CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells

Hepatology

Volumn 30, Issue 4, 1999, Pages 987-996

  Nieto, Natalia ^a   Friedman, Scott L ^a   Greenwel, Patricia ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; COLLAGEN TYPE 1; COMPLEMENTARY DNA; DIMETHYLNITROSAMINE DEMETHYLASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; EXTRACELLULAR MATRIX; FIBROGENESIS; GENE INDUCTION; LIVER FIBROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; CELL LINE; COLLAGEN; CYTOCHROME P-450 CYP2E1; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR MEMBRANES; LIPID PEROXIDES; LIVER; OXIDATIVE STRESS; OXIDOREDUCTASES; RATS; RNA, MESSENGER; SUPEROXIDES; TRANSCRIPTION, GENETIC; TRANSFECTION; VITAMIN E;

EID: 0032835657     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300433     Document Type: Article

References (8)

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4. Olaso E, Friedman SL. Molecular regulation of hepatic fibrogenesis. J Hepatol 1998;29:836-847.
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6. Friedman SL. Hepatic Stellate Cells. In: Seminars in Liver Diseases 1996;14:101-130.
7. DeLeve LD. Glutathione defense in non-parenchymal cells. Semin Liver Dis 1998;18(4):43-53.
8. Whalen R, Rockey DC, Friedman SL, Boyer TD. Activation of rat hepatic stellate cells leads to loss of glutathione-S-transferases and their enzymatic activity against products of oxidative stress. (In press).