Disease-induced drug targeting using novel peptide-ligand albumins

Journal of Controlled Release

Volumn 72, Issue 1-3, 2001, Pages 157-164

  Meijer, D K F ^a   Beljaars, L ^a   Molema, G ^a   Poelstra, K ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Collagen type VI; Cyclic peptides; Disease induced targeting; Drug targeting hepatic drug delivery; Ligand peptides; Liver fibrosis; PDGF; Stellate cell

Indexed keywords

ANTIFIBROTIC AGENT; COLLAGEN TYPE 6; CYCLOPEPTIDE; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN G; LIGAND; OCTAPEPTIDE; PLATELET DERIVED GROWTH FACTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; DRUG TRANSPORT; ENDOCYTOSIS; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER FIBROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR UPREGULATION; STELLATE CELL; TARGET ORGAN; TEMPERATURE DEPENDENCE; TISSUE EXPANSION;

ALBUMINS; ANIMALS; DRUG DELIVERY SYSTEMS; ENDOTHELIUM, VASCULAR; HEPATOCYTES; KUPFFER CELLS; LIGANDS; LIVER; LIVER CIRRHOSIS; OLIGOPEPTIDES; RATS; UP-REGULATION;

EID: 0035858292     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00271-1     Document Type: Article

References (19)

1. Mechanisms for the hepatic clearance of oligopeptides and proteins
2. Hepatobiliary disposition and targeting of drugs and genes
3. Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis
4. Targeting of sugar- and charge modified albumins to fibrotic rat livers; the accessibility of hepatic cells after chronic bile duct ligation
5. Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of anti-fibrotic drugs to rat and human hepatic stellate cells
6. Successful targeting of albumin to rat hepatic stellate cells after attachment of cyclic peptides recognizing the collagen type VI receptor
7. A cyclic peptide recognizing platelet derived growth factor receptor as a homing device for targeting to hepatic stellate cells in fibrotic rat livers
8. Targeting of drugs to the liver
9. Specific targeting of the antiviral drug 5-Iodo 2′-deoxyuridine to the parenchymal liver cell using lactosylated poly-L-lysine
10. Targeting naproxen coupled to human serum albumin to nonparenchymal cells reduces endotoxin-induced mortality in rats with biliary cirrhosis
11. Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor
12. A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentation of rat hepatic stellate cells in primary culture
13. Inhibition of NFkB in activated rat hepatic stellate cells by proteosome inhibitors and an IkB super-repressor
14. Insulinlike growth factor-II/mannose 6-phosphate receptor is expressed on CC14-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells
15. Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis
16. The crucial role of spacer groups in macromolecular prodrug design
17. Adenine arabinoside monophosphate coupled to lactosaminated human albumin administered for 4 weeks in patients with chronic type B hepatitis decreased viremia without producing significant side effects
18. Targeting of antiviral drugs to the liver using glycoprotein carriers
19. Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activity of hepatic cells