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Volumn 27, Issue 1, 2007, Pages 13-27

Genetics, genomics, and proteomics: Implications for the diagnosis and the treatment of chronic hepatitis C

Author keywords

Fibrosis progression; HLA loci; Microarray; Pegylated interferon; Prediction

Indexed keywords

ANTIVIRUS AGENT; BLOOD CLOTTING FACTOR; CHEMOKINE RECEPTOR CCR5; CYTOKINE; HFE PROTEIN; HLA ANTIGEN; INTERFERON; PEGINTERFERON; RIBAVIRIN;

EID: 33847054368     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-960168     Document Type: Review
Times cited : (57)

References (132)
  • 1
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo QL, Kuo G, Werner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989;244:359-362
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Werner, A.J.3
  • 2
    • 0035235411 scopus 로고    scopus 로고
    • The chimpanzee model of hepatitis C virus infections
    • Lanford RE, Bigger C, Bassett S, Klimpel G. The chimpanzee model of hepatitis C virus infections. ILAR J 2001;42:117-126
    • (2001) ILAR J , vol.42 , pp. 117-126
    • Lanford, R.E.1    Bigger, C.2    Bassett, S.3    Klimpel, G.4
  • 3
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann V, Korner F, Koch J, et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999;285:110-113
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1    Korner, F.2    Koch, J.3
  • 4
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight KJ, Kolykhalov AA, Rice CM. Efficient initiation of HCV RNA replication in cell culture. Science 2000;290: 1972-1974
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 5
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T, Pietschmann T, Kato T, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005;11:791-796
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3
  • 6
  • 7
    • 23044437222 scopus 로고    scopus 로고
    • Complete replication of hepatitis C virus in cell culture
    • Lindenbach BD, Evans MJ, Syder AJ, et al. Complete replication of hepatitis C virus in cell culture. Science 2005; 309:623-626
    • (2005) Science , vol.309 , pp. 623-626
    • Lindenbach, B.D.1    Evans, M.J.2    Syder, A.J.3
  • 8
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • Gale M Jr, Foy EM. Evasion of intracellular host defence by hepatitis C virus. Nature 2005;436:939-945
    • (2005) Nature , vol.436 , pp. 939-945
    • Gale Jr, M.1    Foy, E.M.2
  • 9
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003;300:1145-1148
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3
  • 10
    • 0033545996 scopus 로고    scopus 로고
    • NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling
    • Tan SL, Nakao H, He Y, et al. NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. Proc Natl Acad Sci USA 1999;96:5533-5538
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5533-5538
    • Tan, S.L.1    Nakao, H.2    He, Y.3
  • 11
    • 0034629092 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP
    • Ghosh AK, Majumder M, Steele R, et al. Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. J Biol Chem 2000; 275:7184-7188
    • (2000) J Biol Chem , vol.275 , pp. 7184-7188
    • Ghosh, A.K.1    Majumder, M.2    Steele, R.3
  • 12
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong G, Waris G, Tanveer R, Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci USA 2001;98:9599-9604
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 13
    • 0034969251 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
    • Polyak SJ, Khabar KS, Paschal DM, et al. Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response. J Virol 2001;75:6095-6106
    • (2001) J Virol , vol.75 , pp. 6095-6106
    • Polyak, S.J.1    Khabar, K.S.2    Paschal, D.M.3
  • 14
    • 0036067898 scopus 로고    scopus 로고
    • An altered cellular response to Interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis
    • Girard S, Shalhoub P, Lescure P, et al. An altered cellular response to Interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis. Virology 2002;295:272-283
    • (2002) Virology , vol.295 , pp. 272-283
    • Girard, S.1    Shalhoub, P.2    Lescure, P.3
  • 15
    • 0037293053 scopus 로고    scopus 로고
    • Modulation of Interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1
    • Ghosh AK, Majumder M, Steele R, et al. Modulation of Interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1. Virology 2003; 306:51-59
    • (2003) Virology , vol.306 , pp. 51-59
    • Ghosh, A.K.1    Majumder, M.2    Steele, R.3
  • 16
    • 4544275336 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses
    • Girard S, Vossman E, Misek DE, et al. Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses. Hepatology 2004;40:708-718
    • (2004) Hepatology , vol.40 , pp. 708-718
    • Girard, S.1    Vossman, E.2    Misek, D.E.3
  • 17
    • 0038703409 scopus 로고    scopus 로고
    • Gene expression profiling of the cellular transcriptional network regulated by alpha/ beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein
    • Geiss GK, Carter VS, He Y, et al. Gene expression profiling of the cellular transcriptional network regulated by alpha/ beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol 2003;77:6367-6375
    • (2003) J Virol , vol.77 , pp. 6367-6375
    • Geiss, G.K.1    Carter, V.S.2    He, Y.3
  • 18
    • 0041888351 scopus 로고    scopus 로고
    • Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells
    • Zhu Q, Guo JT, Seeger C. Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells. J Virol 2003;77:9204-9210
    • (2003) J Virol , vol.77 , pp. 9204-9210
    • Zhu, Q.1    Guo, J.T.2    Seeger, C.3
  • 19
    • 17444394858 scopus 로고    scopus 로고
    • The transcriptome of HCV replicon expressing cell lines in the presence of alpha interferon
    • Hayashi J, Stoyanova R, Seeger C. The transcriptome of HCV replicon expressing cell lines in the presence of alpha interferon. Virology 2005;335:264-275
    • (2005) Virology , vol.335 , pp. 264-275
    • Hayashi, J.1    Stoyanova, R.2    Seeger, C.3
  • 20
    • 0033604281 scopus 로고    scopus 로고
    • Impaired antiviral response in human hepatoma cells
    • Keskinen P, Nyqvist M, Sareneva T, et al. Impaired antiviral response in human hepatoma cells. Virology 1999;263:364-375
    • (1999) Virology , vol.263 , pp. 364-375
    • Keskinen, P.1    Nyqvist, M.2    Sareneva, T.3
  • 21
    • 0034948009 scopus 로고    scopus 로고
    • DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection
    • Bigger CB, Brasky KM, Lanford RE. DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol 2001;75:7059-7066
    • (2001) J Virol , vol.75 , pp. 7059-7066
    • Bigger, C.B.1    Brasky, K.M.2    Lanford, R.E.3
  • 22
    • 7244240339 scopus 로고    scopus 로고
    • Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees
    • Bigger CB, Guerra B, Brasky KM, et al. Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol 2004;78:13779-13792
    • (2004) J Virol , vol.78 , pp. 13779-13792
    • Bigger, C.B.1    Guerra, B.2    Brasky, K.M.3
  • 23
    • 0029852580 scopus 로고    scopus 로고
    • Use of a cDNA microarray to analyse gene expression patterns in human cancer
    • DeRisi J, Penland L, Brown PO, et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet 1996;14:457-460
    • (1996) Nat Genet , vol.14 , pp. 457-460
    • DeRisi, J.1    Penland, L.2    Brown, P.O.3
  • 24
    • 28844464258 scopus 로고    scopus 로고
    • Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C
    • Asselah T, Bieche I, Laurendeau I, et al. Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C. Gastroenterology 2005;129:2064-2075
    • (2005) Gastroenterology , vol.129 , pp. 2064-2075
    • Asselah, T.1    Bieche, I.2    Laurendeau, I.3
  • 25
    • 19944430095 scopus 로고    scopus 로고
    • Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection
    • Bieche I, Asselah T, Laurendeau I, et al. Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. Virology 2005;332:130-144
    • (2005) Virology , vol.332 , pp. 130-144
    • Bieche, I.1    Asselah, T.2    Laurendeau, I.3
  • 26
    • 24144487496 scopus 로고    scopus 로고
    • Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector
    • Helbig KJ, Lau DT, Semendric L, et al. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology 2005;42:702-710
    • (2005) Hepatology , vol.42 , pp. 702-710
    • Helbig, K.J.1    Lau, D.T.2    Semendric, L.3
  • 27
    • 0028966217 scopus 로고
    • Non-A, non-B hepatitis unrelated to the hepatitis C virus (non-ABC)
    • Alter HJ, Bradley DW. Non-A, non-B hepatitis unrelated to the hepatitis C virus (non-ABC). Semin Liver Dis 1995; 15:110-120
    • (1995) Semin Liver Dis , vol.15 , pp. 110-120
    • Alter, H.J.1    Bradley, D.W.2
  • 28
    • 14644391458 scopus 로고    scopus 로고
    • Management and treatment of injection drug users with hepatitis C virus (HCV) infection and HCV/human immunodeficiency virus coinfection
    • Dore GJ, Thomas DL. Management and treatment of injection drug users with hepatitis C virus (HCV) infection and HCV/human immunodeficiency virus coinfection. Semin Liver Dis 2005;25:18-32
    • (2005) Semin Liver Dis , vol.25 , pp. 18-32
    • Dore, G.J.1    Thomas, D.L.2
  • 29
    • 14644386813 scopus 로고    scopus 로고
    • Acute hepatitis C: A multifaceted disease
    • Heller T, Rehermann B. Acute hepatitis C: a multifaceted disease. Semin Liver Dis 2005;25:7-17
    • (2005) Semin Liver Dis , vol.25 , pp. 7-17
    • Heller, T.1    Rehermann, B.2
  • 30
    • 0035892032 scopus 로고    scopus 로고
    • Treatment of acute hepatitis C with interferon alfa-2b
    • Jaeckel E, Cornberg M, Wedemeyer H, et al. Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med 2001;345:1452-1457
    • (2001) N Engl J Med , vol.345 , pp. 1452-1457
    • Jaeckel, E.1    Cornberg, M.2    Wedemeyer, H.3
  • 31
    • 0033054813 scopus 로고    scopus 로고
    • EASL International Consensus Conference on Hepatitis C Consensus statement
    • EASL International Consensus Conference on Hepatitis C Consensus statement. J Hepatol 1999;30:956-961
    • (1999) J Hepatol , vol.30 , pp. 956-961
  • 32
    • 33847063694 scopus 로고    scopus 로고
    • National Institutes of Health Consensus Development Conference Statement. Management of Hepatitis C: 2002. Hepatology 2002;36(suppl 1):S3-S21
    • National Institutes of Health Consensus Development Conference Statement. Management of Hepatitis C: 2002. Hepatology 2002;36(suppl 1):S3-S21
  • 33
    • 7244255737 scopus 로고    scopus 로고
    • Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance
    • Spada E, Mele A, Berton A, et al. Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut 2004;53:1673-1681
    • (2004) Gut , vol.53 , pp. 1673-1681
    • Spada, E.1    Mele, A.2    Berton, A.3
  • 34
    • 3242759735 scopus 로고    scopus 로고
    • Host genetic determinants in hepatitis C virus infection
    • Yee LJ. Host genetic determinants in hepatitis C virus infection. Genes Immun 2004;5:237-245
    • (2004) Genes Immun , vol.5 , pp. 237-245
    • Yee, L.J.1
  • 35
    • 16144362422 scopus 로고    scopus 로고
    • HLA class II genes in chronic hepatitis C virus-infection and associated immunological disorders
    • Congia M, Clemente MG, Dessi C, et al. HLA class II genes in chronic hepatitis C virus-infection and associated immunological disorders. Hepatology 1996;24:1338-1341
    • (1996) Hepatology , vol.24 , pp. 1338-1341
    • Congia, M.1    Clemente, M.G.2    Dessi, C.3
  • 36
    • 0029860025 scopus 로고    scopus 로고
    • Evidence that the HLA DQA1*03 allele confers protection from chronic HCV-infection in Northern European Caucasoids
    • Tibbs C, Donaldson P, Underbill J, et al. Evidence that the HLA DQA1*03 allele confers protection from chronic HCV-infection in Northern European Caucasoids. Hepatology 1996;24:1342-1345
    • (1996) Hepatology , vol.24 , pp. 1342-1345
    • Tibbs, C.1    Donaldson, P.2    Underbill, J.3
  • 37
    • 0030831653 scopus 로고    scopus 로고
    • Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection
    • Alric L, Fort M, Izopet J, et al. Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection. Gastroenterology 1997;113: 1675-1681
    • (1997) Gastroenterology , vol.113 , pp. 1675-1681
    • Alric, L.1    Fort, M.2    Izopet, J.3
  • 38
    • 0343765761 scopus 로고    scopus 로고
    • MHC class II genes influence the susceptibility to chronic active hepatitis C
    • Hohler T, Gerken G, Notghi A, et al. MHC class II genes influence the susceptibility to chronic active hepatitis C. J Hepatol 1997;27:259-264
    • (1997) J Hepatol , vol.27 , pp. 259-264
    • Hohler, T.1    Gerken, G.2    Notghi, A.3
  • 39
    • 0032146913 scopus 로고    scopus 로고
    • Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia
    • Cramp ME, Carucci P, Underbill J, et al. Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia. J Hepatol 1998;29:207-213
    • (1998) J Hepatol , vol.29 , pp. 207-213
    • Cramp, M.E.1    Carucci, P.2    Underbill, J.3
  • 40
    • 0031952381 scopus 로고    scopus 로고
    • Association between HLA class II alleles and protection from or susceptibility to chronic hepatitis C
    • Zavaglia C, Martinetti M, Silini E, et al. Association between HLA class II alleles and protection from or susceptibility to chronic hepatitis C. J Hepatol 1998; 28:1-7
    • (1998) J Hepatol , vol.28 , pp. 1-7
    • Zavaglia, C.1    Martinetti, M.2    Silini, E.3
  • 41
    • 0031962298 scopus 로고    scopus 로고
    • Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus
    • Kuzushita N, Hayashi N, Moribe T, et al. Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus. Hepatology 1998;27:240-244
    • (1998) Hepatology , vol.27 , pp. 240-244
    • Kuzushita, N.1    Hayashi, N.2    Moribe, T.3
  • 42
    • 0031845494 scopus 로고    scopus 로고
    • Association between MHC class II alleles and clearance of circulating hepatitis C virus. Members of the Trent Hepatitis C Virus Study Group
    • Minton EJ, Smillie D, Neal KR, et al. Association between MHC class II alleles and clearance of circulating hepatitis C virus. Members of the Trent Hepatitis C Virus Study Group. J Infect Dis 1998;178:39-44
    • (1998) J Infect Dis , vol.178 , pp. 39-44
    • Minton, E.J.1    Smillie, D.2    Neal, K.R.3
  • 43
    • 0032901388 scopus 로고    scopus 로고
    • Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease
    • Asti M, Martinetti M, Zavaglia C, et al. Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease. Hepatology 1999;29: 1272-1279
    • (1999) Hepatology , vol.29 , pp. 1272-1279
    • Asti, M.1    Martinetti, M.2    Zavaglia, C.3
  • 44
    • 0033057855 scopus 로고    scopus 로고
    • HLA class II favors clearance of HCV infection and progression of the chronic liver damage
    • Mangia A, Gentile R, Cascavilla I, et al. HLA class II favors clearance of HCV infection and progression of the chronic liver damage. J Hepatol 1999;30:984-989
    • (1999) J Hepatol , vol.30 , pp. 984-989
    • Mangia, A.1    Gentile, R.2    Cascavilla, I.3
  • 45
    • 0033582107 scopus 로고    scopus 로고
    • Influence of MHC class II genotype on outcome of infection with hepatitis C virus
    • Thursz M, Yallop R, Goldin R, et al. Influence of MHC class II genotype on outcome of infection with hepatitis C virus. Lancet 1999;354:2119-2124
    • (1999) Lancet , vol.354 , pp. 2119-2124
    • Thursz, M.1    Yallop, R.2    Goldin, R.3
  • 46
    • 0033064363 scopus 로고    scopus 로고
    • Association of the HLA-DRB1*01 allele with spontaneous viral clearance in an Irish cohort infected with hepatitis C virus via contaminated anti-D immunoglobulin
    • Barren S, Ryan E, Crowe J. Association of the HLA-DRB1*01 allele with spontaneous viral clearance in an Irish cohort infected with hepatitis C virus via contaminated anti-D immunoglobulin. J Hepatol 1999;30:979-983
    • (1999) J Hepatol , vol.30 , pp. 979-983
    • Barren, S.1    Ryan, E.2    Crowe, J.3
  • 47
    • 0035192823 scopus 로고    scopus 로고
    • HLA class II genes determine the natural variance of hepatitis C viral load
    • Fanning LJ, Levis J, Kenny-Walsh E, et al. HLA class II genes determine the natural variance of hepatitis C viral load. Hepatology 2001;33:224-230
    • (2001) Hepatology , vol.33 , pp. 224-230
    • Fanning, L.J.1    Levis, J.2    Kenny-Walsh, E.3
  • 48
    • 0034086271 scopus 로고    scopus 로고
    • The MHC is a major determinant of viral status, but not fibrotic stage, in individuals infected with hepatitis C
    • McKiernan SM, Hagan R, Curry M, et al. The MHC is a major determinant of viral status, but not fibrotic stage, in individuals infected with hepatitis C. Gastroenterology 2000;118:1124-1130
    • (2000) Gastroenterology , vol.118 , pp. 1124-1130
    • McKiernan, S.M.1    Hagan, R.2    Curry, M.3
  • 49
    • 0036010981 scopus 로고    scopus 로고
    • HLA-Cw*04 and hepatitis C virus persistence
    • Thio CL, Gao X, Goedert JJ, et al. HLA-Cw*04 and hepatitis C virus persistence. J Virol 2002;76:4792-4797
    • (2002) J Virol , vol.76 , pp. 4792-4797
    • Thio, C.L.1    Gao, X.2    Goedert, J.J.3
  • 50
    • 3042715432 scopus 로고    scopus 로고
    • Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    • McKiernan SM, Hagan R, Curry M, et al. Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology 2004;40:108-114
    • (2004) Hepatology , vol.40 , pp. 108-114
    • McKiernan, S.M.1    Hagan, R.2    Curry, M.3
  • 51
    • 0028979682 scopus 로고
    • Requirement of MIP-1 alpha for an inflammatory response to viral infection
    • Cook DN, Beck MA, Coffman TM, et al. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science 1995;269:1583-1585
    • (1995) Science , vol.269 , pp. 1583-1585
    • Cook, D.N.1    Beck, M.A.2    Coffman, T.M.3
  • 52
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86:367-377
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 53
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996;382:722-725
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 54
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
    • Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-1862
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3
  • 55
    • 16044367526 scopus 로고    scopus 로고
    • The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
    • Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996;2:1240-1243
    • (1996) Nat Med , vol.2 , pp. 1240-1243
    • Huang, Y.1    Paxton, W.A.2    Wolinsky, S.M.3
  • 56
    • 0031041571 scopus 로고    scopus 로고
    • The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression
    • Michael NL, Chang G, Louie LG, et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med 1997;3:338-340
    • (1997) Nat Med , vol.3 , pp. 338-340
    • Michael, N.L.1    Chang, G.2    Louie, L.G.3
  • 57
    • 0036083009 scopus 로고    scopus 로고
    • Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C
    • Woitas RP, Ahlenstiel G, Iwan A, et al. Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Gastroenterology 2002;122:1721-1728
    • (2002) Gastroenterology , vol.122 , pp. 1721-1728
    • Woitas, R.P.1    Ahlenstiel, G.2    Iwan, A.3
  • 58
    • 0344796403 scopus 로고    scopus 로고
    • Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection
    • Hellier S, Frodsham AJ, Hennig BJ, et al. Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology 2003;38:1468-1476
    • (2003) Hepatology , vol.38 , pp. 1468-1476
    • Hellier, S.1    Frodsham, A.J.2    Hennig, B.J.3
  • 60
    • 0037373044 scopus 로고    scopus 로고
    • High frequency of CCR5-delta32 homozygosity in HCV-infected, HIV-1-uninfected hemophiliacs results from resistance to HIV-1
    • Zhang M, Goedert JJ, O'Brien TR. High frequency of CCR5-delta32 homozygosity in HCV-infected, HIV-1-uninfected hemophiliacs results from resistance to HIV-1. Gastroenterology 2003;124:867-868
    • (2003) Gastroenterology , vol.124 , pp. 867-868
    • Zhang, M.1    Goedert, J.J.2    O'Brien, T.R.3
  • 61
    • 0037308259 scopus 로고    scopus 로고
    • Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C
    • Promrat K, McDermott DH, Gonzalez CM, et al. Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology 2003;124:352-360
    • (2003) Gastroenterology , vol.124 , pp. 352-360
    • Promrat, K.1    McDermott, D.H.2    Gonzalez, C.M.3
  • 62
    • 22644440543 scopus 로고    scopus 로고
    • The CCR5-delta32 mutation: Impact on disease outcome in individuals with hepatitis C infection from a single source
    • Goulding C, McManus R, Murphy A, et al. The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. Gut 2005;54:1157-1161
    • (2005) Gut , vol.54 , pp. 1157-1161
    • Goulding, C.1    McManus, R.2    Murphy, A.3
  • 63
    • 4043062982 scopus 로고    scopus 로고
    • Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C
    • Wasmuth HE, Werth A, Mueller T, et al. Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. Hepatology 2004;40:327-334
    • (2004) Hepatology , vol.40 , pp. 327-334
    • Wasmuth, H.E.1    Werth, A.2    Mueller, T.3
  • 64
    • 0036172224 scopus 로고    scopus 로고
    • Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-betal genes in chronic hepatitis C patients treated with interferon and ribavirin
    • Vidigal PG, Germer JJ, Zein NN. Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-betal genes in chronic hepatitis C patients treated with interferon and ribavirin. J Hepatol 2002;36:271-277
    • (2002) J Hepatol , vol.36 , pp. 271-277
    • Vidigal, P.G.1    Germer, J.J.2    Zein, N.N.3
  • 66
    • 15244356690 scopus 로고    scopus 로고
    • Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications
    • Friedman SL. Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 2004;1:98-105
    • (2004) Nat Clin Pract Gastroenterol Hepatol , vol.1 , pp. 98-105
    • Friedman, S.L.1
  • 67
    • 0036829652 scopus 로고    scopus 로고
    • Fibrosis and disease progression in hepatitis C
    • Marcellin P, Asselah T, Boyer N. Fibrosis and disease progression in hepatitis C. Hepatology 2002;36:S47-S56
    • (2002) Hepatology , vol.36
    • Marcellin, P.1    Asselah, T.2    Boyer, N.3
  • 68
    • 29244484291 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: Why does it really matter?
    • Asselah T, Rubbia-Brandt L, Marcellin P, Negro F. Steatosis in chronic hepatitis C: why does it really matter? Gut 2006;55:123-130
    • (2006) Gut , vol.55 , pp. 123-130
    • Asselah, T.1    Rubbia-Brandt, L.2    Marcellin, P.3    Negro, F.4
  • 69
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR, et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002;122:366-375
    • (2002) Gastroenterology , vol.122 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3
  • 70
    • 29244466499 scopus 로고    scopus 로고
    • Dose dependent and divergent effects of superoxide anion on cell death, proliferation, and migration of activated human hepatic stellate cells
    • Novo E, Marra F, Zamara E, et al. Dose dependent and divergent effects of superoxide anion on cell death, proliferation, and migration of activated human hepatic stellate cells. Gut 2006;55:90-97
    • (2006) Gut , vol.55 , pp. 90-97
    • Novo, E.1    Marra, F.2    Zamara, E.3
  • 71
    • 0036061080 scopus 로고    scopus 로고
    • Serum tumour necrosis factor-alpha and transforming growth factor-beta levels in chronic hepatitis C patients are immunomodulated by therapy
    • Neuman MG, Benhamou JP, Bourliere M, et al. Serum tumour necrosis factor-alpha and transforming growth factor-beta levels in chronic hepatitis C patients are immunomodulated by therapy. Cytokine 2002;17:108-117
    • (2002) Cytokine , vol.17 , pp. 108-117
    • Neuman, M.G.1    Benhamou, J.P.2    Bourliere, M.3
  • 72
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997;349:825-832
    • (1997) Lancet , vol.349 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 73
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff LB. Natural history of chronic hepatitis C. Hepatology 2002;36(suppl 1):S35-S46
    • (2002) Hepatology , vol.36 , Issue.SUPPL. 1
    • Seeff, L.B.1
  • 74
    • 0033594380 scopus 로고    scopus 로고
    • Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin
    • Kenny-Walsh E. Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research Group. N Engl J Med 1999;340: 1228-1233
    • (1999) Irish Hepatology Research Group. N Engl J Med , vol.340 , pp. 1228-1233
    • Kenny-Walsh, E.1
  • 75
    • 0034235962 scopus 로고    scopus 로고
    • Low frequency of cirrhosis in a hepatitis C (genotype 1b) single-source outbreak in Germany: A 20-year multicenter study
    • Wiese M, Berr F, Lafrenz M, Porst H, Oesen U. Low frequency of cirrhosis in a hepatitis C (genotype 1b) single-source outbreak in Germany: a 20-year multicenter study. Hepatology 2000;32:91-96
    • (2000) Hepatology , vol.32 , pp. 91-96
    • Wiese, M.1    Berr, F.2    Lafrenz, M.3    Porst, H.4    Oesen, U.5
  • 76
    • 33847027782 scopus 로고    scopus 로고
    • Codes L, Asselah T, Cazals-Hatem D, et al. Liver fibrosis in women with chronic hepatitis C: evidence for the negative role of menopause and steatosis and the potential benefit of hormone replacement therapy. Gut 2006; September 27 (Epub ahead of print)
    • Codes L, Asselah T, Cazals-Hatem D, et al. Liver fibrosis in women with chronic hepatitis C: evidence for the negative role of menopause and steatosis and the potential benefit of hormone replacement therapy. Gut 2006; September 27 (Epub ahead of print)
  • 77
    • 0030175370 scopus 로고    scopus 로고
    • DR human leukocyte antigens and disease severity in chronic hepatitis C
    • Czaja AJ, Carpenter H, Santrach PJ, Moore SB. DR human leukocyte antigens and disease severity in chronic hepatitis C. J Hepatol 1996;24:666-673
    • (1996) J Hepatol , vol.24 , pp. 666-673
    • Czaja, A.J.1    Carpenter, H.2    Santrach, P.J.3    Moore, S.B.4
  • 78
    • 0034065997 scopus 로고    scopus 로고
    • Human leukocyte antigen DRB1 1302 protects against bile duct damage and portal lymphocyte infiltration in patients with chronic hepatitis C
    • Haruna Y, Miyamoto T, Yasunami R, et al. Human leukocyte antigen DRB1 1302 protects against bile duct damage and portal lymphocyte infiltration in patients with chronic hepatitis C. J Hepatol 2000;32:837-842
    • (2000) J Hepatol , vol.32 , pp. 837-842
    • Haruna, Y.1    Miyamoto, T.2    Yasunami, R.3
  • 79
    • 0033880496 scopus 로고    scopus 로고
    • Human leukocyte antigen DR markers as predictors of progression to liver transplantation in patients with chronic hepatitis C
    • Brandhagen DJ, Gross JB Jr, Poterucha JJ, et al. Human leukocyte antigen DR markers as predictors of progression to liver transplantation in patients with chronic hepatitis C. Am J Gastroenterol 2000;95:2056-2060
    • (2000) Am J Gastroenterol , vol.95 , pp. 2056-2060
    • Brandhagen, D.J.1    Gross Jr, J.B.2    Poterucha, J.J.3
  • 80
    • 0035029193 scopus 로고    scopus 로고
    • Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease
    • Tillmann HL, Chen DF, Trautwein C, et al. Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease. Gut 2001;48:714-718
    • (2001) Gut , vol.48 , pp. 714-718
    • Tillmann, H.L.1    Chen, D.F.2    Trautwein, C.3
  • 81
    • 0036786191 scopus 로고    scopus 로고
    • Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels
    • Renou C, Halfon P, Pol S, et al. Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels. Gut 2002;51:585-590
    • (2002) Gut , vol.51 , pp. 585-590
    • Renou, C.1    Halfon, P.2    Pol, S.3
  • 82
    • 0034056296 scopus 로고    scopus 로고
    • Iron deposition and progression of disease in chronic hepatitis C: Role of interface hepatitis, portal inflammation, and HFE missense mutations
    • Pirisi M, Scott CA, Avellini C, et al. Iron deposition and progression of disease in chronic hepatitis C: role of interface hepatitis, portal inflammation, and HFE missense mutations. Am J Clin Pathol 2000;113:546-554
    • (2000) Am J Clin Pathol , vol.113 , pp. 546-554
    • Pirisi, M.1    Scott, C.A.2    Avellini, C.3
  • 83
    • 0037336495 scopus 로고    scopus 로고
    • HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis
    • Erhardt A, Maschner-Olberg A, Mellenthin C, et al. HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. J Hepatol 2003;38:335-342
    • (2003) J Hepatol , vol.38 , pp. 335-342
    • Erhardt, A.1    Maschner-Olberg, A.2    Mellenthin, C.3
  • 84
    • 0344129013 scopus 로고    scopus 로고
    • Liver iron accumulation in patients with chronic active hepatitis C: Prevalence and role of hemochromatosis gene mutations and relationship with hepatic histological lesions
    • Hézode C, Cazeneuve C, Cou O, et al. Liver iron accumulation in patients with chronic active hepatitis C: prevalence and role of hemochromatosis gene mutations and relationship with hepatic histological lesions. J Hepatol 1999;31:979-984
    • (1999) J Hepatol , vol.31 , pp. 979-984
    • Hézode, C.1    Cazeneuve, C.2    Cou, O.3
  • 85
    • 85058249320 scopus 로고    scopus 로고
    • Hemochromatosis mutation in hepatitis C: Histopathology
    • Knoll A, Kreuzpaintner B, Kreuzpaintner E, et al. Hemochromatosis mutation in hepatitis C: histopathology. Gastroenterology 1998;115:1307-1309
    • (1998) Gastroenterology , vol.115 , pp. 1307-1309
    • Knoll, A.1    Kreuzpaintner, B.2    Kreuzpaintner, E.3
  • 86
    • 0031801787 scopus 로고    scopus 로고
    • Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C
    • Smith BC, Gorve J, Guzail MA, et al. Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C. Hepatology 1998;27:1695-1699
    • (1998) Hepatology , vol.27 , pp. 1695-1699
    • Smith, B.C.1    Gorve, J.2    Guzail, M.A.3
  • 87
    • 0036155984 scopus 로고    scopus 로고
    • The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C
    • Thorburn D, Curry G, Spooner R, et al. The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C. Gut 2002;50:248-252
    • (2002) Gut , vol.50 , pp. 248-252
    • Thorburn, D.1    Curry, G.2    Spooner, R.3
  • 88
    • 0034672363 scopus 로고    scopus 로고
    • Spontaneous thrombosis in mice carrying the factor V Leiden mutation
    • Cui J, Eitzman DT, Westrick RJ, et al. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood 2000;96:4222-4226
    • (2000) Blood , vol.96 , pp. 4222-4226
    • Cui, J.1    Eitzman, D.T.2    Westrick, R.J.3
  • 89
    • 0037369783 scopus 로고    scopus 로고
    • Thrombotic risk factors and extent of liver fibrosis in chronic viral hepatitis
    • Papatheodoridis GV, Papakonstantinou E, Andrioti E, et al. Thrombotic risk factors and extent of liver fibrosis in chronic viral hepatitis. Gut 2003;52:404-409
    • (2003) Gut , vol.52 , pp. 404-409
    • Papatheodoridis, G.V.1    Papakonstantinou, E.2    Andrioti, E.3
  • 90
    • 0038637369 scopus 로고    scopus 로고
    • Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    • Wright M, Goldin R, Hellier S, et al. Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection. Gut 2003;52:1206-1210
    • (2003) Gut , vol.52 , pp. 1206-1210
    • Wright, M.1    Goldin, R.2    Hellier, S.3
  • 91
    • 0031891508 scopus 로고    scopus 로고
    • Expression of the thrombin receptor in human liver: Up-regulation during acute and chronic injury
    • Marra F, DeFranco R, Grappone C, et al. Expression of the thrombin receptor in human liver: up-regulation during acute and chronic injury. Hepatology 1998;27:462-471
    • (1998) Hepatology , vol.27 , pp. 462-471
    • Marra, F.1    DeFranco, R.2    Grappone, C.3
  • 92
    • 0032952504 scopus 로고    scopus 로고
    • Involvement of transporter associated with antigen processing 2 (TAP2) gene polymorphisms in hepatitis C virus infection
    • Kuzushita N, Hayashi N, Kanto T, et al. Involvement of transporter associated with antigen processing 2 (TAP2) gene polymorphisms in hepatitis C virus infection. Gastroenterology 1999;116:1149-1154
    • (1999) Gastroenterology , vol.116 , pp. 1149-1154
    • Kuzushita, N.1    Hayashi, N.2    Kanto, T.3
  • 93
    • 0034024356 scopus 로고    scopus 로고
    • Host genetic factors influence disease progression in chronic hepatitis C
    • Powell EE, Edwards-Smith CJ, Hay JL, et al. Host genetic factors influence disease progression in chronic hepatitis C. Hepatology 2000;31:828-833
    • (2000) Hepatology , vol.31 , pp. 828-833
    • Powell, E.E.1    Edwards-Smith, C.J.2    Hay, J.L.3
  • 94
    • 18444409370 scopus 로고    scopus 로고
    • Polymorphisms of microsomal epoxide hydrolase gene and severity of HCV-related liver disease
    • Sonzogni L, Silvestri L, De Silvestri A, et al. Polymorphisms of microsomal epoxide hydrolase gene and severity of HCV-related liver disease. Hepatology 2002;36: 195-201
    • (2002) Hepatology , vol.36 , pp. 195-201
    • Sonzogni, L.1    Silvestri, L.2    De Silvestri, A.3
  • 95
    • 0035984436 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus
    • Wozniak MA, Itzhaki RF, Faragher EB, et al. Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Hepatology 2002;36:456-463
    • (2002) Hepatology , vol.36 , pp. 456-463
    • Wozniak, M.A.1    Itzhaki, R.F.2    Faragher, E.B.3
  • 96
    • 33745532017 scopus 로고    scopus 로고
    • Keratin variants associate with progression of fibrosis during chronic hepatitis C infection
    • Strnad P, Lienau TC, Tao GZ, et al. Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology 2006;43:1354-1363
    • (2006) Hepatology , vol.43 , pp. 1354-1363
    • Strnad, P.1    Lienau, T.C.2    Tao, G.Z.3
  • 97
    • 17844385292 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients
    • Adinolfi LE, Ingrosso D, Cesaro G, et al. Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 2005;41:995-1003
    • (2005) Hepatology , vol.41 , pp. 995-1003
    • Adinolfi, L.E.1    Ingrosso, D.2    Cesaro, G.3
  • 98
    • 33646351020 scopus 로고    scopus 로고
    • Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C
    • Huang H, Shiffman ML, Cheung RC, et al. Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Gastroenterology 2006;130:1679-1687
    • (2006) Gastroenterology , vol.130 , pp. 1679-1687
    • Huang, H.1    Shiffman, M.L.2    Cheung, R.C.3
  • 99
    • 10744224571 scopus 로고    scopus 로고
    • SLCIlAl promoter gene polymorphisms and fibrosis progression in chronic hepatitis C
    • Romero-Gomez M, Montes-Cano MA, Otero-Fernandez MA, et al. SLCIlAl promoter gene polymorphisms and fibrosis progression in chronic hepatitis C. Gut 2004;53: 446-450
    • (2004) Gut , vol.53 , pp. 446-450
    • Romero-Gomez, M.1    Montes-Cano, M.A.2    Otero-Fernandez, M.A.3
  • 100
    • 0041828182 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphisms and liver fibrosis progression in patients with chronic hepatitis C in Japan
    • Hamada H, Yatsuhashi H, Yano K, et al. Interleukin-10 promoter polymorphisms and liver fibrosis progression in patients with chronic hepatitis C in Japan. J Hepatol 2003;39:457-458
    • (2003) J Hepatol , vol.39 , pp. 457-458
    • Hamada, H.1    Yatsuhashi, H.2    Yano, K.3
  • 101
    • 17144459376 scopus 로고    scopus 로고
    • A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease
    • Muhlbauer M, Bosserhoff AK, Hartmann A, et al. A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease. Gastroenterology 2003;125:1085-1093
    • (2003) Gastroenterology , vol.125 , pp. 1085-1093
    • Muhlbauer, M.1    Bosserhoff, A.K.2    Hartmann, A.3
  • 103
    • 2342642869 scopus 로고    scopus 로고
    • Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication
    • Goh PY, Tan YJ, Lim SP, et al. Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication. J Virol 2004;78:5288-5298
    • (2004) J Virol , vol.78 , pp. 5288-5298
    • Goh, P.Y.1    Tan, Y.J.2    Lim, S.P.3
  • 104
    • 0345017740 scopus 로고    scopus 로고
    • Sampling variability of liver fibrosis in chronic hepatitis C
    • Bedossa P, Dargere D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003;38: 1449-1457
    • (2003) Hepatology , vol.38 , pp. 1449-1457
    • Bedossa, P.1    Dargere, D.2    Paradis, V.3
  • 105
    • 0035120328 scopus 로고    scopus 로고
    • Differential gene expression between chronic hepatitis B and C hepatic lesion
    • Honda M, Kaneko S, Kawai H, et al. Differential gene expression between chronic hepatitis B and C hepatic lesion. Gastroenterology 2001;120:955-966
    • (2001) Gastroenterology , vol.120 , pp. 955-966
    • Honda, M.1    Kaneko, S.2    Kawai, H.3
  • 106
    • 0036172292 scopus 로고    scopus 로고
    • Insights into the pathobiology of hepatitis C virus-associated cirrhosis: Analysis of intrahepatic differential gene expression
    • Shackel NA, McGuinness PH, Abbott CA, et al. Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression. Am J Pathol 2002;160:641-654
    • (2002) Am J Pathol , vol.160 , pp. 641-654
    • Shackel, N.A.1    McGuinness, P.H.2    Abbott, C.A.3
  • 107
    • 0344155169 scopus 로고    scopus 로고
    • Hepatitis C virus and liver disease global transcriptional profiling and identification of potential markers
    • Smith MW, Yue ZN, Korth MJ, et al. Hepatitis C virus and liver disease global transcriptional profiling and identification of potential markers. Hepatology 2003;38: 1458-1467
    • (2003) Hepatology , vol.38 , pp. 1458-1467
    • Smith, M.W.1    Yue, Z.N.2    Korth, M.J.3
  • 108
    • 0036905805 scopus 로고    scopus 로고
    • Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosis
    • Neuman MG, Benhamou JP, Malkiewicz IM, et al. Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosis. J Viral Hepat 2002; 9:134-140
    • (2002) J Viral Hepat , vol.9 , pp. 134-140
    • Neuman, M.G.1    Benhamou, J.P.2    Malkiewicz, I.M.3
  • 109
    • 0038580440 scopus 로고    scopus 로고
    • A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy
    • Pockros PJ, Patel K, O'Brien C, et al. A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy. Hepatology 2003;37:1368-1374
    • (2003) Hepatology , vol.37 , pp. 1368-1374
    • Pockros, P.J.1    Patel, K.2    O'Brien, C.3
  • 110
    • 15644380122 scopus 로고    scopus 로고
    • Long term histologic improvement and disappearance of intra hepatic HCV RNA after alpha interferon therapy in patients with chronic hepatitis C
    • Marcellin P, Boyer N, Gervais A, et al. Long term histologic improvement and disappearance of intra hepatic HCV RNA after alpha interferon therapy in patients with chronic hepatitis C. Ann Intern Med 1997;127:875-881
    • (1997) Ann Intern Med , vol.127 , pp. 875-881
    • Marcellin, P.1    Boyer, N.2    Gervais, A.3
  • 111
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with IFN-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with IFN-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958-965
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 112
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975-982
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 113
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
    • Hadziyannis SJ, Sette H Jr, ,Morgan TR, et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004;140:346-355
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette Jr, H.2    Morgan, T.R.3
  • 114
    • 0032213578 scopus 로고    scopus 로고
    • Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferon-resistant hepatitis C virus infection in Japanese patients
    • Matsushita M, Hijikata M, Ohta Y, Mishiro S. Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferon-resistant hepatitis C virus infection in Japanese patients. J Hepatol 1998;29:695-700
    • (1998) J Hepatol , vol.29 , pp. 695-700
    • Matsushita, M.1    Hijikata, M.2    Ohta, Y.3    Mishiro, S.4
  • 115
    • 0032769836 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alpha
    • Edwards-Smith CJ, Jonsson JR, Purdie DM, et al. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alpha. Hepatology 1999; 30:526-530
    • (1999) Hepatology , vol.30 , pp. 526-530
    • Edwards-Smith, C.J.1    Jonsson, J.R.2    Purdie, D.M.3
  • 116
    • 0035123858 scopus 로고    scopus 로고
    • Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection
    • Yee LJ, Tang J, Gibson AW, et al. Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection. Hepatology 2001;33:708-712
    • (2001) Hepatology , vol.33 , pp. 708-712
    • Yee, L.J.1    Tang, J.2    Gibson, A.W.3
  • 117
    • 0036087591 scopus 로고    scopus 로고
    • HFE gene mutations prevent sustained virological response to interferon plus ribavirin in chronic hepatitis C patients with serum markers of iron overload
    • Coelho-Borges S, Cheinquer H, Cheinquer N, et al. HFE gene mutations prevent sustained virological response to interferon plus ribavirin in chronic hepatitis C patients with serum markers of iron overload. Am J Gastroenterol 2002;97:1570-1572
    • (2002) Am J Gastroenterol , vol.97 , pp. 1570-1572
    • Coelho-Borges, S.1    Cheinquer, H.2    Cheinquer, N.3
  • 118
    • 0037661445 scopus 로고    scopus 로고
    • Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection
    • Hennig BJ, Hellier S, Frodsham AJ, et al. Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection. Genes Immun 2002;3:359-367
    • (2002) Genes Immun , vol.3 , pp. 359-367
    • Hennig, B.J.1    Hellier, S.2    Frodsham, A.J.3
  • 119
    • 0036126282 scopus 로고    scopus 로고
    • Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C
    • Rosen HR, McHutchison JG, Conrad AJ, et al. Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C. Am J Gastroenterol 2002;97:714-720
    • (2002) Am J Gastroenterol , vol.97 , pp. 714-720
    • Rosen, H.R.1    McHutchison, J.G.2    Conrad, A.J.3
  • 120
    • 0036172224 scopus 로고    scopus 로고
    • Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-beta1 genes in chronic hepatitis C patients treated with interferon and ribavirin
    • Vidigal PG, Germer JJ, Zein NN. Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-beta1 genes in chronic hepatitis C patients treated with interferon and ribavirin. J Hepatol 2002;36:271-277
    • (2002) J Hepatol , vol.36 , pp. 271-277
    • Vidigal, P.G.1    Germer, J.J.2    Zein, N.N.3
  • 121
    • 0036304385 scopus 로고    scopus 로고
    • Differential expansion of T-cell receptor variable beta subsets after antigenic stimulation in patients with different outcomes of hepatitis C infection
    • Woitas RP, Sippel M, Althausen EM, et al. Differential expansion of T-cell receptor variable beta subsets after antigenic stimulation in patients with different outcomes of hepatitis C infection. Immunology 2002;106:419-427
    • (2002) Immunology , vol.106 , pp. 419-427
    • Woitas, R.P.1    Sippel, M.2    Althausen, E.M.3
  • 122
    • 19044361835 scopus 로고    scopus 로고
    • Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection
    • Chen L, Borozan I, Feld J, et al. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology 2005;128:1437-1444
    • (2005) Gastroenterology , vol.128 , pp. 1437-1444
    • Chen, L.1    Borozan, I.2    Feld, J.3
  • 123
    • 22444450656 scopus 로고    scopus 로고
    • Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients
    • Hayashida K, Daiba A, Sakai A, et al. Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. Clin Gastroenterol Hepatol 2005;3:1253-1259
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 1253-1259
    • Hayashida, K.1    Daiba, A.2    Sakai, A.3
  • 124
    • 0037369731 scopus 로고    scopus 로고
    • Interferon alfa regulated gene expression in patients initiating interferon treatment for chronic hepatitis C
    • Ji X, Cheung R, Cooper S, et al. Interferon alfa regulated gene expression in patients initiating interferon treatment for chronic hepatitis C. Hepatology 2003;37:610-621
    • (2003) Hepatology , vol.37 , pp. 610-621
    • Ji, X.1    Cheung, R.2    Cooper, S.3
  • 125
    • 23744481169 scopus 로고    scopus 로고
    • Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C
    • Butera D, Marukian S, Iwamaye AE, et al. Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C. Blood 2005;106:1175-1182
    • (2005) Blood , vol.106 , pp. 1175-1182
    • Butera, D.1    Marukian, S.2    Iwamaye, A.E.3
  • 126
    • 33645463194 scopus 로고    scopus 로고
    • Multiplexed protein measurement: Technologies and applications of protein and antibody arrays
    • Kingsmore SF. Multiplexed protein measurement: technologies and applications of protein and antibody arrays. Nat Rev Drug Discov 2006;5:310-320
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 310-320
    • Kingsmore, S.F.1
  • 127
    • 19944419128 scopus 로고    scopus 로고
    • Proteome analysis of liver cells expressing a full-length hepatitis C virus replicon and biopsy specimens of posttransplantation liver from HCV-infected patients
    • Jacobs JM, Diamond DL, Chan EY, et al. Proteome analysis of liver cells expressing a full-length hepatitis C virus replicon and biopsy specimens of posttransplantation liver from HCV-infected patients. J Virol 2005;79:7558-7569
    • (2005) J Virol , vol.79 , pp. 7558-7569
    • Jacobs, J.M.1    Diamond, D.L.2    Chan, E.Y.3
  • 128
    • 10644250718 scopus 로고    scopus 로고
    • A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers
    • Low TY, Leow CK, Salto-Tellez M, et al. A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. Proteomics 2004;4:3960-3974
    • (2004) Proteomics , vol.4 , pp. 3960-3974
    • Low, T.Y.1    Leow, C.K.2    Salto-Tellez, M.3
  • 129
    • 0033866513 scopus 로고    scopus 로고
    • Proteome analysis of rat hepatic stellate cells
    • Kristensen DB, Kawada N, Imamura K, et al. Proteome analysis of rat hepatic stellate cells. Hepatology 2000;32: 268-277
    • (2000) Hepatology , vol.32 , pp. 268-277
    • Kristensen, D.B.1    Kawada, N.2    Imamura, K.3
  • 130
    • 5644221313 scopus 로고    scopus 로고
    • Molecular classification of liver cirrhosis in a rat model by proteomics and bioinformatics
    • Xu XQ, Leow CK, Lu X, et al. Molecular classification of liver cirrhosis in a rat model by proteomics and bioinformatics. Proteomics 2004;4:3235-3245
    • (2004) Proteomics , vol.4 , pp. 3235-3245
    • Xu, X.Q.1    Leow, C.K.2    Lu, X.3
  • 131
    • 12944295220 scopus 로고    scopus 로고
    • Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: A pilot study
    • Poon TC, Hui AY, Chan HL, et al. Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: a pilot study. Clin Chem 2005;51:328-335
    • (2005) Clin Chem , vol.51 , pp. 328-335
    • Poon, T.C.1    Hui, A.Y.2    Chan, H.L.3
  • 132
    • 33744521643 scopus 로고    scopus 로고
    • Serum proteome to predict virologic response in patients with hepatitis C treated by pegylated interferon plus ribavirin
    • Paradis V, Asselah T, Dargere D, et al. Serum proteome to predict virologic response in patients with hepatitis C treated by pegylated interferon plus ribavirin. Gastroenterology 2006;130:2189-2197
    • (2006) Gastroenterology , vol.130 , pp. 2189-2197
    • Paradis, V.1    Asselah, T.2    Dargere, D.3


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