Characterization of ion transport mechanisms regulating intracellular pH in hepatic stellate cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 1 36-1, 1997, Pages

  Di Sario, Antonio ^a   Baroni, Gianluca Svegliati ^a   Bendia, Emanuele ^a   D'Ambrosio, Letizia ^a   Ridolfi, Francesco ^a   Marileo, Julio Ricardo ^a   Jezequel, Anne Marie ^a   Benedetti, Antonio ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Activated hepatic stellate cells; Amiloride; Nonactivated hepatic stellate cells; Platelet derived growth factor; Sodium hydrogen exchanger

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; AMILORIDE; ANTIPORTER; BICARBONATE; ION; PLATELET DERIVED GROWTH FACTOR; SODIUM;

ANIMAL CELL; ARTICLE; CELL PH; CONTROLLED STUDY; ION TRANSPORT; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; STELLATE CELL;

EID: 0030841159     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.1.g39     Document Type: Article

References (29)

1. Alvaro, D., P. Della Guardia, A. Bini, A. Gigliozzi, S. Furfaro, T. La Rosa, C. Piat, and L. Capocaccia. Effect of glucagon on intracellular pH regulation in isolated rat hepatocyte couplets. J. Clin. Invest. 96: 665-675, 1995.
2. Bachem, M. G., D. Meyer, R. Melchior, K. M. Sell, and A. M. Gressner. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. J. Clin. Invest. 89: 19-27, 1992.
3. Baliga, B. S., L. J. Sindel, L. D. Jenkins, S. Rashatwar, and M. Artman. Inhibition of T-lymphocyte activation by amiloride. J. Cell. Biochem. 33: 151-160, 1987.
4. 1 increases the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes. Hepatology 22: 1488-1498, 1995.
5. - exchanger in rat hepatocytes. Proc. Natl. Acad. Sci. USA 91: 792-796, 1994.
6. Benedetti, A., G. Svegliati Baroni, L. Marucci, R. Mancini, A. M. Jezequel, and F. Orlandi. Regulation of intracellular pH in isolated periportal and perivenular rat hepatocytes. Gastroenterology 105: 1797-1805, 1993.
7. Blaner, W. S. Retinoid (vitamin A) metabolism and the liver. In: The Liver: Biology and Pathobiology, edited by I. M. Arias, J. L. Boyer, N. Fausto, W. B. Jakoby, D. A. Schachter, and D. A. Shafritz. New York: Raven, 1994, p. 529-541.
8. i. Am. J. Physiol. 246 (Regulatory Integrative Comp. Physiol. 15): R409-R438, 1984.
9. + exchange and induces cytoplasmic alkalinization in NR6 cells. Proc. Natl. Acad. Sci. USA 80: 6224-6228, 1983.
10. Friedman, S. L. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med. 328: 1828-1835, 1993.
11. Geerts, A., R. Vrijsen, J. Rauterberg, A. Burt, P. Schellinck, and E. Wisse. In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion. J. Hepatol. 9: 59-68, 1989.
12. Gressner, A. M., and M. G. Bachem. Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis. Semin. Liver Dis. 10: 30-46, 1990.
13. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim. Biophys. Acta 988: 73-97, 1989.
14. + exchange activity by insulin and EGF. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G364-G370, 1994.
15. Kleyman, T. R., and E. J. Cragoe. Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol. 105: 1-21, 1988.
16. Koch, K. S., and H. L. Leffert. Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation. Cell 18: 153-163, 1979.
17. Li, J. J., C. I. Kin, M. A. Leo, R. M. Mak, M. Rojkind, and C. S. Lieber. Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes. Hepatology 15: 373-381, 1992.
18. Moolenaar, W. H. Effects of growth factors on intracellular pH regulation. Annu. Rev. Physiol. 48: 363-376, 1986.
19. Moshage, H., A. Casini, and C. S. Lieber. Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology 12: 511-518, 1990.
20. Pinzani, M., P. Gentilini, and H. E. Abboud. Phenotypical modulation of liver fat-storing cells by retinoids. Influence of unstimulated and growth factor-induced cell proliferation. J. Hepatol. 14: 211-220, 1992.
21. Pinzani, M., L. Gesualdo, G. M. Sabbah, and H. E. Abboud. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J. Clin. Invest. 84: 1786-1793, 1989.
22. Pinzani, M., S. Milani, C. Grappone, F. L. Weber, P. Gentilini, and H. E. Abboud. Expression of platelet-derived growth factor in a model of acute liver injury. Hepatology 19: 701-707, 1994.
23. + antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. Proc. Natl. Acad. Sci. USA 81: 4833-4837, 1984.
24. + antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization. Proc. Natl. Acad. Sci. USA 79: 7778-7782, 1982.
25. Strazzabosco, M., A. Mennone, and J. L. Boyer. Intracellular pH regulation in isolated rat bile duct epithelial cells. J. Clin. Invest. 87: 1503-1512, 1991.
26. + exchange activity. Hepatology 22: 588-597, 1995.
27. Svegliati Baroni, G., L. D'Ambrosio, P. Curto, A. Casini, R. Mancini, A. M. Jezequel, and A. Benedetti. Interferon-γ decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology 23: 1189-1199, 1996.
28. Takase, S., M. A. Leo, T. Nouchi, and C. S. Lieber. Desmin distinguishes fat-storing cells from myofibroblasts, smooth muscle cells and fibroblasts in rat. J. Hepatol. 6: 267-276, 1988.
29. + antiport inhibitors. J. Biol. Chem. 267: 19043-19046, 1992.