The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis

Laboratory Investigation

Volumn 83, Issue 2, 2003, Pages 163-173

  Kinnman, Nils ^a,b   Francoz, Claire ^a   Barbu, Véronique ^a   Wendum, Dominique ^a   Rey, Colette ^a   Hultcrantz, Rolf ^b   Poupon, Raoul ^a   Housset, Chantal ^a,c  

^a HÔPITAL TENON   (France)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; DESMIN; FIBULIN; IMATINIB; INTERLEUKIN 6; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FIBROGENESIS; HISTOPATHOLOGY; IMMUNOREACTIVITY; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER SINUSOID; MALE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE; STELLATE CELL;

EID: 0037329896     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000054178.01162.E4     Document Type: Article

References (41)

1. Barbu V and Dautry F (1989). Northern blot normalization with a 28S rRNA oligonucleotide probe. Nucleic Acids Res 17: 7115.
2. Brandsten C, Lundmark C, Christersson C, Hammarstrom L, and Wurtz T (1999). Expression of collagen alpha1(I) mRNA variants during tooth and bone formation in the rat. J Dent Res 78:11-19.
3. Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, and Lydon NB (2000). Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295:139-145.
4. Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ, and Lydon NB (1996). Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 56:100-104.
5. Cassiman D, Libbrecht L, Desmet V, Denef C, and Roskams T (2002). Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36:200-209.
6. Chomczynski P and Sacchi N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156-159.
7. Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, Housset C, and Rosmorduc O (2002). Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 35:1010-1021.
8. Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, and Taub R (1996). Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274:1379-1383.
9. de Leeuw AM, McCarthy SP, Geerts A, and Knook DL (1984). Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 4:392-403.
10. Desmet V, Roskams T, and Van Eyken P (1995). Ductular reaction in the liver. Pathol Res Pract 191:513-524.
11. Friedman SL (2000). Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275:2247-2250.
12. Friedman SL and Roll FR (1987). Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan. Anal Biochem 161:207-218.
13. Geerts A, Lazou JM, De Bleser P, and Wisse E (1991). Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured rat liver. Hepatology 13:1193-1202.
14. Grappone C, Pinzani M, Parola M, Pellegrini G, Caligiuri A, DeFranco R, Marra F, Herbst H, Alpini G, and Milani S (1999). Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats. J Hepatol 31:100-109.
15. Grinko I, Geerts A, and Wisse E (1995). Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia. J Hepatol 23:449-458.
16. Hines JE, Johnson SJ, and Burt AD (1993). In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury. Am J Pathol 142:511-518.
17. Ikeda K, Wakahara T, Wang YQ, Kadoya H, Kawada N, and Kaneda K (1999). In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 29:1760-1767.
18. Kinnman N, Goria O, Wendum D, Gendron M-C, Rey C, Poupon R, and Housset C (2001). Hepatic stellate proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury. Lab Invest 81:1709-1716.
19. Kinnman N, Hultcrantz R, Barbu V, Rey C, Wendum D, Poupon R, and Housset C (2000). PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury. Lab Invest 80:697-707.
20. Knittel T, Kobold D, Piscaglia F, Saile B, Neubauer K, Mehde M, Timpl R, and Ramadori G (1999a). Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: Distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol 112:387-401.
21. Knittel T, Kobold D, Saile B, Grundmann A, Neubauer K, Piscaglia F, and Ramadori G (1999b). Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 117:1205-1221.
22. Knook DL, Seffelaar AM, and de Leeuw AM (1982). Fat-storing cells of the rat liver: Their isolation and purification. Exp Cell Res 139:468-471.
23. Kohnen G, Kertschanska S, Demir R, and Kaufmann P (1996). Placental villous stroma as a model system for myofibroblast differentiation. Histochem Cell Biol 105:415-429.
24. Kountouras J, Billing BH, and Scheuer PJ (1984). Prolonged bile duct obstruction: A new experimental model for cirrhosis in the rat. Br J Exp Pathol 65:305-311.
25. Krause AW, Carley WW, and Webb WW (1984). Fluorescent erythrosin B is preferable to trypan blue as a vital exclusion dye for mammalian cells in monolayer culture. J Histochem Cytochem 32:1084-1090.
26. Maher JJ and McGuire RF (1990). Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 86:1641-1648.
27. Mennone A, Alvaro D, Cho W, and Boyer JL (1995). Isolation of small polarized bile duct units. Proc Natl Acad Sci USA 92:6527-6531.
28. Milani S, Herbst H, Schuppan D, Grappone C, and Heinrichs OE (1995). Cellular sources of extracellular matrix proteins in normal and fibrotic liver: Studies of gene expression by in situ hybridization. J Hepatol 22:71-76.
29. Morrison TB, Weis JJ, and Wittwer CT (1998). Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification. Biotechniques 24:954-958,960,962.
30. Oh SJ, Kurz H, Christ B, and Wilting J (1998). Platelet-derived growth factor-β induces transformation of fibrocytes into spindle-shaped myofibroblasts in vivo. Histochem Cell Biol 109:349-357.
31. Pfaffl MW (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: 2003-2007.
32. Pinzani M, Gesualdo L, Sabbah GM, and Abboud HE (1989). Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 84:1786-1793.
33. Rockey DC, Fouassier L, Chung JJ, Carayon A, Vallee P, Rey C, and Housset C (1998). Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells. Hepatology 27:472-480.
34. Schmitt-Graff A, Desmouliere A, and Gabbiani G (1994). Heterogeneity of myofibroblast phenotypic features: An example of fibroblastic cell plasticity. Virchows Arch 425:3-24.
35. Takase S, Leo MA, Nouchi T, and Lieber CS (1988). Desmin distinguishes cultured fat-storing cells from myofibroblasts, smooth muscle cells and fibroblasts in the rat. J Hepatol 6:267-276.
36. Tang L, Tanaka Y, Marumo F, and Sato C (1994). Phenotypic change in portal fibroblasts in biliary fibrosis. Liver 14:76-82.
37. Tao LH, Enzan H, Hayashi Y, Miyazaki E, Saibara T, Hiroi M, Toi M, Kuroda N, Naruse K, Jin YL, and Guo LM (2000). Appearance of denuded hepatic stellate cells and their subsequent myofibroblast-like transformation during the early stage of biliary fibrosis in the rat. Med Electron Microsc 33:217-230.
38. Tiggelman AM, Boers W, Linthorst C, Brand HS, Sala M, and Chamuleau RA (1995). Interleukin-6 production by human liver (myo)fibroblasts in culture: Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha. J Hepatol 23:295-306.
39. Tuchweber B, Desmouliere A, Bochaton-Piallat ML, Rubbia-Brandt L, and Gabbiani G (1996). Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat. Lab Invest 74:265-278.
40. Uchio K, Tuchweber B, Manabe N, Gabbiani G, Rosenbaum J, and Desmouliere A (2002). Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts. Lab Invest 82:619-628.
41. Wong L, Yamasaki G, Johnson RJ, and Friedman SL (1994). Induction of β-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 94:1563-1569.