Leptin enhances α1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways

Journal of Cellular Biochemistry

Volumn 97, Issue 1, 2006, Pages 188-197

  Cao, Qi ^a   Mak, Ki M ^a   Lieber, Charles S ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Collagen; ERK1 2; H2O2; Hepatic stellate cells; Leptin; p38

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; COLLAGEN TYPE 1; CYTOKINE; HYDROGEN PEROXIDE; JANUS KINASE; JANUS KINASE INHIBITOR; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; OXIDIZING AGENT; TISSUE INHIBITOR OF METALLOPROTEINASE 1; ENZYME INHIBITOR; JAK1 PROTEIN, HUMAN; JAK2 PROTEIN, HUMAN; JANUS KINASE 1; JANUS KINASE 2; MESSENGER RNA; ONCOPROTEIN; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL LINE; COLLAGEN SYNTHESIS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROGENESIS; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; LIVER FIBROSIS; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; STELLATE CELL; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

COLLAGEN TYPE I; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; JANUS KINASE 1; JANUS KINASE 2; LEPTIN; LIVER; MAP KINASE SIGNALING SYSTEM; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 30044443872     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20622     Document Type: Article

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