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Volumn 27, Issue 12, 2004, Pages 855-868

An adipocentric view of liver fibrosis and cirrhosis

Author keywords

Adipocytokine adipokine; Adiponectin; Cirrhosis; Hepatic stellate cells; Insulin; Insulin like growth factor; Leptin; Liver fibrosis; Nonalcoholic fatty liver disease; Obesity; Preadipocyte factor1 delta like protein1

Indexed keywords

ADIPONECTIN; ALCOHOL; CELL NUCLEUS RECEPTOR; CYTOKINE; HORMONE; INSULIN; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREADIPOCYTE FACTOR 1; SOMATOMEDIN C; UNCLASSIFIED DRUG;

EID: 13644256160     PISSN: 02558270     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (22)

References (120)
  • 2
    • 0033853732 scopus 로고    scopus 로고
    • New insights into hepatic stellate cell activation: The simple becomes complex
    • Eng FJ, Friedman SL. New insights into hepatic stellate cell activation: the simple becomes complex. Am J Physiol Gastrointest Liver Physiol 2000;279:G7-11.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279
    • Eng, F.J.1    Friedman, S.L.2
  • 3
    • 0036784417 scopus 로고    scopus 로고
    • Beauty is in the eye of the beholder: Emerging concepts and pitfalls in hepatic stellate cell research
    • Cassiman D, Roskams T. Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research. J Hepatol 2002;37:527-35.
    • (2002) J Hepatol , vol.37 , pp. 527-535
    • Cassiman, D.1    Roskams, T.2
  • 4
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, and integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, and integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-50.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 6
    • 0024215032 scopus 로고
    • Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets
    • Moriwaki H, Blaner WS, Piantedosi R, Goodman DS. Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets. J Lipid Res 1988;29:1523-34.
    • (1988) J Lipid Res , vol.29 , pp. 1523-1534
    • Moriwaki, H.1    Blaner, W.S.2    Piantedosi, R.3    Goodman, D.S.4
  • 7
    • 0036551274 scopus 로고    scopus 로고
    • Activation of hepatic stellate cells-a key issue in liver fibrosis
    • Reeves HL, Friedman SL. Activation of hepatic stellate cells-a key issue in liver fibrosis. Front Biosci 2002;7: d808-26.
    • (2002) Front Biosci , vol.7
    • Reeves, H.L.1    Friedman, S.L.2
  • 8
    • 0042322996 scopus 로고    scopus 로고
    • Obesity and its nurturing effect on hepatitis C
    • McCullough AJ. Obesity and its nurturing effect on hepatitis C. Hepatology 2003;38:557-9.
    • (2003) Hepatology , vol.38 , pp. 557-559
    • McCullough, A.J.1
  • 10
    • 0016915956 scopus 로고
    • Epidemiology of alcoholic liver disease
    • Popper H, Schaffner F, eds. Philadelphia: Grune and Stratton
    • Lelbach WK. Epidemiology of alcoholic liver disease. In: Popper H, Schaffner F, eds. Progress in Liver Diseases. Philadelphia: Grune and Stratton, 1976:434-515.
    • (1976) Progress in Liver Diseases , pp. 434-515
    • Lelbach, W.K.1
  • 12
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990;12:1106-10.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 13
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study
    • Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995;22:1714-9.
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 14
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999;30:1356-62.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3    Lindor, K.D.4
  • 15
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003;37:1202-19.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 17
    • 0043037223 scopus 로고    scopus 로고
    • High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    • Bressler BL, Guindi M, Tomlinson G, Heathcote J. High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Hepatology 2003;38:639-44.
    • (2003) Hepatology , vol.38 , pp. 639-644
    • Bressler, B.L.1    Guindi, M.2    Tomlinson, G.3    Heathcote, J.4
  • 18
    • 0025367559 scopus 로고
    • Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
    • Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 1990;263:2893-8.
    • (1990) JAMA , vol.263 , pp. 2893-2898
    • Haffner, S.M.1    Stern, M.P.2    Hazuda, H.P.3    Mitchell, B.D.4    Patterson, J.K.5
  • 19
    • 0345059390 scopus 로고    scopus 로고
    • Insulin resistance and tissue repair: A "fatological" phenomenon
    • Sanyal AJ. Insulin resistance and tissue repair: a " fatological" phenomenon. Gastroenterology 2003;125:1886-9.
    • (2003) Gastroenterology , vol.125 , pp. 1886-1889
    • Sanyal, A.J.1
  • 23
    • 0037356826 scopus 로고    scopus 로고
    • The role of the novel adipocyte-derived hormone adiponectin in human disease
    • Diez JD, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Europ J Endocrin 2003;148:293-300.
    • (2003) Europ J Endocrin , vol.148 , pp. 293-300
    • Diez, J.D.1    Iglesias, P.2
  • 24
    • 0032994264 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways
    • Svegliati-Baroni G, Ridolfi F, Di Sario A, Cassini A, Marucci L, Gaggiotti G, Orlandoni P, Macarri G, Perego L, Benedetti A, Folli F. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology 1999;29:1743-51.
    • (1999) Hepatology , vol.29 , pp. 1743-1751
    • Svegliati-Baroni, G.1    Ridolfi, F.2    Di Sario, A.3    Cassini, A.4    Marucci, L.5    Gaggiotti, G.6    Orlandoni, P.7    Macarri, G.8    Perego, L.9    Benedetti, A.10    Folli, F.11
  • 25
    • 0034802171 scopus 로고    scopus 로고
    • High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    • Paradis V, Perlemuter G, Bonvoust F, Dargere D, Parfait B, Vidaud M, Conti M, Huet S, Ba N, Buffet C, Bedossa P. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology 2001;34:738-44.
    • (2001) Hepatology , vol.34 , pp. 738-744
    • Paradis, V.1    Perlemuter, G.2    Bonvoust, F.3    Dargere, D.4    Parfait, B.5    Vidaud, M.6    Conti, M.7    Huet, S.8    Ba, N.9    Buffet, C.10    Bedossa, P.11
  • 26
    • 0029994141 scopus 로고    scopus 로고
    • High insulin-like growth factor binding protein 1 levels in cirrhosis: Link with insulin resistance
    • Shmueli E, Miell JP, Stewart M, Alberti KG, Record CO. High insulin-like growth factor binding protein 1 levels in cirrhosis: link with insulin resistance. Hepatology 1996; 24:127-33.
    • (1996) Hepatology , vol.24 , pp. 127-133
    • Shmueli, E.1    Miell, J.P.2    Stewart, M.3    Alberti, K.G.4    Record, C.O.5
  • 27
    • 0036623365 scopus 로고    scopus 로고
    • Regulation of the growth hormone receptor/binding protein, insulin-like growth factor ternary complex system in human cirrhosis
    • Donaghy AJ, Delhanty PJ, Ho KK, Williams R, Baxter RC. Regulation of the growth hormone receptor/binding protein, insulin-like growth factor ternary complex system in human cirrhosis. J Hepatol 2002;36:751-8.
    • (2002) J Hepatol , vol.36 , pp. 751-758
    • Donaghy, A.J.1    Delhanty, P.J.2    Ho, K.K.3    Williams, R.4    Baxter, R.C.5
  • 30
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of nonalcoholic steatohepatitis
    • Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001;21:27-41.
    • (2001) Semin Liver Dis , vol.21 , pp. 27-41
    • Chitturi, S.1    Farrell, G.C.2
  • 31
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001;121:91-100.
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 34
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oliver D, Bacon BR. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003;38:1008-17.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 35
    • 0037900979 scopus 로고    scopus 로고
    • Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
    • Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003;144:2201-7.
    • (2003) Endocrinology , vol.144 , pp. 2201-2207
    • Lee, C.H.1    Olson, P.2    Evans, R.M.3
  • 36
    • 0034076888 scopus 로고    scopus 로고
    • The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease
    • Everett L, Galli A, Crabb D. The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. Liver 2000;20:191-9.
    • (2000) Liver , vol.20 , pp. 191-199
    • Everett, L.1    Galli, A.2    Crabb, D.3
  • 38
    • 0037663778 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth
    • Xu J, Fu Y, Chen A. Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am J Physiol Gastrointest Liver Physiol 2003;285:G20-30.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Xu, J.1    Fu, Y.2    Chen, A.3
  • 44
    • 0032489223 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatic stellate cells results in leptin expression
    • Potter JJ, Womack L, Mezey E, Anania FA. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 1998; 244:178-82.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 178-182
    • Potter, J.J.1    Womack, L.2    Mezey, E.3    Anania, F.A.4
  • 46
    • 0033023477 scopus 로고    scopus 로고
    • Increased circulating leptin in alcoholic cirrhosis: Relation to release and disposal
    • Henriksen JH, Holst JJ, Moller S, Brinch K, Bendtsen F. Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. Hepatology 1999;29:1818-24.
    • (1999) Hepatology , vol.29 , pp. 1818-1824
    • Henriksen, J.H.1    Holst, J.J.2    Moller, S.3    Brinch, K.4    Bendtsen, F.5
  • 50
    • 0034927064 scopus 로고    scopus 로고
    • Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
    • Ikejima K, Honda H, Yoshikawa M, Hirose M, Kitamura T, Takei Y, Sato N. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 2001;34:288-97.
    • (2001) Hepatology , vol.34 , pp. 288-297
    • Ikejima, K.1    Honda, H.2    Yoshikawa, M.3    Hirose, M.4    Kitamura, T.5    Takei, Y.6    Sato, N.7
  • 53
    • 0036288818 scopus 로고    scopus 로고
    • Leptin, liver and obese mice - Fibrosis in the fat lane
    • Anania FA. Leptin, liver and obese mice - fibrosis in the fat lane. Hepatology 2002;36:246-8.
    • (2002) Hepatology , vol.36 , pp. 246-248
    • Anania, F.A.1
  • 54
    • 0029980285 scopus 로고    scopus 로고
    • cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)
    • Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996;221:286-9.
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 286-289
    • Maeda, K.1    Okubo, K.2    Shimomura, I.3    Funahashi, T.4    Matsuzawa, Y.5    Matsubara, K.6
  • 58
    • 3042744039 scopus 로고    scopus 로고
    • Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics
    • Tietge UJ, Boker KH, Manns MP, Bahr MJ. Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics. Am J Physiol Endocrinol Metab 2004;287:E82-9.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Tietge, U.J.1    Boker, K.H.2    Manns, M.P.3    Bahr, M.J.4
  • 62
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003;112:91-100.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 63
    • 0027245963 scopus 로고
    • Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
    • Smas CM, Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993; 73:725-34.
    • (1993) Cell , vol.73 , pp. 725-734
    • Smas, C.M.1    Sul, H.S.2
  • 64
    • 0027467416 scopus 로고
    • dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line
    • Laborda J, Sausville EA, Hoffman T, Notario V. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 1993;268:3817-20.
    • (1993) J Biol Chem , vol.268 , pp. 3817-3820
    • Laborda, J.1    Sausville, E.A.2    Hoffman, T.3    Notario, V.4
  • 65
    • 0034161309 scopus 로고    scopus 로고
    • A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells
    • Han W, Ye Q, Moore MA. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. Blood 2000;95:1616-25.
    • (2000) Blood , vol.95 , pp. 1616-1625
    • Han, W.1    Ye, Q.2    Moore, M.A.3
  • 69
    • 0035083958 scopus 로고    scopus 로고
    • Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    • Issa R, Williams E, Trim N, Kendall T, Arthur MJ, Reichen J, Benyon RC, Iredale JP. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 2001;48: 548-57.
    • (2001) Gut , vol.48 , pp. 548-557
    • Issa, R.1    Williams, E.2    Trim, N.3    Kendall, T.4    Arthur, M.J.5    Reichen, J.6    Benyon, R.C.7    Iredale, J.P.8
  • 70
    • 0036936550 scopus 로고    scopus 로고
    • Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease
    • Krein PM, Winston BW. Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease. Chest 2002;122:289S-93S.
    • (2002) Chest , vol.122
    • Krein, P.M.1    Winston, B.W.2
  • 72
    • 0038369150 scopus 로고    scopus 로고
    • Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    • Cappola AR, Xue QL, Ferrucci L, Guralnik JM, Volpato S, Fried LP. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab 2003;88:2019-25.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2019-2025
    • Cappola, A.R.1    Xue, Q.L.2    Ferrucci, L.3    Guralnik, J.M.4    Volpato, S.5    Fried, L.P.6
  • 73
    • 0043264091 scopus 로고    scopus 로고
    • C-reactive protein and the insulin-like growth factor (IGF)-system in relation to risk of cardiovascular disease in different ethnic groups
    • Heald AH, Anderson SG, Ivison F, Laing I, Gibson JM, Cruickshank K. C-reactive protein and the insulin-like growth factor (IGF)-system in relation to risk of cardiovascular disease in different ethnic groups. Atherosclerosis 2003;170:79-86.
    • (2003) Atherosclerosis , vol.170 , pp. 79-86
    • Heald, A.H.1    Anderson, S.G.2    Ivison, F.3    Laing, I.4    Gibson, J.M.5    Cruickshank, K.6
  • 74
    • 0037470488 scopus 로고    scopus 로고
    • Evolutionary medicine: From dwarf model systems to healthy centenarians?
    • Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 2003; 299:1342-6.
    • (2003) Science , vol.299 , pp. 1342-1346
    • Longo, V.D.1    Finch, C.E.2
  • 75
    • 1642331710 scopus 로고    scopus 로고
    • Insulin treatment improves the systemic inflammatory reaction to severe trauma
    • Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg 2004;239:553-60.
    • (2004) Ann Surg , vol.239 , pp. 553-560
    • Jeschke, M.G.1    Klein, D.2    Herndon, D.N.3
  • 77
    • 0033793133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
    • Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 2000;49:497-505.
    • (2000) Inflamm Res , vol.49 , pp. 497-505
    • Chinetti, G.1    Fruchart, J.C.2    Staels, B.3
  • 79
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 2001;7:48-52.
    • (2001) Nat Med , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 82
    • 0042377452 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene transfer into the liver via the portal vein using electroporation attenuates rat liver cirrhosis
    • Matsuno Y, Iwata H, Umeda Y, Takagi H, Mori Y, Kosugi A, Matsumoto K, Nakamura T, Hirose H. Hepatocyte growth factor gene transfer into the liver via the portal vein using electroporation attenuates rat liver cirrhosis. Gene Ther 2003;10:1559-66.
    • (2003) Gene Ther , vol.10 , pp. 1559-1566
    • Matsuno, Y.1    Iwata, H.2    Umeda, Y.3    Takagi, H.4    Mori, Y.5    Kosugi, A.6    Matsumoto, K.7    Nakamura, T.8    Hirose, H.9
  • 83
    • 0042847330 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice
    • Fischer M, You M, Matsumoto M, Crabb DW. Peroxisome proliferator- activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem 2003;278:27997-8004.
    • (2003) J Biol Chem , vol.278 , pp. 27997-28004
    • Fischer, M.1    You, M.2    Matsumoto, M.3    Crabb, D.W.4
  • 84
    • 2342644813 scopus 로고    scopus 로고
    • Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice
    • Ip E, Farrell G, Hall P, Robertson G, Leclercq I. Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 2004;39:1286-96.
    • (2004) Hepatology , vol.39 , pp. 1286-1296
    • Ip, E.1    Farrell, G.2    Hall, P.3    Robertson, G.4    Leclercq, I.5
  • 85
    • 0038644530 scopus 로고    scopus 로고
    • Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells
    • Saxena NK, Saliba G, Floyd JJ, Anania FA. Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells. J Cell Biochem 2003; 89:311-20.
    • (2003) J Cell Biochem , vol.89 , pp. 311-320
    • Saxena, N.K.1    Saliba, G.2    Floyd, J.J.3    Anania, F.A.4
  • 86
    • 0041327882 scopus 로고    scopus 로고
    • Leptin receptor-deficient Zucker (fa/fa) rat retards the development of pig serum-induced liver fibrosis with Kupffer cell dysfunction
    • Sakaida I, Jinhua S, Uchida K, Terai S, Okita K. Leptin receptor-deficient Zucker (fa/fa) rat retards the development of pig serum-induced liver fibrosis with Kupffer cell dysfunction. Life Sci 2003;73:2491-501.
    • (2003) Life Sci , vol.73 , pp. 2491-2501
    • Sakaida, I.1    Jinhua, S.2    Uchida, K.3    Terai, S.4    Okita, K.5
  • 87
    • 0035195887 scopus 로고    scopus 로고
    • Leptin regulation of the immune response and the immunodeficiency of malnutrition
    • Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001;15:2565-71.
    • (2001) FASEB J , vol.15 , pp. 2565-2571
    • Faggioni, R.1    Feingold, K.R.2    Grunfeld, C.3
  • 90
  • 94
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • Pinzani M, Gesualdo L, Sabbah GM, Abboud HE. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 1989;84:1786-93.
    • (1989) J Clin Invest , vol.84 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 97
    • 0347986520 scopus 로고    scopus 로고
    • Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR
    • Chinetti G, Zawadski C, Fruchart JC, Staels B. Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. Biochem Biophys Res Commun 2004;314:151-8.
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 151-158
    • Chinetti, G.1    Zawadski, C.2    Fruchart, J.C.3    Staels, B.4
  • 98
  • 99
    • 0029026661 scopus 로고
    • Cytokines and cellular crosstalk involved in the activation of fat-storing cells
    • Gressner AM. Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J Hepatol 1995; 22:28-36.
    • (1995) J Hepatol , vol.22 , pp. 28-36
    • Gressner, A.M.1
  • 101
    • 0342369599 scopus 로고    scopus 로고
    • Expression of epidermal growth factor and its receptor in cirrhotic liver disease
    • Komuves LG, Feren A, Jones AL, Fodor E. Expression of epidermal growth factor and its receptor in cirrhotic liver disease. J Histochem Cytochem 2000;48:821-30.
    • (2000) J Histochem Cytochem , vol.48 , pp. 821-830
    • Komuves, L.G.1    Feren, A.2    Jones, A.L.3    Fodor, E.4
  • 102
    • 1642398160 scopus 로고    scopus 로고
    • Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1
    • Jensen CH, Jauho EI, Santoni-Rugiu E, Holmskov U, Teisner B, Tygstrup N, Bisgaard HC. Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. Am J Pathol 2004;164:1347-59.
    • (2004) Am J Pathol , vol.164 , pp. 1347-1359
    • Jensen, C.H.1    Jauho, E.I.2    Santoni-Rugiu, E.3    Holmskov, U.4    Teisner, B.5    Tygstrup, N.6    Bisgaard, H.C.7
  • 103
    • 0036631089 scopus 로고    scopus 로고
    • Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears
    • Samulewicz SJ, Seitz A, Clark L, Heber-Katz E. Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears. Wound Repair Regen 2002;10:215-21.
    • (2002) Wound Repair Regen , vol.10 , pp. 215-221
    • Samulewicz, S.J.1    Seitz, A.2    Clark, L.3    Heber-Katz, E.4
  • 104
    • 0842305691 scopus 로고    scopus 로고
    • The escalating pandemics of obesity and sedentary lifestyle. A call to action for clinicians
    • Manson JE, Skerrett PJ, Greenland P, Vanltallie TB. The escalating pandemics of obesity and sedentary lifestyle. A call to action for clinicians. Arch Intern Med 2004; 164:249-58.
    • (2004) Arch Intern Med , vol.164 , pp. 249-258
    • Manson, J.E.1    Skerrett, P.J.2    Greenland, P.3    Vanltallie, T.B.4
  • 105
    • 0346266078 scopus 로고    scopus 로고
    • Weight-for-height reference and the prevalence of obesity for school children and adolescents in Taiwan and Fuchien Areas
    • Huang YC, Wu JY, Yang MJ. Weight-for-height reference and the prevalence of obesity for school children and adolescents in Taiwan and Fuchien Areas. J Chin Med Assoc 2003;66:599-606.
    • (2003) J Chin Med Assoc , vol.66 , pp. 599-606
    • Huang, Y.C.1    Wu, J.Y.2    Yang, M.J.3
  • 106
    • 1342268112 scopus 로고    scopus 로고
    • Overweight in childhood and adolescence
    • Dietz WH. Overweight in childhood and adolescence. N Engl J Med 2004;350:855-7.
    • (2004) N Engl J Med , vol.350 , pp. 855-857
    • Dietz, W.H.1
  • 107
    • 1542285988 scopus 로고    scopus 로고
    • Surgery for severe obesity
    • Steinbrook R. Surgery for severe obesity. N Engl J Med 2004;350:1075-9.
    • (2004) N Engl J Med , vol.350 , pp. 1075-1079
    • Steinbrook, R.1
  • 110
    • 0141594639 scopus 로고    scopus 로고
    • Is obesity a risk factor for cirrhosis-related death or hospitalization? A population-based cohort study
    • Ioannou GN, Weiss NS, Kowdley KV, Dominitz JA. Is obesity a risk factor for cirrhosis-related death or hospitalization? A population-based cohort study. Gastroenterology 2003;125:1053-9.
    • (2003) Gastroenterology , vol.125 , pp. 1053-1059
    • Ioannou, G.N.1    Weiss, N.S.2    Kowdley, K.V.3    Dominitz, J.A.4
  • 113
    • 0037840403 scopus 로고    scopus 로고
    • Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: A randomized trial
    • Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, Giugliano D. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003;289: 1799-804.
    • (2003) JAMA , vol.289 , pp. 1799-1804
    • Esposito, K.1    Pontillo, A.2    Di Palo, C.3    Giugliano, G.4    Masella, M.5    Marfella, R.6    Giugliano, D.7
  • 116
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004;126:586-97.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3    Carulli, N.4    Ruggiero, G.5    Day, C.P.6
  • 118
    • 4344701247 scopus 로고    scopus 로고
    • The multi-dimensional regulation of gene expression by fatty acids: Polyunsaturated fats as nutrient sensors
    • Clarke SD. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr Opin Lipidol 2004;15:13-8.
    • (2004) Curr Opin Lipidol , vol.15 , pp. 13-18
    • Clarke, S.D.1
  • 119
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004;114:147-52.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 120
    • 0034071520 scopus 로고    scopus 로고
    • Diabetes mellitus as a risk factor of liver cirrhosis in patients with chronic hepatitis B virus infection
    • Huo TI, Wu JC, Lee PC, Tsay SH, Chang FY, Lee SD. Diabetes mellitus as a risk factor of liver cirrhosis in patients with chronic hepatitis B virus infection. J Clin Gastroenterol 2000;30:250-4.
    • (2000) J Clin Gastroenterol , vol.30 , pp. 250-254
    • Huo, T.I.1    Wu, J.C.2    Lee, P.C.3    Tsay, S.H.4    Chang, F.Y.5    Lee, S.D.6


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