Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: Implications for wound healing and fibrogenesis

Cell Death and Differentiation

Volumn 14, Issue 2, 2007, Pages 275-285

  Mann, J ^a   Oakley, F ^a   Akiboye, F ^a   Elsharkawy, A ^a   Thorne, A W ^b   Mann, D A ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA; I KAPPA B ALPHA; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA METHYLATION; DRUG ACTIVITY; FIBROGENESIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER DISEASE; LIVER FIBROSIS; LIVER INJURY; MALE; MYOFIBROBLAST; NONHUMAN; PHARMACOLOGICAL BLOCKING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; STELLATE CELL; WOUND HEALING;

ANIMALS; AZACITIDINE; CELL DIFFERENTIATION; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FIBROBLASTS; HEPATOCYTES; HUMANS; I-KAPPA B PROTEINS; LIVER; LIVER CIRRHOSIS; MALE; METHYL-CPG-BINDING PROTEIN 2; MICE; MODELS, GENETIC; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; WOUND HEALING;

EID: 33846200332     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401979     Document Type: Article

References (39)

1. Desmouliere A, Chaponnier C, Gabbiani G. Tissue repair, contraction and the myofibroblast. Wound Repair Regen 2005; 13: 7-12.
2. Desmouliere A, Darby IA, Gabbiani G. Normal and pathological soft tissue remodeling: Role of the myofibroblast, with specific emphasis on liver and kidney fibrosis. Lab Invest 2003; 83: 1689-1707.
3. Thannickal VJ, Toews GB, White ES, Lynch III JP, Martinez FJ. Mechanisms of pulmonary fibrosis. Annu Rev Med 2004; 55: 395-417.
4. Apte MV, Wilson JS. Mechanisms of pancreatic fibrosis. Dig Dis 2004; 22: 272-279.
5. Wheeler MT, McNally EM. The interaction of coronary tone and cardiac fibrosis. Curr Atheroscler Rep 2005; 7: 219-226.
6. Desmouliere A, Guyot C, Gabbiani G. The stroma reaction myofibroblast: A key player in the control of tumor cell behaviour. Int J Dev Biol 2004; 48: 509-517.
7. Mann DA, Smart DE. Transcriptional regulation of hepatic stellate cell activation. Gut 2002; 50: 891-896.
8. Burke ZD, Tosh D. Therapeutic potential of transdifferentiated cells. Clin Sci (London) 2005; 108: 309-321.
9. Fuja TJ, Probst-Fuja MN, Titze IR. Transdifferentiation of vocal-fold stellate cells and all-trans retinol-induced deactivation. Cell Tissue Res 2005; 27: 1-8.
10. Benyon RC, Arthur MJ. Extracellular matrix degadation and the role of hepatic stellate cells. Semin Liver Dis 2001; 21: 373-384.
11. Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X et al. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 2005; 128: 108-120.
12. Sancho-Bru P, Bataller R, Gasull X, Colmenero J, Khurdayan V, Gual A et al. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005; 43: 272-282.
13. Kristensen DB, Kawada N, Imamura K, Miyamoto Y, Tateno C, Seki S et al. Proteome analysis of rat hepatic stellate cells. Hepatology 2000; 32: 268-277.
14. Marra F, Valante AJ, Pinzani M, Abboud HE. Cultured human liver fat-storing cells produce monocyte chemotactic protein-1: Regulation by pro-inflammatory cytokines. J Clin Invest 1993; 92: 1674-1680.
15. Sprenger H, Kaufmann A, Garn H, Lahme B, Gemsa D, Gressner AM. Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells. Gastroenterology 1997; 113: 277-285.
16. Oakley F, Mann J, Nailard S, Smart DE, Mungalsingh N, Constandinou C et al. Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. Am J Pathol 2005; 166: 695-708.
17. Pinzani M, Marra F. Cytokine receptors and signalling in hepatic stellate cells. Semin Liver Dis 2001; 21: 397-416.
18. Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania F. The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Path 2005; 166: 1655-1669.
19. Massy ZA, Guijarro C, O'Donnell MP, Kim Y, Kashtan CE, Egido J et al. The central role of nuclear factor-kappa B in mesangial cell activation. Kidney Int Suppl 1999; 71: S76-S79.
20. Masamune A, Kikuta K, Satoh M, Sakai Y, Satoh A, Shimosegawa T. Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells. J Biol Chem 2002; 277: 141-147.
21. Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M et al. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: Implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2005; 288: L1146-L1153.
22. Fitzner B, Sparmann G, Emmrich J, Liebe S, Jaster R. Involvement of AP-1 proteins in pancreatic stellate cell activation in vitro. Int J Colorectal Dis 2004; 19: 414-420.
23. Jaenisch R, Bird A. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet Suppl 2003; 33: 245-254.
24. Margueron R, Trojer P, Reinberg D. The key to development: Interpreting the histone code? Curr Opin Genet Dev 2005; 15: 163-176.
25. Xu L, Hui AY, Albanis E, Arthur MJ, O'Byrne SM, Blaner WS et al. Human hepatic stellate cell lines, LX-1 and LX-2: New tools for analysis of hepatic fibrosis. Gut 2005; 54: 142-151.
26. Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA. Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF-1) and its activator Notch1. J Biol Chem 2003; 278: 24359-24370.
27. Kadesch T. Notch signaling: The demise of elegant simplicity. Curr Opin Genet Dev 2004; 14: 506-512.
28. Nofziger D, Miyamoto A, Lyons KM, Weinmaster G. Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development 1999; 126: 1689-1702.
29. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A et al. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet 2003; 33: 61-65.
30. Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T et al. 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 2005; 25: 4727-4741.
31. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 1999; 23: 185-188.
32. Tudor M, Akbarian S, Chen RZ, Jaenisch R. Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci USA 2002; 26: 15536-15541.
33. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 2003; 302: 885-889.
34. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y et al. DNA methylation-related chromatin remodelling in activity-dependent BDNF gene regulation. Science 2003; 302: 890-893.
35. She H, Xiong S, Hazra S, Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem 2005; 280: 4959-4967.
36. Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T et al. The Ski protein family is required for MeCP2-mediated transcriptional repression. J Biol Chem 2001; 276: 34115-34121.
37. Stancheva I, Collins AL, Van den Veyver IB, Zoghbi H, Meehan RR. A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos. Mol Cell 2003; 12: 425-435.
38. Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet 2005; 37: 31-40.
39. Iredale JP, Goddard S, Murphy G, Benyon RC, Arthur MJ. Tissue inhibitor of metalloproteinases-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin Sci (London) 1995; 89: 75-81.