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Volumn 117, Issue 3, 2007, Pages 539-548

Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELL CULTURE; HUMAN; INFLAMMATION; INNATE IMMUNITY; LIVER FIBROSIS; LIVER INJURY; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; T LYMPHOCYTE; TISSUE REPAIR;

EID: 33847363203     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI30542     Document Type: Review
Times cited : (749)

References (120)
  • 1
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis - from bench to bedside
    • Friedman, S.L. 2003. Liver fibrosis - from bench to bedside. J. Hepatol. 38(Suppl. 1):S38-S53.
    • (2003) J. Hepatol , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 3
    • 0038455747 scopus 로고    scopus 로고
    • Cirrhosis: New research provides a basis for rational and targeted treatments
    • Iredale, J.P. 2003. Cirrhosis: new research provides a basis for rational and targeted treatments. BMJ. 327:143-147.
    • (2003) BMJ , vol.327 , pp. 143-147
    • Iredale, J.P.1
  • 5
    • 85035392112 scopus 로고    scopus 로고
    • Liver fibrosis
    • doi:10.1172/JCI200524282
    • Bataller, R., and Brenner, D.A. 2005. Liver fibrosis. J. Clin. Invest. 115:209-231. doi:10.1172/JCI200524282.
    • (2005) J. Clin. Invest , vol.115 , pp. 209-231
    • Bataller, R.1    Brenner, D.A.2
  • 6
    • 0035019334 scopus 로고    scopus 로고
    • Hepatic fibrosis. Pathogenesis and principles of therapy
    • Albanis, E., and Friedman, S.L. 2001. Hepatic fibrosis. Pathogenesis and principles of therapy. Clin. Liver Dis. 5:315-334, v-vi.
    • (2001) Clin. Liver Dis , vol.5
    • Albanis, E.1    Friedman, S.L.2
  • 7
    • 0034809414 scopus 로고    scopus 로고
    • Hepatic stellate cell behaviour during resolution of liver fibrosis
    • Iredale, J.P. 2001. Hepatic stellate cell behaviour during resolution of liver fibrosis. Semin. Liver Dis. 21:427-436.
    • (2001) Semin. Liver Dis , vol.21 , pp. 427-436
    • Iredale, J.P.1
  • 8
    • 0001520008 scopus 로고
    • Hepatic lipocytes: The principal collagen-producing cells of normal rat liver
    • Friedman, S.L., Roll, F.J., Boyles, J., and Bissell, D.M. 1985. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc. Natl. Acad. Sci. U. S. A. 82:8681-8685.
    • (1985) Proc. Natl. Acad. Sci. U. S. A , vol.82 , pp. 8681-8685
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Bissell, D.M.4
  • 9
    • 0034808310 scopus 로고    scopus 로고
    • History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells
    • Geerts, A. 2001. History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin. Liver Dis. 21:311-335.
    • (2001) Semin. Liver Dis , vol.21 , pp. 311-335
    • Geerts, A.1
  • 10
    • 0026537533 scopus 로고
    • Isolated hepatic lipocytes and Kupffer cells from normal human liver: Morphological and functional characteristics in primary culture
    • Friedman, S.L., et al. 1992. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology. 15:234-243.
    • (1992) Hepatology , vol.15 , pp. 234-243
    • Friedman, S.L.1
  • 11
    • 0026775513 scopus 로고
    • Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients
    • Pinzani, M., et al. 1992. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J. Clin. Invest. 90:642-646.
    • (1992) J. Clin. Invest , vol.90 , pp. 642-646
    • Pinzani, M.1
  • 12
    • 0018863008 scopus 로고
    • Isolation of a lipocyte-rich fraction from rat liver nonparenchymal cells
    • Otto, D.A., and Veech, R.L. 1980. Isolation of a lipocyte-rich fraction from rat liver nonparenchymal cells. Adv. Exp. Med. Biol. 132:509-517.
    • (1980) Adv. Exp. Med. Biol , vol.132 , pp. 509-517
    • Otto, D.A.1    Veech, R.L.2
  • 13
    • 0030030039 scopus 로고    scopus 로고
    • Increased expression of tissue inhibitor of metalloproteinases-1 and -2 relative to interstitial collagenase in fibrotic human liver
    • Benyon, R.C., Iredale, J.P., Goddard, S., Winwood, P.J., and Arthur, M.J.P. 1996. Increased expression of tissue inhibitor of metalloproteinases-1 and -2 relative to interstitial collagenase in fibrotic human liver. Gastroenterology. 110:821-831.
    • (1996) Gastroenterology , vol.110 , pp. 821-831
    • Benyon, R.C.1    Iredale, J.P.2    Goddard, S.3    Winwood, P.J.4    Arthur, M.J.P.5
  • 14
    • 0033749190 scopus 로고    scopus 로고
    • Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis
    • Wanless, I.R., Nakashima, E., and Sherman, M. 2000. Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis. Arch. Pathol. Lab. Med. 124:1599-1607.
    • (2000) Arch. Pathol. Lab. Med , vol.124 , pp. 1599-1607
    • Wanless, I.R.1    Nakashima, E.2    Sherman, M.3
  • 15
    • 0030692704 scopus 로고    scopus 로고
    • Reversibility of hepatic fibrosis is autoimmune hepatitis
    • Dufour, J.F., DeLellis, R., and Kaplan, M.M. 1997. Reversibility of hepatic fibrosis is autoimmune hepatitis. Ann. Intern. Med. 127:981-985.
    • (1997) Ann. Intern. Med , vol.127 , pp. 981-985
    • Dufour, J.F.1    DeLellis, R.2    Kaplan, M.M.3
  • 17
    • 0025320936 scopus 로고
    • Experimental models of hepatic fibrosis: A review
    • Tsukamoto, H., Matsuoka, M., and French, S.W. 1990. Experimental models of hepatic fibrosis: a review. Semin. Liver Dis. 10:56-65.
    • (1990) Semin. Liver Dis , vol.10 , pp. 56-65
    • Tsukamoto, H.1    Matsuoka, M.2    French, S.W.3
  • 18
    • 0023683873 scopus 로고
    • Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer
    • Maher, J.J., Bissell, D.M., Friedman, S.L., and Roll, F.J. 1988. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J. Clin. Invest. 82:450-459.
    • (1988) J. Clin. Invest , vol.82 , pp. 450-459
    • Maher, J.J.1    Bissell, D.M.2    Friedman, S.L.3    Roll, F.J.4
  • 19
    • 0025000652 scopus 로고
    • Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo
    • Maher, J.J., and McGuire, R.F. 1990. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J. Clin. Invest. 86:1641-1648.
    • (1990) J. Clin. Invest , vol.86 , pp. 1641-1648
    • Maher, J.J.1    McGuire, R.F.2
  • 20
    • 84856401734 scopus 로고    scopus 로고
    • Liver fibrosis: Signals leading to the amplification of the fibrogenic hepatic stellate cell
    • Gabele, E., Brenner, D.A., and Rippe, R.A. 2003. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front. Biosci. 8:D69-D77.
    • (2003) Front. Biosci , vol.8
    • Gabele, E.1    Brenner, D.A.2    Rippe, R.A.3
  • 21
    • 33847370342 scopus 로고    scopus 로고
    • History of hepatology
    • 2nd edition. J. Bircher, J.-P. Benhamou, N. McIntyre, M. Rizetto, and J. Rodes, editors. Oxford University Press. Oxford, United Kingdom
    • Franken, F.H., and Falk, H. 1999. History of hepatology. In Oxford textbook of clinical hepatology. 2nd edition. J. Bircher, J.-P. Benhamou, N. McIntyre, M. Rizetto, and J. Rodes, editors. Oxford University Press. Oxford, United Kingdom. 2067-2076.
    • (1999) Oxford textbook of clinical hepatology , pp. 2067-2076
    • Franken, F.H.1    Falk, H.2
  • 22
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Anstee, Q.M., and Goldin, R.D. 2006. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int. J. Exp. Pathol. 87:1-16.
    • (2006) Int. J. Exp. Pathol , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 23
    • 0035078599 scopus 로고    scopus 로고
    • Animal models of steatosis
    • Koteish, A., and Diehl, A.M. 2001. Animal models of steatosis. Semin. Liver Dis. 21:89-104.
    • (2001) Semin. Liver Dis , vol.21 , pp. 89-104
    • Koteish, A.1    Diehl, A.M.2
  • 24
    • 0344010170 scopus 로고    scopus 로고
    • Rodent nutritional model of non-alcoholic steatohepatitis: Species, strain and sex difference studies
    • Kirsch, R., et al. 2003. Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies. J. Gastroenterol. Hepatol. 18:1272-1282.
    • (2003) J. Gastroenterol. Hepatol , vol.18 , pp. 1272-1282
    • Kirsch, R.1
  • 25
    • 2642547397 scopus 로고    scopus 로고
    • A choline-deficient diet in mice inhibits neither the CDP-choine pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion
    • Kulinski, A., Vance, D.E., and Vance, J.E. 2004. A choline-deficient diet in mice inhibits neither the CDP-choine pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion. J. Biol. Chem. 279:23916-23924.
    • (2004) J. Biol. Chem , vol.279 , pp. 23916-23924
    • Kulinski, A.1    Vance, D.E.2    Vance, J.E.3
  • 26
    • 3042587904 scopus 로고    scopus 로고
    • Vitamin C and vitamin E in prevention of nonalcoholic fatty liver disease (NAFLD) in choline deficient diet fed rats
    • Oliviera, C.P.M.S., et al. 2003. Vitamin C and vitamin E in prevention of nonalcoholic fatty liver disease (NAFLD) in choline deficient diet fed rats. Nutr. J. 2:9-14.
    • (2003) Nutr. J , vol.2 , pp. 9-14
    • Oliviera, C.P.M.S.1
  • 27
    • 33747079056 scopus 로고    scopus 로고
    • A choline deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high fat diet
    • Raubenheimer, P.J., Nyirenda, M.J., and Walker, B.R. 2006. A choline deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high fat diet. Diabetes. 55:2015-2020.
    • (2006) Diabetes , vol.55 , pp. 2015-2020
    • Raubenheimer, P.J.1    Nyirenda, M.J.2    Walker, B.R.3
  • 28
    • 33644507137 scopus 로고    scopus 로고
    • The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice
    • Vig, P., et al. 2006. The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice. Hepatology. 43:316-324.
    • (2006) Hepatology , vol.43 , pp. 316-324
    • Vig, P.1
  • 29
    • 0022397571 scopus 로고
    • A transgenic mouse model of the chronic hepatitis B surface antigen carrier state
    • Chisari, F.V., et al. 1985. A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science. 230:1157-1160.
    • (1985) Science , vol.230 , pp. 1157-1160
    • Chisari, F.V.1
  • 30
    • 0029888478 scopus 로고    scopus 로고
    • TIMP-1 and interstitial collagenase expression in liver fibrosis; implications for pathogenesis
    • Iredale, J.P., et al. 1996. TIMP-1 and interstitial collagenase expression in liver fibrosis; implications for pathogenesis. Hepatology. 24:176-184.
    • (1996) Hepatology , vol.24 , pp. 176-184
    • Iredale, J.P.1
  • 31
    • 0016343603 scopus 로고
    • Collagenase activity in experimental hepatic fibrosis
    • Okazaki, I., and Maruyama, K. 1974. Collagenase activity in experimental hepatic fibrosis. Nature. 252:49-50.
    • (1974) Nature , vol.252 , pp. 49-50
    • Okazaki, I.1    Maruyama, K.2
  • 32
    • 0018104310 scopus 로고
    • Collagenase in experimental carbon tetrachloride cirrhosis of the liver
    • Montfort, I., and Perez-Tamayo, R. 1978. Collagenase in experimental carbon tetrachloride cirrhosis of the liver. Am. J. Pathol. 92:411-420.
    • (1978) Am. J. Pathol , vol.92 , pp. 411-420
    • Montfort, I.1    Perez-Tamayo, R.2
  • 33
    • 0031688428 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis
    • Arthur, M.J., Mann, D.A., and Iredale, J.P. 1998. Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis. J. Gastroenterol. Hepatol. 13(Suppl.):S33-S38.
    • (1998) J. Gastroenterol. Hepatol , vol.13 , Issue.SUPPL.
    • Arthur, M.J.1    Mann, D.A.2    Iredale, J.P.3
  • 34
    • 1942454793 scopus 로고    scopus 로고
    • Nonalcoholic steatoherpatits
    • Brunt, E.M. 2004. Nonalcoholic steatoherpatits. Semin. Liver Dis. 24:3-20.
    • (2004) Semin. Liver Dis , vol.24 , pp. 3-20
    • Brunt, E.M.1
  • 35
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease
    • Ludwig, J., Viggiano, T.R., McGill, D.B., and Oh, B.J. 1980. Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. 55:434-438.
    • (1980) Mayo Clin. Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Oh, B.J.4
  • 36
    • 0021173477 scopus 로고
    • Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis
    • Sorensen, T.I., et al. 1984. Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis. Lancet. 2:241-244.
    • (1984) Lancet , vol.2 , pp. 241-244
    • Sorensen, T.I.1
  • 37
    • 0034804406 scopus 로고    scopus 로고
    • Hepatic blood flow regulation by stellate cells in normal and injured liver
    • Rockey, D.C. 2001. Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin. Liver Dis. 21:337-349.
    • (2001) Semin. Liver Dis , vol.21 , pp. 337-349
    • Rockey, D.C.1
  • 38
    • 0025058042 scopus 로고
    • Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis
    • Milani, S., et al. 1990. Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis. Gastroenterology. 98:175-184.
    • (1990) Gastroenterology , vol.98 , pp. 175-184
    • Milani, S.1
  • 39
    • 0032731751 scopus 로고    scopus 로고
    • Hepatic stellate cells and the regulation of liver inflammation
    • Marra, F. 1999. Hepatic stellate cells and the regulation of liver inflammation. J. Hepatol. 31:1120-1130.
    • (1999) J. Hepatol , vol.31 , pp. 1120-1130
    • Marra, F.1
  • 40
    • 0037371341 scopus 로고    scopus 로고
    • Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis
    • Olaso, E., et al. 2003. Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis. Hepatology. 37:674-685.
    • (2003) Hepatology , vol.37 , pp. 674-685
    • Olaso, E.1
  • 41
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman, S.L. 2000. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275:2247-2250.
    • (2000) J. Biol. Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 42
    • 0034120267 scopus 로고    scopus 로고
    • Angiotensin II induces contraction and proliferation of human hepatic stellate cells
    • Bataller, R., et al. 2000. Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology. 118:1149-1156.
    • (2000) Gastroenterology , vol.118 , pp. 1149-1156
    • Bataller, R.1
  • 43
    • 0034856044 scopus 로고    scopus 로고
    • Cellular pathophysiology of portal hypertension and prospects for management with gene therapy
    • Rockey, D.C. 2001. Cellular pathophysiology of portal hypertension and prospects for management with gene therapy. Clin. Liver Dis. 5:851-865.
    • (2001) Clin. Liver Dis , vol.5 , pp. 851-865
    • Rockey, D.C.1
  • 45
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • Pinzani, M., Gesualdo, L., Sabbah, G.M., and Abboud, H.E. 1989. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J. Clin. Invest. 84:1786-1793.
    • (1989) J. Clin. Invest , vol.84 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 46
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis
    • George, J., Roulot, D., Koteliansky, V.E., and Bissell, D.M. 1999. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proc. Natl. Acad. Sci. U. S. A. 96:12719-12724.
    • (1999) Proc. Natl. Acad. Sci. U. S. A , vol.96 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 47
    • 3242751775 scopus 로고    scopus 로고
    • Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis
    • Borkham-Kamphorst, E., Stoll, D., Gressner, A.M., and Weiskirchen, R. 2004. Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis. Biochem. Biophys. Res. Commun. 321:413-423.
    • (2004) Biochem. Biophys. Res. Commun , vol.321 , pp. 413-423
    • Borkham-Kamphorst, E.1    Stoll, D.2    Gressner, A.M.3    Weiskirchen, R.4
  • 48
    • 1542305557 scopus 로고    scopus 로고
    • Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan
    • Gao, R., and Brigstock, D.R. 2004. Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J. Biol. Chem. 279:8848-8855.
    • (2004) J. Biol. Chem , vol.279 , pp. 8848-8855
    • Gao, R.1    Brigstock, D.R.2
  • 49
    • 0342264463 scopus 로고    scopus 로고
    • Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells
    • Williams, E.J., Gaca, M.D., Brigstock, D.R., Arthur, M.J., and Benyon, R.C. 2000. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J. Hepatol. 32:754-761.
    • (2000) J. Hepatol , vol.32 , pp. 754-761
    • Williams, E.J.1    Gaca, M.D.2    Brigstock, D.R.3    Arthur, M.J.4    Benyon, R.C.5
  • 51
    • 2642545495 scopus 로고    scopus 로고
    • Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: Evidence for matrix-dependent deactivation of stellate cells
    • Gaca, M.D., et al. 2003. Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells. Matrix Biol. 22:229-239.
    • (2003) Matrix Biol , vol.22 , pp. 229-239
    • Gaca, M.D.1
  • 52
    • 2642537690 scopus 로고    scopus 로고
    • Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells
    • Zhou, X., et al. 2004. Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. J. Biol. Chem. 279:23996-24006.
    • (2004) J. Biol. Chem , vol.279 , pp. 23996-24006
    • Zhou, X.1
  • 53
    • 0035179839 scopus 로고    scopus 로고
    • DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells
    • doi:10.1172/JCI200112373
    • Olaso, E., et al. 2001. DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J. Clin. Invest. 108:1369-1378. doi:10.1172/JCI200112373.
    • (2001) J. Clin. Invest , vol.108 , pp. 1369-1378
    • Olaso, E.1
  • 54
    • 0024314801 scopus 로고
    • Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
    • Friedman, S.L., Roll, F.J., Boyles, J., Arenson, D.M., and Bissell, D.M. 1989. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J. Biol. Chem. 264:10756-10762.
    • (1989) J. Biol. Chem , vol.264 , pp. 10756-10762
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Arenson, D.M.4    Bissell, D.M.5
  • 55
    • 33845973033 scopus 로고    scopus 로고
    • Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: Implication for regulation of liver fibrosis
    • Zhou, X., et al. 2006. Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: Implication for regulation of liver fibrosis. J. Biol. Chem. 281:39757-39765.
    • (2006) J. Biol. Chem , vol.281 , pp. 39757-39765
    • Zhou, X.1
  • 56
    • 15444379753 scopus 로고    scopus 로고
    • The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis
    • Wells, R.G. 2005. The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis. J. Clin. Gastroenterol. 39(Suppl. 2):S158-S161.
    • (2005) J. Clin. Gastroenterol , vol.39 , Issue.SUPPL. 2
    • Wells, R.G.1
  • 57
    • 33847367730 scopus 로고    scopus 로고
    • Liver fibrosis: Cellular mechanisms of progression and resolution
    • Henderson, N.C., and Iredale, J.P. 2007. Liver fibrosis: cellular mechanisms of progression and resolution. Clin. Sci. 112:265-280.
    • (2007) Clin. Sci , vol.112 , pp. 265-280
    • Henderson, N.C.1    Iredale, J.P.2
  • 58
    • 0025272893 scopus 로고
    • Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: Implication for a pathogenetic role in alcoholic liver fibrogenesis
    • Matsuoka, M., and Tsukamoto, H. 1990. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology. 11:599-605.
    • (1990) Hepatology , vol.11 , pp. 599-605
    • Matsuoka, M.1    Tsukamoto, H.2
  • 59
    • 0024852111 scopus 로고
    • Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors
    • Friedman, S.L., and Arthur, M.J. 1989. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J. Clin. Invest. 84:1780-1785.
    • (1989) J. Clin. Invest , vol.84 , pp. 1780-1785
    • Friedman, S.L.1    Arthur, M.J.2
  • 60
    • 23844531047 scopus 로고    scopus 로고
    • Effects of gadolinium chloride (GdCl(3)) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions
    • Ide, M., Kuwamura, M., Kotani, T., Sawamoto, O., and Yamate, J. 2005. Effects of gadolinium chloride (GdCl(3)) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions. J. Comp. Pathol. 133:92-102.
    • (2005) J. Comp. Pathol , vol.133 , pp. 92-102
    • Ide, M.1    Kuwamura, M.2    Kotani, T.3    Sawamoto, O.4    Yamate, J.5
  • 61
    • 11144281835 scopus 로고    scopus 로고
    • Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats
    • Imamura, M., Ogawa, T., Sasaguri, Y., Chayama, K., and Ueno, H. 2005. Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology. 128:138-146.
    • (2005) Gastroenterology , vol.128 , pp. 138-146
    • Imamura, M.1    Ogawa, T.2    Sasaguri, Y.3    Chayama, K.4    Ueno, H.5
  • 62
    • 13744255589 scopus 로고    scopus 로고
    • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    • doi:10.1172/JCI200522675
    • Duffield, J.S., et al. 2005. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 115:56-65. doi:10.1172/JCI200522675.
    • (2005) J. Clin. Invest , vol.115 , pp. 56-65
    • Duffield, J.S.1
  • 63
    • 32044443617 scopus 로고    scopus 로고
    • Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
    • Radaeva, S., et al. 2006. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology. 130:435-452.
    • (2006) Gastroenterology , vol.130 , pp. 435-452
    • Radaeva, S.1
  • 64
    • 0036254001 scopus 로고    scopus 로고
    • Kinetics of macrophages, myofibroblasts and mast cells in carbon tetrachloride-induced rat liver cirrhosis
    • Jeong, W.I., Lee, C.S., Park, S.J., Chung, J.Y., and Jeong, K.S. 2002. Kinetics of macrophages, myofibroblasts and mast cells in carbon tetrachloride-induced rat liver cirrhosis. Anticancer Res. 22:869-877.
    • (2002) Anticancer Res , vol.22 , pp. 869-877
    • Jeong, W.I.1    Lee, C.S.2    Park, S.J.3    Chung, J.Y.4    Jeong, K.S.5
  • 65
    • 0036202125 scopus 로고    scopus 로고
    • Mastocytosis and fibrosis: Role of cytokines
    • Li, C.Y., and Baek, J.Y. 2002. Mastocytosis and fibrosis: role of cytokines. Int. Arch. Allergy Immunol. 127:123-126.
    • (2002) Int. Arch. Allergy Immunol , vol.127 , pp. 123-126
    • Li, C.Y.1    Baek, J.Y.2
  • 66
    • 0033001318 scopus 로고    scopus 로고
    • Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice
    • Sugihara, A., Tsujimura, T., Fujita, Y., Nakata, Y., and Terada, N. 1999. Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice. J. Hepatol. 30:859-867.
    • (1999) J. Hepatol , vol.30 , pp. 859-867
    • Sugihara, A.1    Tsujimura, T.2    Fujita, Y.3    Nakata, Y.4    Terada, N.5
  • 67
    • 0031762190 scopus 로고    scopus 로고
    • Increase of mast cells in the liver and lung may be associated with but not a cause of fibrosis: Demonstration using mast cell-deficient Ws/Ws rats
    • Okazaki, T., et al. 1998. Increase of mast cells in the liver and lung may be associated with but not a cause of fibrosis: demonstration using mast cell-deficient Ws/Ws rats. Lab. Invest. 78:1431-1438.
    • (1998) Lab. Invest , vol.78 , pp. 1431-1438
    • Okazaki, T.1
  • 68
    • 0037310566 scopus 로고    scopus 로고
    • Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis
    • Saito, J.M., Bostick, M.K., Campe, C.B., Xu, J., and Maher, J.J. 2003. Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis. Hepatol. Res. 25:180-191.
    • (2003) Hepatol. Res , vol.25 , pp. 180-191
    • Saito, J.M.1    Bostick, M.K.2    Campe, C.B.3    Xu, J.4    Maher, J.J.5
  • 69
    • 4143084854 scopus 로고    scopus 로고
    • Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate- induced liver injury
    • Xu, J., Lee, G., Wang, H., Vierling, J.M., and Maher, J.J. 2004. Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate- induced liver injury. Am. J. Physiol. Gastrointest. Liver Physiol. 287:G734-G741.
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol , vol.287
    • Xu, J.1    Lee, G.2    Wang, H.3    Vierling, J.M.4    Maher, J.J.5
  • 71
    • 33645666489 scopus 로고    scopus 로고
    • Platelet-derived serotonin mediates liver regeneration
    • Lesurtel, M., et al. 2006. Platelet-derived serotonin mediates liver regeneration. Science. 312:104-107.
    • (2006) Science , vol.312 , pp. 104-107
    • Lesurtel, M.1
  • 72
    • 0036549755 scopus 로고    scopus 로고
    • Coagulation cascade proteases and tissue fibrosis
    • Chambers, R.C., and Lurent, G.J. 2002. Coagulation cascade proteases and tissue fibrosis. Biochem. Soc. Trans. 30:194-200.
    • (2002) Biochem. Soc. Trans , vol.30 , pp. 194-200
    • Chambers, R.C.1    Lurent, G.J.2
  • 73
    • 0038637369 scopus 로고    scopus 로고
    • Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    • Wright, M., et al. 2003. Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection. Gut. 52:1206-1210.
    • (2003) Gut , vol.52 , pp. 1206-1210
    • Wright, M.1
  • 74
    • 4444289142 scopus 로고    scopus 로고
    • Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes
    • Safadi, R., et al. 2004. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology. 127:870-882.
    • (2004) Gastroenterology , vol.127 , pp. 870-882
    • Safadi, R.1
  • 75
    • 27644501080 scopus 로고    scopus 로고
    • Attenuated liver fibrosis in the absence of B cells
    • doi:10.1172/JCI24798
    • Novobrantseva, T.I., et al. 2005. Attenuated liver fibrosis in the absence of B cells. J. Clin. Invest. 115:3072-3082. doi:10.1172/JCI24798.
    • (2005) J. Clin. Invest , vol.115 , pp. 3072-3082
    • Novobrantseva, T.I.1
  • 76
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • Chiaramonte, M.G., Donaldson, D.D., Cheever, A.W., and Wynn, T.A. 1999. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104:777-785.
    • (1999) J. Clin. Invest , vol.104 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4
  • 77
    • 0030885185 scopus 로고    scopus 로고
    • Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses
    • Shi, Z., Wakil, A.E., and Rockey, D.C. 1997. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc. Natl. Acad. Sci. U. S. A. 94:10663-10668.
    • (1997) Proc. Natl. Acad. Sci. U. S. A , vol.94 , pp. 10663-10668
    • Shi, Z.1    Wakil, A.E.2    Rockey, D.C.3
  • 78
    • 0038476330 scopus 로고    scopus 로고
    • Apoptotic body engulfment by a human stellate cell line is profibrogenic
    • Canbay, A., et al. 2003. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab. Invest. 83:655-663.
    • (2003) Lab. Invest , vol.83 , pp. 655-663
    • Canbay, A.1
  • 79
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
    • Fadok, V.A., et al. 1998. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J. Clin. Invest. 101:890-898.
    • (1998) J. Clin. Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1
  • 80
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik, Y.H., et al. 2003. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 37:1043-1055.
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.H.1
  • 81
    • 1842531265 scopus 로고    scopus 로고
    • A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis
    • Forbes, S.J., et al. 2004. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology. 126:955-963.
    • (2004) Gastroenterology , vol.126 , pp. 955-963
    • Forbes, S.J.1
  • 82
    • 33646372957 scopus 로고    scopus 로고
    • The bone marrow functionally contributes to liver fibrosis
    • Russo, F.P., et al. 2006. The bone marrow functionally contributes to liver fibrosis. Gastroenterology. 130:1807-1821.
    • (2006) Gastroenterology , vol.130 , pp. 1807-1821
    • Russo, F.P.1
  • 83
    • 33746494050 scopus 로고    scopus 로고
    • Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis
    • Kisseleva, T., et al. 2006. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J. Hepatol. 45:429-438.
    • (2006) J. Hepatol , vol.45 , pp. 429-438
    • Kisseleva, T.1
  • 84
    • 0036484205 scopus 로고    scopus 로고
    • Peribiliary myofibroblasts in biliary type liver fibrosis
    • Kinnman, N., and Housset, C. 2002. Peribiliary myofibroblasts in biliary type liver fibrosis. Front. Biosci. 7:496-503.
    • (2002) Front. Biosci , vol.7 , pp. 496-503
    • Kinnman, N.1    Housset, C.2
  • 85
    • 0032742051 scopus 로고    scopus 로고
    • Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential
    • Knittel, T., et al. 1999. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology. 117:1205-1221.
    • (1999) Gastroenterology , vol.117 , pp. 1205-1221
    • Knittel, T.1
  • 86
    • 0036696026 scopus 로고    scopus 로고
    • Mesenchymal cells in the liver - one cell type or two?
    • Ramadori, G., and Saile, B. 2002. Mesenchymal cells in the liver - one cell type or two? Liver. 22:283-294.
    • (2002) Liver , vol.22 , pp. 283-294
    • Ramadori, G.1    Saile, B.2
  • 87
    • 0036166579 scopus 로고    scopus 로고
    • Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers
    • Cassiman, D., Libbrecht, L., Desmet, V., Denef, C., and Roskams, T. 2002. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J. Hepatol. 36:200-209.
    • (2002) J. Hepatol , vol.36 , pp. 200-209
    • Cassiman, D.1    Libbrecht, L.2    Desmet, V.3    Denef, C.4    Roskams, T.5
  • 88
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • doi:10.1172/JCI200320530
    • Kalluri, R., and Neilson, E.G. 2003. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112:1776-1784. doi:10.1172/JCI200320530.
    • (2003) J. Clin. Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 89
    • 0442323488 scopus 로고    scopus 로고
    • Autocrine release of TGF-beta by portal fiboblasts regulates cell growth
    • Wells, R.G., Kruglov, E., and Dranoff, J.A. 2004. Autocrine release of TGF-beta by portal fiboblasts regulates cell growth. FEBS Lett. 559:107-110.
    • (2004) FEBS Lett , vol.559 , pp. 107-110
    • Wells, R.G.1    Kruglov, E.2    Dranoff, J.A.3
  • 90
    • 0034691557 scopus 로고    scopus 로고
    • Hepatocytes from non-hepatic adult stem cells
    • Alison, M.R., et al. 2000. Hepatocytes from non-hepatic adult stem cells. Nature. 406:257.
    • (2000) Nature , vol.406 , pp. 257
    • Alison, M.R.1
  • 91
    • 0242584006 scopus 로고    scopus 로고
    • Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    • Alvarez-Dolado, M., et al. 2003. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature. 425:968-973.
    • (2003) Nature , vol.425 , pp. 968-973
    • Alvarez-Dolado, M.1
  • 92
    • 1342322770 scopus 로고    scopus 로고
    • Hepatic stem cells: From inside and outside the liver?
    • Alison, M.R., et al. 2004. Hepatic stem cells: from inside and outside the liver? Cell Prolif. 37:1-21.
    • (2004) Cell Prolif , vol.37 , pp. 1-21
    • Alison, M.R.1
  • 93
    • 7044284840 scopus 로고    scopus 로고
    • A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations
    • Magness, S.T., Bataller, R., Yang, L., and Brenner, D.A. 2004. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 40:1151-1159.
    • (2004) Hepatology , vol.40 , pp. 1151-1159
    • Magness, S.T.1    Bataller, R.2    Yang, L.3    Brenner, D.A.4
  • 94
    • 0032974347 scopus 로고    scopus 로고
    • Regulatory role of the conserved stem-loop structure at the 5′ end of collagen alpha1(I)mRNA
    • Stefanovic, B., Hellerbrand, C., and Brenner, A. 1999. Regulatory role of the conserved stem-loop structure at the 5′ end of collagen alpha1(I)mRNA. Mol. Cell. Biol. 19:4334-4342.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 4334-4342
    • Stefanovic, B.1    Hellerbrand, C.2    Brenner, A.3
  • 95
    • 0034814405 scopus 로고    scopus 로고
    • Extracellular matrix degradation and the role of hepatic stellate cells
    • Benyon, R.C., and Arthur, M.J. 2001. Extracellular matrix degradation and the role of hepatic stellate cells. Semin. Liver Dis. 21:373-384.
    • (2001) Semin. Liver Dis , vol.21 , pp. 373-384
    • Benyon, R.C.1    Arthur, M.J.2
  • 96
    • 0029360385 scopus 로고
    • Rat hepatic lipocytes synthesize and secrete transin (stromelysin) in early primary culture
    • Vyas, S.K., Leyland, H., Gentry, J., and Arthur, M.J. 1995. Rat hepatic lipocytes synthesize and secrete transin (stromelysin) in early primary culture. Gastroenterology. 109:889-898.
    • (1995) Gastroenterology , vol.109 , pp. 889-898
    • Vyas, S.K.1    Leyland, H.2    Gentry, J.3    Arthur, M.J.4
  • 97
    • 0024431505 scopus 로고
    • Lipocytes from normal rat liver release aneutral metalloproteinase that degrades basement membrane (type IV) collagen
    • Arthur, M.J., Friedman, S.L., Roll, F.J., and Bissell, D.M. 1989. Lipocytes from normal rat liver release aneutral metalloproteinase that degrades basement membrane (type IV) collagen. J. Clin. Invest. 84:1076-1085.
    • (1989) J. Clin. Invest , vol.84 , pp. 1076-1085
    • Arthur, M.J.1    Friedman, S.L.2    Roll, F.J.3    Bissell, D.M.4
  • 98
    • 0026453596 scopus 로고
    • Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity
    • Arthur, M.J., et al. 1992. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. Biochem. J. 287:701-707.
    • (1992) Biochem. J , vol.287 , pp. 701-707
    • Arthur, M.J.1
  • 99
    • 0030030039 scopus 로고    scopus 로고
    • Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver
    • Benyon, R.C., Iredale, J.P., Goddard, S., Winwood, P.J., and Arthur, M.J. 1996. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver. Gastroenterology. 110:821-831.
    • (1996) Gastroenterology , vol.110 , pp. 821-831
    • Benyon, R.C.1    Iredale, J.P.2    Goddard, S.3    Winwood, P.J.4    Arthur, M.J.5
  • 100
    • 20644465610 scopus 로고    scopus 로고
    • Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
    • Benyon, R.C., et al. 1999. Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation. Hepatology. 30:977-986.
    • (1999) Hepatology , vol.30 , pp. 977-986
    • Benyon, R.C.1
  • 101
    • 16644402719 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis
    • Zhou, X., et al. 2004. Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Int. 24:492-501.
    • (2004) Liver Int , vol.24 , pp. 492-501
    • Zhou, X.1
  • 102
    • 2942622398 scopus 로고    scopus 로고
    • Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking
    • Issa, R., et al. 2004. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology. 126:1795-1808.
    • (2004) Gastroenterology , vol.126 , pp. 1795-1808
    • Issa, R.1
  • 103
    • 0026720588 scopus 로고
    • Human hepatic lipcytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver
    • Iredale, J.P., Murphy, G., Hembry, R.M., Friedman, S.L., and Arthur, M.J. 1992. Human hepatic lipcytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. J. Clin. Invest. 90:282-287.
    • (1992) J. Clin. Invest , vol.90 , pp. 282-287
    • Iredale, J.P.1    Murphy, G.2    Hembry, R.M.3    Friedman, S.L.4    Arthur, M.J.5
  • 104
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale, J.P., et al. 1998. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J. Clin. Invest. 102:538-549.
    • (1998) J. Clin. Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1
  • 105
    • 0035083958 scopus 로고    scopus 로고
    • Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    • Issa, R., et al. 2001. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut. 48:548-557.
    • (2001) Gut , vol.48 , pp. 548-557
    • Issa, R.1
  • 106
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • Elsharkawy, A.M., Oakley, F., and Mann, D.A. 2005. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis. 10:927-939.
    • (2005) Apoptosis , vol.10 , pp. 927-939
    • Elsharkawy, A.M.1    Oakley, F.2    Mann, D.A.3
  • 107
    • 0033646761 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model
    • Yoshiji, H., et al. 2000. Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model. Hepatology. 32:1248-1254.
    • (2000) Hepatology , vol.32 , pp. 1248-1254
    • Yoshiji, H.1
  • 108
    • 0036787684 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse
    • Yoshiji, H., et al. 2002. Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse. Hepatology. 36:850-860.
    • (2002) Hepatology , vol.36 , pp. 850-860
    • Yoshiji, H.1
  • 109
    • 11144357753 scopus 로고    scopus 로고
    • Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis
    • Siller-Lopex, F., et al. 2004. Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology. 126:1122-1133.
    • (2004) Gastroenterology , vol.126 , pp. 1122-1133
    • Siller-Lopex, F.1
  • 110
    • 7044226525 scopus 로고    scopus 로고
    • Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats
    • Parsons, C.J., et al. 2004. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. 40:1106-1115.
    • (2004) Hepatology , vol.40 , pp. 1106-1115
    • Parsons, C.J.1
  • 111
    • 0033817966 scopus 로고    scopus 로고
    • An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1 antagonist
    • Roeb, E., Behrmann, I., Grotzinger, J., Breuer, B., and Matern, S. 2000. An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1 antagonist. FASEB J. 14:1671-1673.
    • (2000) FASEB J , vol.14 , pp. 1671-1673
    • Roeb, E.1    Behrmann, I.2    Grotzinger, J.3    Breuer, B.4    Matern, S.5
  • 112
    • 33645798836 scopus 로고    scopus 로고
    • Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice
    • Roderfeld, M., et al. 2006. Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. FASEB J. 20:444-454.
    • (2006) FASEB J , vol.20 , pp. 444-454
    • Roderfeld, M.1
  • 113
    • 0037221907 scopus 로고    scopus 로고
    • Histological outcome during long-term lamivudine therapy
    • Dienstag, J.L., et al. 2003. Histological outcome during long-term lamivudine therapy. Gastroenterology. 124:105-117.
    • (2003) Gastroenterology , vol.124 , pp. 105-117
    • Dienstag, J.L.1
  • 114
    • 0036242165 scopus 로고    scopus 로고
    • Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C
    • Poynard, T., et al. 2002. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology. 122:1303-1313.
    • (2002) Gastroenterology , vol.122 , pp. 1303-1313
    • Poynard, T.1
  • 115
    • 0035825721 scopus 로고    scopus 로고
    • Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct
    • Hammel, P., et al. 2001. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N. Engl. J. Med. 344:418-423.
    • (2001) N. Engl. J. Med , vol.344 , pp. 418-423
    • Hammel, P.1
  • 116
    • 1942470986 scopus 로고    scopus 로고
    • Cirrhosis reversal: A duel between dogma and myth
    • Desmet, V.J., and Roskams, T. 2004. Cirrhosis reversal: a duel between dogma and myth. J. Hepatol. 40:860-867.
    • (2004) J. Hepatol , vol.40 , pp. 860-867
    • Desmet, V.J.1    Roskams, T.2
  • 117
    • 0037268098 scopus 로고    scopus 로고
    • Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CC14-induced liver fibrosis, persistance of activated hepatic stellate cells and diminished hepatocyte regeneration
    • Issa, R., et al. 2003. Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CC14-induced liver fibrosis, persistance of activated hepatic stellate cells and diminished hepatocyte regeneration. FASEB J. 17:47-49.
    • (2003) FASEB J , vol.17 , pp. 47-49
    • Issa, R.1
  • 118
    • 0036730388 scopus 로고    scopus 로고
    • Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2
    • Preaux, A.M., D'ortho, M.P., Bralet, M.P., Laperche, Y., and Mavier, P. 2002. Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. Hepatology. 36:615-622.
    • (2002) Hepatology , vol.36 , pp. 615-622
    • Preaux, A.M.1    D'ortho, M.P.2    Bralet, M.P.3    Laperche, Y.4    Mavier, P.5
  • 119
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman, S.L. 2000. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275:2247-2250.
    • (2000) J. Biol. Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 120
    • 0031717454 scopus 로고    scopus 로고
    • Infection of B-cell-deficient mice by the parasite Schistosoma mansoni: Dominstration of the participation of B cells in granuloma modulation
    • Ferru, I., Roye, O., Delacre, M., Auriault, C., and Wolowczuk, I. 1998. Infection of B-cell-deficient mice by the parasite Schistosoma mansoni: dominstration of the participation of B cells in granuloma modulation. Scand. J. Immunol. 48:233-240.
    • (1998) Scand. J. Immunol , vol.48 , pp. 233-240
    • Ferru, I.1    Roye, O.2    Delacre, M.3    Auriault, C.4    Wolowczuk, I.5


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