of a novel collagenase perfusion method to isolate rat pancreatic stellate cells and investigation of their gene expression of TGF-beta1, type I collagen, and CTGF in primary culture or freshly isolated cells. Acta Med Okayama 56:211-218