Signal transduction by the chemokine receptor CXCR3: Activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 9945-9954

  Bonacchi, Andrea ^a   Romagnani, Paola ^a   Romanelli, Roberto G ^a   Efsen, Eva ^a   Annunziato, Francesco ^a   Lasagni, Laura ^a   Francalanci, Michela ^a   Serio, Mario ^a   Laffi, Giacomo ^a   Pinzani, Massimo ^a   Gentilini, Paolo ^a   Marra, Fabio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; DNA; ENZYME KINETICS;

CELL MIGRATION;

ENZYMES;

CHEMOKINE RECEPTOR CXCR3; DNA; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAS PROTEIN; WORTMANNIN; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 5(4' HYDROXYBENZYLIDENOIMINO) 3 METHYLISOTHIAZOLO(5,4 D)PYRIMIDINE (7H) 4,6 DIONE; 5(4'-HYDROXYBENZYLIDENOIMINO)-3-METHYLISOTHIAZOLO(5,4-D)PYRIMIDINE-(7H)-4,6-DIONE; AKT1 PROTEIN, HUMAN; ANDROSTANE DERIVATIVE; ANTINEOPLASTIC AGENT; CHEMOKINE RECEPTOR; CXC CHEMOKINE RECEPTOR 3; ENZYME INHIBITOR; FLAVONOID; LIGAND; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; PYRIMIDINONE DERIVATIVE; RECOMBINANT PROTEIN; THIAZOLE DERIVATIVE;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MESANGIUM CELL; MITOGENESIS; PERICYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STELLATE CELL; TISSUE REPAIR; BIOSYNTHESIS; BLOOD VESSEL; CELL CULTURE; CELL DIVISION; CELL MOTION; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; FLOW CYTOMETRY; LIVER; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; TIME; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANTINEOPLASTIC AGENTS; BLOOD VESSELS; BLOTTING, WESTERN; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; FLOW CYTOMETRY; GENISTEIN; HUMANS; LIGANDS; LIVER; MITOGEN-ACTIVATED PROTEIN KINASES; PERICYTES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINONES; RAS PROTEINS; RECEPTORS, CHEMOKINE; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; THIAZOLES; TIME FACTORS;

EID: 0035971215     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010303200     Document Type: Article

References (51)

1. Collins, T. (1999) Robbin's Pathological Basis of Disease, 6th Ed., pp. 50-88, W. B. Saunders, Philadelphia
2. Abboud, H. E. (1995) Annu. Rev. Physiol. 57, 297-309
3. Friedman, S. L. (2000) J. Biol. Chem. 275, 2247-2250
4. Luster, A. D. (1998) N. Engl. J. Med. 338, 436-445
5. Rossi, D., and Zlotnik, A. (2000) Annu. Rev. Immunol. 18, 217-242
6. Romagnani, P., Beltrame, C., Annunziato, F., Lasagni, L., Luconi, M., Galli, G., Cosmi, L., Maggi, E., Salvadori, M., Pupilli, C., and Serio, M. (1999) J. Am. Soc. Nephrol. 10, 2518-2526
7. Marra, F., DeFranco, R., Grappone, C., Milani, S., Pastacaldi, S., Pinzani, M., Romanelli, R. G., Laffi, G., and Gentilini, P. (1998) Am. J. Pathol. 152, 423-430
8. Gharaee-Kermani, M., Denholm, E. M., and Phan, S. H. (1996) J. Biol. Chem. 271, 17779-17784
9. Wang, X., Yue, T. L., Ohlstein, E. H., Sung, C. P., and Feuerstein, G. Z. (1996) J. Biol. Chem. 271, 24286-24293
10. Schecter, A. D., Rollins, B. J., Zhang, Y. J., Charo, I. F., Fallon, J. T., Rossikhina, M., Giesen, P. L., Nemerson, Y., and Taubman, M. B. (1997) J. Biol. Chem. 272, 28568-28573
11. Marra, F., Romanelli, R. G., Giannini, C., Failli, P., Pastacaldi, S., Arrighi, M. C., Pinzani, M., Laffi, G., Montalto, P., and Gentilini, P. (1999) Hepatology 29, 140-148
12. Banas, B., Luckow, B., Moller, M., Klier, C., Nelson, P. J., Schadde, E., Brigl, M., Halevy, D., Holthofer, H., Reinhart, B., and Schlondorff, D. (1999) J. Am. Soc. Nephrol. 10, 2314-2322
13. Schecter, A. D., Calderon, T. M., Berman, A. B., McManus, C. M., Fallon, J. T., Rossikhina, M., Zhao, W., Christ, G., Berman, J. W., and Taubman, M. B. (2000) J. Biol. Chem. 275, 5466-5471
14. Piali, L., Weber, C., LaRosa, G., Mackay, C. R., Springer, T. A., Clark-Lewis, I., and Moser, B. (1998) Eur. J. Immunol. 28, 961-972
15. Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., Sahagan, B. G., and Neote, K. (1998) J. Exp. Med. 187, 2009-2021
16. Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., Clark-Lewis, I., Baggiolini, M., and Moser, B. (1996) J. Exp. Med. 184, 963-969
17. Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A., and Sinigaglia, F. (1998) J. Exp. Med. 187, 129-134
18. Casini, A., Pinzani, M., Milani, S., Grappone, C., Galli, G., Jezequel, A. M., Schuppan, D., Rotella, C. M., and Surrenti, C. (1993) Gastroenterology 105, 245-253
19. Pupilli, C., Lasagni, L., Romagnani, P., Bellini, F., Mannelli, M., Misciglia, N., Mavilia, C., Vellei, U., Villari, D., and Serio, M. (1999) J. Am. Soc. Nephrol. 10, 245-255
20. Pinzani, M., Gesualdo, L., Sabbah, G. M., and Abboud, H. E. (1989) J. Clin. Invest. 84, 1786-1793
21. Marra, F., Efsen, E., Romanelli, R. G., Caligiuri, A., Pastacaldi, S., Batignani, G., Bonacchi, A., Caporale, R., Laffi, G., Pinzani, M., and Gentilini, P. (2000) Gastroenterology 119, 466-478
22. Choudhury, G. G., Wang, L. M., Pierce, J., Harvey, S. A., and Sakaguchi, A. Y. (1991) J. Biol. Chem. 266, 8068-8072
23. Marra, F., Choudhury, G. G., and Abboud, H. E. (1996) J. Clin. Invest. 98, 1218-1230
24. deRooij, J., and Bos, J. L. (1997) Oncogene 14, 623-625
25. Ishida, M., Marrero, M. B., Schieffer, B., Ishida, T., Bernstein, K. E., and Berk, B. C. (1995) Circ. Res. 77, 1053-1059
26. Robino, G., Parola, M., Marra, F., Caligiuri, A., DeFranco, R. M., Zamara, E., Bellomo, G., Gentilini, P., Pinzani, M., and Dianzani, M. U. (2000) J. Biol. Chem. 275, 40561-40567
27. Venkatakrishnan, G., Salgia, R., and Groopman, J. (2000) J. Biol. Chem. 275, 6868-6875
28. Treisman, R. (1996) Curr. Opin. Cell Biol. 8, 205-215
29. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A., and Schlessinger, J. (1996) Nature 383, 547-550
30. Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Genes Dev. 13, 2905-2927
31. Romashkova, J. A., and Makarov, S. S. (1999) Nature 401, 86-90
32. Luttrell, L. M., Hawes, B. E., van Biesen, T., Luttrell, D. K., Lansing, T. J., and Lefkowitz, R. J. (1996) J. Biol. Chem. 271, 19443-19450
33. Hawes, B. E., Luttrell, L. M., van Biesen, T., and Lefkowitz, R. J. (1996) J. Biol. Chem. 271, 12133-12136
34. Gutkind, J. S. (1998) J. Biol. Chem. 273, 1839-1842
35. Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., and Connelly, P. A. (1996) J. Biol. Chem. 271, 695-701
36. Daub, H., Weiss, F. U., Wallasch, C., and Ullrich, A. (1996) Nature 379, 557-560
37. Cunnick, J. M., Dorsey, J. F., Standley, T., Turkson, J., Kraker, A. J., Fry, D. W., Jove, R., and Wu, J. (1998) J. Biol. Chem. 273, 14468-14475
38. Levitzki, A., and Gazit, A. (1995) Science 267, 1782-1788
39. Marra, F., Arrighi, M. C., Fazi, M., Caligiuri, A., Pinzani, M., Romanelli, R. G., Efsen, E., Laffi, G., and Gentilini, P. (1999) Hepatology 30, 951-958
40. Shields, P. L., Morland, C. M., Salmon, M., Qin, S., Hubscher, S. G., and Adams, D. H. (1999) J. Immunol. 163, 6236-6243
41. Tilton, B., Ho, L., Oberlin, E., Loetscher, P., Baleux, F., Clark-Lewis, I., and Thelen, M. (2000) J. Exp. Med. 192, 313-324
42. Aronica, S. M., Gingras, A. C., Sonenberg, N., Cooper, S., Hague, N., and Broxmeyer, H. E. (1997) Blood 89, 3582-3595
43. Wymann, M. P., and Pirola, L. (1998) Biochim. Biophys. Acta 1436, 127-150
44. Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., and Downward, J. (1994) Nature 370, 527-532
45. Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Science 268, 100-102
46. Ghosh Choudhury, G., Karamitsos, C., Hernandez, J., Gentilini, A., Bardgette, J., and Abboud, H. E. (1997) Am. J. Physiol. 273, F931-F938
47. Marra, F., Gentilini, A., Pinzani, M., Ghosh Choudhury, G., Parola, M., Herbst, H., Dianzani, M. U., Laffi, G., Abboud, H. E., and Gentilini, P. (1997) Gastroenterology 112, 1297-1306
48. Tamemoto, H., Kadowaki, T., Tobe, K., Ueki, K., Izumi, T., Chatani, Y., Kohno, M., Kasuga, M., Yazaki, Y., and Akanuma, Y. (1992) J. Biol. Chem. 267, 20293-20297
49. Wright, J. H., Munar, E., Jameson, D. R., Andreassen, P. R., Margolis, R. L., Seger, R., and Krebs, E. G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11335-11340
50. Holdsworth, S. R., Kitching, A. R., and Tipping, P. G. (1999) Kidney Int. 55, 1198-1216
51. Romagnani, P., Annunziato, F., Lasagni, L., Lazzeri, E., Beltrame, C., Francalanci, M., Uguccioni, M., Galli, G., Cosmi, L., Maurenzig, L., Baggiolini, M., Maggi, E., Romagnani, S., and Serio, M. (2001) J. Clin. Invest. 107, 53-63